1,013 research outputs found
RUOLO DEI "RECETTORI ATIPICI" PER CITOCHINE E CHEMOCHINE, TIR8 E D6, NELLA REGOLAZIONE DELLE RISPOSTE INFIAMMATORIE INDOTTE DA MYCOBACTERIUM TUBERCULOSIS
Ultracold fermions in a one-dimensional bipartite optical lattice: metal-insulator transitions driven by shaking
We describe the behavior of a system of fermionic atoms loaded in a bipartite
one-dimensional optical lattice that is under the action of an external
time-periodic driving force. By using Floquet theory, an effective model with
renormalized hopping coefficients is derived. The insulating behavior
characterizing the system at half-filling in the absence of driving is
dynamically suppressed and for particular values of the driving parameter the
system becomes either a standard metal or an unconventional metal with four
Fermi points. We use the bosonization technique to investigate the effect of
on-site Hubbard interactions on the four Fermi-point metal-insulator phase
transition. Attractive interactions are expected to enlarge the regime of
parameters where the unconventional metallic phase arises, whereas repulsive
interactions reduce it. This metallic phase is known to be a Luther-Emery
liquid (spin gapped metal) for both, repulsive and attractive interactions,
contrarily to the usual Hubbard model which exhibits a Mott insulator phase for
repulsive interactions. Ultracold fermions in driven one-dimensional bipartite
optical lattices provide an interesting platform for the realization of this
long studied four Fermi-point unconventional metal.Comment: 11 pages, 6 figure
Misura tridimensionale dei tempi di rilassamento longitudinali (spin - reticolo) di un dosimetro Fricke mediante una apparecchiatura di diagnostica RMN da 1.5 T
A quantum mechanical insight into SN2 reactions: Semiclassical initial value representation calculations of vibrational features of the Cl--CHCl pre-reaction complex with the VENUS suite of codes
The role of vibrational excitation of reactants in driving reactions
involving polyatomic species has been often studied by means of classical or
quasi-classical trajectory simulations. We propose a different approach based
on investigation of vibrational features of the Cl--CHCl pre-reaction
complex for the Cl + CHCl SN reaction. We present vibrational power
spectra and frequency estimates for the title pre-reaction complex calculated
at the level of classical, semiclassical, and second-order vibrational
perturbation theory on a pre-existing analytical potential energy surface. The
main goals of the paper are the study of anharmonic effects and understanding
of vibrational couplings that permit energy transfer between the collisional
kinetic energy and the internal vibrations of the reactants. We provide both
classical and quantum pictures of intermode couplings and show that the SN2
mechanism is favored by the coupling of a C--Cl bend involving the Cl
projectile with the CH rocking motion of the target molecule. We also
illustrate how the routines needed for semiclassical vibrational spectroscopy
simulations can be interfaced in a user-friendly way to pre-existing molecular
dynamics software. In particular, we present an implementation of semiclassical
spectroscopy into the VENUS suite of codes, thus providing a useful
computational tool for users who are not experts of semiclassical dynamics
On the evolution of decoys in plant immune systems
The Guard-Guardee model for plant immunity describes how resistance proteins
(guards) in host cells monitor host target proteins (guardees) that are
manipulated by pathogen effector proteins. A recently suggested extension of
this model includes decoys, which are duplicated copies of guardee proteins,
and which have the sole function to attract the effector and, when modified by
the effector, trigger the plant immune response. Here we present a
proof-of-principle model for the functioning of decoys in plant immunity,
quantitatively developing this experimentally-derived concept. Our model links
the basic cellular chemistry to the outcomes of pathogen infection and
resulting fitness costs for the host. In particular, the model allows
identification of conditions under which it is optimal for decoys to act as
triggers for the plant immune response, and of conditions under which it is
optimal for decoys to act as sinks that bind the pathogen effectors but do not
trigger an immune response.Comment: 15 pages, 6 figure
Spectrally resolved observations of atmospheric emitted radiance in the H2O rotation band
This paper presents the project Earth Cooling by Water
Vapor Radiation, an observational programme, which aims at
developing a database of spectrally resolved far infrared
observations, in atmospheric dry conditions, in order to
validate radiative transfer models and test the quality of water
vapor continuum and line parameters. The project provides
the very first set of far-infrared spectral downwelling
radiance measurements, in dry atmospheric conditions,
which are complemented with Raman Lidar-derived
temperature and water vapor profiles
Granzyme A is an additional marker for tuberculosis (TB) to discriminate between patients with active disease and subjects with latent infection
Oral Mucosa of celiac disease patients produces anti-endomysial and anti-transglutaminase antibodes. Diagnostic usefulness of an in vitro culture system
Interleukin-9 over-expression and T helper 9 polarization in systemic sclerosis patients.
T helper 9 (Th9) cells and interleukin (IL)-9 are involved in the pathogenesis of several autoimmune diseases. The exact role of IL-9 and Th9 cells in patients with systemic sclerosis (SSc) have not yet been studied adequately. IL-9, IL-9R, transcription factor PU.1 (PU.1), IL-4, thymic stromal lymphopoietin (TSLP) and transforming growth factor (TGF)-\u3b2 expression were assessed in skin and kidney biopsies of SSc patients and healthy controls (HC) by immunohistochemistry (IHC). The cellular source of IL-9 was also analysed by confocal microscopy analysis. Peripheral IL-9-producing cells were also studied by flow cytometry. The functional relevance of IL-9 increased expression in SSc was also investigated. Our results demonstrated a strong expression of IL-9, IL-9R, IL-4, TSLP and TGF-\u3b2 in skin tissues of patients with both limited and diffuse SSc. IL-9 expression was observed mainly in the context of skin infiltrating mononuclear cells and keratinizing squamous epithelium. IL-9 over-expression was also observed in renal biopsies of patients with SSc. IL-9 producing cells in the skin were identified as Th9 cells. Similarly, Th9 cells were expanded and were the major source of IL-9 among SSc peripheral blood mononuclear cells (PBMC), their percentage being correlated directly with the modified Rodnan skin score. Infiltrating mononuclear cells, mast cells and neutrophils expressed IL-9R. In in-vitro studies stimulation with rIL-9 significantly induced NET (neutrophil extracellular traps) release by dying cells (NETosis) in neutrophils, expansion of mast cells and increase of anti-systemic scleroderma 70 (Scl70) production by B cells. Our findings suggest that Th9 cells and IL-9 could be implicated in the pathogenesis of SSc
Phase transitions in the Potts spin glass model
We have studied the Potts spin glass with 2-state Ising spins and s-state
Potts variables using a cluster Monte Carlo dynamics. The model recovers the +-
J Ising spin glass (SG) for s=1 and exhibits for all s a SG transition at
T_{SG}(s) and a percolation transition at higher temperature T_p(s). We have
shown that for all values of at T_p(s) there is a thermodynamical
transition in the universality class of a ferromagnetic s-state Potts model.
The efficiency of the cluster dynamics is compared with that of standard spin
flip dynamics.Comment: 8 pages, Latex, with 8 EPS fig
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