11,215 research outputs found
Quiver Structure of Heterotic Moduli
We analyse the vector bundle moduli arising from generic heterotic
compactifications from the point of view of quiver representations. Phenomena
such as stability walls, crossing between chambers of supersymmetry, splitting
of non-Abelian bundles and dynamic generation of D-terms are succinctly encoded
into finite quivers. By studying the Poincar\'e polynomial of the quiver moduli
space using the Reineke formula, we can learn about such useful concepts as
Donaldson-Thomas invariants, instanton transitions and supersymmetry breaking.Comment: 38 pages, 5 figures, 1 tabl
Heterotic domain wall solutions and SU(3) structure manifolds
We examine compactifications of heterotic string theory on manifolds with
SU(3) structure. In particular, we study N = 1/2 domain wall solutions which
correspond to the perturbative vacua of the 4D, N =1 supersymmetric theories
associated to these compactifications. We extend work which has appeared
previously in the literature in two important regards. Firstly, we include two
additional fluxes which have been, heretofore, omitted in the general analysis
of this situation. This allows for solutions with more general torsion classes
than have previously been found. Secondly, we provide explicit solutions for
the fluxes as a function of the torsion classes. These solutions are
particularly useful in deciding whether equations such as the Bianchi
identities can be solved, in addition to the Killing spinor equations
themselves. Our work can be used to straightforwardly decide whether any given
SU(3) structure on a six-dimensional manifold is associated with a solution to
heterotic string theory. To illustrate how to use these results, we discuss a
number of examples taken from the literature.Comment: 34 pages, minor corrections in second versio
Automatic estimation of harmonic tension by distributed representation of chords
The buildup and release of a sense of tension is one of the most essential
aspects of the process of listening to music. A veridical computational model
of perceived musical tension would be an important ingredient for many music
informatics applications. The present paper presents a new approach to
modelling harmonic tension based on a distributed representation of chords. The
starting hypothesis is that harmonic tension as perceived by human listeners is
related, among other things, to the expectedness of harmonic units (chords) in
their local harmonic context. We train a word2vec-type neural network to learn
a vector space that captures contextual similarity and expectedness, and define
a quantitative measure of harmonic tension on top of this. To assess the
veridicality of the model, we compare its outputs on a number of well-defined
chord classes and cadential contexts to results from pertinent empirical
studies in music psychology. Statistical analysis shows that the model's
predictions conform very well with empirical evidence obtained from human
listeners.Comment: 12 pages, 4 figures. To appear in Proceedings of the 13th
International Symposium on Computer Music Multidisciplinary Research (CMMR),
Porto, Portuga
Topologically protected quantum bits from Josephson junction arrays
All physical implementations of quantum bits (qubits), carrying the
information and computation in a putative quantum computer, have to meet the
conflicting requirements of environmental decoupling while remaining
manipulable through designed external signals. Proposals based on quantum
optics naturally emphasize the aspect of optimal isolation, while those
following the solid state route exploit the variability and scalability of
modern nanoscale fabrication techniques. Recently, various designs using
superconducting structures have been successfully tested for quantum coherent
operation, however, the ultimate goal of reaching coherent evolution over
thousands of elementary operations remains a formidable task. Protecting qubits
from decoherence by exploiting topological stability, a qualitatively new
proposal due to Kitaev, holds the promise for long decoherence times, but its
practical physical implementation has remained unclear so far. Here, we show
how strongly correlated systems developing an isolated two-fold degenerate
quantum dimer liquid groundstate can be used in the construction of
topologically stable qubits and discuss their implementation using Josephson
junction arrays.Comment: 6 pages, 4 figure
A Transfer Matrix Method for Resonances in Randall-Sundrum Models
In this paper we discuss in detail a numerical method to study resonances in
membranes generated by domain walls in Randall-Sundrum-like scenarios. It is
based on similar works to understand the quantum mechanics of electrons subject
to the potential barriers that exist in heterostructures in semiconductors.
