Payroll employment data: measuring the effects of annual benchmark revisions

During the recovery from the 2001 recession, the business press and economic analysts used payroll employment data released monthly by the U.S. Bureau of Labor Statistics (BLS) as evidence of protracted weakness in the labor market. But using these monthly releases for this type of analysis can be premature and potentially misleading. The initial BLS releases can differ substantially from payroll employment data that are revised to incorporate information from less timely but more complete sources. ; This article highlights the historical revisions to the aggregate nonfarm payroll employment series. Examining both monthly survey-based revisions and the more extensive annual benchmark revisions, the authors focus specifically on how the sequence of data revisions modifies payroll employment estimates from their initial release. The graphs in the article display the magnitude and direction of each revision from the initial estimate for a particular month to its currently published value, demonstrating that the largest portion of enduring change for the estimates occurs in the benchmark revisions. ; The authors then investigate empirically whether these revisions contain information that can be exploited to anticipate future revisions. The analysis shows that previous benchmark data revisions are useful for explaining the variation in subsequent payroll employment benchmark data. Such information, the authors note, could prove useful for further research aimed at modeling better real-time estimates of employment conditions.Employment (Economic theory)

Development implementation, and assessment of course learning outcomes: Working paper series--02-01

This paper describes a process for developing program learning outcomes for an undergraduate business major program and mapping more specific course-level learning outcomes to these program-level outcomes. Also described is a process for assessing the effectiveness with which the course-level learning outcomes have been achieved. The processes is designed to provide a mechanism for making broad program level outcomes meaningful to instructors in their ongoing delivery of the program

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.

Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic and chemical approaches kills human AML cells at all stages of development in vitro and in vivo. Tigecycline is an antimicrobial that we found inhibits mitochondrial protein synthesis in AML cells. Therefore, we conducted a phase 1 dose-escalation study of tigecycline administered intravenously daily 5 of 7 days for 2 weeks to patients with AML. A total of 27 adult patients with relapsed and refractory AML were enrolled in this study with 42 cycles being administered over seven dose levels (50-350 mg/day). Two patients experienced DLTs related to tigecycline at the 350 mg/day level resulting in a maximal tolerated dose of tigecycline of 300 mg as a once daily infusion. Pharmacokinetic experiments showed that tigecycline had a markedly shorter half-life in these patients than reported for noncancer patients. No significant pharmacodynamic changes or clinical responses were observed. Thus, we have defined the safety of once daily tigecycline in patients with refractory AML. Future studies should focus on schedules of the drug that permit more sustained target inhibition

[(11)C]PiB PET in Gerstmann-Sträussler-Scheinker disease

Gerstmann-Sträussler-Scheinker Disease (GSS) is a familial neurodegenerative disorder characterized clinically by ataxia, parkinsonism, and dementia, and neuropathologically by deposition of diffuse and amyloid plaques composed of prion protein (PrP). The purpose of this study was to evaluate if [(11)C]Pittsburgh Compound B (PiB) positron emission tomography (PET) is capable of detecting PrP-amyloid in PRNP gene carriers. Six individuals at risk for GSS and eight controls underwent [(11)C]PiB PET scans using standard methods. Approximately one year after the initial scan, each of the three asymptomatic carriers (two with PRNP P102L mutation, one with PRNP F198S mutation) underwent a second [(11)C]PiB PET scan. Three P102L carriers, one F198S carrier, and one non-carrier of the F198S mutation were cognitively normal, while one F198S carrier was cognitively impaired during the course of this study. No [(11)C]PiB uptake was observed in any subject at baseline or at follow-up. Neuropathologic study of the symptomatic individual revealed PrP-immunopositive plaques and tau-immunopositive neurofibrillary tangles in cerebral cortex, subcortical nuclei, and brainstem. PrP deposits were also numerous in the cerebellar cortex. This is the first study to investigate the ability of [(11)C]PiB PET to bind to PrP-amyloid in GSS F198S subjects. This finding suggests that [(11)C]PiB PET is not suitable for in vivo assessment of PrP-amyloid plaques in patients with GSS

Moon-sur-Elle – Le Bourg

Cette affaire concerne la perte d’un « Thunderbolt » P-47 piloté par le second lieutenant William McGowan lors d’une opération de chasse au-dessus de Moon-sur-Elle dans le département de la Manche, en opération de soutien au débarquement de la plage de Normandie le 6 juin 1944. Le lieutenant d’aviation, Paul E. Stryker, qui accompagnait le SLT McGowan, a rapporté que l’avion du SLT McGowan avait été touché par un tir anti-aérien à environ 152,4 m d’altitude, avait percuté le sol après être pa..

