Digital Manufacturing in SMEs based on the context of the Industry 4.0 framework-one approach

Serbia is rapidly working on the development and implementation of digital manufacturing models in SMEs, through the national Industry 4.0 Platform. The aim is to create a pilot intelligent workshop which would be used to develop and showcase examples of best practice for digital manufacturing. Currently, most SMEs use CAD, CAM, ERP models, which form the basis for the development of the concept of digital manufacturing through cloud computing, BDA, IIoT and smart supply-chains, as elements of Industry 4.0. This paper gives a practical example of an SME with all the above-mentioned elements of digital manufacturing

Laboratorijske analize krvnog seruma i urina pasa sa akutnom renalnom insuficijencijom izazvanom gentamicinom

The use of aminoglucoside antibiotics can be a potential risk for renal parenchyma damage and consequently acute renal failure (ARF). ARF is a syndrome that develops from progressive nephron damage resulting in the loss of renal function. Numerous experimental models have been used to study acute renal failure mainly describing histo-pathological changes in the structure of this organ. Our investigations were conducted in order to evaluate the functional capacity of kidneys in dogs with ARF induced by application of gentamicin in high doses of 80 mg/kg/24 , during 7 days. For that purpose, physico-chemical properties of the urine, concentrations of relevant parameters in the sera and urine and endogenous creatinine clearance were estimated. Our results indicate that gentamicin, in doses 20 times higher than therapeutic ones, causes progressive ARF starting from the 3 day of application.Pod određenim uslovima upotreba aminoglukozidnih antibiotika može predstavljati potencijalni rizik za nastanak oštećenja u parenhimu bubrega i posledične akutne renalne insuficijencije (ARI). ARI je sindrom koji nastaje usled progresivnog propadanja nefrona, što dovodi do gubitka sposobnosti bubrega da obavljaju svoju funkciju. Za proučavanje akutne renalne insuficijencije korišćen je veći broj različitih eksperimentainih modela pri čemu su uglavnom opisivane histopatološke promene u ovom organu. Naša ispitivanja su imala za cilj da se utvrdi funkcionalna sposobnost bubrega pasa u toku akutne renalne insuficijencije, izazvane visokim dozama gentamicina (80 mg/kg/24h), aplikovanim tokom 7 dana. U tom cilju su određivane fizičko-hemijske karakteristike mokraće, koncentracija relevantnih sastojaka u serumu i urinu kao i klirens endogenog kreatininina. Dobijeni rezultati ukazuju da se dozama gentamicina, dvadeset puta većim od terapijskih, već posle tri dana aplikacije izaziva ARI koja ima progresivan tok do kraja ogleda

Novel methods for axial fan impeller geometry analysis and experimental investigations of the generated swirl turbulent flow

Geometry analysis of the axial fan impeller, experimentally obtained operating characteristics and experimental investigations of the turbulent swirl flow generated behind the impeller are presented in this paper. Formerly designed and manufactured, axial fan impeller blade geometry (originally designed by Prof Dr-Ing. Z. Protic(dagger)) has been digitized using a three-dimensional scanner. In parallel, the same impeller has been modeled by beta version software for modeling axial turbomachines, based on modified classical calculation. These results were compared. Afterwards, the axial fan operating characteristics were measured on the standardized test rig in the Laboratory for Hydraulic Machinery and Energy Systems, Faculty of Mechanical Engineering, University of Belgrade. Optimum blade impeller position was determined on the basis of these results. Afterwards, impeller with angle 22 without outlet vanes, was positioned in a circular pipe. Rotational speed has been varied in the range from 500 till 2500 rpm. Reynolds numbers generated in this way, calculated for axial velocity component, was in the range from 0.68.10(5) till 2.5.10(5). Laser Doppler anemometry measurements and stereo particle image velocimetry measurements of the three-dimensional velocity field in the swirl turbulent fluid flow behind the axial fan have been performed for each regime. Obtained results point out extraordinary complexity of the structure of generated three-dimensional turbulent velocity fields

Risk assessment of the exposure to organohalogenated contaminants and heavy metals in food

