Photometric metallicity for 694233 Galactic giant stars from Gaia DR3 synthetic Stromgren photometry. Metallicity distribution functions of halo sub-structures

We use the calibrations by Calamida et al. and by Hilker et al., and the standardised synthetic photometry in the v, b, and y Stromgren passbands from Gaia DR3 BP/RP spectra, to obtain photometric metallicities for a selected sample of 694233 old Galactic giant stars having |b|>20.0 and parallax uncertainties lower than 10%. The zero point of both sets of photometric metallicities has been shifted to to ensure optimal match with the spectroscopic [Fe/H] values for 44785 stars in common with APOGEE DR17, focusing on the metallicity range where they provide the highest accuracy. The metallicities derived in this way from the Calamida et al. calibration display a typical accuracy of ~0.1 dex and 1 sigma precision ~0.2 dex in the range -2.2 <=[Fe/H]<= -0.4, while they show a systematic trend with [Fe/H] at higher metallicity, beyond the applicability range of the relation. Those derived from the Hilker et al. calibration display, in general, worse precision, and lower accuracy in the metal-poor regime, but have a median accuracy < 0.05 dex for [Fe/H]>= -0.8. These results are confirmed and, consequently, the metallicities validated, by comparison with large sets of spectroscopic metallicities from various surveys. The newly obtained metallicities are used to derive metallicity distributions for several previously identified sub-structures in the Galactic halo with an unprecedented number of stars. The catalogue including both sets of metallicities and the associated uncertainties is made publicly available.Comment: Accepted for publication by Astronomy & Astrophysics. Latex. 20 pages, 21 color figures. The catalogue will be publicly available at CDS. In the meanwhile it is available upon request to the first autho

Inclisiran in lipid management: A Literature overview and future perspectives

Primary and secondary prevention protocols aim at reducing the plasma levels of lipids - with particular reference to low-density lipoprotein cholesterol (LDL-C) plasma concentrations – in order to improve the overall survival and reduce the occurrence of major adverse cardiovascular events. The use of statins has been widely considered as the first-line approach in lipids management as they can dramatically impact on the cardiovascular risk profile of individuals. The introduction of ezetimibe and proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors overcame the adverse effects of statins and ameliorate the achievement of the target lipids levels. Indeed, advances in therapies promote the use of specific molecules – i.e. short strands of RNA named small-interfering RNAs (siRNAs) – to suppress the transcription of genes related to lipids metabolism. Recently, the inclisiran has been developed: this is a siRNA able to block the mRNA of the PCSK9 gene. About 50% reduction in low-density lipoprotein cholesterol levels have been observed in randomized controlled trials with inclisiran. The aim of this review was to summarize the literature regarding inclisiran and its possible role in the general management of patients with lipid disorders and/or in primary/secondary prevention protocols

Seedless hydrothermal growth of ZnO nanorods as a promising route for flexible tactile sensors

Hydrothermal growth of ZnO nanorods has been widely used for the development of tactile sensors, with the aid of ZnO seed layers, favoring the growth of dense and vertically aligned nanorods. However, seed layers represent an additional fabrication step in the sensor design. In this study, a seedless hydrothermal growth of ZnO nanorods was carried out on Au-coated Si and polyimide substrates. The effects of both the Au morphology and the growth temperature on the characteristics of the nanorods were investigated, finding that smaller Au grains produced tilted rods, while larger grains provided vertical rods. Highly dense and high-aspect-ratio nanorods with hexagonal prismatic shape were obtained at 75 °C and 85 °C, while pyramid-like rods were grown when the temperature was set to 95 °C. Finite-element simulations demonstrated that prismatic rods produce higher voltage responses than the pyramid-shaped ones. A tactile sensor, with an active area of 1 cm2, was fabricated on flexible polyimide substrate and embedding the nanorods forest in a polydimethylsiloxane matrix as a separation layer between the bottom and the top Au electrodes. The prototype showed clear responses upon applied loads of 2–4 N and vibrations over frequencies in the range of 20–800 Hz

Fiber bragg gratings for medical applications and future challenges: A review

In the last decades, fiber Bragg gratings (FBGs) have become increasingly attractive to medical applications due to their unique properties such as small size, biocompatibility, immunity to electromagnetic interferences, high sensitivity and multiplexing capability. FBGs have been employed in the development of surgical tools, assistive devices, wearables, and biosensors, showing great potentialities for medical uses. This paper reviews the FBG-based measuring systems, their principle of work, and their applications in medicine and healthcare. Particular attention is given to sensing solutions for biomechanics, minimally invasive surgery, physiological monitoring, and medical biosensing. Strengths, weaknesses, open challenges, and future trends are also discussed to highlight how FBGs can meet the demands of next-generation medical devices and healthcare system

INTRAHEPATIC CHOLANGIOCARCINOMA DEVELOPMENT IN A PATIENT WITH A NOVEL BAP1 GERMLINE MUTATION AND LOW EXPOSURE TO ASBESTOS

