Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease

23 women with a chronic form of coronary heart disease (CHD) were examined before and after two months of taking simvastatin at doses of 40 and 80 mg/day. Regardless of the dosage the reduction in total cholesterol (TC) level, low-density lipoprotein cholesterol (LDL-C) and atherogenic index (Al) was found that pointed at the strengthening of receptor-mediated endocytosis in LDL-C cells with all portable fatty acids (FA) in them by apoB-100 cells, in various forms of esters. The spectrum of FA in the erythrocyte membrane phospholipids (FL) was researched by gas-liquid chromatography-mass spectrometry. Redistribution of FA was revealed after treatment with different doses: reduction of the unsaturation index (UI) of the membranes erythrocytes indicated a violation of physical, chemical and functional properties of cell membranes. The content of the FA-membrane substrates and substrates of vitamin F, triglycerol substrates (TGL) decreased and FA-energy substrates cells increased. Probably, the ability of statins to activate the desaturase enzymes had an effect of the increasing of long-chain ω-9 FA content. In this case the reduction of oleic ω-9 FA influenced the reduction of TGL. Unlike doses of 40 mg/day treatment at a dosage of 80 mg/day in women resulted the increase of relation ω-3/ω-6 LC and the decrease of dihomo-γ-linolenic LCD. It indicated the formation of favorable conditions of the normalization of cell function in vivo. Under these conditions the level of palmitic FA and, correspondingly, the activity of atheromatosis decreased

Slaughter weight rather than sex affects carcass cuts and tissue composition of Bisaro pigs

Carcass cuts and tissue composition were assessed in Bisaro pigs (n=64) from two sexes (31 gilts and 33 entire males) reared until three target slaughter body-weights (BW) means: 17 kg, 32 kg, and 79 kg. Dressing percentage and backfat thickness increased whereas carcass shrinkage decreased with increasing BW. Slaughter weight affected most of the carcass cut proportions, except shoulder and thoracic regions. Bone proportion decreased linearly with increasing slaughter BW, while intermuscular and subcutaneous adipose tissue depots increased concomitantly. Slaughter weight increased the subcutaneous adipose tissue proportion but this impaired intramuscular and intermuscular adipose tissues in the loin primal. The sex of the pigs minimally affected the carcass composition, as only the belly weight and the subcutaneous adipose tissue proportions were greater in gilts than in entire males. Light pigs regardless of sex are recommended to balance the trade-offs between carcass cuts and their non-edible compositional outcomes.Work included in the Portuguese PRODER research Project BISOPORC – Pork extensive production of Bísara breed, in two alternative systems: fattening on concentrate vs chesnut, Project PRODER SI I&DT Medida 4.1 “Cooperação para a Inovação”. The authors are grateful to Laboratory of Carcass and Meat Quality of Agriculture School of Polytechnic Institute of Bragança ‘Cantinho do Alfredo’. The authors are members of the MARCARNE network, funded by CYTED (ref. 116RT0503).info:eu-repo/semantics/publishedVersio

Forced-ferromagnetic state in a Tm2Fe17H5 single crystal

International audienceWe report the attainment of the ferromagnetic state in an interstitially modified heavy rare-earth-iron intermetallic compound in an external magnetic field. The starting composition is RE2Fe17, which is the RE-Fe binary richest in iron. We concentrate on the Tm-Fe compound, which is the most sensitive to magnetic field. The maximum possible amount of hydrogen (5 at. H/f.u.) is inserted into a Tm2Fe17 single crystal. We demonstrate that in a magnetic field of 57 T Tm2Fe17H5 reaches the ferromagnetic state with an enviably high polarization of 2.25 T

Magnetocrystalline anisotropy of SmFe_11-xCo_xTiH_y

The magnetocrystalline anisotropy of bunched single crystals of SmFe11-xCoxHy (x = 0, 1, 2, 3, y < 1) was studied using a fitting procedure of magnetization curves. The anisotropy constants obtained were compared to those of the corresponding nonhydrided compounds. A drastic change in anisotropy as a result of hydrogenation was found which is discussed in terms of a point charge model. An unexpectedly high room temperature value of the first anisotropy constant was observed