La diversidad de mosasaurios ibéricos

La Península Ibérica presenta una interesante riqueza potencial en cuanto a fósiles de mosasaurios, aunque estos se reduzcan a restos fragmentarios axiales o coronas dentarias. De todas maneras es importante resaltar el valor de dichos restos a la hora de realizar estudios estratigráficos, tafonómicos, taxonómicos y de diversidad. Gracias a estos fósiles encontrados se puede sugerir que en la Península Ibérica sí existió una diversidad de mosasaurios de cierta relevancia al final del Cretácico, con al menos 7 taxones diferentes. Entre estos restos ibéricos aparece el registro más al sur del hemisferio norte de un tilosaurino, y un diente del pterigoides de un Prognathodon encontrado en la Comunidad Valenciana que amplía el registro fósil de mosasaurios en la Península Ibérica. También es importante resaltar que en la Península Ibérica se encuentra el yacimiento del Maastrichtiense más rico del sur de Europa en cuanto a fósiles y diversidad de mosasaurios: Albaina, en la cantera de Laño (norte de España).The Iberian Peninsula presents an impressive potential richness in terms of mosasaur remains, although all of them are fragmentary axial remains or teeth crowns. However, it is important to highlight the value of these fossils when studying stratigraphy, taphonomy, taxonomy or diversity. Thanks to these mosasaur remains we can hypothesise the presence of a relevant mosasaur diversity at the end of the Cretaceous in the Iberian Peninsula with, at least, 7 different taxa. Here we can find the most southern tilosaurine record found in the northern hemisphere, and a pterygoid tooth of a Prognathodon found in the Comunidad Valenciana which widen the previously known Iberian mosasaur fossil record. It is also important to highlight the presence in the Iberian Peninsula of the richest fossil site from the Maastrichtian of south Europe in terms of fossil remains and diversity of mosasaurs: Albaina, in the Laño quarry (north Spain)

Los dinosaurios titanosaurios (Sauropoda) del Cretácico Superior del suroeste de Europa

Desde que en 1869 el geólogo francés Philippe Matheron describiese los primeros restos atribuibles a titanosaurios del Cretácico Superior de Francia hasta nuestros días el conocimiento de estos saurópodos se ha incrementado de manera exponencial. A día de hoy son tres las especies de titanosaurios descritas en el suroeste europeo: Lirainosaurus astibiae de la Península Ibérica, y Ampelosaurus atacis y Atsinganosaurus velauciensis de Francia. Además, los hallazgos realizados en varios yacimientos de España y del sur de Francia apuntan a una diversidad aún mayor, a la espera de la publicación de material perteneciente como mínimo a un taxon inédito.Since 1869, when the geologist Philippe Matheron described the first titanosaurian remains from the Late Cretaceous of France, until our days the knowledge about these sauropods has been greatly improved. Currently, three titanosaurian species are well-known in southwestern Europe: Lirainosaurus astibiae from the Iberian Peninsula, and Ampelosaurus atacis and Atsinganosaurus velauciensis from France. In addition, the discoveries made in several fossil-sites from Spain and France point to an even higher diversity, awaiting for the publication of the material belonging to at least one unpublished taxon.Este trabajo forma parte de la tesis doctoral de la autora, llevada a cabo gracias a la beca predoctoral BES-2008-006370 asociada a los proyectos CGL2007-6461/BTE y CGL2010-18851 del Ministerio de Ciencia e Innovación (ahora Ministerio de Economía y Competitividad) de España

Who are Leibniz PostDocs and what is it like to work at a Leibniz institute? Report of the first Leibniz PostDoc Survey 2020

Postdoctoral researchers play a critical role in scientific research. This is the case not only for the Leibniz Association but for research worldwide. However, postdoctoral researchers are often overlooked or misrepresented as a homogeneous group of researchers. The principal aim of the Leibniz PostDoc Survey was to understand who Leibniz PostDocs are and to provide some insight into their experiences, interests, and needs. This report summarizes the results of the first Leibniz PostDoc Survey, which was open for submission from July to October 2020. The report includes a summary of the key findings and recommendations as well as a comprehensive description of all results from each survey question

