89 research outputs found

    The assessment of riboflavin status

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    The physical origins and dominant emission mechanisms of Lyman alpha haloes: Results from the TNG50 simulation in comparison to MUSE observations

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    Extended Lyman alpha emission is now commonly detected around high-redshift galaxies through stacking and even on individual basis. Despite recent observational advances, the physical origin of these Lyman alpha haloes (LAHs), as well as their relationships to galaxies, quasars, circumgalactic gas, and other environmental factors remains unclear. We present results from our new Lyman alpha full radiative transfer code voroiltis which runs directly on the unstructured Voronoi tessellation of cosmological hydrodynamical simulations. We make use of the TNG50 simulation and simulate LAHs from redshift z = 2 to z = 5, focusing on star-forming galaxies with 8.0 < log10 (M∗ M⊙) < 10.5. While TNG50 does not directly follow ionizing radiation, it includes an on-the-fly treatment for active galactic nuclei (AGNs) and ultraviolet background radiation with self-shielding, which are important processes impacting the cooling and ionization of the gas. Based on this model, we present the predictions for the stacked radial surface brightness profiles of Ly α as a function of galaxy mass and redshift. Comparison with data from the MUSE UDF at z > 3 reveals a promising level of agreement. We measure the correlations of LAH size and central brightness with galaxy properties, finding that at the masses of 8.5 ≀ log10 (M∗/M⊙) ≀ 9.5, physical LAH sizes roughly double from z = 2 to z = 5. Finally, we decompose the profiles into contributions from diffuse emission and scattered photons from star-forming regions. In our simulations, we find rescattered photons from star-forming regions to be the major source in observed LAHs. Unexpectedly, we find that the flattening of LAH profiles at large radii becomes dominated by photons originating from other nearby haloes rather than diffuse emission itself

    Contrasting CO2 and water vapour fluxes in dry forest and pasture sites of central Argentina

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    The dry forests of South America are a key player of the global carbon cycle and the regional water cycle, but they are being intensively deforested. We used eddy covariance measurements to compare the temporal patterns of CO2 and water vapour fluxes and their relationships with environmental variables in dry forest and pastures sites of central Argentina. Ecosystem fluxes showed clear contrasts in magnitude, timing and response to environmental controls between ecosystems. The dry forest displayed higher daily gross primary productivity (GPP, 10.6 vs. 7.8 g CO2 m−2 d−1) and ecosystem respiration (Reco, 9.1 vs. 7.0 g CO2 m−2 d−1) and lower net ecosystem exchange (NEE, −1.5 vs. −0.7 g CO2 m−2 d−1) than the pasture. These differences were explained by a lower tolerance of the pasture to cool temperatures and drought. The lowest NEE rates were observed between 26°C and 34°C in the pasture, but below this range, NEE increased sharply, switching to a carbon source with temperatures <20°C. By contrast, the dry forest remained as a strong carbon sink down to 18°C. The pasture also showed a stronger drop of GPP with drought compared with the dry forest, becoming a carbon source with soil wetness <25% of soil available water. Rainfall was strongly coupled with GPP in both ecosystems, but the dry forest responded to longer rainfall integration periods. This study helps to understand how ecosystems can respond to climate change, improve global scale modelling and increase the productivity and resilience of rangelands.Fil: Nosetto, Marcelo Daniel. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Centro CientĂ­fico TecnolĂłgico Conicet - San Luis. Instituto de MatemĂĄtica Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias FĂ­sico, MatemĂĄticas y Naturales. Instituto de MatemĂĄtica Aplicada de San Luis "Prof. Ezio Marchi"; ArgentinaFil: Luna Toledo, Emanuel Santiago. Instituto Nacional de TecnologĂ­a Agropecuaria; Argentina. Universidad Nacional de Chilecito; Argentina. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas; ArgentinaFil: Magliano, Patricio NicolĂĄs. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Centro CientĂ­fico TecnolĂłgico Conicet - San Luis. Instituto de MatemĂĄtica Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias FĂ­sico, MatemĂĄticas y Naturales. Instituto de MatemĂĄtica Aplicada de San Luis "Prof. Ezio Marchi"; ArgentinaFil: Figuerola, Patricia Irene. Universidad Nacional de Chilecito; ArgentinaFil: Blanco, Lisandro Javier. Instituto Nacional de TecnologĂ­a Agropecuaria; ArgentinaFil: Jobbagy Gampel, Esteban Gabriel. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Centro CientĂ­fico TecnolĂłgico Conicet - San Luis. Instituto de MatemĂĄtica Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias FĂ­sico, MatemĂĄticas y Naturales. Instituto de MatemĂĄtica Aplicada de San Luis "Prof. Ezio Marchi"; Argentin

