'I just want a job' : what do we really know about young people in jobs without training?

Over recent years, a central concern of policy has been to drive up post-16 participation rates in full-time education and address the needs of young people not in education, employment or training (NEET). As a result, young people who enter work which is classified as 'without training' at 16/17 have largely been ignored. However, the decision to Raise the Participation Age (RPA) for continuing in learning for all 17-year olds from 2013 and for all 18-year olds from 2015 in England, together with a growing unease about the impact of the current recession on youth unemployment rates, have revived interest in the 'jobs without training' (JWT) group. This paper draws on the findings from two studies: first, a qualitative study in two contrasting local labour markets, of young people in JWT, together with their employers and parents; and second, an evaluation of the Learning Agreement Pilots (LAP), which was the first policy initiative in England targeted at the JWT group. Both studies reveal a dearth of understanding about early labour market entrants and a lack of policy intervention and infrastructure to support the needs of the JWT group throughout the UK. From this, it is concluded that questionable assumptions have been made about the composition and the aspirations of young people in JWT, and their employers, on the basis of little or no evidence. As a consequence, a policy 'quick fix' to satisfy the RPA agenda will not easily be achieved. If the decision to raise the participation age is adopted also by the Welsh and Scottish parliaments, similar challenges may have to be faced

'See No Evil' Collusion in Northern Ireland

The publication of the official report into the 1994 Loughinisland massacre, when loyalist gunmen shot dead six people in a small, rural bar, provides an opportunity to examine the nature of institutionalised collusion, the state practices it involved and the sectarianised social order which made it possible during the conflict in Northern Ireland. Building on an earlier analysis of the colonial and counter-insurgency roots of collusion (Race & Class, 57, no. 2) this article provides a commentary on the findings of the Loughinisland report and explores two issues. The first concerns new evidence (directly contradicting earlier official inquiries) of state collusion in the importation of arms used by loyalists to escalate their campaign of assassination in this period. Second, the extent to which collusive practices facilitated the actions of loyalist paramilitaries and confounded the investigation of the mass killings at Loughinisland as elsewhere. In terms of both, it will be argued, there is a need to place an understanding of collusion in the wider context of a social order shaped by long-term sectarianised social divisions and violence, embedded in localised power structures, which framed the very institutions and agencies of the state, not least the police and other state forces

The impact and penetration of location-based services

Since the invention of digital technology, its development has followed an entrenched path ofminiaturisation and decentralisation with increasing focus on individual and niche applications. Computerhardware has moved from remote centres to desktop and hand held devices whilst being embedded invarious material infrastructures. Software has followed the same course. The entire process has convergedon a path where various analogue devices have become digital and are increasingly being embedded inmachines at the smallest scale. In a parallel but essential development, there has been a convergence ofcomputers with communications ensuring that the delivery and interaction mechanisms for computersoftware is now focused on networks of individuals, not simply through the desktop, but in mobilecontexts. Various inert media such as fixed television is becoming more flexible as computers and visualmedia are becoming one.With such massive convergence and miniaturisation, new software and new applications define the cuttingedge. As computers are being increasingly tailored to individual niches, then new digital services areemerging, many of which represent applications which hitherto did not exist or at best were rarely focusedon a mass market. Location based services form one such application and in this paper, we will bothspeculate on and make some initial predictions of the geographical extent to which such services willpenetrate different markets. We define such services in detail below but suffice it to say at this stage thatsuch functions involve the delivery of traditional services using digital media and telecommunications.High profile applications are now being focused on hand held devices, typically involving information onproduct location and entertainment but wider applications involve fixed installations on the desktop whereservices are delivered through traditional fixed infrastructure. Both wire and wireless applications definethis domain. The market for such services is inevitably volatile and unpredictable at this early stage but wewill attempt here to provide some rudimentary estimates of what might happen in the next five to tenyears.The ?network society? which has developed through this convergence, is, according to Castells (1989,2000) changing and re-structuring the material basis of society such that information has come todominate wealth creation in a way that information is both a raw material of production and an outcome ofproduction as a tradable commodity. This has been fuelled by the way technology has expanded followingMoore?s Law and by fundamental changes in the way telecommunications, finance, insurance, utilitiesand so on is being regulated. Location based services are becoming an integral part of this fabric and thesereflect yet another convergence between geographic information systems, global positioning systems, andsatellite remote sensing. The first geographical information system, CGIS, was developed as part of theCanada Land Inventory in 1965 and the acronym ?GIS? was introduced in 1970. 1971 saw the firstcommercial satellite, LANDSAT-1. The 1970s also saw prototypes of ISDN and mobile telephone and theintroduction of TCP/IP as the dominant network protocol. The 1980s saw the IBM XT (1982) and thebeginning of de-regulation in the US, Europe and Japan of key sectors within the economy. Finally in the 1990s, we saw the introduction of the World Wide Web and the ubiquitous pervasion of business andrecreation of networked PC?s, the Internet, mobile communications and the growing use of GPS forlocational positioning and GIS for the organisation and visualisation of spatial data. By the end of the 20thcentury, the number of mobile telephone users had reached 700 million worldwide. The increasingmobility of individuals, the anticipated availability of broadband communications for mobile devices andthe growing volumes of location specific information available in databases will inevitably lead to thedemand for services that will deliver location related information to individuals on the move. Suchlocation based services (LBS) although in a very early stage of development, are likely to play anincreasingly important part in the development of social structures and business in the coming decades.In this paper we begin by defining location based services within the context we have just sketched. Wethen develop a simple model of the market for location-based services developing the standard non-linearsaturation model of market penetration. We illustrate this for mobile devices, namely mobile phones in thefollowing sections and then we develop an analysis of different geographical regimes which arecharacterised by different growth rates and income levels worldwide. This leads us to speculate on theextent to which location based services are beginning to take off and penetrate the market. We concludewith scenarios for future growth through the analogy of GIS and mobile penetration

Taming tosyl azide: the development of a scalable continuous diazo transfer process

Heat and shock sensitive tosyl azide was generated and used on demand in a telescoped diazo transfer process. Small quantities of tosyl azide were accessed in a one pot batch procedure using shelf stable, readily available reagents. For large scale diazo transfer reactions tosyl azide was generated and used in a telescoped flow process, to mitigate the risks associated with handling potentially explosive reagents on scale. The in situ formed tosyl azide was used to rapidly perform diazo transfer to a range of acceptors, including β-ketoesters, β-ketoamides, malonate esters and β-ketosulfones. An effective in-line quench of sulfonyl azides was also developed, whereby a sacrificial acceptor molecule ensured complete consumption of any residual hazardous diazo transfer reagent. The telescoped diazo transfer process with in-line quenching was used to safely prepare over 21 g of an α-diazocarbonyl in >98% purity without any column chromatography

The Makapansgat Limeworks grey breccia: hominids, hyaenas, hystricids or hillwash?

Main articleThe question of the origin of the Makapansgat Limeworks grey breccia is here considered from two viewpoints: (a) the accumulation of bones within a catchment area; and (b) the possible concentration of the bones in their final resting place. The potential role of hyaenas and porcupines as bone-accumulating agents is investigated. Nine categories of hyaena damage to bone surfaces could be distinguished on collections of bone taken from a series of recent hyaena breeding dens. All nine categories can be demonstrated in identical form on fossil bones from the grey breccia. It is concluded that carnivores have played a more substantial role as accumulators of the bones in this breccia than has previously been acknowledged. Porcupines are excluded as major contributors to the grey breccia bone assemblage on the basis of the low percentage of porcupine-gnawed bones present compared with recent porcupine accumulations. Furthermore, the pattern of damage observed on porcupine-collected skeletal elements does not resemble that documented for the grey breccia. A 3-dimensional computer plot of the topography of the Limeworks travertine floor shows the presence of two larger and two smaller basins separated from each other by floor "highs". A floor "high" around the grey breccia is demonstrated and may have been a significant factor in bone concentration. Sedimentation within separate basins need -not necessarily have been synchronous or equivalent, and the practice of equating Members from one part of the cavern to another is questioned. Stereographic projections of the dip and strike orientations of the long axes of a number of in situ grey breccia bones in two separate areas indicate orientation patterns and imbrication. The results of the projections suggest that a combination of water current action and gravity may have been responsible for the present configuration of the bones.Non

Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates

As α-carboxy nucleoside phosphonates (α-CNPs) have demonstrated a novel mode of action of HIV-1 reverse transcriptase inhibition, structurally related derivatives were synthesized, namely the malonate 2, the unsaturated and saturated bisphosphonates 3 and 4, respectively and the amide 5. These compounds were evaluated for inhibition of HIV-1 reverse transcriptase in cell-free assays. The importance of the α-carboxy phosphonoacetic acid moiety for achieving reverse transcriptase inhibition, without the need for prior phosphorylation, was confirmed. The malonate derivative 2 was less active by two orders of magnitude than the original α-CNPs, while displaying the same pattern of kinetic behavior; interestingly the activity resides in the “L”-enantiomer of 2, as seen with the earlier series of α-CNPs. A crystal structure with an RT/DNA complex at 2.95 Å resolution revealed the binding of the “L”-enantiomer of 2, at the polymerase active site with a weaker metal ion chelation environment compared to 1a (T-α-CNP) which may explain the lower inhibitory activity of 2

The tropospheric gas composition of Jupiter's north equatorial belt (NH3, PH3, CH3D, GeH4, H2O) and the Jovian D/H isotropic ratio

The gas composition of the troposphere of Jupiter in the clearest regions of the North Equatorial Belt (NEB) was derived from the Voyager 1 IRIS data. The infrared spectrum for this homogeneous cloud free region was modeled to infer altitude profiles for NH3, PH3, GeH4 and H2O. The Profiles for NH3 and PH3 were found to be depleted in the upper troposphere but otherwise in agreement with their solar values at the 1 bar level. The mole fraction for CH3D was determined to be 3.5(+1.0 or -1.3) x 10 to the minus 7th power. The GeH4 mole fraction of 7+ or -2 x 10 to the minus 10th power at the 2 to 3 bar level is a factor of 10 lower than the solar value. The H2O mole fraction is approximately 1 x 0.00001 at the 2.5 bar level and is increasing to approximately 3 x 0.00001 at 4 bars where it is a factor of 30 lower than solar. Using IRIS infrared values for the mole fractions of CH3D and CH4 a value of D/H = 3.6(+1.0 or -1.4)x 0.00001 is derived. Assuming this Jovian D/H ratio is representative of the protosolar nebula, and correcting for chemical galactic evolution, yields a value of 5.5 - 9.0 x 0.00001 for the primordial D/H ratio and an upper limit of 1.8 to 2.4 x 10 to the minus 31st power cu cm for the present day baryon density

Tonic inhibition of accumbal spiny neurons by extrasynaptic 4 GABAA receptors modulates the actions of psychostimulants

Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine. We demonstrate that both dopamine D1- and D2-receptor-expressing MSNs (D-MSNs) additionally harbor extrasynaptic GABAARs incorporating α4, β, and δ subunits that mediate tonic inhibition, thereby influencing neuronal excitability. Both the selective δ-GABAAR agonist THIP and DS2, a selective positive allosteric modulator, greatly increased the tonic current of all MSNs from wild-type (WT), but not from δ−/− or α4−/− mice. Coupling dopamine and tonic inhibition, the acute activation of D1 receptors (by a selective agonist or indirectly by amphetamine) greatly enhanced tonic inhibition in D1-MSNs but not D2-MSNs. In contrast, prolonged D2 receptor activation modestly reduced the tonic conductance of D2-MSNs. Behaviorally, WT and constitutive α4−/− mice did not differ in their expression of cocaine-conditioned place preference (CPP). Importantly, however, mice with the α4 deletion specific to D1-expressing neurons (α4D1−/−) showed increased CPP. Furthermore, THIP administered systemically or directly into the NAc of WT, but not α4−/− or α4D1−/− mice, blocked cocaine enhancement of CPP. In comparison, α4D2−/− mice exhibited normal CPP, but no cocaine enhancement. In conclusion, dopamine modulation of GABAergic tonic inhibition of D1- and D2-MSNs provides an intrinsic mechanism to differentially affect their excitability in response to psychostimulants and thereby influence their ability to potentiate conditioned reward. Therefore, α4βδ GABAARs may represent a viable target for the development of novel therapeutics to better understand and influence addictive behaviors