210 research outputs found
Flight test results from a supercritical mission adaptive wing with smooth variable camber
The mission adaptive wing (MAW) consisted of leading- and trailing-edge variable-camber surfaces that could be deflected in flight to provide a near-ideal wing camber shape for any flight condition. These surfaces featured smooth, flexible upper surfaces and fully enclosed lower surfaces, distinguishing them from conventional flaps that have discontinuous surfaces and exposed or semiexposed mechanisms. Camber shape was controlled by either a manual or automatic flight control system. The wing and aircraft were extensively instrumented to evaluate the local flow characteristics and the total aircraft performance. This paper discusses the interrelationships between the wing pressure, buffet, boundary-layer and flight deflection measurement system analyses and describes the flight maneuvers used to obtain the data. The results are for a wing sweep of 26 deg, a Mach number of 0.85, leading and trailing-edge cambers (delta(sub LE/TE)) of 0/2 and 5/10, and angles of attack from 3.0 deg to 14.0 deg. For the well-behaved flow of the delta(sub LE/TE) = 0/2 camber, a typical cruise camber shape, the local and global data are in good agreement with respect to the flow properties of the wing. For the delta(sub LE/TE) = 5/10 camber, a maneuvering camber shape, the local and global data have similar trends and conclusions, but not the clear-cut agreement observed for cruise camber
Flight Wing Surface Pressure and Boundary-Layer Data Report from the F-111 Smooth Variable-Camber Supercritical Mission Adaptive Wing
Flight tests were conducted using the advanced fighter technology integration F-111 (AFTI/F-111) aircraft modified with a variable-sweep supercritical mission adaptive wing (MAW). The MAW leading- and trailing-edge variable-camber surfaces were deflected in flight to provide a near-ideal wing camber shape for the flight condition. The MAW features smooth, flexible upper surfaces and fully enclosed lower surfaces, which distinguishes it from conventional flaps that have discontinuous surfaces and exposed or semi-exposed mechanisms. Upper and lower surface wing pressure distributions were measured along four streamwise rows on the right wing for cruise, maneuvering, and landing configurations. Boundary-layer measurements were obtained near the trailing edge for one of the rows. Cruise and maneuvering wing leading-edge sweeps were 26 deg for Mach numbers less than 1 and 45 deg or 58 deg for Mach numbers greater than 1. The landing wing sweep was 9 deg or 16 deg. Mach numbers ranged from 0.27 to 1.41, angles of attack from 2 deg to 13 deg, and Reynolds number per unit foot from 1.4 x 10(exp 6) to 6.5 x 10(exp 6). Leading-edge cambers ranged from O deg to 20 deg down, and trailing-edge cambers ranged from 1 deg up to 19 deg down. Wing deflection data for a Mach number of 0.85 are shown for three cambers. Wing pressure and boundary-layer data are given. Selected data comparisons are shown. Measured wing coordinates are given for three streamwise semispan locations for cruise camber and one spanwise location for maneuver camber
Gene expression in acute Stanford type A dissection: a comparative microarray study
BACKGROUND: We compared gene expression profiles in acutely dissected aorta with those in normal control aorta. MATERIALS AND METHODS: Ascending aorta specimen from patients with an acute Stanford A-dissection were taken during surgery and compared with those from normal ascending aorta from multiorgan donors using the BD Atlas⹠Human1.2 Array I, BD Atlas⹠Human Cardiovascular Array and the Affymetrix HG-U133A GeneChip(Ÿ). For analysis only genes with strong signals of more than 70 percent of the mean signal of all spots on the array were accepted as being expressed. Quantitative real-time polymerase chain reaction (RT-PCR) was used to confirm regulation of expression of a subset of 24 genes known to be involved in aortic structure and function. RESULTS: According to our definition expression profiling of aorta tissue specimens revealed an expression of 19.1% to 23.5% of the genes listed on the arrays. Of those 15.7% to 28.9% were differently expressed in dissected and control aorta specimens. Several genes that encode for extracellular matrix components such as collagen IV α2 and -α5, collagen VI α3, collagen XIV α1, collagen XVIII α1 and elastin were down-regulated in aortic dissection, whereas levels of matrix metalloproteinases-11, -14 and -19 were increased. Some genes coding for cell to cell adhesion, cell to matrix signaling (e.g., polycystin1 and -2), cytoskeleton, as well as several myofibrillar genes (e.g., α-actinin, tropomyosin, gelsolin) were found to be down-regulated. Not surprisingly, some genes associated with chronic inflammation such as interleukin -2, -6 and -8, were up-regulated in dissection. CONCLUSION: Our results demonstrate the complexity of the dissecting process on a molecular level. Genes coding for the integrity and strength of the aortic wall were down-regulated whereas components of inflammatory response were up-regulated. Altered patterns of gene expression indicate a pre-existing structural failure, which is probably a consequence of insufficient remodeling of the aortic wall resulting in further aortic dissection
Decellularized tissue engineered pericardium as replacement for tricuspid valve in cardiac surgery
Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover Germany and Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School, Hannover, Germany, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016Introduction: Tricuspid valve replacement is the last treatment choice in tricuspid valve
pathology. The choice to insert mechanical or bioprosthetic valve remains controversial. Both prostheses
have some limitations such as infection, risk of thromboembolism, need for life-long anticoagulation or
limited durability. The following study aimed to develop a novel tissue-engineered tricuspid valve based
on decellularized pericardium allograft.
