Automorphisms of the affine SU(3) fusion rules

We classify the automorphisms of the (chiral) level-k affine SU(3) fusion rules, for any value of k, by looking for all permutations that commute with the modular matrices S and T. This can be done by using the arithmetic of the cyclotomic extensions where the problem is naturally posed. When k is divisible by 3, the automorphism group (Z_2) is generated by the charge conjugation C. If k is not divisible by 3, the automorphism group (Z_2 x Z_2) is generated by C and the Altsch\"uler--Lacki--Zaugg automorphism. Although the combinatorial analysis can become more involved, the techniques used here for SU(3) can be applied to other algebras.Comment: 21 pages, plain TeX, DIAS-STP-92-4

Fe Ka line emission from the Arches cluster region - evidence for ongoing particle bombardment?

We present the results of eight years of XMM-Newton observations of the region surrounding the Arches cluster in the Galactic Center. We study the spatial distribution and temporal behaviour of the Fe-Ka line emission with the objective of identifying the likely source of the excitation. We investigate the variability of the 6.4-keV line emission of four clouds through spectral fitting of the EPIC MOS data with the use of a modelled background, which avoids many of the systematics inherent in local background subtraction. We also employ spectral stacking of both EPIC PN and MOS data to search for evidence of an Fe-K edge feature imprinted on the underlying X-ray continuum. The lightcurves of the Fe-Ka line from three bright molecular knots close to the Arches cluster are found to be constant over the 8-year observation window. West of the cluster, however, we found a bright cloud exhibiting the fastest Fe-Ka variability yet seen in a molecular cloud in the Galactic Center region. The time-averaged spectra of the molecular clouds reveal no convincing evidence of the 7.1-keV edge feature. The EW of the 6.4-keV line emitted by the clouds near the cluster is found to be ~1.0 keV. The observed Fe-Ka line flux and the high EW suggest the fluorescence has a photoionization origin, although excitation by cosmic-ray particles is not specifically excluded. For the three clouds nearest to the cluster, an identification of the source of photo-ionizing photons with an earlier outburst of Sgr A* is however at best tentative. The hardness of the nonthermal component associated with the 6.4-keV line emission might be best explained in terms of bombardment by cosmic-ray particles from the Arches cluster itself. The relatively short-timescale variability seen in the 6.4-keV line emission from the cloud to the West of the cluster is most likely the result of illumination by a nearby transient X-ray source.Comment: 13 pages, 6 figures, accepted for publication in Astronomy and Astrophysic

Feasibility of manufacturing a patient-specific spinal implant

Spinal fusion is performed for degenerative spinal condition when conservative measures fail. Implant size and shape are not standardised between manufacturers, and best match often means compromises. Bioprinting offers a unique opportunity to create a tailor-made solution. PURPOSE: The goal of this study was to design and manufacture a 3D-printed lumbar cage for lumbar interbody fusion

AUTOMATIC ASSESSMENT OF LAKE STATUS USING AN OPEN SOURCE APPROACH: LAKE LUGANO'S CASE STUDY

Abstract. Climate change and human activities are increasingly threatening water resources. In particular sub-alpine lakes are fundamental not only for tourism or other economical activities, but also as a source of water. In this context, there is a strong need to monitor such resources to understand, study and react to known and unknown impacts, so that appropriate mitigation actions can be taken. Unfortunately, although monitoring data already exist for many of these lakes, the information is archived in different formats and servers undermining the full exploitation of data and preventing a more efficient data management. The aim of this work is to improve this situation by implementing a system that integrates and standardizes data coming from different sources. In addition, the system integrates web based tools that estimate lake state indicators using open source software and standard. Thanks to this system, it will be possible to exploit the data potential more fully. This paper focuses on the achievements reached by the research carried out on Lake Lugano in the context of the project SIMILE after two years of work

Evolution of frustrated and stabilising contacts in reconstructed ancient proteins

Energetic properties of a protein are a major determinant of its evolutionary fitness. Using a reconstruction algorithm, dating the reconstructed proteins and calculating the interaction network between their amino acids through a coevolutionary approach, we studied how the interactions that stabilise 890 proteins, belonging to five families, evolved for billions of years. In particular, we focused our attention on the network of most strongly attractive contacts and on that of poorly optimised, frustrated contacts. Our results support the idea that the cluster of most attractive interactions extends its size along evolutionary time, but from the data, we cannot conclude that protein stability or that the degree of frustration tends always to decrease

Computational models for characterisation and design of patient-specific spinal implant

BACKGROUND CONTEXT: Spinal fusion is designed to reduce movements between vertebrae and therefore pain. The most used devices for this procedure are mainly made of titanium or polyether ether ketone (PEEK). However, the mismatch between devices, with standard shapes and materials, and the surrounding bones can lead to suboptimal outcomes. Computational models, namely, Finite Element Analyses (FEA), can be employed to optimise existing device and design more effective solutions. PURPOSE: The goal of this study was to compare the performance of different materials and material densities for spinal cages, and to design a novel geometry which can ideally match the anatomical characteristics of a patient. STUDY DESIGN/SETTING: Computational. PATIENT SAMPLE: Nil. OUTCOME MEASURES: Nil. METHODS: FEA were set up to simulate compression (400 N) and bending (7.5 Nm) on a generic cage design. Three materials were modelled: titanium, PEEK and polycarbonate. Polycarbonate was included as widely available within additive manufacturing techniques. For each of the cages, four designs were modelled with varying material filling density. Furthermore, a new cage was modelled to match the pre-operative computed tomography (CT) of a patient exactly. The patient-specific cage was also tested by means of FEA. RESULTS: Stress distribution was compared between all the three materials tested. Consistently, stresses increased with reducing material density. Stress peak values were lower than the respective risk of failure in all the simulated cases, confirming the feasibility of polycarbonate implants. The patient-specific design showed even stress distribution consistently within anatomical constraints. CONCLUSIONS: Computational analyses suggested the feasibility of a lighter, cheaper and patient-specific cage for spinal fusion