Towards the development of an EIT-based stretchable sensor for multi-touch industrial human-computer interaction systems

In human-computer interaction studies, an interaction is often considered as a kind of information or discrete internal states of an individual that can be transmitted in a loss-free manner from people to computing interfaces (or robotic interfaces) and vice-versa. This project aims to investigate processes capable of communicating and cooperating by adjusting their schedules to match the evolving execution circumstances, in a way that maximise the quality of their joint activities. By enabling human-computer interactions, the process will emerge as a framework based on the concept of expectancy, demand, and need of the human and computer together, for understanding the interplay between people and computers. The idea of this work is to utilise touch feedback from humans as a channel for communication thanks to an artificial sensitive skin made of a thin, flexible, and stretchable material acting as transducer. As a proof of concept, we demonstrate that the first prototype of our artificial sensitive skin can detect surface contacts and show their locations with an image reconstructing the internal electrical conductivity of the sensor

The Ethical Responsibilities of Forensic Science Organizations in an Era of Oppressive Legislative Action

In 2023 and 2024, a wave of anti-DEI (diversity, equity, and inclusion) legislation has been passed in multiple states, representing a dramatic reversal from 2019–2022, when violence and systemic injustices against minority individuals were highlighted and DEI measures increased. In forensic anthropology, where practitioners frequently work with remains of individuals from marginalized identities, these events have forced a necessary period of disciplinary and individual self-reflection regarding our complicity in the entrenched racism and cis-heteropatriarchy that underlies our society. This article reflects on the role that professional forensic science organizations play in perpetuating and/or combatting inequity. It discusses how recent anti-DEI legislation negatively impacts forensic science, hurting both practitioners and scholarly output, and the ethical responsibilities of professional organizations to publicly affirm support for minority members and contradict scientific misinformation around these legislative measures. In particular, the authors highlight how the American Academy of Forensic Sciences (AAFS) has responded—often with silence and a lack of meaningful change—and propose potential remedies to promote long-term equitable changes both within the AAFS and external to it. The role of professional organizations in supporting all of their members, and good science, is more important now than ever, and it is time we expect and demand more from them

Differentiation syndrome in patients with acute promyelocytic leukemia treated with all- trans retinoic acid and anthracycline chemotherapy: Characteristics, outcome, and prognostic factors

Differentiation syndrome (DS) can be a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy with all- trans retinoic acid (ATRA). Detailed knowl- edge about DS has remained limited. We present an analysis of the incidence, char- acteristics, prognostic factors, and out- come of 739 APL patients treated with ATRA plus idarubicin in 2 consecutive trials (Programa Espanol de Tratamientos en Hematologíc [PETHEMA] LPA96 and LPA99). Overall, 183 patients (24.8%) ex- perienced DS, 93 with a severe form (12.6%) and 90 with a moderate form (12.2%). Severe but not moderate DS was associated with an increase in mortality. A bimodal incidence of DS was observed, with peaks occurring in the first and third weeks after the start of ATRA therapy. A multivariate analysis indicated that a WBC count greater than 5 x 109/L and an abnor- mal serum creatinine level correlated with an increased risk of developing severe DS. Patients receiving systematic pred- nisone prophylaxis (LPA99 trial) in con- trast to those receiving selective prophy- laxis with dexamethasone (LPA96 trial) had a lower incidence of severe DS. Pa- tients developing severe DS showed a reduced 7-year relapse-free survival in the LPA96 trial (60% vs 85%, P = .003), but this difference was not apparent in the LPA99 trial

Vertical integration for full outsourcing: growth and internationalization of a portuguese packaging firm

Based on a case study of a Portuguese packaging firm, this paper examines how vertical integration of the supplier serves as a vehicle for the full outsourcing of the client firms' needs in a solution that reduces transaction costs, favors specialization, and permits small and mediumsized firms to develop competencies that may be exploited in a wide array of projects. Vertical integration by the supplier (a governance decision) is a strategic response to changes in the sourcing model of the clients. Client-supplier relationships have inter-spatial and inter-temporal value that surpasses spot market exchanges

The Impact of a Dealer's Failure on Otc Derivatives Market Liquidity During Volatile Periods

This paper develops a model in which information losses may be an important part of the cost of an OTC derivatives dealer's failure. A dealer failure forces solvent counterparties of a failed dealer to seek replacement hedges with other dealers. However, by forcing good firms into the derivatives market, the failure provides camouflage for insolvent firms seeking to speculate with a dealer that does not know their credit status. The paper models this information loss and uses the model to quantitatively evaluate a range of scenarios. The results suggest that a market breakdown is unlikely but not quite impossible