Calibration of material parameters for the Chang-Mander model for unconfined concrete

The current basic OpenSees distribution includes several uniaxial models for concrete. Among them, the model proposed by Chang and Mander in 1994 offers a comprehensive setting applicable both to confined and unconfined concrete, by a proper selection of material parameters. The model offers the possibility to smoothly combine Tsai equation, for the first part of the curve, with a linear branch for the final part. This option is useful to model spalling of unconfined concrete while keeping the smoothness of the curve. Two basic parameters of the Chang-Mander model for compression, denoted by n and r, govern initial and post-peak stiffness of the Tsai equation, respectively. Besides them, there is a further parameter, denoted by α, which received less attention in the literature and determines the position of the switch between nonlinear and linear parts of the curve. In the first part of this work, the calibration of the parameters n and r is discussed in some detail. In the second part, the problem of the calibration of α is analyzed. Changes in the value of α may produce large variations in the evaluation of the spalling strain for unconfined concrete. After some comparative analyses with existing models, a simple expression to calibrate α parameter is finally proposed

The DAG1 transcription factor negatively regulates the seed-to-seedling transition in Arabidopsis acting on ABA and GA levels

BACKGROUND: In seeds, the transition from dormancy to germination is regulated by abscisic acid (ABA) and gibberellins (GAs), and involves chromatin remodelling. Particularly, the repressive mark H3K27 trimethylation (H3K27me3) has been shown to target many master regulators of this transition. DAG1 (DOF AFFECTING GERMINATION1), is a negative regulator of seed germination in Arabidopsis, and directly represses the GA biosynthetic gene GA3ox1 (gibberellin 3-β-dioxygenase 1). We set to investigate the role of DAG1 in seed dormancy and maturation with respect to epigenetic and hormonal control. RESULTS: We show that DAG1 expression is controlled at the epigenetic level through the H3K27me3 mark during the seed-to-seedling transition, and that DAG1 directly represses also the ABA catabolic gene CYP707A2; consistently, the ABA level is lower while the GA level is higher in dag1 mutant seeds. Furthermore, both DAG1 expression and protein stability are controlled by GAs. CONCLUSIONS: Our results point to DAG1 as a key player in the control of the developmental switch between seed dormancy and germination

A Non-Sequential Representation of Sequential Data for Churn Prediction

We investigate the length of event sequence giving best predictions when using a continuous HMM approach to churn prediction from sequential data. Motivated by observations that predictions based on only the few most recent events seem to be the most accurate, a non-sequential dataset is constructed from customer event histories by averaging features of the last few events. A simple K-nearest neighbor algorithm on this dataset is found to give significantly improved performance. It is quite intuitive to think that most people will react only to events in the fairly recent past. Events related to telecommunications occurring months or years ago are unlikely to have a large impact on a customer’s future behaviour, and these results bear this out. Methods that deal with sequential data also tend to be much more complex than those dealing with simple nontemporal data, giving an added benefit to expressing the recent information in a non-sequential manner

Factors in Patient Responsiveness to Directional Preference-Matched Treatment of Neck Pain With or Without Upper Extremity Radiation

Purpose: Patient-related predictive factors in responsiveness to directional preference therapy for neck pain with or without upper extremity radiation (NP/R) have not been reported. A directional preference is any neck movement that, when performed repeatedly to end range, results in centralization and/or alleviation of NP/R. It was hypothesized that patient compliance with a prescribed, directional preference-matched home exercise program would improve positive responsiveness to NP/R treatment. Methods: Patient-related factors thought to affect responsiveness to care were collected retrospectively from charts and de-identified for patients with NP/R who underwent chiropractic treatment at a multispecialty spine clinic from January 2014 through June 2015. Responsiveness was measured by calculating the percentage change in Neck Bournemouth Questionnaire (NBQ) scores over treatment time. Multiple linear regression was used to identify factors associated with positive responsiveness. Results: Mean percentage change in patient NBQ score from initial intake to discharge was 50% (standard deviation: 32%). Of 104 patients meeting study inclusion criteria, 86 (83%) reported experiencing improvement after the first treatment session. Bivariate analysis of patient characteristics by compliance with directional preference-matched exercise indicated that compliant patients (n = 95, 91%) demonstrated significantly greater responsiveness to care than did noncompliant patients, at 55% versus 25% change in NBQ score, respectively (P = 0.0041). Four factors were statistically significant predictors of patient responsiveness to directional preference therapy for NP/R: patient compliance with directional preference-matched exercise (P = 0.0023), patient age (P = 0.0029), condition chronicity (P < 0.0001), and whether the patient reported improvement of symptoms following initial treatment session (P = 0.0003). Conclusions: The results of this study suggest that patient compliance with directional preference exercise is associated with patient responsiveness to conservative treatment of NP/R, as are age, chronicity and report of immediate symptom improvement

OpenSeesPy-based web application for pushover curve computation of RC bridge piers subject to arbitrarily non-uniform corrosion patterns

