Work and information processing in a solvable model of Maxwell's demon

We describe a minimal model of an autonomous Maxwell demon, a device that delivers work by rectifying thermal fluctuations while simultaneously writing information to a memory register. We solve exactly for the steady-state behavior of our model, and we construct its phase diagram. We find that our device can also act as a "Landauer eraser", using externally supplied work to remove information from the memory register. By exposing an explicit, transparent mechanism of operation, our model offers a simple paradigm for investigating the thermodynamics of information processing by small systems.Comment: Main Text (6 pages, 3 figures) + Suppl. Info. (3 pages). To appear in PNA

Organic Carbon Burial following the Middle Eocene Climatic Optimum (MECO) in the central - western Tethys

We present trace metal geochemistry and stable isotope records for the middle Eocene Alano di Piave section, NE Italy, deposited during magnetochron C18n in the marginal Tethys Ocean. We identify a $\sim$ 500 kyr long carbon isotope perturbation event we infer to be the middle Eocene Climatic Optimum (MECO) confirming the northern hemisphere expression and global occurrence of MECO. Interpreted peak climatic conditions are followed by the rapid deposition of two organic rich intervals ($\le$3\% TOC) and contemporaneous positive $\delta^{13}$C excursions. These two intervals are associated with increases in the concentration of sulphur and redox-sensitive trace metals, and low concentrations of Mn, as well as coupled with the occurrence of pyrite. Together these changes imply low, possibly dysoxic, bottom water O$_{2}$ conditions promoting increased organic carbon burial. We hypothesize that this rapid burial of organic carbon lowered global {\it p}CO$_{2}$ following the peak warming and returned the climate system to the general Eocene cooling trend

Extracellular cysteine in connexins: Role as redox sensors

Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and molecules between the cytoplasm and contacting cells. The controlled opening of hemichannels has been associated with several physiological cellular processes; thereby unregulated hemichannel activity may induce loss of cellular homeostasis and cell death. Hemichannel activity can be regulated through several mechanisms, such as phosphorylation, divalent cations and changes in membrane potential. Additionally, it was recently postulated that redox molecules could modify hemichannels properties in vitro. However, the molecular mechanism by which redox molecules interact with hemichannels is poorly understood. In this work, we discuss the current knowledge on connexin redox regulation and we propose the hypothesis that extracellular cysteines could be important for sensing changes in redox potential. Future studies on this topic will offer new insight into hemichannel function, thereby expanding the understanding of the contribution of hemichannels to disease progression.http://journal.frontiersin.org/article/10.3389/fphys.2016.00001/ful

Arresting bubble coarsening: A two-bubble experiment to investigate grain growth in presence of surface elasticity

Many two-phase materials suffer from grain-growth due to the energy cost which is associated with the interface that separates both phases. While our understanding of the driving forces and the dynamics of grain growth in different materials is well advanced by now, current research efforts address the question of how this process may be slowed down, or, ideally, arrested. We use a model system of two bubbles to explore how the presence of a finite surface elasticity may interfere with the coarsening process and the final grain size distribution. Combining experiments and modelling in the analysis of the evolution of two bubbles, we show that clear relationships can be predicted between the surface tension, the surface elasticity and the initial/final size ratio of the bubbles. We rationalise these relationships by the introduction of a modified Gibbs criterion. Besides their general interest, the present results have direct implications for our understanding of foam stability

