The effects of particle loading on turbulence structure and modelling

The objective of the present research was to extend the Direct Numerical Simulation (DNS) approach to particle-laden turbulent flows using a simple model of particle/flow interaction. The program addressed the simplest type of flow, homogeneous, isotropic turbulence, and examined interactions between the particles and gas phase turbulence. The specific range of problems examined include those in which the particle is much smaller than the smallest length scales of the turbulence yet heavy enough to slip relative to the flow. The particle mass loading is large enough to have a significant impact on the turbulence, while the volume loading was small enough such that particle-particle interactions could be neglected. Therefore, these simulations are relevant to practical problems involving small, dense particles conveyed by turbulent gas flows at moderate loadings. A sample of the results illustrating modifications of the particle concentration field caused by the turbulence structure is presented and attenuation of turbulence by the particle cloud is also illustrated

Religiosity and Sexual Risk Behaviors Among Latina Adolescents: Trends from 1995 to 2008

Purpose: The purpose of this study was to determine trends in the influence of religiosity on sexual activity of Latina adolescents in the United States from 1995 to 2008 and to determine if differences existed between the Mexican American and other Latina groups. Methods: The sample comprised the subset of unmarried, 15–21-year-old (mean 17 years) Latina female respondents in the 1995 (n=267), 2002 (n=306), and 2006–2008 (n=400) National Survey of Family Growth (NSFG) datasets. Associations between religiosity (importance of religion and service attendance) and history of ever having sex, number of sex partners, and age of sexual debut were investigated. Results: Less than one half of Latinas in 1995 (44%) and in 2006–2008 (44%) reported that religion was very important to them, whereas in 2002, 50% reported it was important. Only in 1995 did Latinas who viewed religion as very important have a significantly lower level of sexual initiation. In 1995 and in 2006–2008, Latinas who held religion as very important had significantly fewer partners. In all three cohorts, the higher religious importance group had higher virgin survival rates. Across cohorts, approximately one third of respondents reported frequent religious attendance. In all cohorts, frequent attenders were less likely to have had sex, had fewer partners, and had older age at sexual debut. The survival rate as virgins for Mexican origin Latinas was higher in 1995 and 2002 compared to non-Mexican Latinas but was almost the same in 2006–2008. Conclusions: Religiosity had a protective association with sexual activity among Latina adolescents. The association of importance of religion with sexual activity has diminished from 1995 to 2008, however, whereas the importance of service attendance has remained stable. The influence of religion was more apparent among the Latinas of Mexican origin, but this greater influence also diminished by 2006–2008

Is Steam a Modern Heating Medium or a Victorian Hangover?

In the UK many hospitals use steam as a heating medium. It is an accepted fact that steam can carry considerable amounts of heat energy, but is heating by steam really a cost effective and energy efficient method for hospital engineering services? This paper examines some steam and MTHW case studies in terms of energy and operation, and some quantifiable parameters for comparison of the two have been obtained. An important feature revealed by the study is that optimum energy and operational performance for both steam and MTHW systems is directly related to management and maintenance. Other factors affecting the choice of steam are also examined. For example, when choosing between steam and MTHW, how important a factor are those unique hospital applications such as laundries and sterilization equipment, that are traditionally provided for by steam? Interviews were conducted with engineering professionals at a large North-West hospital in order to consider the specialist health service applications for steam. The investigation concludes that although steam retains a Victorian image, in hospital applications its energy and financial performance costs are comparable, and sometimes better than hot water alternatives

Interactive Methods for Teaching Action Potentials, an Example of Teaching Innovation from Neuroscience Postdoctoral Fellows in the Fellowships in Research and Science Teaching (FIRST) Program

Acquiring a faculty position in academia is extremely competitive and now typically requires more than just solid research skills and knowledge of one’s field. Recruiting institutions currently desire new faculty that can teach effectively, but few postdoctoral positions provide any training in teaching methods. Fellowships in Research and Science Teaching (FIRST) is a successful postdoctoral training program funded by the National Institutes of Health (NIH) providing training in both research and teaching methodology. The FIRST program provides fellows with outstanding interdisciplinary biomedical research training in fields such as neuroscience. The postdoctoral research experience is integrated with a teaching program which includes a How to Teach course, instruction in classroom technology and course development and mentored teaching. During their mentored teaching experiences, fellows are encouraged to explore innovative teaching methodologies and to perform science teaching research to improve classroom learning. FIRST fellows teaching neuroscience to undergraduates have observed that many of these students have difficulty with the topic of neuroscience. Therefore, we investigated the effects of interactive teaching methods for this topic. We tested two interactive teaching methodologies to determine if they would improve learning and retention of this information when compared with standard lectures. The interactive methods for teaching action potentials increased understanding and retention. Therefore, FIRST provides excellent teaching training, partly by enhancing the ability of fellows to integrate innovative teaching methods into their instruction. This training in turn provides fellows that matriculate from this program more of the characteristics that hiring institutions desire in their new faculty

