SYNTROPY OF UNCLASSIFIED COMPLEXES OF MULTIPLE CONGENITAL MALFORMATIONS

Statistical analysis of unclassified complexes multiple of congenital malformations was performed . Frequency of the most frequent combination of defects consisting of multiple congenital malformations was determined , syntropy index was defined. "Watching congenital malformations" (anus atresia, cleft lip/palate, congenital umbilical hernia, clubfoot) according to the analysis of association and syntropy index can be used as a marker as to congenital heart defects, central nervous system and kidney

How Malthusian Ideology crept into the Newsroom: British tabloids and the coverage of the ‘underclass’

This article argues that Malthusianism as a series of discursive regimes, developed in the Victorian-era, serves in times of austerity to reproduce an elite understanding of social exclusion in which those in a state of poverty are to blame for their own situation. It highlights that Malthusianism is present in the public discourse, becoming an underlining feature in news coverage of the so-called ‘underclass’. Our findings broadly contradict the normative claim that journalism ‘speaks truth to power’, and suggest instead that overall as a political practice, journalism tends to reproduce and reinforce hegemonic discourses of power. The piece is based on critical discourse analysis (CDA), which has been applied to a significant sample of news articles published by tabloid newspapers in Britain which focussed on the concept of the ‘underclass’. By looking at the evidence, the authors argue that the ‘underclass’ is a concept used by some journalists to cast people living in poverty as ‘undeserving’ of public and state support. In so doing, these journalists help create a narrative which supports cuts in welfare provisions and additional punitive measures against some of the most vulnerable members of society

Complex research of acoustic impact on gas-dust flow in vortex-acoustic dispenser

Introduction The processing of wastes from mining operations is usually related to the needs of related industries in raw materials. The results of numerous studies on the complex processing of various man-made materials have confirmed the feasibility of their use to ensure resource-saving and obtain new types of products [1-3]. One of the most promising areas of industrial waste utilization is their integrated use in the production of building materials, which allows to meet the demand for raw materials up to 40% for this most important industry. The use of industrial waste allows to reduce costs for the manufacture of building materials 10-30% in comparison with their production from natural raw materials. The saving of capital investments makes 35-50% in this case [4-5]. In modern technology of building materials production, fine powders are one of the fundamental components that significantly affect the quality of finished products [6]. The fineness of material grinding is important for the intensification of various technological processes. However, the obtaining of a highly dispersed product is difficult due to increased energy consumption for material grinding, as well as their abrasiveness at an intensive abrasion, which causes a high wear of grinding bodies and other parts of a grinding unit. This leads to the increase of the grinding process cost, as well as to the obtaining of a poor-quality, contaminated product [7,8]. According to the data [9-10], the energy costs for the grinding of various materials reach 20% of the total energy consumption for production. The most promising method for fine and ultrafine grinding of various materials used in lowtonnage and innovative technologies is the jet method of grinding [11-12]

A Hindbrain Inhibitory Microcircuit Mediates Vagally-Coordinated Glucose Regulation

Neurons in the brainstem dorsal vagal complex integrate neural and humoral signals to coordinate autonomic output to viscera that regulate a variety of physiological functions, but how this circuitry regulates metabolism is murky. We tested the hypothesis that premotor, GABAergic neurons in the nucleus tractus solitarius (NTS) form a hindbrain micro-circuit with preganglionic parasympathetic motorneurons of the dorsal motor nucleus of the vagus (DMV) that is capable of modulating systemic blood glucose concentration. In vitro, neuronal activation or inhibition using either excitatory or inhibitory designer receptor exclusively activated by designer drugs (DREADDs) constructs expressed in GABAergic NTS neurons increased or decreased, respectively, action potential firing of GABAergic NTS neurons and downstream synaptic inhibition of the DMV. In vivo, DREADD-mediated activation of GABAergic NTS neurons increased systemic blood glucose concentration, whereas DREADD-mediated silencing of these neurons was without effect. The DREADD-induced hyperglycemia was abolished by blocking peripheral muscarinic receptors, consistent with the hypothesis that altered parasympathetic drive mediated the response. This effect was paralleled by elevated serum glucagon and hepatic phosphoenolpyruvate carboxykinase 1 (PEPCK1) expression, without affecting insulin levels or muscle metabolism. Activity in a hindbrain inhibitory microcircuit is sufficient to modulate systemic glucose concentration, independent of insulin secretion or utilization

