Discovery of Four Gravitationally Lensed Quasars from the Sloan Digital Sky Survey

We present the discovery of four gravitationally lensed quasars selected from the spectroscopic quasar catalog of the Sloan Digital Sky Survey. We describe imaging and spectroscopic follow-up observations that support the lensing interpretation of the following four quasars: SDSS J0832+0404 (image separation \theta=1.98", source redshift z_s=1.115, lens redshift z_l=0.659); SDSS J1216+3529 (\theta=1.49", z_s=2.012); SDSS J1322+1052 (\theta=2.00", z_s=1.716); and SDSS J1524+4409 (\theta=1.67", z_s=1.210, z_l=0.320). Each system has two lensed images. We find that the fainter image component of SDSS J0832+0404 is significantly redder than the brighter component, perhaps because of differential reddening by the lensing galaxy. The lens potential of SDSS J1216+3529 might be complicated by the presence of a secondary galaxy near the main lensing galaxy.Comment: 25 pages, 10 figures, 6 tables, accepted for publication in A

A New Survey for Giant Arcs

We report on the first results of an imaging survey to detect strong gravitational lensing targeting the richest clusters selected from the photometric data of the Sloan Digital Sky Survey (SDSS) with follow-up deep imaging observations from the Wisconsin Indiana Yale NOAO (WIYN) 3.5m telescope and the University of Hawaii 88-inch telescope (UH88). The clusters are selected from an area of 8000 deg^2 using the Red Cluster Sequence technique and span the redshift range 0.1 < z < 0.6, corresponding to a comoving cosmological volume of ~ 2 Gpc^3. Our imaging survey thus targets a volume more than an order of magnitude larger than any previous search. A total of 240 clusters were imaged of which 141 had sub-arcsecond image quality. Our survey has uncovered16 new lensing clusters with definite giant arcs, an additional 12 systems for which the lensing interpretation is very likely, and 9 possible lenses which contain shorter arclets or candidate arcs which are less certain and will require further observations to confirm their lensing origin. The number of new cluster lenses detected in this survey is likely > 30. Among these new systems are several of the most dramatic examples of strong gravitational lensing ever discovered with multiple bright arcs at large angular separation. These will likely become 'poster-child' gravitational lenses similar to Abell 1689 and CL0024+1654. The new lenses discovered in this survey will enable future sysetmatic studies of the statistics of strong lensing and its implications for cosmology and our structure formation paradigm.Comment: 19 pages, 7 pages of Figures, submitted to AJ. Fixed Typo

SDSS J094604.90+183541.8: A Gravitationally Lensed Quasar at z=4.8

We report the discovery of a gravitationally lensed quasar identified serendipitously in the Sloan Digital Sky Survey (SDSS). The object, SDSS J094604.90+183541.8, was initially targeted for spectroscopy as a luminous red galaxy, but the SDSS spectrum has the features of both a z=0.388 galaxy and a z=4.8 quasar. We have obtained additional imaging that resolves the system into two quasar images separated by 3.06 arcsec and a bright galaxy that is strongly blended with one of the quasar images. We confirm spectroscopically that the two quasar images represent a single lensed source at z=4.8 with a total magnification of 3.2, and we derive a model for the lensing galaxy. This is the highest redshift lensed quasar currently known. We examine the issues surrounding the selection of such an unusual object from existing data and briefly discuss implications for lensed quasar surveys.Comment: AJ accepted, 9 pages, 6 figures, referee suggestions include

The Sloan Digital Sky Survey Quasar Lens Search. IV. Statistical Lens Sample from the Fifth Data Release

We present the second report of our systematic search for strongly lensed quasars from the data of the Sloan Digital Sky Survey (SDSS). From extensive follow-up observations of 136 candidate objects, we find 36 lenses in the full sample of 77,429 spectroscopically confirmed quasars in the SDSS Data Release 5. We then define a complete sample of 19 lenses, including 11 from our previous search in the SDSS Data Release 3, from the sample of 36,287 quasars with i<19.1 in the redshift range 0.6<z<2.2, where we require the lenses to have image separations of 1"<\theta<20" and i-band magnitude differences between the two images smaller than 1.25 mag. Among the 19 lensed quasars, 3 have quadruple-image configurations, while the remaining 16 show double images. This lens sample constrains the cosmological constant to be \Omega_\Lambda=0.84^{+0.06}_{-0.08}(stat.)^{+0.09}_{-0.07}(syst.) assuming a flat universe, which is in good agreement with other cosmological observations. We also report the discoveries of 7 binary quasars with separations ranging from 1.1" to 16.6", which are identified in the course of our lens survey. This study concludes the construction of our statistical lens sample in the full SDSS-I data set.Comment: 37 pages, 2 figures and 5 tables, accepted to A

