1,366 research outputs found

    The importance of various work aspects and their organiza tional consequences using Hofstede's cultural dimensions

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    This study examines the importance employees place on various work aspects according to their nation's relative positioning along Hofstede's four cultural dimension: power distance, individualism, uncertainty avoidance, and masculinity/feminity. Based on a cross-national sample of over 5,000 employees representing 20 countries, the results uncover differential patterns of responses by cultural groupings. The data also suggest that importance and satisfaction interactively affect several organizational consequences critería: job satisfaction, company satisfaction, intent to leave the firm, and organizational cornmitment

    The linkages between business strategies and compensation policies using miles and snow's framework

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    This study links a multidimensional measure of compensatíon strategy to Miles and Snow's (1978) business strategies, and examines their interactive impact on firm performance. The results reported here indicate that a more mechanistic compensation strategy makes a greater contribution to firm performance among defenders, while a more organic compensation strategy makes a greater contribution to firm performance among prospector

    The effectiveness of organization-wide compensation strategies in technology intensive firms

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    This study examines compensation strategies formulated and implemented by high technology firms and their relative effectiveness. Based on a sample of 173 firms, empirical results indicate that the following pay strategies are most appropriate for high technology organizations: A greater emphasis on the individual rather than the job as the unit of analysis, sharing of risks between employees and the firm, an external market orientation, dispersed decision making authority for pay allocation purposes, reliance on aggregate incentives and a longer time orientation

    Jurassic rifting to post-rift subsidence analysis in the Central High Atlas and its relation to salt diapirism

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    et. al.The subsidence evolution of the Tethyan Moroccan Atlas Basin, presently inverted as the Central High Atlas, is characterized by an Early Jurassic rifting episode, synchronous with salt diapirism of the Triassic evaporite-bearing rocks. Two contrasting regions of the rift basin – with and without salt diapirism – are examined to assess the effect of salt tectonics in the evolution of subsidence patterns and stratigraphy. The Djebel Bou Dahar platform to basin system, located in the southern margin of the Atlas Basin, shows a Lower Jurassic record of normal faulting and lacks any evidence of salt diapirism. In contrast, the Tazoult ridge and adjacent Amezraï basin, located in the centre of the Atlas Basin, reveals spectacular Early Jurassic diapirism. In addition, we analyse alternative Central High Atlas post-Middle Jurassic geohistories based on new thermal and burial models (GENEX® 4.0.3 software), constrained by new vitrinite reflectance data from the Amezraï basin. The comparison of the new subsidence curves from the studied areas with published subsidence curves from the Moroccan Atlas, the Saharan Atlas (Algeria) and Tunisian Atlas show that fast subsidence peaks were diachronous along the strike, being younger towards the east from Early–Middle Jurassic to Late Cretaceous. This analysis also evidences a close relationship between these high subsidence rate episodes and salt diapirism.This study was part of a collaborative research project funded by Statoil Research Centre, Bergen (Norway) and by the CSIC-FSE 2007-2013 JAE-Doc post-doctoral research contract (E.S.). The Spanish Ministry of Education and Science provided additional funding (MEC) through the projects Intramural Especial (CSIC 201330E030) and MITE (CGL 2014-59516). This research was supported by the Grup Consolidat de Recerca “Geologia Sediment aria” de la Generalitat de Catalunya (2014GSR251).Peer reviewedPreprin

    Fundamentos científicos de la rehabilitación tras la sustitución intraarticular del ligamento cruzado anterior

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    Hay pocos aspectos de la rehabilitación en nuestra especialidad que sean tan complejos y controvertidos como la rehabilitación después de la sustitución intraarticular del ligamento cruzado anterior (LCA). La tendencia actual es utilizar protocolos de rehabilitación acelerada y rápido funcionalismo, todo lo cual está en relación directa con el avance en la investigación sobre el comportamiento biológico de los implantes, una mayor sofisticación en la técnica quirúrgica y los adelantos en las técnicas de rehabilitación. El objetivo de este trabajo es analizar no protocolos concretos, sino los problemas que plantea la cirugía del LCA y como minimizarlos en la medida de lo posible, protegiendo al mismo tiempo la plastia.There are few aspects of rehabilitation in our speciality which are so complex and controversial like rehabilitation after intraarticular replacement of the anterior cruciate ligament (ACL). Nowadays there is a trend to use protocols of accelerated rehabilitation and rapid functioning, and all this is related to the advances in research on the biological behavior of the grafts, a major sophistication in surgical technique and advances in rehabilitation techniques. The objective of this paper is not to analyze concrete protocols but rather the problems that state the surgery of the ACL, and how to diminish them to maximum, protecting at the same time the graft