Preparing future teachers to the basics of health professional in inclusive education

In the article the results of theoretically-experimental research of problem of forming of inclusive competence of a future teacher of the bases of health as a basis of his professional activity in the conditions of inclusionВ статье изложены результаты теоретико-экспериментального исследования проблемы формирования инклюзивной компетентности будущего учителя основ здоровья как неотъемлемой составляющей его готовности к профессиональной деятельности в условиях инклюзи

ОЦІНКА ЯКОСТІ ЖИТТЯ У ЖІНОК ІЗ ФІБРОМІОМОЮ МАТКИ ДО ТА ПІСЛЯ ОПЕРАТИВНОГО ЛІКУВАННЯ.

Experience shows that women suffering from uterine fibroids have an increased level of anxiety. It can lead to social and personal isolation during surgery. Thereby, nowadays the assessment of patients ‘ quality of life becoming increasingly important alongside the main traditional methods of evaluating the effectiveness of treatment and the effects of disease. According to the results, quality of life of women of reproductive and post reproductive age whohave undergone a surgical treatment for uterine fibroids,based on our therapy, improved.Практика показывает, что у женщин с миомой матки повышен уровень тревожности, а это может привести к снижению активности и качества жизни, а в дальнейшем к социальной и личной изоляции в период оперативного лечения. В связи с этим оценка качества жизни пациенток в наше время приобретает все большее значение наряду с основными традиционными методиками оценки эффективности лечения и последствий заболеваемости. По полученным результатам, качество жизни у женщин репродуктивного и пострепродуктивного возраста, перенесших оперативное лечение по поводу миомы матки, на основе предложенной нами терапии улучшилось.Досвід показує, що у жінок з міомою матки підвищений рівень тривожності, а це може призвести до зниження активності і якості життя, а в подальшому до соціальної та особистої ізоляції в період оперативного лікування. У зв’язку з цим оцінка якості життя пацієнток в наш час набуває все більшого значення поряд з основними традиційними методиками оцінки ефективності лікування та наслідків захворюваності. За отриманими результатами, якість життя у жінок репродуктивного та пострепродуктивного віку, які перенесли оперативне лікування з приводу міоми матки, на основі запропонованої нами терапії покращилася

