Thermal tides in the Martian middle atmosphere as seen by the Mars Climate Sounder

The first systematic observations of the middle atmosphere of Mars (35–80km) with the Mars Climate Sounder (MCS) show dramatic patterns of diurnal thermal variation, evident in retrievals of temperature and water ice opacity. At the time of writing, the data set of MCS limb retrievals is sufficient for spectral analysis within a limited range of latitudes and seasons. This analysis shows that these thermal variations are almost exclusively associated with a diurnal thermal tide. Using a Martian general circulation model to extend our analysis, we show that the diurnal thermal tide dominates these patterns for all latitudes and all seasons

Observations of the martian atmosphere with the mars climate sounder

The Mars Climate Sounder (MCS) has obtained measurements of the Martian atmosphere for one Mars year. Onboard the Mars Reconnaissance Orbiter (MRO), MCS continues to acquire high vertical resolution profiles of temperature, dust, condensates of CO2 and H2O, and water vapor by observing the limb of the atmosphere from the surface to 80 km in the spectral intervals 0.3 – 3 ?m and 11.5 – 45 ?m [1]. This paper describes the investigation and introduces some of the observations being studied by the MCS science team. Other presentations by the team at this workshop will describe in greater detail results of ongoing research using MCS data

Structure and dynamics of the Martian lower and middle atmosphere as observed by the Mars Climate Sounder: Seasonal variations in zonal mean temperature, dust, and water ice aerosols

The first Martian year and a half of observations by the Mars Climate Sounder aboard the Mars Reconnaissance Orbiter has revealed new details of the thermal structure and distributions of dust and water ice in the atmosphere. The Martian atmosphere is shown in the observations by the Mars Climate Sounder to vary seasonally between two modes: a symmetrical equinoctial structure with middle atmosphere polar warming and a solstitial structure with an intense middle atmosphere polar warming overlying a deep winter polar vortex. The dust distribution, in particular, is more complex than appreciated before the advent of these high (~5 km) vertical resolution observations, which extend from near the surface to above 80 km and yield 13 dayside and 13 nightside pole-to-pole cross sections each day. Among the new features noted is a persistent maximum in dust mass mixing ratio at 15–25 km above the surface (at least on the nightside) during northern spring and summer. The water ice distribution is very sensitive to the diurnal and seasonal variation of temperature and is a good tracer of the vertically propagating tide

The Exomars Climate Sounder (EMCS) Investigation

The ExoMars Climate Sounder (EMCS) investigation is developed at the Jet Propulsion Laboratory (Principal Investigator J. T. Schofield) in collaboration with an international scientific team from France, the United Kingdom and the USA. EMCS plans to map daily, global, pole-to-pole profiles of temperature, dust, water and CO2 ices, and water vapor from the proposed 2016 ExoMars Trace Gas Orbiter (EMTGO). These profiles are to be assimilated into Mars General Circulation Models (MGCMs) to generate global, interpolated fields of measured and derived parameters such as wind

Phase I Evaluation of STA-1474, a Prodrug of the Novel HSP90 Inhibitor Ganetespib, in Dogs with Spontaneous Cancer

The novel water soluble compound STA-1474 is metabolized to ganetespib (formerly STA-9090), a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts. The purpose of the following study was to extend these observations and investigate the safety and efficacy of STA-1474 in dogs with spontaneous tumors.This was a Phase 1 trial in which dogs with spontaneous tumors received STA-1474 under one of three different dosing schemes. Pharmacokinetics, toxicities, biomarker changes, and tumor responses were assessed. Twenty-five dogs with a variety of cancers were enrolled. Toxicities were primarily gastrointestinal in nature consisting of diarrhea, vomiting, inappetence and lethargy. Upregulation of HSP70 protein expression was noted in both tumor specimens and PBMCs within 7 hours following drug administration. Measurable objective responses were observed in dogs with malignant mast cell disease (n = 3), osteosarcoma (n = 1), melanoma (n = 1) and thyroid carcinoma (n = 1), for a response rate of 24% (6/25). Stable disease (>10 weeks) was seen in 3 dogs, for a resultant overall biological activity of 36% (9/25).This study provides evidence that STA-1474 exhibits biologic activity in a relevant large animal model of cancer. Given the similarities of canine and human cancers with respect to tumor biology and HSP90 activation, it is likely that STA-1474 and ganetespib will demonstrate comparable anti-cancer activity in human patients

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, one year survival rates are only around ~45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human osteosarcoma. Finally, the current position of canine osteosarcoma genetic research is discussed and areas for additional work within the canine population are identified

A Meta-Analysis of the Relationship between Role Stress and Organizational Commitment: the Moderating Effects of Occupational Type and Culture

The demand for employees to be more productive while also being adaptable to new organizational pressures has intensified the nature of work and the demands placed upon employees. We meta-analyzed the relationship between employee role stress and organizational commitment and tested the effects of two potential moderators of this relationship. One-hundred and five studies (N = 37,993 individuals) conducted from 2001 to 2019 were included in the meta-analysis. Significant negative relationships were found between three forms of role stress (role ambiguity, role conflict, and role overload) and affective organizational commitment. All role stressors had stronger relationships with affective commitment than with continuance commitment which was not found to be significantly related to any of the types of role stress tested. Overall, employees’ perceived role stress was inversely associated with their desire to stay with the organization (affective commitment) but not their need to stay (continuance commitment) with the organization. Moderator analyses revealed that occupational type and culture significantly influenced role stressor-affective commitment relationships. Specifically, stronger relationships were found for studies conducted in transactional occupations and western cultures. Implications of findings for organizations are discussed and directions for future research are provided.Ye