This method was used recently to study resonances of a three form field and
lately generalized to arbitrary forms. We apply it to a lot of important
models, namely those that contain the Gauge, Gravity and Spinor fields. In many
cases we find a rich structure of resonances which depends on the parameters
involved.Comment: 25 pages, 17 figure
Physical activity and clustered cardiovascular disease risk factors in young children: a cross-sectional study (the IDEFICS study)
<p>Background
The relevance of physical activity (PA) for combating cardiovascular disease (CVD) risk in children has been highlighted, but to date there has been no large-scale study analyzing that association in children aged ≤9 years of age. This study sought to evaluate the associations between objectively-measured PA and clustered CVD risk factors in a large sample of European children, and to provide evidence for gender-specific recommendations of PA.</p>
<p>Methods
Cross-sectional data from a longitudinal study in 16,224 children aged 2 to 9 were collected. Of these, 3,120 (1,016 between 2 to 6 years, 2,104 between 6 to 9 years) had sufficient data for inclusion in the current analyses. Two different age-specific and gender-specific clustered CVD risk scores associated with PA were determined. First, a CVD risk factor (CRF) continuous score was computed using the following variables: systolic blood pressure (SBP), total triglycerides (TG), total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-c) ratio, homeostasis model assessment of insulin resistance (HOMA-IR), and sum of two skinfolds (score CRFs). Secondly, another CVD risk score was obtained for older children containing the score CRFs + the cardiorespiratory fitness variable (termed score CRFs + fit). Data used in the current analysis were derived from the IDEFICS (‘Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS’) study.</p>
<p>Results
In boys <6 years, the odds ratios (OR) for CVD risk were elevated in the least active quintile of PA (OR: 2.58) compared with the most active quintile as well as the second quintile for vigorous PA (OR: 2.91). Compared with the most active quintile, older children in the first, second and third quintiles had OR for CVD risk score CRFs + fit ranging from OR 2.69 to 5.40 in boys, and from OR 2.85 to 7.05 in girls.</p>
<p>Conclusions
PA is important to protect against clustering of CVD risk factors in young children, being more consistent in those older than 6 years. Healthcare professionals should recommend around 60 and 85 min/day of moderate-to-vigorous PA, including 20 min/day of vigorous PA.</p>
Congenital anomalies in low- and middle-income countries: the unborn child of global surgery.
Surgically correctable congenital anomalies cause a substantial burden of global morbidity and mortality. These anomalies disproportionately affect children in low- and middle-income countries (LMICs) due to sociocultural, economic, and structural factors that limit the accessibility and quality of pediatric surgery. While data from LMICs are sparse, available evidence suggests that the true human and financial cost of congenital anomalies is grossly underestimated and that pediatric surgery is a cost-effective intervention with the potential to avert significant premature mortality and lifelong disability
The effect of high dose antibiotic impregnated cement on rate of surgical site infection after hip hemiarthroplasty for fractured neck of femur : a protocol for a double-blind quasi randomised controlled trial
Background:
Mortality following hip hemiarthroplasty is in the range of 10-40% in the first year, with much attributed to post-operative complications. One such complication is surgical site infection (SSI), which at the start of this trial affected 4.68% of patients in the UK having this operation. Compared to SSI rates of elective hip surgery, at less than 1%, this figure is elevated. The aim of this quasi randomised controlled trial (RCT) is to determine if high dose antibiotic impregnated cement can reduce the SSI in patients at 12-months after hemiarthroplasty for intracapsular fractured neck of femur.
Methods:
848 patients with an intracapsular fractured neck of femur requiring a hip hemiarthroplasty are been recruited into this two-centre double-blind quasi RCT. Participants were recruited before surgery and quasi randomised to standard care or intervention group. Participants, statistician and outcome assessors were blind to treatment allocation throughout the study. The intervention consisted of high dose antibiotic impregnated cement consisting of 1 gram Clindamycin and 1 gram of Gentamicin. The primary outcome is Health Protection Agency (HPA) defined deep surgical site infection at 12 months. Secondary outcomes include HPA defined superficial surgical site infection at 30 days, 30 and 90-day mortality, length of hospital stay, critical care stay, and complications.
Discussion:
Large randomised controlled trials assessing the effectiveness of a surgical intervention are uncommon, particularly in the speciality of orthopaedics. The results from this trial will inform evidence-based recommendations for antibiotic impregnated cement in the management of patients with a fractured neck of femur undergoing a hip hemiarthroplasty. If high dose antibiotic impregnated cement is found to be an effective intervention, implementation into clinical practice could improve long-term outcomes for patients undergoing hip hemiarthroplasty
Comparison and Mapping Facilitate Relation Discovery and Predication
Relational concepts play a central role in human perception and cognition, but little is known about how they are acquired. For example, how do we come to understand that physical force is a higher-order multiplicative relation between mass and acceleration, or that two circles are the same-shape in the same way that two squares are? A recent model of relational learning, DORA (Discovery of Relations by Analogy; Doumas, Hummel & Sandhofer, 2008), predicts that comparison and analogical mapping play a central role in the discovery and predication of novel higher-order relations. We report two experiments testing and confirming this prediction
- …