Effectiveness of the spot-on combination of moxidectin and imidacloprid (Advocate®) in the treatment of ocular thelaziosis by Thelazia callipaeda in naturally infected cats

Background: The present study evaluated the therapeutic effectiveness of moxidectin 1.0% (w/v) and imidacloprid 10% (w/v) (Advocate® spot-on solution for cats, Bayer Animal Health) against natural infections with the eyeworm Thelazia callipaeda in cats. This study was conducted as a GCP, negative-controlled, blinded and randomised field study in privately owned cats living in an area in southern Italy where T. callipaeda is enzootic. Methods: The study was carried out in 30 cats (19 females and 11 males, aged from 8 months to 5 years, weighing 1.2-5.2 kg) of different breeds, naturally infected by T. callipaeda. At study inclusion (Day 0), animals were physically examined and the infection level was assessed by examination of both eyes for clinical score and live adult T. callipaeda count. Each cat was weighed and randomly assigned to one of the treatment groups (G1: Advocate, G2: untreated control). Clinical assessments and T. callipaeda adult counts were performed on Day 14. At the study completion visit on Day 28, clinical assessments and counts of T. callipaeda adults and larvae were performed. All cats were daily observed by their owners and general health conditions were recorded during the entire period of the study. Results: The primary effectiveness variable was the percentage of animals in G1 group (Advocate) showing a complete elimination (parasitological cure) of adult eye worms at Day 14 and Day 28. The effectiveness of the treatment in the G1 group was 93.3 and 100% at Day 14 and Day 28, respectively, when compared to group G2. Total worm count reduction from both eyes for Advocate was 96.3% on Day 14 and 100% on Day 28. Clinical data were confirmed by the examination of conjunctival pouch flushing. An overall reduction in the number of cats with lacrimation and conjunctivitis was observed following treatment despite the fact that in a few cats treated with Advocate clinical signs persisted due to the chronic nature of the disease. Conclusions: Based on the results of the present trial, a single dose of Advocate was found to be safe and highly effective in the treatment of natural T. callipaeda infection in cats

The X-ray lightcurve of Sgr A* over the past 150 years inferred from Fe-Ka line reverberation in Galactic Centre molecular clouds

We examine the temporal and spectral properties of nine Fe-Ka bright molecular clouds within about 30 pc of Sgr A*, in order to understand and constrain the primary energising source of the Fe fluorescence. Significant Fe-Ka variability was detected, with a spatial and temporal pattern consistent with that reported in previous studies. The main breakthrough that sets our paper apart from earlier contributions on this topic is the direct measurement of the column density and the Fe abundance of the MCs in our sample. We used the EW measurements to infer the average Fe abundance within the clouds to be 1.6$\pm$0.1 times solar. The cloud column densities derived from the spectral analysis were typically of the order of 10$^{23}$ cm$^{-2}$, which is significantly higher than previous estimates. This in turn has a significant impact on the inferred geometry and time delays within the cloud system. Past X-ray activity of Sgr A* is the most likely source of ionisation within the molecular clouds in the innermost 30 pc of the Galaxy. In this scenario, the X-ray luminosity required to excite these reflection nebulae is of the order of 10$^{37}-10^{38}$ erg s$^{-1}$, significantly lower than that estimated for the Sgr B2 molecular cloud. Moreover, the inferred Sgr A* lightcurve over the past 150 years shows a long-term downwards trend punctuated by occasional counter-trend brightening episodes of at least 5 years duration. Finally, we found that contributions to the Fe fluorescence by X-ray transient binaries and cosmic-ray bombardment are very likely, and suggest possible ways to study this latter phenomenon in the near future.Comment: 23 pages, 14 figures, accepted for publication in Astronomy & Astrophysic

Design and fabrication of 3D-printed anatomically shaped lumbar cage for intervertebra disc (IVD) degeneration treatment

Spinal fusion is the gold standard surgical procedure for degenerative spinal conditions when conservative therapies have been unsuccessful in rehabilitation of patients. Novel strategies are required to improve biocompatibility and osseointegration of traditionally used materials for lumbar cages. Furthermore, new design and technologies are needed to bridge the gap due to the shortage of optimal implant sizes to fill the intervertebral disc defect. Within this context, additive manufacturing technology presents an excellent opportunity to fabricate ergonomic shape medical implants. The goal of this study is to design and manufacture a 3D-printed lumbar cage for lumbar interbody fusion. Optimisations of the proposed implant design and its printing parameters were achieved via in silico analysis. The final construct was characterised via scanning electron microscopy, contact angle, x-ray micro computed tomography (μCT), atomic force microscopy, and compressive test. Preliminary in vitro cell culture tests such as morphological assessment and metabolic activities were performed to access biocompatibility of 3D-printed constructs. Results of in silico analysis provided a useful platform to test preliminary cage design and to find an optimal value of filling density for 3D printing process. Surface characterisation confirmed a uniform coating of nHAp with nanoscale topography. Mechanical evaluation showed mechanical properties of final cage design similar to that of trabecular bone. Preliminary cell culture results showed promising results in terms of cell growth and activity confirming biocompatibility of constructs. Thus for the first time, design optimisation based on computational and experimental analysis combined with the 3D-printing technique for intervertebral fusion cage has been reported in a single study. 3D-printing is a promising technique for medical applications and this study paves the way for future development of customised implants in spinal surgical applications