An HST Imaging Survey of Low-Mass Stars in the Chamaeleon I Star Forming region

We present new HST/WFPC2 observations of 20 fields centered around T Tauri stars in the Chamaeleon I star forming region. Images have been obtained in the F631N ([OI]6300A), F656N (Ha) and F673N ([SII]6716A+6731A) narrow-band filters, plus the Johnson V-band equivalent F547M filter. We detect 31 T Tauri stars falling within our fields. We discuss the optical morphology of 10 sources showing evidence of either binarity, circumstellar material, or mass loss. We supplement our photometry with a compilation of optical, infrared and sub-millimeter data from the literature, together with new sub-mm data for three objects, to build the Spectral Energy Distributions (SED) of 19 single sources. Using an SED model fitting tool, we self-consistently estimate a number of stellar and disk parameters, while mass accretion rates are directly derived from our Ha photometry. We find that bolometric luminosities derived from dereddened optical data tend to be underestimated in systems with high alpha(2-24} IR spectral index, suggesting that disks seen nearly edge-on may occasionally be interpreted as low luminosity (and therefore more evolved) sources. On the other hand, the same alpha(2-24) spectral index, a tracer of the amount of dust in the warmer layers of the circumstellar disks, and the mass accretion rate appear to decay with the isocronal stellar age, suggesting that the observed age spread (~0.5-5 Myr) within the cluster is real. Our sample contains a few outliers that may have dissipated their circumstellar disks on shorter time-scale.Comment: to appear on Astronomical Journal, accepted April 16, 2012 (AJ-10740

HST measures of Mass Accretion Rates in the Orion Nebula Cluster

The present observational understanding of the evolution of the mass accretion rates (Macc) in pre-main sequence stars is limited by the lack of accurate measurements of Macc over homogeneous and large statistical samples of young stars. Such observational effort is needed to properly constrain the theory of star formation and disk evolution. Based on HST/WFPC2 observations, we present a study of Macc for a sample of \sim 700 sources in the Orion Nebula Cluster, ranging from the Hydrogen-burning limit to M\ast \sim 2M\odot. We derive Macc from both the U-band excess and the H{\alpha} luminosity (LH{\alpha}), after determining empirically both the shape of the typical accretion spectrum across the Balmer jump and the relation between the accretion luminosity (Lacc) and LH{\alpha}, that is Lacc/L\odot = (1.31\pm0.03)\cdotLH{\alpha}/L\odot + (2.63\pm 0.13). Given our large statistical sample, we are able to accurately investigate relations between Macc and the parameters of the central star such as mass and age. We clearly find Macc to increase with stellar mass, and decrease over evolutionary time, but we also find strong evidence that the decay of Macc with stellar age occurs over longer timescales for more massive PMS stars. Our best fit relation between these parameters is given by: log(Macc/M\odot\cdotyr)=(-5.12 \pm 0.86) -(0.46 \pm 0.13) \cdot log(t/yr) -(5.75 \pm 1.47)\cdot log(M\ast/M\odot) + (1.17 \pm 0.23)\cdot log(t/yr) \cdot log(M\ast/M\odot). These results also suggest that the similarity solution model could be revised for sources with M\ast > 0.5M\odot. Finally, we do not find a clear trend indicating environmental effects on the accretion properties of the sources.Comment: 17 pages, 15 figures, accepted for publication in Ap

Variation in plasma oxidative status and testosterone level in relation to egg-eviction effort and age of brood-parasitic common cuckoo nestlings

