78 research outputs found
Migration of giant planets in planetesimal discs
Planets orbiting a planetesimal circumstellar disc can migrate inward from
their initial positions because of dynamical friction between planets and
planetesimals. The migration rate depends on the disc mass and on its time
evolution. Planets that are embedded in long-lived planetesimal discs, having
total mass of , can migrate inward a large distance and
can survive only if the inner disc is truncated or because of tidal interaction
with the star. In this case the semi-major axis, a, of the planetary orbit is
less than 0.1 AU. Orbits with larger are obtained for smaller value of the
disc mass or for a rapid evolution (depletion) of the disc. This model may
explain several of the orbital features of the giant planets that were
discovered in last years orbiting nearby stars as well as the metallicity
enhancement found in several stars associated with short-period planets.Comment: 21 pages; 6 encapsulated figures. Accepted by MNRA
The influence of dynamical friction on the collapse of spherical density pertubation
We solve numerically the equations of motion for the collapse of a shell of baryonic matter falling into the central regions of a cluster of galaxies, taking into account of the presence of the substructure inducing dynamical friction. The evolution of the expansion parameter a(t) of the perturbation is calculated in spherical systems. The effect of dynamical friction is to reduce the binding radius and the total mass accreted by the central regions. Using a peak density profile given by Bardeen et al. (1986) we show how the binding radius of the perturbation is modified by dinamical friction. We show how dynamical friction modifies the collapse parameter of the perturbation slowing down the collapse
A 3-D wavelet analysis of substructure in the Coma cluster: statistics and morphology
Evidence for clustering within the Coma cluster is found by means of a
multiscale analysis of the combined angular-redshift distribution. We have
compiled a catalogue of 798 galaxy redshifts from published surveys from the
region of the Coma cluster. We examine the presence of substructure and of
voids at different scales ranging from Mpc, using
subsamples of the catalogue, ranging from km/s to km/s.
Our substructure detection method is based on the wavelet transform and on the
segmentation analysis. The wavelet transform allows us to find out structures
at different scales and the segmentation method allows us a quantitative
statistical and morphological analysis of the sample. From the whole catalogue
we select a subset of 320 galaxies, with redshifts between cz=5858 km/s and
cz=8168 km/s that we identify as belonging to the central region of Coma and on
which we have performed a deeper analysis, on scales ranging from
kpc to Mpc. Our results are expressed in terms of the number of
structures or voids and their sphericity for different values of the threshold
detection and at all the scales investigated. According to our analysis, there
is strong evidence for multiple hierarchical substructure, on scales ranging
from a few hundreds of kpc to about Mpc. The morphology of these
substructures is rather spherical. On the scale of kpc we find two
main subclusters which where also found before, but our wavelet analysis shows
even more substructures, whose redshift position is approximatively marked by
these bright galaxies: NGC 4934 & 4840, 4889, 4898 & 4864, 4874 & 4839, 4927,
4875.Comment: 24 pages, 6 figures. ApJ (Main Journal), accepted for publication.
Added one section on statistical tests and slightly modified text and
abstrac
Anabolic effects and inhibition of interleukin 6 production induced by neridronate on human osteoblasts
Bisphosphonates (BPs) are pharmacological compounds widely used in the treatment of a variety of bone-related diseases, particularly where the bone-turnover is skewed in favour of osteolysis. The mechanisms by which BPs reduce bone-resorption directly acting on osteoclasts (OCs) are now largely clarified even at molecular level. The researches concerning the BPs effects on osteoblasts (OBs) have instead shown variable results. Objectives: We have investigated the efficacy of neridronate (NER), an amino-BP, as anabolic agent on human OBs. Moreover, we have tried to verify if NER is able to negatively modulate the production of IL-6 on OBs stimulated or not by the pro-inflammatory cytokine Il-1b. Methods: We have tested if different concentrations of NER (from 10-11M to 10-3M), added to primary human OB cultures, could affect the cells number, the endogenous cellular alkaline phosphatase (ALP) activity, the collagen I (COLI) synthesis, the formation of mineralized nodules and the IL-6 production. Our experimental approach was performed testing a wide range of NER concentrations because, under physiological conditions, OBs seems to be exposed to variable and transient levels of the drug. Results: Our results show that NER doesn't negatively affect in vitro the viability, proliferation and cellular activity of human OBs, even after 20 days of exposure to concentrations ²10-5 M (therapeutic dose). In addition, NER seems to enhance the differentiation of cultured OBs in mature bone-forming cells. A maximum increase of COL-I synthesis (+25% after 4 days; p<0.05), ALP activity (+50% after 10 days; p<0.01) and mineralized nodules (+48% after 20 days; p<0.05) was observed in cultures treated with NER 10-8M. A maximal reduction of IL-6 secretion (-24% on IL-1b stimulated cultures and -29% on unstimulated cultures) was observed for NER 10-9 M. Conclusions: These results encourage the use of neridronate in therapy of demineralizing metabolic bone disorders
c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells
Mesenchymal progenitor cells (MPCs) have been hypothesized as cells of origin for sarcomas, and c-Fos transcription factor has been showed to act as an oncogene in bone tumors. In this study, we show c-Fos is present in most sarcomas with chondral phenotype, while multiple other genes are related to c-Fos expression pattern. To further define the role of c-Fos in sarcomagenesis, we expressed it in primary human MPCs (hMPCs), immortalized hMPCs and transformed murine MPCs (mMPCs). In immortalized hMPCs, c-Fos expression generated morphological changes, reduced mobility capacity and impaired adipogenic- and osteogenic-differentiation potentials. Remarkably, immortalized hMPCs or mMPCs expressing c-Fos generated tumors harboring a chondrogenic phenotype and morphology. Thus, here we show that c-Fos protein has a key role in sarcomas and that c-Fos expression in immortalized MPCs yields cell transformation and chondrogenic tumor formation
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