Different Patterns of Chromospheric Evaporation in a Flaring Region Observed with Hinode/EIS

We investigate the chromospheric evaporation in the flare of 2007 January 16 using line profiles observed by the EUV Imaging Spectrometer (EIS) onboard Hinode. Three points at flare ribbons of different magnetic polarities are analyzed in detail. We find that the three points show different patterns of upflows and downflows in the impulsive phase of the flare. The spectral lines at the first point are mostly blue shifted, with the hotter lines showing a dominant blue-shifted component over the stationary one. At the second point, however, only weak upflows are detected; in stead, notable downflows appear at high temperatures (up to 2.5-5.0 MK). The third point is similar to the second one only that it shows evidence of multi-component downflows. While the evaporated plasma falling back down as warm rain is a possible cause of the redshifts at points 2 and 3, the different patterns of chromospheric evaporation at the three points imply existence of different heating mechanisms in the flaring active region.Comment: 18 pages, 7 figures, 2 tables. Accepted for publication in Ap

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs

G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential. One in particular that has been gaining attention in recent times is that of GPCR ligands that bind to allosteric sites on the receptor distinct from the orthosteric site of the endogenous ligand. As therapeutics, allosteric ligands possess many theoretical advantages over their orthosteric counterparts, including more complex modes of action, improved safety, more physiologically appropriate responses, better target selectivity, and reduced likelihood of desensitisation and tachyphylaxis. Despite these advantages, the development of allosteric ligands is often difficult from a medicinal chemistry standpoint due to the more complex challenge of identifying allosteric leads and their often flat or confusing SAR. The present review will consider the advantages and challenges associated with allosteric GPCR ligands, and examine how the particular properties of these ligands may be exploited to uncover the therapeutic potential for free fatty acid sensitive GPCRs

Evidence of Explosive Evaporation in a Microflare Observed by Hinode/EIS

We present a detailed study of explosive chromospheric evaporation during a microflare which occurred on 2007 December 7 as observed with the EUV Imaging Spectrometer (EIS) onboard Hinode. We find temperature-dependent upflows for lines formed from 1.0 to 2.5 MK and downflows for lines formed from 0.05 to 0.63 MK in the impulsive phase of the flare. Both the line intensity and the nonthermal line width appear enhanced in most of the lines and are temporally correlated with the time when significant evaporation was observed. Our results are consistent with the numerical simulations of flare models, which take into account a strong nonthermal electron beam in producing the explosive chromospheric evaporation. The explosive evaporation observed in this microflare implies that the same dynamic processes may exist in events with very different magnitudes.Comment: 14 pages, 8 figures. Accepted for publication in the Astrophysical Journa

Anemia in athletes

This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of anemia in athletes

Blood doping

This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of blood doping

Micromechanics of cyclic deformation in SSME turbopump blade materials

Current and candidate Space Shuttle Main Engine (SSME) turbopump blade materials are anisotropic, both in their elastic and plastic response. The major objective is to characterize the plastic deformation behavior of a typical single crystal nickel-base superalloy, PWA 1480, and to use this information to help guide the development of anisotropic constitutive models

Low-density polybenzimidazole foams for thermal insulation and fire protection

Fire-resistant and nonsmoking foam can be prepared in desirable density range of 24 to 50 kg/cu m by controlled thermal crosslinking of polybenzimidazole prepolymer. Reproducible foams of specific density can be produced by controlling volative content and melting temperature of prepolymer