Materials and methods: Fresh ovine pericardium was harvested at the local slaughter house and
decellularized using detergents. For disinfection all samples were treated for 24h with Phosphate
Buffered Solution supplemented with 1% gentamicin and 1% streptomycin. The effectiveness of
decellularization was evaluated by histological staining (hematoxylin-eosin, Movatâs Pentachrom and
Van Gieson), Isolectin B4 staining (a-gal xenoantigen) and by DNA-quantification. Two valvular
leaflets were manufactured out of decellularized pericardium and sutured ex-vivo into the tricuspid
annulus of an ovine heart and suspended on papillary muscles. Hydraulic test were performed to prove
valve competency.
Discussion results: After detergent treatment pericardial tissue has been converted in a cell-free
scaffold as proven by standard histological analysis. Immunofluorescent examinations revealed the
absence of a-gal xenoantigens. DNA-quantification showed a substantial reduction in DNA content
compared to the normal tissue. The alignment of collagenous fibers in decellularized scaffolds appeared
well-preserved and was not affected by detergent decellularization procedure as proven by histological
staining. Graft disinfection and storage in antibiotic solution after decellularization did not affect the
texture of the scaffold. Furthermore, two leaflet structure created out of decellularized pericardium and
surgically sutured in tricuspid position of ovine heart resulted in a competent valve prosthesis.
Conclusion: The present results have shown successful decellularization of the ovine
pericardium using detergents. Decellularized pericardial allograft can be used in cardiac surgery as a
scaffold for valvular tissue engineering or for in-vivo guided tissue regeneration in tricuspid valve
replacement
Implications of LHC Searches on SUSY Particle Spectra: The pMSSM Parameter Space with Neutralino Dark Matter
We study the implications of LHC searches on SUSY particle spectra using flat
scans of the 19-parameter pMSSM phase space. We apply constraints from flavour
physics, g_mu-2, dark matter and earlier LEP and Tevatron searches. The
sensitivity of the LHC SUSY searches with jets, leptons and missing energy is
assessed by reproducing with fast simulation the recent CMS analyses after
validation on benchmark points. We present results in terms of the fraction of
pMSSM points compatible with all the constraints which are excluded by the LHC
searches with 1 fb^{-1} and 15 fb^{-1} as a function of the mass of strongly
and weakly interacting SUSY particles. We also discuss the suppression of Higgs
production cross sections for the MSSM points not excluded and contrast the
region of parameter space tested by the LHC data with the constraints from dark
matter direct detection experiments.Comment: 14 pages, 13 figures. v2: increased statistics, to appear in EPJ
Hadronic Contributions to the Muon Anomaly in the Constituent Chiral Quark Model
The hadronic contributions to the anomalous magnetic moment of the muon which
are relevant for the confrontation between theory and experiment at the present
level of accuracy, are evaluated within the same framework: the constituent
chiral quark model. This includes the contributions from the dominant hadronic
vacuum polarization as well as from the next--to--leading order hadronic vacuum
polarization, the contributions from the hadronic light-by-light scattering,
and the contributions from the electroweak hadronic vertex.
They are all evaluated as a function of only one free parameter: the
constituent quark mass. We also comment on the comparison between our results
and other phenomenological evaluations.Comment: Several misprints corrected and a clarifying sentence added. Three
figures superposed and two references added. Version to appear in JHE
Looking into the matter of light-quark hadrons
In tackling QCD, a constructive feedback between theory and extant and
forthcoming experiments is necessary in order to place constraints on the
infrared behaviour of QCD's \beta-function, a key nonperturbative quantity in
hadron physics. The Dyson-Schwinger equations provide a tool with which to work
toward this goal. They connect confinement with dynamical chiral symmetry
breaking, both with the observable properties of hadrons, and hence provide a
means of elucidating the material content of real-world QCD. This contribution
illustrates these points via comments on: in-hadron condensates; dressed-quark
anomalous chromo- and electro-magnetic moments; the spectra of mesons and
baryons, and the critical role played by hadron-hadron interactions in
producing these spectra.Comment: 11 pages, 7 figures. Contribution to the Proceedings of "Applications
of light-cone coordinates to highly relativistic systems - LIGHTCONE 2011,"
23-27 May, 2011, Dallas. The Proceedings will be published in Few Body
System
- âŠ