229 research outputs found
Implementing "mutually supportive" access and benefit sharing mechanisms under the Plant Treaty, Convention on Biological Diversity, and Nagoya Protocol
Educating Health Professionals about Disability: A Review of Interventions
Health professionals need to understand the human rights and health needs of disabled people. This review of evidence on interventions demonstrates that a range of often innovative approaches have been trialled. Lectures by faculty are less effective in changing attitudes than contact with disabled people themselves. Existing examples of good practice need to be scaled up, and better and more long-term evaluations of impact are required
Implementation and Evaluation of Critical Care Pain Observation Tool (CPOT)
Background: Pain assessment in critically ill patients using an evidence-based and reliable tool is crucial in providing pain management and promoting recovery of the patients in the Intensive Care Units (ICU). Inadequate pain management can have short-term and long-term complications. Critical Care Pain Observation Tool (CPOT) has been rigorously tested and has been recommended as a valid and reliable pain assessment tool by the Society of Critical Care Medicine and the American Association of Critical Care Medicine.Objective: To implement CPOT and evaluate the impacts of CPOT implementation in the ICUs at NorthBay Medical Center and Vacavalley Hospital. Methods: This evidence-based project utilized the IOWA Model of evidence-based practice change to implement CPOT. Nurses were provided education on CPOT for twenty minutes during mandatory quarterly ICU skills fairs in November 2017. The CPOT was implemented in both ICUs in April 2018. A descriptive study design was used to compare the before and after implementation groups. Forty patient charts were reviewed from the pre-implementation group and another forty patient charts were reviewed from the post-implementation group. Data was collected on number of pain assessments, pain reports, pain reassessments, amount of analgesia administered, ventilator days, and ICU days. Nursing feasibility and applicability survey were collected during pre-implementation and two months’ post-implementation.Results: An inter-rater reliability of 93.3% from thirty pain observations was obtained during the pilot trial. There were no significant differences found between pre-and post-implementation groups in regards to pain assessment frequency, pain reports, analgesia usage, ventilator days, and ICU days. However, there was a statistically significant increase in the pain reassessment frequency (t=2.22, p=0.02). The mean of frequency of pain reassessment was 0.55 for the preimplementation group and 1.425 for the post-implementation group. Nursing survey results showed positive evaluations for CPOT with 100% of the nurses agreeing that CPOT is easy to use and 100% of the nurses agreed that they received adequate CPOT education. 95.9% of the nurses believed that CPOT helped to assess pain accurately in critically ill adult patients on ventilator and 93.8% believed that CPOT positively influenced their practice
Determining major climatic factors and their variations in the central agricultural region of Mongolia
Non-Peer ReviewedIn accordance of the World Meteorological Organization, the weather conditions between 1961
and 1990 is defined as the climate and mean of climatic factors over that time-period is
considered as the climatic normal. Climate is formed as a result of interactions between
atmosphere, hydrosphere, lithosphere (geosphere), biosphere, and cryosphere. It develops and
changes due to various external factors, periodic and non-periodic fluctuations in these systems.
Number of studies has shown some strong indications of global warming in Mongolia.
Objective of this study was to determine the changes and trends in the major climatic factors
such as annual air temperature and precipitation in Orkhon-Selenge Basin, the Central
Agricultural Region of Mongolia, over the last 15 years (1991-2006). Our study has revealed that
over the past 15 years, from 1991 to 2006, the mean annual air temperature in the Central
Agricultural Region of Mongolia has risen by 0.7-1.2 degrees Celsius or 0.04-0.07 degrees
Celsius per year. Consequently, there has been higher frequency of years exhibiting drought like
conditions negatively impacting vegetation growth. The warming has been causing a higher
frequency of occurrence of drier years with moisture deficit for vegetation growth
Probabilistic adaptive model predictive power pinch analysis (PoPA) energy management approach to uncertainty
This paper proposes a probabilistic power pinch analysis (PoPA) approach based on Monte–Carlo simulation (MCS) for energy management of hybrid energy systems uncertainty. The systems power grand composite curve is formulated with the chance constraint method to consider load stochasticity. In a predictive control horizon, the power grand composite curve is shaped based on the pinch analysis approach. The robust energy management strategy effected in a control horizon is inferred from the likelihood of a bounded predicted power grand composite curve, violating the pinch. Furthermore, the response of the system using the energy management strategies (EMS) of the proposed method is evaluated against the day-ahead (DA) and adaptive power pinch strategy
The Fruit Flies (Diptera, Tephritidae) in Bhutan: New Faunistic Records and Compendium of Fauna
Based on a field survey from 2017, twenty-three species are reported from Bhutan for the first time: Acroceratitis ceratitina, A. hardyi, Anomoia approximata, Bactrocera connecta, B. latifrons, B. nigrifacia, B. syzygii, Campiglossa sororcula, Cecidochares connexa, Dacus jacobi, Gastrozona fasciventris, Hoplandromyia antelopa, Lenitovena ultima, Ptilona confinis, Rioxoptilona dunlopi, R. formosana, R. vaga, Spathulina acroleuca, Themara yunnana, Trypeta indica, Zeugodacus apiciflavus, Z. diversus, and Z. fereuncinatus. Four species of the genera Cornutrypeta, Hemilea, Morinowotome, and Vidalia are also recorded for the first time, but the precise determination to species needs additional study and material. As the result, 71 species is listed from Bhutan by far. Their taxonomic position and key characters are discussed. Illustrations for most of the newly recorded species are given
