An introduction to Elinor Glyn : her life and legacy

This special issue of Women: A Cultural Review re-evaluates an author who was once a household name, beloved by readers of romance, and whose films were distributed widely in Europe and the Americas. Elinor Glyn (1864–1943) was a British author of romantic fiction who went to Hollywood and became famous for her movies. She was a celebrity figure of the 1920s, and wrote constantly in Hearst's press. She wrote racy stories which were turned into films—most famously, Three Weeks (1924) and It (1927). These were viewed by the judiciary as scandalous, but by others—Hollywood and the Spanish Catholic Church—as acceptably conservative. Glyn has become a peripheral figure in histories of this period, marginalized in accounts of the youth-centred ‘flapper era’. Decades on, the idea of the ‘It Girl’ continues to have great pertinence in the post-feminist discourses of the twenty-first century. The 1910s and 1920s saw the development of intermodal networks between print, sound and screen cultures. This introduction to Glyn's life and legacy reviews the cross-disciplinary debate sparked by renewed interest in Glyn by film scholars and literary and feminist historians, and offers a range of views of Glyn's cultural and historical significance and areas for future research

Das Ertragsniveau von Composite Cross Winterweizenpopulationen mit unterschiedlichen Managementhistorien in zwei Bodenbearbeitungssystemen

Die Züchtung heterogener Composite Cross Populationen (CCPs) und ihre darauffolgende Anpassung an lokal vorherrschende biotische und abiotische Stressfaktoren hat zum Ziel, die Ertragsstabilität und Resilienz des Weizens zu steigern. Die Ertragsleistung von sechs CCPs mit identischem genetischen Hintergrund aber unterschiedlichen Managementhistorien wurde in einem Langzeitversuch mit verschiedenen Bodenbearbeitungs- und Düngungssystemen getestet. Diejenigen CCPs, die seit 2005 konventionell angebaut wurden, erzielten einen signifikant höheren Ertrag unter Pflug- als unter Minimalbodenbearbeitung. Für die seit 2005 ökologisch angebauten CCPs konnte kein signifikanter Ertragsunterschied zwischen den Bearbeitungssystemen festgestellt werden. Die seit 2008 in einem Breitsaatverfahren ohne Unkrautkontrolle angebauten ökologischen CCPs waren sogar tendenziell ertragsstärker unter Minimalbodenbearbeitung. Daraus ergibt sich, dass die jeweiligen Selektionskräfte, die durch langfristiges Management auf die CCPs eingewirkt haben, zu einer unterschiedlichen Anpassung an spezifischen Umweltbedingungen geführt haben

Molecular Marker Linkage Map for Apple

Linkage maps for two apple clones, White Angel and Rome Beauty, were constructed using isozyme and DNA polymorphisms segregating in a population produced from a Rome Beauty × White Angel cross. The linkage map for White Angel consists of 253 markers arranged in 24 linkage groups and extends over 950 cM. The Rome Beauty map contains 156 markers on 21 linkage groups. The White Angel map was taken as the standard, and we were able to identify linkage groups in Rome Beauty homologous to 13 White Angel linkage groups. The location of several genes not segregating in the Rome Beauty × White Angel population could be determined on the basis of known linkages with segregating markers. Hence, the standard map for apple now contains about 360 markers, with most linkage groups saturated at 10-15 cM. The double pseudotestcross format of the mapping population permitted the comparison of recombination frequencies in male and female parents in certain regions of the genome where appropriate markers were available. The recombination frequencies observed for the approximately 170 cM that were comparable gave no indication that a sex-related difference in recombination rate was characteristic of appl

Anpassungsprozesse in der Frühentwicklung von Weizenpopulationen über 11 Generationen an das Anbausystem

Eine wichtige Anpassung an den ökologischen Anbau ist eine zügige Frühentwicklung und ein Wurzelsystem, das an organische Düngung angepasst ist. Eine Halbdiallelkreuzung aus insgesamt 20 europäischen Winterweizensorten wurde 2001 hergestellt und insgesamt drei Subpopulationen aus neun Hochertragseltern (CY), eine mit 12 Backqualitätseltern (CQ) und eine aus allen Eltern (CYQ) zusammengestellt. Seit der F5 wird Saatgut unter konventionellen und ökologischen Anbaubedingungen in jeweils zwei parallelen Populationen getrennt nachgebaut. Saat jeder Generation wird bei -20o C aufbewahrt. Für die Versuche wurden Generationen F6, F10, F11, F15 in einem Feld zu F6.1, F10.1, F11.1, F15.1 vermehrt. Frisches Saatgut wurde im Hydrokultursystem zwei Wochen bei 18/12 oC (Tag/Nacht) angebaut und die Wurzel- und Sproßlängen und Gewichte gemessen. Von der F6.1 zur F15.1 verlängerten sich die Seminalwurzeln unter ökologischen aber nicht unter konventionellen Bedingungen signifikant. Eine Ausnahme stellt die F11.1 Generation dar, die in der F11 extremem Kahlfrost durchlitten hatte und unter beiden Anbaubedingungen deutlich kürzere Wurzeln produzierte als ein Jahr zuvor oder vier Jahre später. Die Seminalwurzellänge in den konventionell angebauten Y CCPs signifikant kürzer als in den ökologisch angebauten. Im Gegensatz dazu unterschieden sich die Q Populationen nicht, während sich die YQ Populationen unter ökologischen Bedingungen wie die Q CCPs verhielten, unter konventionellen Bedingungen aber eine Zwischenposition zwischen Y und Q einnahmen. Insgesamt nahmen die Sproßlängen in allen Populationen leicht zu in den ersten vier Generationen und blieben danach gleich. Die CCPs zeigen auch nach 15 Generationen konsistent ihre ursprünglichen genetischen Unterschiede. Der Nachbau in großen Parzellen kann die genetische Breite der CCPs auch durch einmaligen Extremereignisse grundsätzlich erhalten

