Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005

The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producing Escherichia coli (VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders

Quantum Logic with a Single Trapped Electron

We propose the use of a trapped electron to implement quantum logic operations. The fundamental controlled-NOT gate is shown to be feasible. The two quantum bits are stored in the internal and external (motional) degrees of freedom.Comment: 7 Pages, REVTeX, No Figures, To appear in Phys. Rev.

Cavity Control of a Single-Electron Quantum Cyclotron:\\Measuring the Electron Magnetic Moment

Measurements with a one-electron quantum cyclotron determine the electron magnetic moment, given by $g/2 = 1.001\,159\,652\,180\,73\,(28)\,[0.28~\textrm{ppt}]$, and the fine structure constant, $\alpha^{-1}=137.035\,999\,084\,(51)\,[0.37~\textrm{ppb}]$. Brief announcements of these measurements are supplemented here with a more complete description of the one-electron quantum cyclotron and the new measurement methods, a discussion of the cavity control of the radiation field, a summary of the analysis of the measurements, and a fuller discussion of the uncertainties

Social and physical environmental correlates of adults\u27 weekend sitting time and moderating effects of retirement status and physical health

Emerging research suggests that prolonged sedentary behaviour (SB) is detrimental to health. Changes in SB patterns are likely to occur during particular life stages, for example at retirement age (55-65-year-old). Evidence on socio-ecological SB correlates is scarce and inconsistent in this age group. Moreover, the influence of socio-ecological correlates may vary depending on health and retirement status. This study examined social and environment correlates of overall weekend day sitting among adults at or approaching retirement age, and moderating effects of perceived physical health and retirement status. Baseline data from the Wellbeing, Eating and Exercise for a Long Life study in 2839 Australian adults (55-65-year-old) were analysed. Participants self-reported proximal social factors, neighbourhood social and physical environment, physical health and retirement status. MLwiN multilevel regression analyses were conducted. In the multivariable model, only social support from friends/colleagues to discourage sitting (B = -0.891; p = 0.036) was associated with overall weekend day sitting. No moderation of retirement status, nor physical health were found in the multivariable results. Results from this study suggest the importance of social factors in relation to weekend day sitting among 55-65-year-old adults. Health promotion initiatives in this age group should pay special attention to enhancing social interaction opportunities. Moreover, findings suggest that SB-specific correlates may need to be examined in future research

CPT and Lorentz Tests in Penning Traps

A theoretical analysis is performed of Penning-trap experiments testing CPT and Lorentz symmetry through measurements of anomalous magnetic moments and charge-to-mass ratios. Possible CPT and Lorentz violations arising from spontaneous symmetry breaking at a fundamental level are treated in the context of a general extension of the SU(3) x SU(2) x U(1) standard model and its restriction to quantum electrodynamics. We describe signals that might appear in principle, introduce suitable figures of merit, and estimate CPT and Lorentz bounds attainable in present and future Penning-trap experiments. Experiments measuring anomaly frequencies are found to provide the sharpest tests of CPT symmetry. Bounds are attainable of approximately $10^{-20}$ in the electron-positron case and of $10^{-23}$ for a suggested experiment with protons and antiprotons. Searches for diurnal frequency variations in these experiments could also limit certain types of Lorentz violation to the level of $10^{-18}$ in the electron-positron system and others at the level of $10^{-21}$ in the proton-antiproton system. In contrast, measurements comparing cyclotron frequencies are sensitive within the present theoretical framework to different kinds of Lorentz violation that preserve CPT. Constraints could be obtained on one figure of merit in the electron-positron system at the level of $10^{-16}$, on another in the proton-antiproton system at $10^{-24}$, and on a third at $10^{-25}$ using comparisons of $H^-$ ions with antiprotons.Comment: 31 pages, published in Physical Review

Possible Spontaneous Breaking of Lorentz and CPT Symmetry

One possible ramification of unified theories of nature such as string theory that may underlie the conventional standard model is the possible spontaneous breakdown of Lorentz and CPT symmetry. In this talk, the formalism for inclusion of such effects into a low-energy effective field theory is presented. An extension of the standard model that includes Lorentz- and CPT-breaking terms is developed. The restriction of the standard model extension to the QED sector is then discussed.Comment: Talk presented at Non-Accelerator New Physics, Dubna, Russia, July 199