Existing reinforced concrete (RC) bridge piers are often subject to complex spatially non-uniform steel corrosion patterns typically due to water percolation and exposition to environmental agents. This produces degradation of strength and ductility of the pier, which may significantly influence the seismic performances of bridges. The computation of pushover curves of corroded RC piers can be carried out by fiber-beam-column elements combined with suitable degradation laws for the uniaxial materials. For this purpose, a multi-level fiber-based modeling procedure is proposed based on a partition of the pier into zones characterized by different cross-sections with fiber discretizations reproducing the sectional deterioration pattern. A web application based on OpenSeesPy is defined to implement this procedure. This includes an interface developed by React JS and Boostrap V5 and an APIs layer based on the Flask framework. Through the interface, users can insert the parameters needed for the structural response simulation, which is, then, performed by employing the numerical procedure developed in Python. At the end of the computation, users can visualize and download the results or vary the input parameters to perform new simulations. The web application runs in a Docker container, making it easy to deploy on cloud platforms or on-premises solutions. Numerical simulations of real specimens affected by material deterioration are performed

Couch-based motion compensation: modelling, simulation and real-time experiments

Abstract The paper presents a couch-based active motion compensation strategy evaluated in simulation and validated experimentally using both a research and a clinical Elekta Precise Table™. The control strategy combines a Kalman filter to predict the surrogate motion used as a reference by a linear model predictive controller with the control action calculation based on estimated position and velocity feedback provided by an observer as well as predicted couch position and velocity using a linearized state space model. An inversion technique is used to compensate for the dead-zone nonlinearity. New generic couch models are presented and applied to model the Elekta Precise Table™ dynamics and nonlinearities including dead zone. Couch deflection was measured for different manufacturers and found to be up to 25 mm. A feed-forward approach is proposed to compensate for such couch deflection. Simultaneous motion compensation for longitudinal, lateral and vertical motions was evaluated using arbitrary trajectories generated from sensors or loaded from files. Tracking errors were between 0.5 and 2 mm RMS. A dosimetric evaluation of the motion compensation was done using a sinusoidal waveform. No notable differences were observed between films obtained for a fixed- or motion-compensated target. Further dosimetric improvement could be made by combining gating, based on tracking error together with beam on/off time, and PSS compensation.</jats:p

Influence of spatially heterogeneous deterioration patterns on strength and ductility of corroded reinforced concrete bridge piers

This work reports on some preliminary results obtained within the framework of a wide research project aimed to study the influence of the corrosion of in Reinforced Concrete (RC) piers on the overall seismic performances of bridges. In this context, after the statistical evaluation of a large database of real structures, a consistent set of bridges and piers has been selected as a sample representative of typical bridge profiles, pier heights and cross-sections as well as of material properties. In the first part of the project, pushover analyses of isolated piers with different corrosion patterns and intensity are carried out to evaluate the residual strength and ductility of corroded piers. In the second part, nonlinear static and dynamic seismic analyses of bridges with corroded piers are carried out to evaluate the influence of the deterioration on the overall seismic performance. Due to specific environmental conditions exposure or to water percolation from the superstructures, it is often the case that corrosion is non-uniformly distributed over piers producing non-homogeneous spatial deterioration patterns. The nonlinear modeling of this type of situations represents specific challenges related to the description of the deterioration patterns and the calibration of material properties. To this end, a multi-level modeling approach based on fiber-based finite elements has been developed and implemented in a specific OpenSeesPy software that allows users to accurately model RC piers subject to arbitrary corrosion patterns, up to their ultimate limit states. In this work, a specific case study of a typical RC rectangular hollow bridge extracted from the mentioned above database subject to different corrosion intensity and patterns is studied. In particular, the influence of the corrosion-induced deterioration on residual strength and ductility are studied. Results show that depending on the intensity and on the patterns significant variations of both strength and ductility can be observed with respect to the undamaged conditions

Elevated fetal steroidogenic activity in autism

Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor. Utilizing the Danish Historic Birth Cohort and Danish Psychiatric Central Register, we identified all amniotic fluid samples of males born between 1993 and 1999 who later received ICD-10 (International Classification of Diseases, 10th Revision) diagnoses of autism, Asperger syndrome or PDD-NOS (pervasive developmental disorder not otherwise specified) (n=128) compared with matched typically developing controls. Concentration levels of Δ4 sex steroids (progesterone, 17α-hydroxy-progesterone, androstenedione and testosterone) and cortisol were measured with liquid chromatography tandem mass spectrometry. All hormones were positively associated with each other and principal component analysis confirmed that one generalized latent steroidogenic factor was driving much of the variation in the data. The autism group showed elevations across all hormones on this latent generalized steroidogenic factor (Cohen's d=0.37, P=0.0009) and this elevation was uniform across ICD-10 diagnostic label. These results provide the first direct evidence of elevated fetal steroidogenic activity in autism. Such elevations may be important as epigenetic fetal programming mechanisms and may interact with other important pathophysiological factors in autism

Coverage and Energy Analysis of Mobile Sensor Nodes in Obstructed Noisy Indoor Environment: A Voronoi Approach

The rapid deployment of wireless sensor network (WSN) poses the challenge of finding optimal locations for the network nodes, especially so in (i) unknown and (ii) obstacle-rich environments. This paper addresses this challenge with BISON (Bio-Inspired Self-Organizing Network), a variant of the Voronoi algorithm. In line with the scenario challenges, BISON nodes are restricted to (i) locally sensed as well as (ii) noisy information on the basis of which they move, avoid obstacles and connect with neighboring nodes. Performance is measured as (i) the percentage of area covered, (ii) the total distance traveled by the nodes, (iii) the cumulative energy consumption and (iv) the uniformity of nodes distribution. Obstacle constellations and noise levels are studied systematically and a collision-free recovery strategy for failing nodes is proposed. Results obtained from extensive simulations show the algorithm outperforming previously reported approaches in both, convergence speed, as well as deployment cost.Comment: 17 pages, 24 figures, 1 tabl