22 research outputs found
One-phase preparation of palladium nanoparticles using thiol-functionalized ionic liquid
Fabrication of silver nanoparticles via self-regulated reduction by 1-(2-hydroxyethyl)-3-methylimidazolium tetrafluoroborate
Properties of Didecyldimethylammonium Formate and Sodium Fatty Alcohol Ether Carboxylate Mixed Systems
Synthesis and antibacterial activity screening of quaternary ammonium derivatives of triazolyl pyranochromenones
Amino Acid-Derived Imidazolium Zwitterions: Building Blocks for Renewable Ionic Liquids and Materials
A smart and versatile theranostic nanomedicine platform based on nanoporphyrin
Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nano-construct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart “all-in-one” nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumor detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumors. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumors for photothermal-therapy (PTT), and light to singlet oxygen for photodynamic-therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs into tumors