31 research outputs found
The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics
A global genome database of all of Earth’s species diversity could be a treasure trove of
scientific discoveries. However, regardless of the major advances in genome sequencing
technologies, only a tiny fraction of species have genomic information available. To contribute to
a more complete planetary genomic database, scientists and institutions across the world have
united under the Earth BioGenome Project (EBP), which plans to sequence and assemble
high-quality reference genomes for all ~1.5 million recognized eukaryotic species through a
stepwise phased approach. As the initiative transitions into Phase II, where 150,000 species are
to be sequenced in just four years, worldwide participation in the project will be fundamental to
success. As the European node of the EBP, the European Reference Genome Atlas (ERGA)
seeks to implement a new decentralised, accessible, equitable and inclusive model for producing
high-quality reference genomes, which will inform EBP as it scales. To embark on this mission,
ERGA launched a Pilot Project to establish a network across Europe to develop and test the first
infrastructure of its kind for the coordinated and distributed reference genome production on 98
European eukaryotic species from sample providers across 33 European countries. Here we
outline the process and challenges faced during the development of a pilot infrastructure for the
production of reference genome resources, and explore the effectiveness of this approach in
terms of high-quality reference genome production, considering also equity and inclusion. The
outcomes and lessons learned during this pilot provide a solid foundation for ERGA while
offering key learnings to other transnational and national genomic resource projects.info:eu-repo/semantics/draf
Extension of antimicrobial treatment in patients with left-sided native valve endocarditis based on elevated C-reactive protein values
How genomics can help biodiversity conservation
The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main approaches and applications in biodiversity and conservation genomics, considering practical factors, such as cost, time, prerequisite skills, and current shortcomings of applications. Most approaches perform best in combination with reference genomes from the target species or closely related species. We review case studies to illustrate how reference genomes can facilitate biodiversity research and conservation across the tree of life. We conclude that the time is ripe to view reference genomes as fundamental resources and to integrate their use as a best practice in conservation genomics.info:eu-repo/semantics/publishedVersio
The era of reference genomes in conservation genomics
Progress in genome sequencing
now enables the large-scale
generation of reference genomes.
Various international initiatives
aim to generate reference genomes
representing global biodiversity.
These genomes provide
unique insights into genomic diversity
and architecture, thereby enabling
comprehensive analyses
of population and functional
genomics, and are expected
to revolutionize conservation
genomics
The era of reference genomes in conservation genomics
Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional
genomics, and are expected to revolutionize conservation genomics
How genomics can help biodiversity conservation
The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main approaches and applications in biodiversity and conservation genomics, considering practical factors, such as cost, time, prerequisite skills, and current shortcomings of applications. Most approaches perform best in combination with reference genomes from the target species or closely related species. We review case studies to illustrate how reference genomes can facilitate biodiversity research and conservation across the tree of life. We conclude that the time is ripe to view reference genomes as fundamental resources and to integrate their use as a best practice in conservation genomics