Shell-model description of monopole shift in neutron-rich Cu

Variations in the nuclear mean-field, in neutron-rich nuclei, are investigated within the framework of the nuclear shell model. The change is identified to originate mainly from the monopole part of the effective two-body proton-neutron interaction. Applications for the low-lying states in odd-$A$ Cu nuclei are presented. We compare the results using both schematic and realistic forces. We also compare the monopole shifts with the results obtained from large-scale shell-model calculations, using the same realistic interaction, in order to study two-body correlations beyond the proton mean-field variations.Comment: Phys. Rev. C (in press

Penning traps as a versatile tool for precise experiments in fundamental physics

This review article describes the trapping of charged particles. The main principles of electromagnetic confinement of various species from elementary particles to heavy atoms are briefly described. The preparation and manipulation with trapped single particles, as well as methods of frequency measurements, providing unprecedented precision, are discussed. Unique applications of Penning traps in fundamental physics are presented. Ultra-precise trap-measurements of masses and magnetic moments of elementary particles (electrons, positrons, protons and antiprotons) confirm CPT-conservation, and allow accurate determination of the fine-structure constant alpha and other fundamental constants. This together with the information on the unitarity of the quark-mixing matrix, derived from the trap-measurements of atomic masses, serves for assessment of the Standard Model of the physics world. Direct mass measurements of nuclides targeted to some advanced problems of astrophysics and nuclear physics are also presented

Neighborhood perceptions moderate the association between the family environment and children\u27s objectively assessed physical activity

This study aimed to investigate whether parents\u27 perceptions of the neighborhood environment moderate associations between the family environment and children\u27s moderate- to vigorous-intensity physical activity (MVPA) outside of school hours. In total, 929 parents of 10-12 year-old children completed a questionnaire concerning the family environment, MVPA levels, and the neighborhood environment. Children wore an Actigraph (AM7164-2.2C) accelerometer. Compared with neighborhood environment factors, the family environment was more frequently associated with children\u27s MVPA. Parental MVPA was positively associated with children\u27s MVPA, but only among children whose parents reported a high presence of sporting venues. Having more restrictive physical activity rules was negatively associated with children\u27s weekday MVPA in neighborhoods with high perceived stranger danger

Neighbourhood, Route and Workplace-Related Environmental Characteristics Predict Adults' Mode of Travel to Work

Commuting provides opportunities for regular physical activity which can reduce the risk of chronic disease. Commuters' mode of travel may be shaped by their environment, but understanding of which specific environmental characteristics are most important and might form targets for intervention is limited. This study investigated associations between mode choice and a range of objectively assessed environmental characteristics.Participants in the Commuting and Health in Cambridge study reported where they lived and worked, their usual mode of travel to work and a variety of socio-demographic characteristics. Using geographic information system (GIS) software, 30 exposure variables were produced capturing characteristics of areas around participants' homes and workplaces and their shortest modelled routes to work. Associations between usual mode of travel to work and personal and environmental characteristics were investigated using multinomial logistic regression.Of the 1124 respondents, 50% reported cycling or walking as their usual mode of travel to work. In adjusted analyses, home-work distance was strongly associated with mode choice, particularly for walking. Lower odds of walking or cycling rather than driving were associated with a less frequent bus service (highest versus lowest tertile: walking OR 0.61 [95% CI 0.20–1.85]; cycling OR 0.43 [95% CI 0.23–0.83]), low street connectivity (OR 0.22, [0.07–0.67]; OR 0.48 [0.26–0.90]) and free car parking at work (OR 0.24 [0.10–0.59]; OR 0.55 [0.32–0.95]). Participants were less likely to cycle if they had access to fewer destinations (leisure facilities, shops and schools) close to work (OR 0.36 [0.21–0.62]) and a railway station further from home (OR 0.53 [0.30–0.93]). Covariates strongly predicted travel mode (pseudo r-squared 0.74).Potentially modifiable environmental characteristics, including workplace car parking, street connectivity and access to public transport, are associated with travel mode choice, and could be addressed as part of transport policy and infrastructural interventions to promote active commuting