Turning the tide of antimicrobial resistance: Europe shows the way

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldTen years ago, European officials, experts and other stakeholders met in Copenhagen, Denmark, at the invitation of the Danish Ministry of Health and the Danish Ministry of Food, Agriculture and Fisheries. This European conference on "The Microbial Threat" due to antimicrobial resistance resulted in the publication of "Copenhagen Recommendations" calling for action to limit the emerging problem of antimicrobial-resistant microorganisms [1]. Following the conference, the European Commission prepared a comprehensive Community strategy against antimicrobial resistance, which was published in 2001 [2] and presented in Eurosurveillance [3]. Later the same year, European Union (EU) Health Ministers adopted a Council Recommendation on the prudent use of antimicrobial agents in human medicine with a series of specific measures aimed at containing the spread of antimicrobial resistance by prudent use of antimicrobial agents [4

Amorphization of ZnAl2O4 spinel under heavy ion irradiation

ZnAl2O4 spinels have been irradiated with several ions (Ne, S, Kr and Xe) at the IRRSUD beam-line of the GANIL facility, in order to determine irradiation conditions (stopping power, fluence) for amorphisation. We observed by Transmission Electron Microscopy (TEM) that with Xe ions at 92 MeV, individual ion tracks are still crystalline, whereas an amorphisation starts below a fluence of 5.1012 cm-2 up to a total amorphisation between 1x1013 and 1x1014 cm-2. The coexistence of amorphous and crystalline domains in the same pristine grain is clearly visible in the TEM images. All the crystalline domains remain close to the same orientation as the original grain. According to TEM and X-Ray Diffraction (XRD) results, the stopping power threshold for amorphisation is between 9 and 12 keV.nm-1

Scalable N-body code for the modelling of early-type galaxies

Early-type galaxies exhibit a wealth of photometric and dynamical structures. These signatures are fossil records of their formation and evolution processes. In order to examine these structures in detail, we build models aimed at reproducing the observed photometry and kinematics. The developed method is a generalization of the one introduced by Syer and Tremaine (1996), consisting in an N-body representation, in which the weights of the particles are changing with time. Our code is adapted for integral-field spectroscopic data, and is able to reproduce the photometric as well as stellar kinematic data of observed galaxies. We apply this technique on SAURON data of early-type galaxies, and present preliminary results on NGC 3377.Comment: 6 pages, 2 figures. Original version printed in the Proceedings of "Science perspective for 3D spectroscopy", 2005, Eds Kissler-Patig, Walsh, Roth, ES0, Springe

The FALCON concept: multi-object spectroscopy combined with MCAO in near-IR

A large fraction of the present-day stellar mass was formed between z=0.5 and z~3 and our understanding of the formation mechanisms at work at these epochs requires both high spatial and high spectral resolution: one shall simultaneously} obtain images of objects with typical sizes as small as 1-2kpc(~0''.1), while achieving 20-50 km/s (R >= 5000) spectral resolution. The obvious instrumental solution to adopt in order to tackle the science goal is therefore a combination of multi-object 3D spectrograph with multi-conjugate adaptive optics in large fields. A partial, but still competitive correction shall be prefered, over a much wider field of view. This can be done by estimating the turbulent volume from sets of natural guide stars, by optimizing the correction to several and discrete small areas of few arcsec2 selected in a large field (Nasmyth field of 25 arcmin) and by correcting up to the 6th, and eventually, up to the 60th Zernike modes. Simulations on real extragalactic fields, show that for most sources (>80%), the recovered resolution could reach 0".15-0".25 in the J and H bands. Detection of point-like objects is improved by factors from 3 to >10, when compared with an instrument without adaptive correction. The proposed instrument concept, FALCON, is equiped with deployable mini-integral field units (IFUs), achieving spectral resolutions between R=5000 and 20000. Its multiplex capability, combined with high spatial and spectral resolution characteristics, is a natural ground based complement to the next generation of space telescopes.Comment: ESO Workshop Proceedings: Scientific Drivers for ESO Future VLT/VLTI Instrumentation, 10 pages and 5 figure

Characterisation of dislocation behaviour in RPV steel

Results obtained in the framework of the European project PERFECT (FI60-CT-2003- 208840) are presented.Наводяться результати, отримані у рамках Європейського проекту PERFECT (F160-CT- 2003-208840).Приводятся результаты, полученные в рамках Европейского проекта PERFECT (F160- CT-2003-208840)

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.

OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock. METHODS: The European Society of Intensive Care Medicine invited 12 experts to form a Task Force to update a previous consensus (Antonelli et al.: Intensive Care Med 33:575-590, 2007). The same five questions addressed in the earlier consensus were used as the outline for the literature search and review, with the aim of the Task Force to produce statements based on the available literature and evidence. These questions were: (1) What are the epidemiologic and pathophysiologic features of shock in the intensive care unit ? (2) Should we monitor preload and fluid responsiveness in shock ? (3) How and when should we monitor stroke volume or cardiac output in shock ? (4) What markers of the regional and microcirculation can be monitored, and how can cellular function be assessed in shock ? (5) What is the evidence for using hemodynamic monitoring to direct therapy in shock ? Four types of statements were used: definition, recommendation, best practice and statement of fact. RESULTS: Forty-four statements were made. The main new statements include: (1) statements on individualizing blood pressure targets; (2) statements on the assessment and prediction of fluid responsiveness; (3) statements on the use of echocardiography and hemodynamic monitoring. CONCLUSIONS: This consensus provides 44 statements that can be used at the bedside to diagnose, treat and monitor patients with shock

Molecular Gas Dynamics in NGC 6946: a Bar-driven Nuclear Starburst "Caught in the Act"

We present high angular resolution ~1" and 0.6" mm-interferometric observations of the 12CO(1-0) and 12CO(2-1) line emission in the central 300pc of the late-type spiral galaxy NGC6946. The data, obtained with the IRAM Plateau de Bure Interferometer (PdBI), allow the first detection of a molecular gas spiral in the inner ~10" (270pc) with a large concentration of molecular gas (M(H_2) ~1.6x10^7M_sun) within the inner 60pc. This nuclear clump shows evidence for a ring-like geometry with a radius of ~10pc as inferred from the p-v diagrams. Both the distribution of the molecular gas as well as its kinematics can be well explained by the influence of an inner stellar bar of about 400pc length. A qualitative model of the expected gas flow shows that streaming motions along the leading sides of this bar are a plausible explanation for the high nuclear gas density. Thus, NGC6946 is a prime example of molecular gas kinematics being driven by a small-scale, secondary stellar bar.Comment: accepted for publication in the Astrophysical Journal; 47 pages, 17 figures, 1 tabl