    Diapiric growth within an Early Jurassic rift basin: The Tazoult salt wall (central High Atlas, Morocco)

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    The central High Atlas (Morocco) constitutes a diapiric province that hosts a complex array of elongated diapirs and minibasins that formed during the Lower Jurassic rift of the Atlas Basin. This paper aims to study the structure and growth evolution of the Tazoult diapiric wall, located in the central High Atlas, by means of structural and sedimentological fieldwork integrated with remote sensing mapping. The Tazoult salt wall is a 20km long×3km wide NE-SW trending ridge that exposes Upper Triassic red beds and basalts along its core. The succession flanking the salt wall ranges from Hettangian to Bajocian ages displaying spectacular sedimentary wedges in the SE and NW flanks. The Hettangian-early Sinemurian carbonates mainly crop out as blocks embedded in the core rocks. The ~1km thick Pliensbachian platform carbonates display large subvertical flap structures along the flanks of the Tazoult salt wall with unconformities bounding tapered composite halokinetic sequences. In contrast, the ~2.5km thick late Pliensbachian-Aalenian mixed deposits form tabular composite halokinetic sequences displaying small-scale hook halokinetic sequences. Passive diapirism resulted in the lateral extrusion of the evaporite-bearing rocks to form an allochthonous salt sheet toward the adjacent SE Amezraï minibasin. The Bajocian platform carbonates partially fossilized the Tazoult salt wall and thus constitute a key horizon to constrain the timing of diapir growth and discriminate diapirism from Alpine shortening. The Pliensbachian carbonate platform evolved as a long flap structure during the early growth of the Tazoult salt wall, well before the onset of the Alpine shortening. © 2016. American Geophysical Union. All Rights Reserved.Additional funding was provided by the Spanish Ministry of Education and Science (MEC) through the projects Intramural Especial (CSIC 201330E030) and 201530E082), Atiza (CGL2009-1355), Tecla (CGL2011-26670), and the postdoctoral research contract to E.S. (CSIC-FSE 2007-2013 JAE-Doc), as well as by the Generalitat de Catalunya (2014GSR251).Peer reviewe

    Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer

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    Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose.Methods:Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using 99 Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry.Results:Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1±8.9 vs 31.3±12.9 mg (P=0.01). Both, AUC 24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P<0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P=0.03) in tumour specimens.Conclusion:Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.Fil: Sarduy, M. R.. Medical-surgical Research Center; CubaFil: García, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Coca, M. A.. Clinical Investigation Center; CubaFil: Perera, A.. Clinical Investigation Center; CubaFil: Torres, L. A.. Clinical Investigation Center; CubaFil: Valenzuela, C. M.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Baladrón, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Solares, M.. Hospital Materno Ramón González Coro; CubaFil: Reyes, V.. Center For Genetic Engineering And Biotechnology Havana; CubaFil: Hernández, I.. Isotope Center; CubaFil: Perera, Y.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Martínez, Y. M.. Medical-surgical Research Center; CubaFil: Molina, L.. Medical-surgical Research Center; CubaFil: González, Y. M.. Medical-surgical Research Center; CubaFil: Ancízar, J. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Prats, A.. Clinical Investigation Center; CubaFil: González, L.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Casacó, C. A.. Clinical Investigation Center; CubaFil: Acevedo, B. E.. Centro de Ingeniería Genética y Biotecnología; CubaFil: López Saura, P. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; ArgentinaFil: Gómez, R.. Elea Laboratories; ArgentinaFil: Perea Rodríguez, S. E.. Center For Genetic Engineering And Biotechnology Havana; Cuba. Centro de Ingeniería Genética y Biotecnología; Cub
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