Maximizing nearest neighbour entanglement in finitely correlated qubit--chains

We consider translationally invariant states of an infinite one dimensional chain of qubits or spin-1/2 particles. We maximize the entanglement shared by nearest neighbours via a variational approach based on finitely correlated states. We find an upper bound of nearest neighbour concurrence equal to C=0.434095 which is 0.09% away from the bound C_W=0.434467 obtained by a completely different procedure. The obtained state maximizing nearest neighbour entanglement seems to approximate the maximally entangled mixed states (MEMS). Further we investigate in detail several other properties of the so obtained optimal state.Comment: 12 pages, 4 figures, 2nd version minor change

A One-Dimensional Volcanic Plume Model for Predicting Ash Aggregation

During explosive volcanic eruptions, volcanic ash is ejected into the atmosphere, impacting aircraft safety and downwind communities. These volcanic clouds tend to be dominated by fine ash (μm in diameter), permitting transport over hundreds to thousands of kilometers. However, field observations show that much of this fine ash aggregates into clusters or pellets with faster settling velocities than individual particles. Models of ash transport and deposition require an understanding of aggregation processes, which depend on factors like moisture content and local particle collision rates. In this study, we develop a Plume Model for Aggregate Prediction, a one-dimensional (1D) volcanic plume model that predicts the plume rise height, concentration of water phases, and size distribution of resulting ash aggregates from a set of eruption source parameters. The plume model uses a control volume approach to solve mass, momentum, and energy equations along the direction of the plume axis. The aggregation equation is solved using a fixed pivot technique and incorporates a sticking efficiency model developed from analog laboratory experiments of particle aggregation within a novel turbulence tower. When applied to the 2009 eruption of Redoubt Volcano, Alaska, the 1D model predicts that the majority of the plume is over-saturated with water, leading to a high rate of aggregation. Although the mean grain size of the computed Redoubt aggregates is larger than the measured deposits, with a peak at 1 mm rather than 500 μm, the present results provide a quantitative estimate for the magnitude of aggregation in an eruption

Mycotoxin exposure and human cancer risk : a systematic review of epidemiological studies

In recent years, there has been an increasing interest in investigating the carcinogenicity of mycotoxins in humans. This systematic review aims to provide an overview of data linking exposure to different mycotoxins with human cancer risk. Publications (2019 and earlier) of case–control or longitudinal cohort studies were identified in PubMed and EMBASE. These articles were then screened by independent reviewers and their quality was assessed according to the Newcastle–Ottawa scale. Animal, cross‐sectional, and molecular studies satisfied criteria for exclusion. In total, 14 articles were included: 13 case–control studies and 1 longitudinal cohort study. Included articles focused on associations of mycotoxin exposure with primary liver, breast, and cervical cancer. Overall, a positive association between the consumption of aflatoxin‐contaminated foods and primary liver cancer risk was verified. Two case–control studies in Africa investigated the relationship between zearalenone and its metabolites and breast cancer risk, though conflicting results were reported. Two case–control studies investigated the association between hepatocellular carcinoma and fumonisin B1 exposure, but no significant associations were observed. This systematic review incorporates several clear observations of dose‐dependent associations between aflatoxins and liver cancer risk, in keeping with IARC Monograph conclusions. Only few human epidemiological studies investigated the associations between mycotoxin exposures and cancer risk. To close this gap, more in‐depth research is needed to unravel evidence for other common mycotoxins, such as deoxynivalenol and ochratoxin A. The link between mycotoxin exposures and cancer risk has mainly been established in experimental studies, and needs to be confirmed in human epidemiological studies to support the evidence‐based public health strategies

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency

Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells. We previously demonstrated that VPA_ AFS cells, human amniocytes cultivated with valproic acid (VPA) acquired functional pluripotency while remaining distinct from human embryonic stem cells (hESCs), questioning the relationship between the modulation of cell fate and molecular regulation of the pluripotency network. Here, we used single-cell analysis and functional assays to reveal that VPA treatment resulted in a homogeneous population of self-renewing non-transformed cells that fulfill the hallmarks of pluripotency, i.e., a short G1 phase, a dependence on glycolytic metabolism, expression of epigenetic modifications on histones 3 and 4, and reactivation of endogenous OCT4 and downstream targets at a lower level than that observed in hESCs. Mechanistic insights into the process of VPA-induced reprogramming revealed that it was dependent on OCT4 promoter activation, which was achieved independently of the PI3K (phosphatidylinositol 3-kinase)/ AKT/ mTOR (mammalian target of rapamycin) pathway or GSK3 beta inhibition but was concomitant with the presence of acetylated histones H3K9 and H3K56, which promote pluripotency. Our data identify, for the first time, the pluripotent transcriptional and molecular signature and metabolic status of human chemically induced pluripotent stem cells