Multilingual gendered identities: female undergraduate students in London talk about heritage languages

In this paper I explore how a group of female university students, mostly British Asian and in their late teens and early twenties, perform femininities in talk about heritage languages. I argue that analysis of this talk reveals ways in which the participants enact ‘culturally intelligible’ gendered subject positions. This frequently involves negotiating the norms of ‘heteronormativity’, constituting femininity in terms of marriage, motherhood and maintenance of heritage culture and language, and ‘girl power’, constituting femininity in terms of youth, sassiness, glamour and individualism. For these young women, I ask whether higher education can become a site in which they have the opportunities to explore these identifications and examine other ways of imagining the self and what their stories suggest about ‘doing being’ a young British Asian woman in London

Modelling the overdiagnosis of breast cancer due to mammography screening in women aged 40 to 49 in the United Kingdom

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly cited

Cohort profile: the avon longitudinal study of parents and children: ALSPAC mothers cohort

The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13 761 women (contributing 13 867 pregnancies) were recruited. These women have been followed over the last 19–22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17–18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on >10 000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile

From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein

Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed. We sought to develop a novel model which could incorporate the effects of mutations on distance travelled and velocity. A mechanical model for the dynein mediated transport of endosomes is derived from first principles and solved numerically. The effects of variations in model parameter values are analysed to find those that have a significant impact on velocity and distance travelled. The model successfully describes the processivity of dynein and matches qualitatively the velocity profiles observed in experiments

Overdiagnosis in breast cancer screening: the importance of length of observation period and lead time

PMCID: PMC3706885This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers

This is the final version of the article. Available from Public Library of Science via the DOI in this record.INTRODUCTION: Variability in red blood cell volumes (distribution width, RDW) increases with age and is strongly predictive of mortality, incident coronary heart disease and cancer. We investigated inherited genetic variation associated with RDW in 116,666 UK Biobank human volunteers. RESULTS: A large proportion RDW is explained by genetic variants (29%), especially in the older group (60+ year olds, 33.8%, <50 year olds, 28.4%). RDW was associated with 194 independent genetic signals; 71 are known for conditions including autoimmune disease, certain cancers, BMI, Alzheimer's disease, longevity, age at menopause, bone density, myositis, Parkinson's disease, and age-related macular degeneration. Exclusion of anemic participants did not affect the overall findings. Pathways analysis showed enrichment for telomere maintenance, ribosomal RNA, and apoptosis. The majority of RDW-associated signals were intronic (119 of 194), including SNP rs6602909 located in an intron of oncogene GAS6, an eQTL in whole blood. CONCLUSIONS: Although increased RDW is predictive of cardiovascular outcomes, this was not explained by known CVD or related lipid genetic risks, and a RDW genetic score was not predictive of incident disease. The predictive value of RDW for a range of negative health outcomes may in part be due to variants influencing fundamental pathways of aging.This work was supported by an award to DM, TF, AM and LH by the UK Medical Research Council (grant number MR/M023095/1). SEJ is funded by the Medical Research Council (grant: MR/M005070/1). JT is funded by a Diabetes Research and Wellness Foundation Fellowship. RB is funded by the Wellcome Trust and Royal Society grant: 104150/Z/14/Z. MAT, MNW and AM are supported by the Wellcome Trust Institutional Strategic Support Award (WT097835MF). ARW, HY, and TF are supported by the European Research Council grant: 323195:GLUCOSEGENES-FP7-IDEAS-ERC. LF is supported by the Intramural Research Program of the National Institute on Aging, U.S. National Institutes of Health. Input from MD, CLK and GK was supported by the University of Connecticut Health Center. This research has been conducted using the UK Biobank Resource under Application Number 14631. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript