Data requirements for in-flight synthesis and multiple blender studies

Data requirements for in-flight synthesis and multiple blender studies to improve stability and control of large flexible booster

Support for Integrated Ecosystem Assessments of NOAA’s National Estuarine Research Reserves System (NERRS), Volume I: The Impacts of Coastal Development on the Ecology and Human Well-being of Tidal Creek Ecosystems of the US Southeast

A study was conducted, in association with the Sapelo Island and North Carolina National Estuarine Research Reserves (NERRs), to evaluate the impacts of coastal development on sentinel habitats (e.g., tidal creek ecosystems), including potential impacts to human health and well-being. Uplands associated with southeastern tidal creeks and the salt marshes they drain are popular locations for building homes, resorts, and recreational facilities because of the high quality of life and mild climate associated with these environments. Tidal creeks form part of the estuarine ecosystem characterized by high biological productivity, great ecological value, complex environmental gradients, and numerous interconnected processes. This research combined a watershed-level study integrating ecological, public health and human dimension attributes with watershed-level land use data. The approach used for this research was based upon a comparative watershed and ecosystem approach that sampled tidal creek networks draining developed watersheds (e.g., suburban, urban, and industrial) as well as undeveloped sites. The primary objective of this work was to clearly define the relationships between coastal development with its concomitant land use changes and non-point source pollution loading and the ecological and human health and well-being status of tidal creek ecosystems. Nineteen tidal creek systems, located along the southeastern United States coast from southern North Carolina to southern Georgia, were sampled during summer (June-August), 2005 and 2006. Within each system, creeks were divided into two primary segments based upon tidal zoning: intertidal (i.e., shallow, narrow headwater sections) and subtidal (i.e., deeper and wider sections), and watersheds were delineated for each segment. In total, we report findings on 24 intertidal and 19 subtidal creeks. Indicators sampled throughout each creek included water quality (e.g., dissolved oxygen concentration, salinity, nutrients, chlorophyll-a levels), sediment quality (e.g., characteristics, contaminants levels including emerging contaminants), pathogen and viral indicators, and abundance and genetic responses of biological resources (e.g., macrobenthic and nektonic communities, shellfish tissue contaminants, oyster microarray responses). For many indicators, the intertidally-dominated or headwater portions of tidal creeks were found to respond differently than the subtidally-dominated or larger and deeper portions of tidal creeks. Study results indicate that the integrity and productivity of headwater tidal creeks were impaired by land use changes and associated non-point source pollution, suggesting these habitats are valuable early warning sentinels of ensuing ecological impacts and potential public health threats. For these headwater creeks, this research has assisted the validation of a previously developed conceptual model for the southeastern US region. This conceptual model identified adverse changes that generally occurred in the physical and chemical environment (e.g., water quality indicators such as indicator bacteria for sewage pollution or sediment chemical contamination) when impervious cover levels in the watershed reach 10-20%. Ecological characteristics responded and were generally impaired when impervious cover levels exceed 20-30%. Estimates of impervious cover levels defining where human uses are impaired are currently being determined, but it appears that shellfish bed closures and the flooding vulnerability of headwater regions become a concern when impervious cover values exceed 10-30%. This information can be used to forecast the impacts of changing land use patterns on tidal creek environmental quality as well as associated human health and well-being. In addition, this study applied tools and technologies that are adaptable, transferable, and repeatable among the high quality NERRS sites as comparable reference entities to other nearby developed coastal watersheds. The findings herein will be of value in addressing local, regional and national needs for understanding multiple stressor (anthropogenic and human impacts) effects upon estuarine ecosystems and response trends in ecosystem condition with changing coastal impacts (i.e., development, climate change). (PDF contaions 88 pages

Assessment of sexual difficulties associated with multi-modal treatment for cervical or endometrial cancer: A systematic review of measurement instruments

Background: Practitioners and researchers require an outcome measure that accurately identifies the range of common treatment-induced changes in sexual function and well-being experienced by women after cervical or endometrial cancer. This systematic review critically appraised the measurement properties and clinical utility of instruments validated for the measurement of female sexual dysfunction (FSD) in this clinical population. Methods: A bibliographic database search for questionnaire development or validation papers was completed and methodological quality and measurement properties of selected studies rated using the Consensus-based Standards for the selection of health Measurement Instrument (COSMIN) checklist. Results: 738 articles were screened, 13 articles retrieved for full text assessment and 7 studies excluded, resulting in evaluation of 6 papers; 2 QoL and 4 female sexual morbidity measures. Five of the six instruments omitted one or more dimension of female sexual function and only one instrument explicitly measured distress associated with sexual changes as per DSM V (APA 2013) diagnostic criteria. None of the papers reported measurement error, responsiveness data was available for only two instruments, three papers failed to report on criterion validity, and test-retest reliability reporting was inconsistent. Heterosexual penile-vaginal intercourse remains the dominant sexual activity focus for sexual morbidity PROMS terminology and instruments lack explicit reference to solo or non-coital sexual expression or validation in a non-heterosexual sample. Four out of six instruments included mediating treatment or illness items such as vaginal changes, menopause or altered body image. Conclusions: Findings suggest that the Female Sexual Function Index (FSFI) remains the most robust sexual morbidity outcome measure, for research or clinical use, in sexually active women treated for cervical or endometrial cancer

Qudit Quantum State Tomography

Recently quantum tomography has been proposed as a fundamental tool for prototyping a few qubit quantum device. It allows the complete reconstruction of the state produced from a given input into the device. From this reconstructed density matrix, relevant quantum information quantities such as the degree of entanglement and entropy can be calculated. Generally orthogonal measurements have been discussed for this tomographic reconstruction. In this paper, we extend the tomographic reconstruction technique to two new regimes. First we show how non-orthogonal measurement allow the reconstruction of the state of the system provided the measurements span the Hilbert space. We then detail how quantum state tomography can be performed for multi qudits with a specific example illustrating how to achieve this in one and two qutrit systems.Comment: 6 pages, 4 figures, submitted to PR

Target enrichment of ultraconserved elements from arthropods provides a genomic perspective on relationships among Hymenoptera

Gaining a genomic perspective on phylogeny requires the collection of data from many putatively independent loci collected across the genome. Among insects, an increasingly common approach to collecting this class of data involves transcriptome sequencing, because few insects have high-quality genome sequences available; assembling new genomes remains a limiting factor; the transcribed portion of the genome is a reasonable, reduced subset of the genome to target; and the data collected from transcribed portions of the genome are similar in composition to the types of data with which biologists have traditionally worked (e.g., exons). However, molecular techniques requiring RNA as a template are limited to using very high quality source materials, which are often unavailable from a large proportion of biologically important insect samples. Recent research suggests that DNA-based target enrichment of conserved genomic elements offers another path to collecting phylogenomic data across insect taxa, provided that conserved elements are present in and can be collected from insect genomes. Here, we identify a large set (n$=$1510) of ultraconserved elements (UCE) shared among the insect order Hymenoptera. We use in silico analyses to show that these loci accurately reconstruct relationships among genome-enabled Hymenoptera, and we design a set of baits for enriching these loci that researchers can use with DNA templates extracted from a variety of sources. We use our UCE bait set to enrich an average of 721 UCE loci from 30 hymenopteran taxa, and we use these UCE loci to reconstruct phylogenetic relationships spanning very old ($\geq$220 MYA) to very young ($\leq$1 MYA) divergences among hymenopteran lineages. In contrast to a recent study addressing hymenopteran phylogeny using transcriptome data, we found ants to be sister to all remaining aculeate lineages with complete support

Linear Cosmological Structure Limits on Warm Dark Matter

I consider constraints from observations on a cutoff scale in clustering due to free streaming of the dark matter in a warm dark matter cosmological model with a cosmological constant. The limits are derived in the framework of a sterile neutrino warm dark matter universe, but can be applied to gravitinos and other models with small scale suppression in the linear matter power spectrum. With freedom in all cosmological parameters including the free streaming scale of the sterile neutrino dark matter, limits are derived using observations of the fluctuations in the cosmic microwave background, the 3D clustering of galaxies and 1D clustering of gas in the Lyman-alpha (Ly-alpha) forest in the Sloan Digital Sky Survey (SDSS), as well as the Ly-alpha forest in high-resolution spectroscopic observations. In the most conservative case, using only the SDSS main-galaxy 3D power-spectrum shape, the limit is m_s > 0.11 keV; including the SDSS Ly-alpha forest, this limit improves to m_s > 1.7 keV. More stringent constraints may be placed from the inferred matter power spectrum from high-resolution Ly-alpha forest observations, which has significant systematic uncertainties; in this case, the limit improves to m_s > 3.0 keV (all at 95% CL).Comment: 6 pages, 4 figures; v2: matches PRD version, with note added regarding astro-ph/060243

Masses for the Local Group and the Milky Way

We use the very large Millennium Simulation of the concordance $\Lambda$CDM cosmogony to calibrate the bias and error distribution of Timing Argument estimators of the masses of the Local Group and of the Milky Way. From a large number of isolated spiral-spiral pairs similar to the Milky Way/Andromeda system, we find the interquartile range of the ratio of timing mass to true mass to be a factor of 1.8, while the 5% and 95% points of the distribution of this ratio are separated by a factor of 5.7. Here we define true mass as the sum of the ``virial'' masses $M_{200}$ of the two dominant galaxies. For current best values of the distance and approach velocity of Andromeda this leads to a median likelihood estimate of the true mass of the Local Group of 5.27\times 10^{12}\msun, or $\log M_{LG}/M_\odot = 12.72$, with an interquartile range of $[12.58, 12.83]$ and a 5% to 95% range of $[12.26, 13.01]$. Thus a 95% lower confidence limit on the true mass of the Local Group is 1.81\times 10^{12}\msun. A timing estimate of the Milky Way's mass based on the large recession velocity observed for the distant satellite Leo I works equally well, although with larger systematic uncertainties. It gives an estimated virial mass for the Milky Way of 2.43 \times 10^{12}\msun with a 95% lower confidence limit of 0.80 \times 10^{12}\msun.Comment: 11 pages, 6 figures, MNRAS accepted. Added a new discussion paragraph and a new figure regarding the relative transverse velocity but conclusions unchange

Electron scattering and transport in liquid argon

The transport of excess electrons in liquid argon driven out of equilibrium by an applied electric field is revisited using a multi-term solution of Boltzmann's equation together with ab initio liquid phase cross-sections calculated using the Dirac-Fock scattering equations. The calculation of liquid phase cross-sections extends previous treatments to consider multipole polarisabilities and a non-local treatment of exchange while the accuracy of the electron-argon potential is validated through comparison of the calculated gas phase cross-section with experiment. The results presented highlight the inadequacy of local treatments of exchange that are commonly used in liquid and cluster phase cross-section calculations. The multi-term Boltzmann equation framework accounting for coherent scattering enables the inclusion of the full anisotropy in the differential cross-section arising from the interaction and the structure factor, without an a priori assumption of quasi-isotropy in the velocity distribution function. The model, which contains no free parameters and accounts for both coherent scattering and liquid phase screening effects, was found to reproduce well the experimental drift velocities and characteristic energies.Comment: 32 pages, 16 figures; minor corrections, added 1 figur