To avoid competition for parental care, brood-parasitic Common Cuckoo (Cuculus canorus) nestlings evict all of the host's eggs and nestlings within a few days after hatching. Little is known about the physiological effects of eviction behavior on the cuckoo nestling's oxidative balance or about age-related variation in plasma oxidative status and testosterone level of developing birds. We examined whether the cuckoo nestling's plasma oxidative status was related to prior effort in eviction and quantified variation in the level of reactive oxygen metabolites, of nonenzymatic antioxidant capacity, and of testosterone concentration in plasma at various phases of the cuckoo's development. Levels of both reactive oxygen metabolites and antioxidant capacity were greater in older than in younger nestlings, suggesting that younger nestlings effectively counterbalance their increased production of free radicals, whereas, near fledging, levels of reactive oxygen metabolites increase despite improved antioxidant capacity. Possibly, overall energy expenditure increases with age and elevates the production of reactive oxygen species to a rate higher than what the antioxidant system could eliminate. Plasma testosterone level was the highest at nestlings' intermediate phase of growth. High levels of testosterone may be required during the period of fastest growth, and when the growth rate levels off near fledging, testosterone levels may also decline. Cuckoo chicks that evicted more host eggs from steeper nests had higher plasma levels of reactive oxygen metabolites shortly after the eviction period, suggesting that eviction is costly in terms of an increased level of oxidative stress. Para evitar la competencia por el cuidado parental, los polluelos parásitos de nidada de Cuculus canorus desalojan todos los huevos y los polluelos del hospedador a los pocos días después de la eclosión. Se sabe poco sobre los efectos fisiológicos del comportamiento de desalojo en el balance oxidativo de los polluelos de C. canorus o sobre la variación en el estatus oxidativo del plasma y el nivel de testosterona relacionado con la edad de las aves en desarrollo. Examinamos si el estatus oxidativo del plasma de los polluelos de C. canorus se relacionaba con un esfuerzo previo de desalojo y cuantificamos la variación en el nivel de metabolitos reactivos de oxígeno, la capacidad antioxidante no enzimática y la concentración de testosterona en el plasma en varias fases del desarrollo de C. canorus. Tanto los niveles de metabolitos reactivos de oxígeno como la capacidad antioxidante fueron superiores en los polluelos de mayor edad que en los más jóvenes, lo que sugiere que los polluelos de menor edad contrarrestan eficazmente el aumento de la producción de radicales libres, mientras que, cuando se apróximan al abandono del nido, los niveles de metabolitos reactivos de oxígeno aumentan a pesar de una mejora en la capacidad antioxidante. Posiblemente, el gasto total de energía se incrementa con la edad, elevándose la producción de formas reactivas de oxígeno a una tasa mayor de la que el sistema antioxidante puede eliminar. El nivel de testosterona en el plasma fue máximo en la fase intermedia del crecimiento de los polluelos. Pueden requerirse altos niveles de testosterona durante el período de mayor crecimiento y, cuando la tasa de crecimiento se estabiliza cerca del abandono del nido, los niveles de testosterona también podrián disminuir. Los polluelos de C. canorus que desalojaron más huevos del hospedador en nidos con una estructura más empinada tuvieron niveles de plasma de metabolitos reactivos de oxígeno en plasma más altos poco después del período de desalojo, sugiriendo que el desalojo es costoso en términos de un incremento en el nivel de estrés oxidativo

Spectral and Localization Properties for the One-Dimensional Bernoulli Discrete Dirac Operator

A 1D Dirac tight-binding model is considered and it is shown that its nonrelativistic limit is the 1D discrete Schr?odinger model. For random Bernoulli potentials taking two values (without correlations), for typical realizations and for all values of the mass, it is shown that its spectrum is pure point, whereas the zero mass case presents dynamical delocalization for specific values of the energy. The massive case presents dynamical localization (excluding some particular values of the energy). Finally, for general potentials the dynamical moments for distinct masses are compared, especially the massless and massive Bernoulli cases.Comment: no figure; 24 pages; to appear in Journal of Mathematical Physic

Role of berries in vascular function : a systematic review of human intervention studies

CONTEXT: Berries are a source of polyphenols with recognized health-promoting activities. Several studies suggest that consumption of berries may improve vascular function. OBJECTIVE: The aim of this systematic review is to provide evidence of short- and long-term benefits of berries on outcomes of vascular function. DATA SOURCES: Human intervention studies were collected from PubMed and Scopus databases. STUDY SELECTION: Studies were eligible if they investigated the effects of acute or chronic berry consumption on one or more markers of vascular function in humans and provided a characterization of the berry polyphenolic content. Only randomized controlled trials were included, and studies were excluded if berries were combined with other foods. DATA EXTRACTION: After selection, 22 randomized controlled trials were included and analyzed, most of which were performed in healthy individuals or patients with cardiovascular risk factors. RESULTS: The overall results seem to suggest a protective role of berries in vascular function, likely dependent on the time of exposure, the type and dose of berry, and the biomarkers analyzed. Flow-mediated dilation and reactive hyperemia index (markers of vascular reactivity) improved following short-term interventions, while pulse wave velocity and augmentation index (markers of arterial stiffness) improved only after medium- to long-term intervention. CONCLUSIONS: Current evidence suggests that berries, at physiological relevant doses, may have a role in the modulation of vascular function and stiffness. High-quality human intervention trials are encouraged in order to strengthen these findings and to better elucidate the mechanisms involved in such modulation