Hacia una reforma municipal genuina

El gobierno local es cada vez más importante en un entorno cultural de globalización. Ahí está la responsabilidad de gestar las bases de un desarrollo sustentable, de promover la igualdad de oportunidades y de educar al ciudadano en las responsabilidades políticas y cívicas congruentes con los nuevos retos. Este trabajo reúne la discusión y reflexiones de investigadores, funcionarios municipales y estatales, analistas y otros interesados en los gobiernos locales que intentan identificar los cambios administrativos, políticos, sociales y jurídicos para una reforma de los gobiernos locales capaz de resolver los problemas actuales de los municipios y conducir al desarrollo sustentable.ITESO, A.C

BRAF V600E mutational load as a prognosis biomarker in malignant melanoma

Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma patients of different stages, and investigating its potential as a prognosis factor. Mutational load of BRAF V600E was analyzed by digital PCR in 78 biopsies of melanoma patients of different stages and 10 nevi. The BRAF V600E load was compared among biopsies of different stages. Results showed a great variability in the load of V600E (0%-81%). Interestingly, we observed a significant difference in the load of V600E between the early and late melanoma stages, in the sense of an inverse correlation between BRAF V600E mutational load and melanoma progression. In addition, a machine learning approach showed that the mutational load of BRAF V600E could be a good predictor of metastasis in stage II patients. Our results suggest that BRAF V600E is a promising biomarker of prognosis in stage II patients.This research was supported by the Basque Government (grants ELKARTEK-KK2016-036 and KK2017-041 to MDB, grant IT1138-16 to SA and predoctoral fellowship PRE_2014_1_419 to AS), and by the University of the Basque Country (UPV/EHU) (grant GIU17/066). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Usos del e-learning en las Universidades Andaluzas: Estado de la situación y análisis de buenas prácticas. (Versión completa)

Secretaría General de Universidades, Investigación y Tecnología P07-SE-J.0267

La interdisciplinariedad y el itinerario curricular elegido por el estudiante, ejes fundamentales para desarrollar competencias curriculares en Química

Póster presentado en: V Jornadas de Innovación Docente de la UBU, Burgos, 21-22 de octubre de 2010, organizadas por el Instituto de Formación e Innovación Educativa-IFIE de la Universidad de Burgo

Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Purpose To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). Methods We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m(2)) or >= 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Results Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (beta: 1.87 ml/min/1.73m(2); 95% CI: 1.00-2.73) and had lower odds of >= 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (beta: - 0.87 ml/min/1.73m(2); 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Conclusions Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. Trial Registration Number: ISRCTN89898870 (Data of registration: 2014).Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects leaded by JS-S and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant to JS-S; the European Research Council (Advanced Research Grant 2014-2019; agreement #340918) granted to MAMG.; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 and the PROMETEO 21/2021 grant from the Generalitat Valenciana; the SEMERGEN grant; the Boosting young talent call grant program for the development of IISPV research projects 2019-2021 (Ref.: 2019/IISPV/03 grant to AD-L); the Societat Catalana d'Endocrinologia i Nutricio (SCEN) Clinical-Research Grant 2019 (IPs: JS-S and AD-L). Collaborative Nutrition and/or Obesity Project for Young Researchers 2019 supported by CIBEROBN entitled: Lifestyle Interventions and Chronic Kidney Disease: Inflammation, Oxidative Stress and Metabolomic Profile (LIKIDI study) grant to AD-L. Jordi Salas-Salvado, gratefully acknowledges the financial support by ICREA under the ICREA Academia programme. M.R.-G., is supported by the Ministry of Education of Spain (FPU17/06488). None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication