A comparison of manual handling risks in different domestic waste collection systems using three separate evaluation methods

One of the greatest challenges for Local Authorities (LAs) is to operate sustainable systems of work. The most significant causes of physical absence is attributed to that of musculoskeletal disorders (MSDs). The study’s aim was to compare the reliability of the manual handling element of the Health and Safety Executives (HSEs) risk comparator tool for different domestic waste collection methods with self-reported pain via body-mapping and MSD ill health absence rates. Participatory body-mapping exercises were carried out in five authorities with one authority resurveyed, six months after the move from 35-50 litre containers to a wheeled bin recycling service. The lowest levels of self-reported pain were for services designed with 240l wheeled bins excluding glass; the highest levels were for services that included 100l of garden waste sacks and recycling boxes. Industry data supports previous laboratory studies showing wheeled bins to be associated with less MSD outcomes than boxes, baskets and sacks. Triangulation of data established a statistically significant correlation of 0.85 (Pearson) between average pain count (APC) and the mean MSD absence rates, with a strong correlation of 0.77 (Spearman) between APC and risk rating. The correlation is moderate, 0.49, (Spearman) between MSD absence and risk rating, reflecting possible intervening variables and a low participation rate by LAs. The contribution of this study is to improve the design of sustainable waste collection strategies to minimise MSD associated absence. In the absence of reliable absence data, body mapping should be used as a proxy method of assessing MSD risk

Optimization of Cloud Task Processing with Checkpoint-Restart Mechanism

International audienceIn this paper, we aim at optimizing fault-tolerance tech- niques based on a checkpointing/restart mechanism, in the context of cloud computing. Our contribution is three-fold. (1) We derive a fresh formula to compute the optimal num- ber of checkpoints for cloud jobs with varied distributions of failure events. Our analysis is not only generic with no assumption on failure probability distribution, but also at- tractively simple to apply in practice. (2) We design an adaptive algorithm to optimize the impact of checkpointing regarding various costs like checkpointing/restart overhead. (3) We evaluate our optimized solution in a real cluster en- vironment with hundreds of virtual machines and Berke- ley Lab Checkpoint/Restart tool. Task failure events are emulated via a production trace produced on a large-scale Google data center. Experiments confirm that our solution is fairly suitable for Google systems. Our optimized formula outperforms Young's formula by 3-10 percent, reducing wall- clock lengths by 50-100 seconds per job on average

DEVELOPING A METHODOLOGICAL FRAMEWORK FOR THE PARTICIPATORY MEASUREMENT OF SUSTAINABILITY

The measurement of sustainability can provide significant information in order to plan and implement environmental policies. Several methods have been proposed in the literature in order to select the appropriate indicators along with a variety of techniques for their measurement. These methods are often divided in two main categories: a) a top-down approach where the selection of sustainability indicators is often based on the decision of scientists and policy-makers and b) a bottom-up approach where local stakeholders influence the selection and the measurement of indicators. In this paper we propose a methodological framework which allows the selection of sustainability indicators based on scientific research but at the same time allows citizens to influence both the selection of indicators and their measurement. The benefits of the specific methodological framework are two: a) to incorporate in different stages of the measurement the opinions of local stakeholders, b) to assist in policy decision-making through the assessment of the current situation of sustainability

Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

Placental dysfunction is the underlying cause of pregnancy complications such as fetal growth restriction (FGR) and pre-eclampsia. No therapies are available to treat a poorly functioning placenta, primarily due to the risks of adverse side effects in both the mother and the fetus resulting from systemic drug delivery. The use of targeted liposomes to selectively deliver payloads to the placenta has the potential to overcome these issues. In this study, we assessed the safety and efficacy of epidermal growth factor (EGF)-loaded, peptide-decorated liposomes to improve different aspects of placental function, using tissue from healthy control pregnancies at term, and pregnancies complicated by FGR. Phage screening identified a peptide sequence, CGPSARAPC (GPS), which selectively homed to mouse placentas in vivo, and bound to the outer syncytiotrophoblast layer of human placental explants ex vivo. GPS-decorated liposomes were prepared containing PBS or EGF (50–100 ng/mL), and placental explants were cultured with liposomes for up to 48 h. Undecorated and GPS-decorated liposomes containing PBS did not affect the basal rate of amino acid transport, human chorionic gonadotropin (hCG) release or cell turnover in placental explants from healthy controls. GPS-decorated liposomes containing EGF significantly increased amino acid transporter activity in healthy control explants, but not in placental explants from women with FGR. hCG secretion and cell turnover were unaffected by EGF delivery; however, differential activation of downstream protein kinases was observed when EGF was delivered via GPS-decorated vs. undecorated liposomes. These data indicate that targeted liposomes represent a safe and useful tool for the development of new therapies for placental dysfunction, recapitulating the effects of free EGF