Targeted knock-down of miR21 primary transcripts using snoMEN vectors induces apoptosis in human cancer cell lines

We have previously reported an antisense technology, 'snoMEN vectors', for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use of snoMEN vectors to target the knock-down of micro RNA primary transcripts. We document the specific knock-down of miR21 in HeLa cells using plasmid vectors expressing miR21-targeted snoMEN RNAs and show this induces apoptosis. Knock-down is dependent on the presence of complementary sequences in the snoMEN vector and the induction of apoptosis can be suppressed by over-expression of miR21. Furthermore, we have also developed lentiviral vectors for delivery of snoMEN RNAs and show this increases the efficiency of vector transduction in many human cell lines that are difficult to transfect with plasmid vectors. Transduction of lentiviral vectors expressing snoMEN targeted to pri-miR21 induces apoptosis in human lung adenocarcinoma cells, which express high levels of miR21, but not in human primary cells. We show that snoMEN-mediated suppression of miRNA expression is prevented by siRNA knock-down of Ago2, but not by knock-down of Ago1 or Upf1. snoMEN RNAs colocalise with Ago2 in cell nuclei and nucleoli and can be co-immunoprecipitated from nuclear extracts by antibodies specific for Ago2

Immunologic properties of purified epidermal Langerhans cells: Distinct requirements for stimulation of unprimed and sensitized T lymphocytes

Inaba, K., Schuler, G., Witmer, M., Valinsky, J., Atassi, B., and Steinman, R.M. Immunologic properties of purified epidermal Langerhans cells: Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J. Exp. Med. 164: 605-613, 1986.https://digitalcommons.rockefeller.edu/historical-scientific-reports/1019/thumbnail.jp

Immunologic properties of purified epidermal langerhans cells: Distinct requirements for stimulation of unprimed and sensitized T lymphocytes

[No abstract available

The Sloan Digital Sky Survey Quasar Lens Search. II. Statistical lens sample from the third data release

We report the first results of our systematic search for strongly lensed quasars using the spectroscopically confirmed quasars in the Sloan Digital Sky Survey (SDSS). Among 46,420 quasars from the SDSS Data Release 3 (~4188 deg^2), we select a subsample of 22,683 quasars that are located at redshifts between 0.6 and 2.2 and are brighter than the Galactic extinction-corrected i-band magnitude of 19.1. We identify 220 lens candidates from the quasar subsample, for which we conduct extensive and systematic follow-up observations in optical and near-infrared wavebands, in order to construct a complete lensed quasar sample at image separations between 1" and 20" and flux ratios of faint to bright lensed images larger than 10^(−0.5). We construct a statistical sample of 11 lensed quasars. Ten of these are galaxy-scale lenses with small image separations (~ 1"-2") and one is a large separation (15") system which is produced by a massive cluster of galaxies, representing the first statistical sample of lensed quasars including both galaxy- and cluster-scale lenses. The Data Release 3 spectroscopic quasars contain an additional 11 lensed quasars outside the statistical sample

Bayesian power-spectrum inference for Large Scale Structure data

We describe an exact, flexible, and computationally efficient algorithm for a joint estimation of the large-scale structure and its power-spectrum, building on a Gibbs sampling framework and present its implementation ARES (Algorithm for REconstruction and Sampling). ARES is designed to reconstruct the 3D power-spectrum together with the underlying dark matter density field in a Bayesian framework, under the reasonable assumption that the long wavelength Fourier components are Gaussian distributed. As a result ARES does not only provide a single estimate but samples from the joint posterior of the power-spectrum and density field conditional on a set of observations. This enables us to calculate any desired statistical summary, in particular we are able to provide joint uncertainty estimates. We apply our method to mock catalogs, with highly structured observational masks and selection functions, in order to demonstrate its ability to reconstruct the power-spectrum from real data sets, while fully accounting for any mask induced mode coupling.Comment: 25 pages, 15 figure

Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro

[No abstract available