Sustained, multifaceted improvements in mental well-being following psychedelic experiences in a prospective opportunity sample

In the last 15 years, psychedelic substances, such as LSD and psilocybin, have regained legitimacy in clinical research. In the general population as well as across various psychiatric populations, mental well-being has been found to significantly improve after a psychedelic experience. Mental well-being has large socioeconomic relevance, but it is a complex, multifaceted construct. In this naturalistic observational study, a comprehensive approach was taken to assessing well-being before and after a taking a psychedelic compound to induce a “psychedelic experience.” Fourteen measures of well-being related constructs were included in order to examine the breadth and specificity of change in well-being. This change was then analysed to examine clusters of measures changing together. Survey data was collected from volunteers that intended to take a psychedelic. Four key time points were analysed: 1 week before and 2 weeks, 4 weeks, and 2 years after the experience (N = 654, N = 315, N = 212, and N = 64, respectively). Change on the included measures was found to cluster into three factors which we labelled: 1) “Being well”, 2) “Staying well,” and 3) “Spirituality.” Repeated Measures Multivariate Analysis of Variance revealed all but the spirituality factor to be improved in the weeks following the psychedelic experience. Additional Mixed model analyses revealed selective increases in Being Well and Staying Well (but not Spirituality) that remained statistically significant up to 2 years post-experience, albeit with high attrition rates. Post-hoc examination suggested that attrition was not due to differential acute experiences or mental-health changes in those who dropped out vs. those who did not. These findings suggest that psychedelics can have a broad, robust and sustained positive impact on mental well-being in those that have a prior intention to use a psychedelic compound. Public policy implications are discussed

Australian Sphingidae – DNA Barcodes Challenge Current Species Boundaries and Distributions

© 2014 Rougerie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article

Модернизация автоматической системы регулирования уровня воды в парогенераторе типа ПГВ-440 Нововоронежской АЭС

The Innoslab design, already established for neodymium doped laser crystals, was applied to ytterbium doped laser materials. Recent progresses in brightness of high power diode lasers facilitate efficient pumping of quasi-three-level laser materials. Innoslab amplifiers are compared to competing thin-disk and fiber fs-amplifiers. A compact diode-pumped Yb:YAG Innoslab fs-oscillator-amplifier system, scalable to the kilowatt range, was realized. Numerical simulations result in conditions for high efficiency and beam quality. Nearly transform and diffraction limited 680 fs pulses at 400 W average output power and 76 MHz repetition rate without using CPA technology have been achieved at room temperature so far

Expression of an Arc-Immunoreactive Protein in the Adult Zebrafish Brain Increases in Response to a Novel Environment

Zebrafish are a powerful research tool in the field of neuroscience, offering several logistical and physiological advantages over rodents as a research model. However, the molecular dynamics of this model organism, especially with regards to learning and memory, are scarcely known. The current study explored the zebrafish brain for the presence of a protein bearing a similar function to the activity-regulated, cytoskeleton-associated protein (Arc), a critical player in synaptic plasticity. The adult zebrafish brain was found to express a protein with immunoreactivity against the anti-Arc antibody H-300. Immunoreactivity was detected ubiquitously, especially in areas known as adult progenitor cell zones. The protein, termed Arc-immunoreactive protein (AIP), increased in the telencephalon but not the optic tectum 60 min after exposure to a novel environment. Epileptiform brain activity, however, did not induce AIP expression. Evidence presented herein suggests AIP may be the neuropeptide Y receptor rather than a zebrafish homolog of Arc

Data Transformation and Semantic Log Purging for Process Mining

Existing process mining approaches are able to tolerate a certain degree of noise in the process log. However, processes that contain infrequent paths, multiple (nested) parallel branches, or have been changed in an ad-hoc manner, still pose major challenges. For such cases, process mining typically returns "spaghetti-models", that are hardly usable even as a starting point for process (re-)design. In this paper, we address these challenges by introducing data transformation and pre-processing steps that improve and ensure the quality of mined models for existing process mining approaches. We propose the concept of semantic log purging, the cleaning of logs based on domain specific constraints utilizing semantic knowledge which typically complements processes. Furthermore we demonstrate the feasibility and effectiveness of the approach based on a case study in the higher education domain. We think that semantic log purging will enable process mining to yield better results, thus giving process (re-)designers a valuable tool

A Search for Dark Higgs Bosons

Recent astrophysical and terrestrial experiments have motivated the proposal of a dark sector with GeV-scale gauge boson force carriers and new Higgs bosons. We present a search for a dark Higgs boson using 516 fb-1 of data collected with the BABAR detector. We do not observe a significant signal and we set 90% confidence level upper limits on the product of the Standard Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots for b/w printin

A Case-Based Approach to Business Process Monitoring

International audienceThe agile workflow technology deals with flexible workflow adaptation and overriding, in case of foreseen as well as unforeseen changes and problems in the operating business environment. One key issue that an agile workflow system should address is Business Process (BP) monitoring. This consists in properly highlighting and organizing non-compliances and adaptations with respect to the default process schema. Such an activity can be the starting point for other very critical tasks, such as quality assessment and process reengineering. In this paper, we introduce an automated support to BP monitoring, which exploits the Case-based Reasoning (CBR) methodology. CBR is particularly well suited for managing exceptional situations, and has been proposed in the literature for process change reuse and workflow adaptation support. Our work extends these functionalities by retrieving traces of process execution similar to the current one, which can then be automatically clustered. Retrieval and clustering results can provide support both to end users, in the process instance execution phase, and to process engineers, in (formal) process quality evaluation and long term process schema redefinition. Our approach in practice is illustrated by means of a case study in the field of stroke management

Bilayer manganites: polarons in the midst of a metallic breakdown

The exact nature of the low temperature electronic phase of the manganite materials family, and hence the origin of their colossal magnetoresistant (CMR) effect, is still under heavy debate. By combining new photoemission and tunneling data, we show that in La{2-2x}Sr{1+2x}Mn2O7 the polaronic degrees of freedom win out across the CMR region of the phase diagram. This means that the generic ground state is that of a system in which strong electron-lattice interactions result in vanishing coherent quasi-particle spectral weight at the Fermi level for all locations in k-space. The incoherence of the charge carriers offers a unifying explanation for the anomalous charge-carrier dynamics seen in transport, optics and electron spectroscopic data. The stacking number N is the key factor for true metallic behavior, as an intergrowth-driven breakdown of the polaronic domination to give a metal possessing a traditional Fermi surface is seen in the bilayer system.Comment: 7 pages, 2 figures, includes supplementary informatio