Recent morpho-sedimentary processes in Dove Basin, southern Scotia Sea, Antarctica: A basin-scale case of interaction between bottom currents and mass movements

Multibeam bathymetric imagery and acoustic sub-bottom profiles are used to reveal distribution patterns of sub-surface sedimentation in Dove Basin (Scotia Sea). The goals of the study are to determine the imprint of the inflow of deep Antarctic water masses from the Weddell Sea into the Scotia Sea, to establish the factors driving the styles of contourite deposition and to discern the relative contribution of alongslope versus downslope processes to the construction of the uppermost late Quaternary sedimentary record in the basin. The most significant morpho-sedimentary features in Dove Basin are linked to contouritic processes and to mass movements. Plastered drifts on the flanks of the basin constitute the most common contouritic deposits. Basement-controlled drifts on top of structural elevations are common along the central ridge, the central basin plain and scattered along the basin flanks. Sheeted drifts occur on top of adjacent banks or are restricted to the deep basin. In contrast, mounded drifts are poorly represented in Dove basin. A laterally extensive contouritic channel runs along the central ridge. Contouritic channels are also identified in the upper parts of the lateral banks and slopes. Numerous slide scars along the upper parts of the slopes evolve downslope into semitransparent lens-shaped bodies, with occasional development of across-slope channels. Semitransparent lenses occur intercalated within stratified deposits in the slopes of the basin, in the central ridge and in the deepest basin plain. The spatial arrangement of contouritic morphologies points to the influence of the water column structure and the basin physiography. In the eastern sub-basin, two different fractions (lower and upper) of Weddell Sea Deep Water (WSDW) leave an imprint on contourite deposits owing to the sloping interface between the two fractions. Contouritic influence is more subdued in the western sub-basin, and limited to the imprint of the lower WSDW. The upper parts of the surrounding banks are under the influence of deep-reaching Circumpolar waters (i.e., Lower Circumpolar Deep Water), which develops both depositional and erosional morphologies. The cross-section V-shaped morphology of the basin and the common occurrence of structural highs drive the predominance of plastered and basement-controlled drifts in the sediment record. The frequent alternation between contourites and downslope gravity-flow deposits is likely due to different processes associated with over-steepening in the basin, such as basement-controlled steep slopes, deformed drifts atop basement elevations, and the development of thick contouritic piles. Dove Basin is an example of a basin without mounded, plastered or mixed hybrid drifts in the transition between the lower slope and the deep basin, because the upper boundary of the deepest water mass —the Weddell Sea Deep Water— flows shallower along the middle slope. This fact underlines the relevance of the position and depth of water masses in shaping the morphology of the feet of slopes along continental margins

Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

From MDPI via Jisc Publications RouterHistory: accepted 2021-10-17, pub-electronic 2021-10-25Publication status: PublishedFunder: Medical Research Council; Grant(s): MR/P023401/1Funder: European Regional Development Fund; Grant(s): 2014-2020.4.01.15-0012Funder: Estonian Research Council; Grant(s): PRG230Placental dysfunction is the underlying cause of pregnancy complications such as fetal growth restriction (FGR) and pre-eclampsia. No therapies are available to treat a poorly functioning placenta, primarily due to the risks of adverse side effects in both the mother and the fetus resulting from systemic drug delivery. The use of targeted liposomes to selectively deliver payloads to the placenta has the potential to overcome these issues. In this study, we assessed the safety and efficacy of epidermal growth factor (EGF)-loaded, peptide-decorated liposomes to improve different aspects of placental function, using tissue from healthy control pregnancies at term, and pregnancies complicated by FGR. Phage screening identified a peptide sequence, CGPSARAPC (GPS), which selectively homed to mouse placentas in vivo, and bound to the outer syncytiotrophoblast layer of human placental explants ex vivo. GPS-decorated liposomes were prepared containing PBS or EGF (50–100 ng/mL), and placental explants were cultured with liposomes for up to 48 h. Undecorated and GPS-decorated liposomes containing PBS did not affect the basal rate of amino acid transport, human chorionic gonadotropin (hCG) release or cell turnover in placental explants from healthy controls. GPS-decorated liposomes containing EGF significantly increased amino acid transporter activity in healthy control explants, but not in placental explants from women with FGR. hCG secretion and cell turnover were unaffected by EGF delivery; however, differential activation of downstream protein kinases was observed when EGF was delivered via GPS-decorated vs. undecorated liposomes. These data indicate that targeted liposomes represent a safe and useful tool for the development of new therapies for placental dysfunction, recapitulating the effects of free EGF

Deglacial and Holocene sea-ice and climate dynamics in the Bransfield Strait, northern Antarctic Peninsula