    Losartan Improved Antioxidant Defense, Renal Function and Structure of Postischemic Hypertensive Kidney

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    Ischemic acute renal failure (ARF) is a highly complex disorder involving renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and generation of reactive oxygen species. Due to this complexity, the aim of our study was to explore effects of Angiotensin II type 1 receptor (AT1R) blockade on kidney structure and function, as well as oxidative stress in spontaneously hypertensive rats (SHR) after renal ischemia reperfusion injury. Experiments were performed on anaesthetized adult male SHR in the model of ARF with 40 minutes clamping the left renal artery. The right kidney was removed and 40 minutes renal ischemia was performed. Experimental groups received AT1R antagonist (Losartan) or vehicle (saline) in the femoral vein 5 minutes before, during and 175 minutes after the period of ischemia. Biochemical parameters were measured and kidney specimens were collected 24h after reperfusion. ARF significantly decreased creatinine and urea clearance, increased LDL and lipid peroxidation in plasma. Treatment with losartan induced a significant increase of creatinine and urea clearance, as well as HDL. Lipid peroxidation in plasma was decreased and catalase enzyme activity in erythrocytes was increased after losartan treatment. Losartan reduced cortico-medullary necrosis and tubular dilatation in the kidney. High expression of pro-apoptotic Bax protein in the injured kidney was downregulated after losartan treatment. Our results reveal that angiotensin II (via AT1R) mediates the most postischemic injuries in hypertensive kidney through oxidative stress enhancement. Therefore, blockade of AT1R may have beneficial effects in hypertensive patients who have developed ARF

    Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial

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    Background: Poor micronutrient status is reported among adolescents across Europe and USA. This may be related to the well-documented decline in the regular consumption of breakfast by this group. The regular consumption of a breakfast cereal offers a possible means to improve micronutrient status; fortified cereal is likely to have enhanced benefit. A study was conducted to determine the efficacy of the regular consumption of a fortified cereal with milk, compared with unfortified cereal, consumed either as a breakfast or a supper, in improving micronutrient intake and micronutrient status of adolescent girls. Methods: A randomised, double-blind, placebo-controlled intervention trial was conducted in girls recruited at ages 16–19 years, from schools and colleges in Sheffield, UK. Girls were randomised to receive 50 g fortified or unfortified cereal, with 150 ml semi-skimmed milk, daily, for 12 weeks, as a breakfast or as a supper. Dietary intake was estimated using a 4-d food diary and blood collected for the assessment of nutritional status. Within-group changes were tested using a paired sample t test; two-way ANOVA was used to analyse effects of the intervention, with cereal type and time of consumption as factors, correcting for baseline values. The analysis was conducted on 71 girls who completed the study. Results: Consumption of unfortified cereal elicited an increase in the intake of vitamins B1, B2 and B6; consumption of fortified cereal elicited increases in vitamins B1, B2, B6, B12, folate and iron (P < 0.001) and of vitamin D (P = 0.007), all increases were significantly greater than for unfortified cereal. Consumption of the fortified cereal also led to a significant improvement in biomarkers of status for vitamins B2, B12, folate and of iron, compared with girls receiving the unfortified cereal, and maintained vitamin D status, in contrast with the girls receiving the unfortified cereal (P < 0.001). Conclusions: The daily consumption of cereal with milk for 12 weeks by adolescent girls, increased intakes of micronutrients. The consumption of fortified cereal elicited greater increases than for unfortified cereal and improved biomarkers of micronutrient status. The findings justify strategies to encourage the consumption of fortified cereal with milk by adolescents, either as a breakfast or a supper
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