Renormalization group flows in one-dimensional lattice models: impurity scaling, umklapp scattering and the orthogonality catastrophe

We show that to understand the orthogonality catastrophe in the half-filled lattice model of spinless fermions with repulsive nearest neighbor interaction and a local impurity in its Luttinger liquid phase one has to take into account (i) the impurity scaling, (ii) unusual finite size $L$ corrections of the form $\ln(L)/L$, as well as (iii) the renormalization group flow of the umklapp scattering. The latter defines a length scale $L_u$ which becomes exceedingly large the closer the system is to its transition into the charge-density wave phase. Beyond this transition umklapp scattering is relevant in the renormalization group sense. Field theory can only be employed for length scales larger than $L_u$. For small to intermediate two-particle interactions, for which the regime $L > L_u$ can be accessed, and taking into account the finite size corrections resulting from (i) and (ii) we provide strong evidence that the impurity backscattering contribution to the orthogonality exponent is asymptotically given by $1/16$. While further increasing the two-particle interaction leads to a faster renormalization group flow of the impurity towards the cut chain fixed point, the increased bare amplitude of the umklapp scattering renders it virtually impossible to confirm the expected asymptotic value of $1/16$ given the accessible system sizes. We employ the density matrix renormalization group.Comment: 12 pages, 9 figure

Spectroscopic and Photometric Study of the Contact Binary BO CVn

We present the results of the study of the contact binary system BO CVn. We have obtained physical parameters of the components based on combined analysis of new, multi-color light curves and spectroscopic mass ratio. This is the first time the latter has been determined for this object. We derived the contact configuration for the system with a very high filling factor of about 88 percent. We were able to reproduce the observed light curve, namely the flat bottom of the secondary minimum, only if a third light has been added into the list of free parameters. The resulting third light contribution is significant, about 20-24 percent, while the absolute parameters of components are: M1=1.16, M2=0.39, R1=1.62 and R2=1.00 (in solar units). The O-C diagram shows an upward parabola which, under the conservative mass transfer assumption, would correspond to a mass transfer rate of dM/dt = 6.3 \times 10-8M\odot/yr, matter being transferred from the less massive component to the more massive one. No cyclic, short-period variations have been found in the O-C diagram (but longer-term variations remain a possibility)Comment: 16 pages, 5 figures, 5 tables, accepted for publication by New Astronom

The Levantine Basin - crustal structure and origin

The origin of the Levantine Basin in the Southeastern Mediterranean Sea is related to the opening of the Neo-Tethys. The nature of its crust has been debated for decades. Therefore, we conducted a geophysical experiment in the Levantine Basin. We recorded two refraction seismic lines with 19 and 20 ocean bottom hydrophones, respectively, and developed velocity models. Additional seismic reflection data yield structural information about the upper layers in the first few kilometers. The crystalline basement in the Levantine Basin consists of two layers with a P-wave velocity of 6.06.4 km/s in the upper and 6.56.9 km/s in the lower crust. Towards the center of the basin, the Moho depth decreases from 27 to 22 km. Local variations of the velocity gradient can be attributed to previously postulated shear zones like the Pelusium Line, the DamiettaLatakia Line and the BaltimHecateus Line. Both layers of the crystalline crust are continuous and no indication for a transition from continental to oceanic crust is observed. These results are confirmed by gravity data. Comparison with other seismic refraction studies in prolongation of our profiles under Israel and Jordan and in the Mediterranean Sea near Greece and Sardinia reveal similarities between the crust in the Levantine Basin and thinned continental crust, which is found in that region. The presence of thinned continental crust under the Levantine Basin is therefore suggested. A β-factor of 2.33 is estimated. Based on these findings, we conclude that sea-floor spreading in the Eastern Mediterranean Sea only occurred north of the Eratosthenes Seamount, and the oceanic crust was later subducted at the Cyprus Arc

The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants

Human AlkB homolog 2 (ALKBH2) is a DNA repair enzyme that catalyzes the direct reversal of DNA methylation damage through oxidative demethylation. While ALKBH2 colocalizes with proliferating cell nuclear antigen (PCNA) in DNA replication foci, it remains unknown whether these two proteins alone form a complex or require additional components for interaction. Here, we demonstrate that ALKBH2 can directly interact with PCNA independent from other cellular factors, and we identify the hydrophobic pocket of PCNA as the key domain mediating this interaction. Moreover, we find that PCNA association with ALKBH2 increases significantly during DNA replication, suggesting that ALKBH2 forms a cell-cycle dependent complex with PCNA. Intriguingly, we show that an ALKBH2 germline variant, as well as a variant found in cancer, display altered interaction with PCNA. Our studies reveal the ALKBH2 binding interface of PCNA and indicate that both germline and somatic ALKBH2 variants could have cellular effects on ALKBH2 function in DNA repair.Swiss National Science Foundation (31003A_133100/1)National Institutes of Health (U.S.) (grant CA055042)National Institutes of Health (U.S.) (grant ES002109)Universität Züric

MsrR contributes to cell surface characteristics and virulence in Staphylococcus aureus