The reconstruction of past sea-ice distribution in the Southern Ocean is crucial for an improved understanding of ice–ocean–atmosphere feedbacks and the evaluation of Earth system and Antarctic ice sheet models. The Antarctic Peninsula (AP) has been experiencing a warming since the start of regular monitoring of the atmospheric temperature in the 1950s. The associated decrease in sea-ice cover contrasts the trend of growing sea-ice extent in East Antarctica. To reveal the long-term sea-ice history at the northern Antarctic Peninsula (NAP) under changing climate conditions, we examined a marine sediment core from the eastern basin of the Bransfield Strait covering the last Deglacial and the Holocene. For sea-ice reconstructions, we focused on the specific sea-ice biomarker lipid IPSO25, a highly branched isoprenoid (HBI), and sea-ice diatoms, whereas a phytoplankton-derived HBI triene (C25:3) and warmer open-ocean diatom assemblages reflect predominantly ice-free conditions. We further reconstruct ocean temperatures using glycerol dialkyl glycerol tetraethers (GDGTs) and diatom assemblages and compare our sea-ice and temperature records with published marine sediment and ice core data. A maximum ice cover is observed during the Antarctic Cold Reversal 13 800–13 000 years before present (13.8–13 ka), while seasonally ice-free conditions permitting (summer) phytoplankton productivity are reconstructed for the late Deglacial and the Early Holocene from 13 to 8.3 ka. An overall decreasing sea-ice trend throughout the Middle Holocene coincides with summer ocean warming and increasing phytoplankton productivity. The Late Holocene is characterized by highly variable winter sea-ice concentrations and a sustained decline in the duration and/or concentration of spring sea ice. Overall diverging trends in GDGT-based TEX86L and RI-OH' subsurface ocean temperatures (SOTs) are found to be linked to opposing spring and summer insolation trends, respectively.</p

Late Miocene onset of the modern Antarctic Circumpolar Current

The Antarctic Circumpolar Current plays a pivotal role in global climate through its strong influence on the global overturning circulation, ocean heat and CO uptake. However, when and how the Antarctic Circumpolar Current reached its modern-like characteristics remains disputed. Here we present neodymium isotope and sortable silt records from sediment cores in the Southwest Pacific and South Indian oceans spanning the past 31 million years. Our data indicate that a circumpolar current like that of today did not exist before the late Miocene cooling. These findings suggest that the emergence of a homogeneous and deep-reaching strong Antarctic Circumpolar Current was not linked solely to the opening and deepening of Southern Ocean Gateways triggering continental-scale Antarctic Ice Sheet expansion during the Eocene–Oligocene Transition (∼34 Ma). Instead, we find that besides tectonic pre-conditioning, the expansion of the Antarctic Ice Sheet and sea ice since the middle Miocene Climate Transition (∼14 Ma) played a crucial role. This led to stronger density contrast and intensified Southern Westerly Winds across the Southern Ocean, establishing a vigorous deep-reaching circumpolar flow and an enhanced global overturning circulation, which amplified the late Cenozoic global cooling.This research used samples provided by the International Ocean Discovery Program (IODP). We acknowledge the staff and shipboard party from Leg 28 and Leg 119. We thank the staff at the Gulf Coast core repository (GCR) for curating these cores and for assistance in core handling and shipping. Funding for this research is provided by the Spanish Ministry of Economy, Industry and Competitivity (grant CTM2017-89711-C2-1/2-P; PID2021-126495NB-C31), co-funded by the European Union through FEDER funds. D.E. was funded by the Alexander S. Onassis Public Benefit Foundation PhD research grant (F ZL 016-1/2015-2016), by MOPGA postdoctoral visiting fellowship programme funded by the French Ministry of Europe and Foreign Affairs (grant MOPGA postdoc-3–5669831615), by the Juan de la Cierva-formation postdoctoral research grant (FJC2020-043650-I) funded by MCIN/AEI/ 10.13039/501100011033 and the ‘European Union NextGenerationEU/PRTR’ and by the UK Research and Innovation Engineering and Physical Sciences Research Council (grant number EP/X02623X/1). D.E. received additional funding from an ECORD research grant and IODP-France. I.S. and A.K. were supported by the Australian Research Council Special Research Initiative for Antarctic Gateway Partnership (project ID SR140300001) and the Australian Research Council’s Discovery Project 180102280. Model runs were undertaken with the assistance of resources from the National Computational Infrastructure (NCI), which is supported by the Australian Government. We thank the Paleomagnetic Laboratory CCiTUB-Geo3Bcn CSIC for the support on palaeomagnetic analysis. The GRC Geociències Marines thanks the Generalitat de Catalunya for the Grups de Recerca Consolidats grant 2021SGR01195 and for the ICREA-Academia award to I.C. This paper is a contribution to the SCAR INSTANT Programme.Peer reviewe