Karma and human rights:Bhutanese teachers' perspectives on inclusion and disability
The Sustainable Development Goals call on countries to ensure that all children, especially the most vulnerable, are included in education. The small kingdom of Bhutan has made attempts to embrace inclusion in education at the policy level. However, research on inclusion and disability in this context is limited, and there are few studies focusing on the perspectives of Bhutanese teachers. The study presented here was led by the question ‘how are Inclusion and Disability understood by teachers in Bhutan?’ The research aims were to (a) explore the above concepts from the perspective of participants and (b) construct these concepts in a way that is contextually relevant to Bhutan. Data collection comprised qualitative interviews with 15 Bhutanese teachers. Findings revealed that participants saw disability predominantly from a ‘medical model’ perspective, but at the same time held conflicting views as to what inclusion means. They moreover mentioned lack of teacher training as an obstacle to the implementation of inclusion in Bhutan, and some believed that the country is not yet ready for inclusion. We argue that our findings call for Bhutan to strengthen the preparation of its teachers for inclusive education in order to narrow the current gap between policy and practice.© 2017 Informa UK Limited, trading as Taylor & Francis Group. The attached document (embargoed until 10/02/2019) is an author produced version of a paper published in International Journal of Inclusive Education, uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at http://dx.doi.org/10.1080/13603116.2017.1365274. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it
Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Background
Mutations in the mitochondrial genome have been implicated in mitochondrial disease, often characterized by impaired cellular energy metabolism. Cellular energy metabolism in mitochondria involves mitochondrial proteins (MP) from both the nuclear (NuMP) and mitochondrial (MtMP) genomes. The expression of MP genes in tissues may be tissue specific to meet varying specific energy demands across the tissues. Currently, the characteristics of MP gene expression in tissues of dairy cattle are not well understood. In this study, we profile the expression of MP genes in 29 adult and six foetal tissues in dairy cattle using RNA sequencing and gene expression analyses: particularly differential gene expression and co-expression network analyses.
Results
MP genes were differentially expressed (DE; over-expressed or under-expressed) across tissues in cattle. All 29 tissues showed DE NuMP genes in varying proportions of over-expression and under-expression. On the other hand, DE of MtMP genes was observed in < 50% of tissues and notably MtMP genes within a tissue was either all over-expressed or all under-expressed. A high proportion of NuMP (up to 60%) and MtMP (up to 100%) genes were over-expressed in tissues with expected high metabolic demand; heart, skeletal muscles and tongue, and under-expressed (up to 45% of NuMP, 77% of MtMP genes) in tissues with expected low metabolic rates; leukocytes, thymus, and lymph nodes. These tissues also invariably had the expression of all MtMP genes in the direction of dominant NuMP genes expression. The NuMP and MtMP genes were highly co-expressed across tissues and co-expression of genes in a cluster were non-random and functionally enriched for energy generation pathway. The differential gene expression and co-expression patterns were validated in independent cow and sheep datasets.
Conclusions
The results of this study support the concept that there are biological interaction of MP genes from the mitochondrial and nuclear genomes given their over-expression in tissues with high energy demand and co-expression in tissues. This highlights the importance of considering MP genes from both genomes in future studies related to mitochondrial functions and traits related to energy metabolism
Correction to:Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Following publication of the original article [1], it was reported that Fig. 4 was missing several labels (I-IV) and that Additional files 1, 2, 3, 4, 5, 6, 9, 10, 17 and 18 were published in an incorrect order and Additional file 20 was published with an erroneous caption. The correct Fig. 4 and additional files are provided in this correction article, and the original article [1] has been updated
Impact of COVID-19 on mental health in Bhutan: a way forward for action
The coronavirus disease 2019 (COVID-19) pandemic continues to impact mental health and wellbeing globally. There is a lack of scientific documentation highlighting the mental health impact of COVID-19 in Bhutan. We present the mental health burdens and control measures taken, and suggest ways to further strengthen mental health services in Bhutan. During the pandemic, a rise in depression and anxiety had been reported in Bhutan. Depression rose from an average prevalence of 9 per 10,000 between 2011 and 2019 to 16 per 10,000 in 2020 and 32 per 10,000 in 2021. Similarly, anxiety rose from an average prevalence of 18 per 10,000, to 29 per 10,000 in 2020, and 55 per 10,000 in 2021. Psychological impacts related to isolation due to lockdowns, economic losses, and poor coping abilities were associated with negative outcomes. Stigma and discrimination towards mental health disorders discouraged mentally distressed people from seeking care. In response to increased demand, Bhutan's government initiated a range of interventions including home delivery of medicines and tele-counselling to people in need of urgent mental health care. Mental health care in Bhutan can be further improved through investment in services and human resources, and decentralization of services to the community
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