Zadatak svih činilaca uključenih u proizvodnju hrane je da stvore uslove da hrana koja dolazi do potrošača bude bezbedna. Ocena bezbednosti hrane, između ostalog, podrazumeva i procenu rizika od supstanci prisutnih u hrani, naročito od onih koje nemaju gradivnu ili fiziološku vrednost. U realnim okolnostima ljudi su preko hrane istovremeno izloženi delovanju brojnih ksenobiotika, pa i teških metala i organohalogenih jedinjenja koji su odabrani za proučavanje u ovoj studiji. Pored procene rizika zasnovane na ispitivanju svakog pojedinačnog kontaminanta, cilj ove studije je bio i sprovođenje integrativne procene rizika poređenjem toksičnih efekata pojedinačnih kontaminanata i njihove smeše zbog istovremene izloženosti ovim toksičnim supstancama. Pretpostavka je da, iako ne postoji rizik pri izloženosti pojedinačnim toksičnim supstancama, integralni pristup proceni izloženosti može da ukaže na povećan rizik. Svi uzorci ispitanih namirnica su bili u skladu sa važećim propisom, sa izuzetkom jednog uzorka ribe (Hg) i 16 uzoraka kakaoa (Cd). Kadmijum je detektovan u najvećem broju vrsta namirnica kao i u najvećem broju ispitanih uzoraka; organohalogena jedinjenja su detektovana isključivo u namirnicama animalnog porekla – DDT u mleku, proizvodima od mleka i ribi, a ndl-PCB i PBDE isključivo u ribi. Najviše koncentracije kadmijuma dokazane su u lignjama i školjkama, žive u rečnim ribama, olova u čajevima i začinima, DDT u slatkovodnoj ribi a ndl-PCB i PBDE u morskoj ribi. Zbog značajnog udela u ishrani glavni izvor ekspozicije kadmijumu u sve tri posmatrane grupe bile su žitarice i povrće. Unos žive bio je dominantno preko ribe, a olova preko žitarica, voća i povrća. Determinističkom metodologijom dokazan je povećan rizik od unosa ispitanih kontaminanata u prosečnoj opštoj populaciji, populaciji na mediteranskoj dijeti i populaciji dece samo za ndl-PCB. Pored ndl-PCB, probabilističkom metodologijom je procenjen povećan rizik i od unosa Cd za prosečno izloženu populaciju sve tri ispitivane grupe...The principal goal of food-producing stakeholders is to provide safe food for the consumer. Food safety assessment consists of (among the other) risk assessment in respect to supstances that can be present in food, especially those of no nutritional or physiological significance. In real-life circumstances, humans are exposed to various xenobiotics, even heavy metals and organohalogenated compounds through food consumption, which are chosen for investigation in this study. Besides the risk assessment based on investigation of each contaminant individually, the aim of this study was to conduct integrative risk assessment by comparison of toxic effects between individual contaminants and their mixtures, due to the simultaneous exposure to these toxic substances. The hypothesis is, that even no increased risk exists through exposure to individual toxic substances, integrative approach to risk assessment may reveal increased risk. All samples of investigated foodstuffs were compliant with current legislative except one fish sample (Hg) and 16 cocoa powder samples (Cd). Cadmium was the most detected element in most types of foodstuffs and in largest number of tested samples as well; organohalogenated compounds were detected exclusively in animal-originated foodstuffs – DDT in milk, dairy products and fish, while ndl-PCBs and PBDE were detected in fish only. The highest concentrations of cadmium were found in squids and clams, mercury in freshwater fish, lead in teas and spices, DDT in freshwater fish, while the highest concentrations of ndl-PCBs and PBDE were found in marine fish. Due to the significant contribution to the total diet, the major exposition sources of cadmium in all three investigated groups were cereals and vegetables. Dominant intake of mercury is through fish, while intake of lead occurs through cereals, fruits and vegetables..