BRCA1 associated protein-1 (BAP1) germline mutations define a novel hereditary cancer syndrome, namely BAP1 tumor predisposition syndrome (BAP1-TPDS), characterized by an increased susceptibility to develop different cancer types, including mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and basal cell and squamous cell carcinoma. Currently, the role of BAP1 germline mutations in intrahepatic cholangiocarcinoma (iCCA) pathogenesis is less known. Here we report the first clinical case of a female patient who developed an iCCA when she was 47-years-old and was found to carry a novel germline mutation at a splicing site of exon 4 in BAP1 gene (NM_004656.4: c.255_255+6del). An accurate anamnesis revealed the absence of risk factors linked to iCCA development, except for a low occupational exposure to asbestos. In tumor tissue, BAP1 sequencing, multiplex ligation-dependent probe amplification and immunoistochemistry showed the loss of heterozygosity and lack of nuclear expression, suggesting that BAP1 wild-type allele and functional protein were lost in cancer cells, in line with the classical two-hit model of tumor suppressor genes. Further studies are needed to confirm whether iCCA may be included into BAP1-TPDS cancer phenotypes and whether minimal asbestos exposure may facilitate the development of this malignancy in individuals carrying BAP1 germline mutations

The Cost-Effectiveness Analysis of Philips Motiva Telehealth System

Objectives The clinical effectiveness of Motiva Monitor platform was established in the previous study (TEN-HMS). Patients randomly assigned to receive Usual Care had higher one year mortality (45%) than patients assigned to receive Nurse Telephone Support (27%) or Home Telemonitoring (29%) (p=0.032). Our intention is to provide insights in the cost-effectiveness of Motiva telehealth system by modeling the intervention and running the analysis on top of the reported data. Methods Effectiveness was established by mining the EuroQol-5D from the original database, while the information on costs came from the literature and the manufacturer of the equipment. Direct healthcare costs considered ER visits, GP, Specialist, Hospitalist and Nurse time and resources utilization. The induced (indirect) costs were not considered in the analysis. The approximation of the cost of medical consumption came from the Netherlands only, although the original study was run in three European countries. We assumed the payer perspective for our analysis. Results The results clearly show, within the parameters of our model, the increased effectiveness of Home Telemonitoring and Nurse Telephone Support in comparison to the Usual Care. The deterministic results show ICERs of € 14.842 and € 12.547 per QALY (discounted at 1.5% a year) for HTM and NTS respectfully. Probabilistic results show that NTS was the most effective strategy in health systems that pay more than €12.500 per QALY. In the subgroup analysis HTM dominated both NTS and UC at the threshold of €16.500 in NYHA IV group of Chronic Heart Failure patients. Conclusions Home telemonitoring by Motiva Monitor system reduces mortality and lowers the in-hospital length of stay. On the quality of life dimensions, Home Telemonitoring was similarly effective as the Nurse Telephone Support, but with more costs. The cost-effectiveness analysis shows that both NTS and HTM dominate the Usual Care at WTP of €15.000

The VMC survey - XVII : The proper motions of the Small Magellanic Cloud and the Milky Way globular cluster 47 Tucanae

In this study we use multi-epoch near-infrared observations from the VISTA survey of the Magellanic Cloud system (VMC) to measure the proper motion of different stellar populations in a tile of 1.5 deg sq. in size in the direction of the Galactic globular cluster 47 Tuc. We obtain the proper motion of the cluster itself, of the Small Magellanic Cloud (SMC), and of the field Milky Way stars. Stars of the three main stellar components are selected from their spatial distribution and their distribution in colour-magnitude diagrams. Their average coordinate displacement is computed from the difference between multiple Ks-band observations for stars as faint as Ks=19 mag. Proper motions are derived from the slope of the best-fitting line among 10 VMC epochs over a time baseline of ~1 yr. Background galaxies are used to calibrate the absolute astrometric reference frame. The resulting absolute proper motion of 47 Tuc is (mu_alpha cos(delta), mu_delta)=(+7.26+/-0.03, -1.25+/-0.03) mas/yr. This measurement refers to about 35000 sources distributed between 10 and 60 arcmin from the cluster centre. For the SMC we obtain (mu_alpha cos(delta), mu_delta)=(+1.16+/-0.07, -0.81+/-0.07) mas/yr from about 5250 red clump and red giant branch stars. The absolute proper motion of the Milky Way population in the line-of-sight (l =305.9, b =-44.9) of this VISTA tile is (mu_alpha cos(delta), mu_delta)=(+10.22+/-0.14, -1.27+/-0.12) mas/yr and results from about 4000 sources. Systematic uncertainties associated to the astrometric reference system are 0.18 mas/yr. Thanks to the proper motion we detect 47 Tuc stars beyond its tidal radius.Peer reviewe

Sub-Riemannian Calculus on Hypersurfaces in Carnot Groups

We develope basic geometric quantities and properties of hypersurfaces in Carnot groups