MsrR, a factor contributing to methicillin resistance in Staphylococcus aureus, belongs to the LytR-CpsA-Psr family of cell envelope-associated proteins. Deletion of msrR increased cell size and aggregation, and altered envelope properties, leading to a temporary reduction in cell surface hydrophobicity, diminished colony-spreading ability, and an increased susceptibility to Congo red. The reduced phosphorus content of purified cell walls of the msrR mutant suggested a reduction in wall teichoic acids, which may explain some of the observed phenotypes. Microarray analysis of the msrR deletion mutant revealed only minor changes in the global transcriptome, suggesting that MsrR has structural rather than regulatory functions. Importantly, virulence of the msrR mutant was decreased in a nematode-killing assay as well as in rat experimental endocarditis. MsrR is therefore likely to play a role in cell envelope maintenance, cell separation, and pathogenicity of S. aureu

Cosmological solutions from fake N=2 EYM supergravity

We characterise the (fake) supersymmetric solutions of Wick-rotated N=2 d=4 gauged supergravity coupled to non-Abelian vector multiplets. In the time-like case we obtain generalisations of Kastor & Traschen's cosmological black holes: they have a specific time-dependence and the base-space must be 3-dimensional hyperCR/Gauduchon-Tod space. In the null-case, we find that the metric has a holonomy contained in Sim(2), give a general characterisation of the solutions, and give some examples. Finally, we point out that in some cases the solutions we found are non-BPS solutions to N=2 d=4 supergravity coupled to vector multiplets.Comment: 30 pages. Comments and references added, typos correcte

All the timelike supersymmetric solutions of all ungauged d=4 supergravities

We determine the form of all timelike supersymmetric solutions of all N greater or equal than 2, d=4 ungauged supergravities, for N less or equal than 4 coupled to vector supermultiplets, using the $Usp(n+1,n+1)-symmetric formulation of Andrianopoli, D'Auria and Ferrara and the spinor-bilinears method, while preserving the global symmetries of the theories all the way. As previously conjectured in the literature, the supersymmetric solutions are always associated to a truncation to an N=2 theory that may include hypermultiplets, although fields which are eliminated in the truncations can have non-trivial values, as is required by the preservation of the global symmetry of the theories. The solutions are determined by a number of independent functions, harmonic in transverse space, which is twice the number of vector fields of the theory (n+1). The transverse space is flat if an only if the would-be hyperscalars of the associated N=2 truncation are trivial.Comment: v3: Some changes in the introduction. Version to be published in JHE

1000 Norms Project: Protocol of a cross-sectional study cataloging human variation

Background Clinical decision-making regarding diagnosis and management largely depends on comparison with healthy or ‘normal’ values. Physiotherapists and researchers therefore need access to robust patient-centred outcome measures and appropriate reference values. However there is a lack of high-quality reference data for many clinical measures. The aim of the 1000 Norms Project is to generate a freely accessible database of musculoskeletal and neurological reference values representative of the healthy population across the lifespan. Methods/design In 2012 the 1000 Norms Project Consortium defined the concept of ‘normal’, established a sampling strategy and selected measures based on clinical significance, psychometric properties and the need for reference data. Musculoskeletal and neurological items tapping the constructs of dexterity, balance, ambulation, joint range of motion, strength and power, endurance and motor planning will be collected in this cross-sectional study. Standardised questionnaires will evaluate quality of life, physical activity, and musculoskeletal health. Saliva DNA will be analysed for the ACTN3 genotype (‘gene for speed’). A volunteer cohort of 1000 participants aged 3 to 100 years will be recruited according to a set of self-reported health criteria. Descriptive statistics will be generated, creating tables of mean values and standard deviations stratified for age and gender. Quantile regression equations will be used to generate age charts and age-specific centile values. Discussion This project will be a powerful resource to assist physiotherapists and clinicians across all areas of healthcare to diagnose pathology, track disease progression and evaluate treatment response. This reference dataset will also contribute to the development of robust patient-centred clinical trial outcome measures

Optimizing automated characterization of liver fibrosis histological images by investigating color spaces at different resolutions

Texture analysis (TA) of histological images has recently received attention as an automated method of characterizing liver fibrosis. The colored staining methods used to identify different tissue components reveal various patterns that contribute in different ways to the digital texture of the image. A histological digital image can be represented with various color spaces. The approximation processes of pixel values that are carried out while converting between different color spaces can affect image texture and subsequently could influence the performance of TA. Conventional TA is carried out on grey scale images, which are a luminance approximation to the original RGB (Red, Green, and Blue) space. Currently, grey scale is considered sufficient for characterization of fibrosis but this may not be the case for sophisticated assessment of fibrosis or when resolution conditions vary. This paper investigates the accuracy of TA results on three color spaces, conventional grey scale, RGB, and Hue-Saturation-Intensity (HSI), at different resolutions. The results demonstrate that RGB is the most accurate in texture classification of liver images, producing better results, most notably at low resolution. Furthermore, the green channel, which is dominated by collagen fiber deposition, appears to provide most of the features for characterizing fibrosis images. The HSI space demonstrated a high percentage error for the majority of texture methods at all resolutions, suggesting that this space is insufficient for fibrosis characterization. The grey scale space produced good results at high resolution; however, errors increased as resolution decreased