КЛІНІКО-ПАТОГЕНЕТИЧНІ ПРИЧИНИ РОЗВИТКУ УСКЛАДНЕНЬ ПРИ БАГАТОПЛІДНІЙ ВАГІТНОСТІ

The aim of the study – to investigate the effect of the placental growth factors on gestational process during multiple pregnancies. Materials and Methods. A prospective study of maternity pregnancy in 320 females with multiple pregnancies was conducted, which comprised the main group of the subjects and 40 healthy women with unipolar pregnancy. The level of PlGF in serum was determined by solid phase enzyme analysis using monoclonal antibody sets in the first trimester of pregnancy. Indicators of the hemostasis system (vascular thrombocyte and coagulation link) were evaluated according to generally accepted methods. Dopplerometry of placental and fetal blood flow was performed in uterine arteries, arteries and umbilical cord veins, middle cerebral artery of the fetus. Results and Discussion. Women with multiple pregnancies are at the risk of gestational complications – premature births in 67.8 % (p <0.01), fetoplacental dysfunction, pre-eclampsia – in 17.5 % (p <0.05) cases. The revealed violations of the vascular thrombocyte and coagulation homeostasis in the first trimester of pregnancy are the main risk factors for early premature abortion. It has been shown that the low level of placental growth factor in serum of pregnant women with multiple pregnancies in the case of premature labor, fetoplacental dysfunction and pre-eclampsia (111.23±8.4), (203.24±6.4) and (305.86±7.4) pg/ml) compared with the corresponding indicators for single-pregnancy (418.2±10.4) pg/ml) is a prognostic marker for the development of gestational complications. Conclusions. Timely medical correction of gestational complications during multiple pregnancies with the use of micronized progesterone, low molecular weight heparins, angio protectants allowed prolonging the pregnancy with mono choric type of placentation by 3.2 weeks (up to (34.2±2.4) weeks), and in the case of dichorial twins – to full-term pregnancy.Цель исследования – изучить влияние факторов роста плаценты на течение гестационного процесса при многоплодной беременности. Материалы и методы. Проведено проспективное исследование течения беременности и родов у 320 женщин с многоплодной беременностью, которые составили основную группу обследуемых, и у 40 здоровых женщин с одноплодной беременностью. Уровень PlGF в сыворотке крови определяли методом твердофазного иммуноферментного анализа с использованием наборов моноклональных антител в первом триместре беременности. Показатели системы гемостаза (сосудисто-тромбоцитарное и коагуляционное звено) оценивались по общепринятым методикам. Допплерометрия плацентарного и плодового кровотока проводилась в маточных артериях, артерии и вене пуповины, средней мозговой артерии плода. Результаты исследования и их обсуждение. Женщины с многоплодной беременностью входят в группу риска развития гестационных осложнений: преждевременных родов у 67,8 % (р<0,01), фетоплацентарной дисфункции, преэклампсии – у 17,5 % (р<0,05) случаев. Выявленные нарушения со стороны сосудисто-тромбоцитарного и коагуляционного гомеостаза в I триместре беременности являются основными факторами риска досрочного прерывания беременности. Доказано, что низкий уровень фактора роста плаценты в сыворотке крови беременных при многоплодии в случае развития преждевременных родов, фетоплацентарной дисфункции и преэклампсии – (111,23±8,4), (203,24±6,4) и (305,86±7,4) пг/мл по сравнению с соответствующими показателями при одноплодной беременности – (418,2±10,4) пг/мл является прогностическим маркером развития данных гестационных осложнений. Выводы. Своевременное проведение медикаментозной коррекции гестационных осложнений при многоплодной беременности с использованием микронизированного прогестерона, низкомолекулярных гепаринов, ангиопротекторов позволило пролонгировать беременность при монохориальном типе плацентации на 3,2 недели (до (34,2±2,4) недель), а в случае с дихориальною двойней – к сроку доношенной беременности.Мета дослідження – вивчити вплив факторів росту плаценти на перебіг гестаційного процесу при багатоплідній вагітності. Матеріали та методи. Проведено проспективне дослідження перебігу вагітності та пологів у 320 жінок із багатоплідною вагітністю, котрі склали основну групу обстежуваних, та у 40 здорових жінок з одноплідною вагітністю. Рівень PlGF в сироватці крові визначали методом твердофазного імуноферментного аналізу з використанням наборів моноклональних антитіл у першому триместрі вагітності. Показники системи гемостазу (судинно-тромбоцитарна та коагуляційна ланка) оцінювали за загальноприйнятими методиками. Доплерометрію плацентарного та плодового кровотоку проводили у маткових артеріях, артерії і вені пуповини, середній мозковій артерії плода. Результати дослідження та їх обговорення. Жінки з багатоплідною вагітністю входять до групи ризику розвитку гестаційних ускладнень: передчасних пологів у 67,8 % (р<0,01), фетоплацентарної дисфункції, прееклампсії – у 17,5 % (р<0,05) випадків. Виявлені порушення з боку судинно-тромбоцитарного та коагуляційного гомеостазу у І триместрі вагітності є основними факторами ризику дострокового переривання вагітності. Доведено, що низький рівень фактора росту плаценти в сироватці крові вагітних при багатоплідді у випадку розвитку передчасних пологів, фетоплацентарної дисфункції та прееклампсії – (111,23±8,4), (203,24±6,4) та (305,86±7,4) пг/мл порівняно з відповідними показниками при одноплідній вагітності – (418,2±10,4) пг/мл є прогностичним маркером розвитку даних гестаційних ускладнень. Висновки. Своєчасне проведення медикаментозної корекції гестаційних ускладнень при багатоплідній вагітності з використанням мікронізованого прогестерону, низькомолекулярних гепаринів, ангіопротекторів дозволило пролонгувати вагітність при монохоріальному типі плацентації на 3,2 тижня (до (34,2±2,4) тижнів), а у випадку з дихоріальною двійнею – до терміну доношеної вагітності

Common mechanisms of placental dysfunction in preeclampsia, gestational diabetes, and COVID-19 in pregnant women

COVID-19 infection, preeclampsia and gestational diabetes mellitus in pregnancy cause similar changes in the placenta and influence development of the fetus between conception and birth in gestation. Proper uterine and placental vascularization is essential for normal fetal development. The transplacental exchange is regulated and maintained by the placental endothelium. During placental implantation, the trophoblast differentiates into two distinct layers, the inner cytotrophoblast and outer syncytiotrophoblast, which are key elements of the human placental barrier. Proinflammatory cytokines exacerbate ischemic events and create an upward spiral of an inflammatory reaction in the placenta. Placental pathology in gestational COVID-19 shows desquamation and damage of trophoblast and chronic histiocytic intervillositis. Similar lesions also occur in gestational diabetes mellitus and preeclampsia. The systemic inflammatory response of the mother, the increased inflammation in the placenta and cytokine production by placental trophoblasts should be monitored throughout pregnancy. Placental angiogenesis can be evaluated by serum vascular endothelial growth factor, Annexin A2, placental growth factor or sclerostin. Tissue damage can be assessed by measuring levels of serum lactate dehydrogenase and myeloperoxidase. Blood flow can be monitored with three-dimensional Doppler and pathological changes can be documented with paraffin-embedded tissue sections stained with hematoxylin and eosin, and electron microscope images as well as immunohistochemistry tests for vascular endothelial growth factor, placental growth factor, sclerostin and Annexin A2. The damage of maternal and fetal vascular perfusion (villitis and fibrin deposition) is a common mechanism of gestational diseases. The placenta lesions liberate anti-endothelial factors that lead to anti-angiogenic conditions and are the common mechanism of maternal placental vascular malperfusion in gestational diseases. Keywords: dysfunction, inflammation, pathology, placenta, pregnancy, vascularizatio

Mathematical Model of an Antenna-Waveguide Path with Separation of Signals by Frequency–Polarization

Introduction. The creation of antenna-waveguide paths of multi-band mirror antennas (AWP MMA) is a significant task in the development of antenna-feeder devices for satellite communication systems (SSS). This task involves the construction of an adequate mathematical model of AWP MMA both without and with the implementation of an auto-tracking function built using the "frequency separation – polarization separation" method. However, the existing mathematical models have been developed only for specific AWP MMA types, thus making them unsuitable for the development of new AWP MMA. The model proposed in this paper can be used for an arbitrary number of combined frequency ranges and types of polarization.Aim. Development of a mathematical model of the AWP MMA of SSS both without and with the implementation of an auto-tracking function built using the "frequency separation – polarization separation" method.Materials and methods. The mathematical model under consideration assumes a description of the AWP MMA using block matrices. Each of these matrices describes the complex amplitudes of signals arising in each of the AWP MMA devices. This, in turn, makes it possible to analyze the influence of the parameters of each device on the characteristics of the AWP MMA of SSS as a whole with an arbitrary number of combined frequency ranges and types of polarization.Results. Two options for the construction of AWP MMA of SSS are proposed. The first option can be used in communication system antennas with software support, while the second option is applicable when a monopulse tracking method is implemented. To construct an AWP MMA model, it is proposed to use a matrix description of the characteristics of AWP MMA devices. This allows the structure of the considered AWP MMA to be varied within a wide range.Conclusion. The developed mathematical model makes it possible to describe the characteristics of each of the devices in the AWP MMA system using a certain multipole. The proposed model provides ample opportunities for controlling, at the stages of development, production and debugging, not only the characteristics of each device in the AWP MMA, but also the transmission coefficient and polarization isolation in each frequency range of the entire AWP MMA. The presented dependencies can be used to assess the relationship between parameter tolerances and the limits of changes in the characteristics of the motor vehicle