Etymology in journal "Naš jezik" ; Этимология в журнале "Наш језик"

Предмет дисертације су етимолошки подаци који се налазе у чланцима објављеним у лингвистичком часопису „Наш језик“ у временском распону од 1932/1933. до 2013. године. Међу његовим корицама су се, у складу с програмом часописа, нашли радови посвећени изучавању и нормирању српског (раније српско-хрватског) књижевног језика, решавању питања језичке културе, неговању те културе и усмеравању правца њеног даљег развитка. Иако је у „Нашем језику“ објављен мањи број етимолошких студија, часопис се показао као богат извор етимолошких података, а под тим подразумевамо сваку информацију која се тиче порекла, развоја и/или историје одређене речи, израза или синтаксичке конструкције...The subject of this dissertation is the etymological information found in the papers published in the linguistic journal Naš jezik from 1932/1933 to 2013. In accordance with the journal program, the papers published in these volumes are dealing with topics such as study and standardization of the Serbian (formerly Serbo-Croatian) literary language; they are also addressing various language culture issues, fostering language culture as well as steering the direction of its further development. Even though only a smaller number of etymological studies have been published in the journal Naš jezik, it has proven to be a rich source of etymological information, and by that, we mean any information concerning origin, development, and/or history of a specific word, phrase or syntactic construction..

Digital Manufacturing in SMEs based on the context of the Industry 4.0 framework-one approach

Serbia is rapidly working on the development and implementation of digital manufacturing models in SMEs, through the national Industry 4.0 Platform. The aim is to create a pilot intelligent workshop which would be used to develop and showcase examples of best practice for digital manufacturing. Currently, most SMEs use CAD, CAM, ERP models, which form the basis for the development of the concept of digital manufacturing through cloud computing, BDA, IIoT and smart supply-chains, as elements of Industry 4.0. This paper gives a practical example of an SME with all the above-mentioned elements of digital manufacturing

Ispitivanje auto-(in)kompatibilnosti genotipova badema (Prunus amygdalus batsch) selekcionisanih na Slankamenačkom bregu

Due to the importance of obtaining almond cultivars adapted to the agroecological conditions of Serbia, in the period 2005-2006 pollen viability and self-(in)compatibility in 19 almond genotypes selected from the seedling population on Slankamen hill, were studied. All analyzed almond genotypes had good (50-70%) or high (over 70%) pollen germination. The study of self-(in)compatibility was done by monitoring of the fruit set in the field and observing self-pollen growth by fluorescence microscopy. Self-incompatibility was confirmed in all the 19 genotypes by both methods. Pollen tube penetration was stopped mostly at the upper third of the style of all genotypes, with characteristic irregularities.U cilju stvaranja sorti badema prilagođenih agro-ekološkim uslovima Srbije u periodu 2005.-2006. godine proučavana je klijavost polena i auto (in)kompatibilnost 19 genotipova badema odabranih iz populacije sejanaca na Slankamenačkom bregu. Svi ispitivani genotipovi badema imali su dobru (50-70- %) ili visoku klijavost polena (preko 70%). Ispitivanja auto (in)kompatibilnosti su obavljena praćenjem zametanja u poljskim uslovima i metodom fluorescentne mikroskopije. Auto inkompatibilnost je u oba slučaja bila izražena kod svih 19 genotipova. Kod svih genotipova polenove cevčice su zaustavljale rast najdalje u gornjoj trećini stubića uz karakteristične petlje, zadebljanja i krivudanja

Non-invasive screening: The probability of events

Congenital anomalies are the cause of 20.0-25.0% of cases of perinatal death, while 3.0% of children are born with malformations of varying size. We examined the predictive values and defined the credibility ratio of the combined test results. Sensitivity of the test is 94.0%, and specificity is 99.0%. The positive likelihood ratio [likelihood ratio test (LR+)] is 94.00; a negative likelihood ratio [likelihood ratio test (LR-)] is 0.06. The pretest probability that pregnant women carry a fetus with chromosomal abnormality is 1:250. Posttest odds after the combined test to discover this abnormality are 0.3760, and probability of the same case is 0.2732 if it happens that the test result is positive. The result of our study confirms the justification of combined test usage in routine clinical practice, since the posttest odds rate in the case of a positive screening increases several times over (almost 90 times); the probability of detecting a chromosomal abnormality was about 70 times