Efectividad De Los Geles De Papaína Al 2% Y Al 4% En La Cicatrización De Úlceras Venosas

OBJECTIVE To analyze the effectiveness of 2% and 4% papain gels in tissue repair of venous ulcers. METHOD Quasi-experimental study with consecutive sample of 16 patients with 30 venous ulcers treated at the outpatient clinic of a teaching hospital, from April to November in 2011, using a form for clinical assessment of the patient and its lesion. Variables were analyzed by Wilcoxon and McNemar test (p < 0.05). RESULTS Most participants were female; aged between 51 and 59 years; obese; with hypertension. Regarding ulcers, there was an average decrease of 7.9 cm2 (50% of its original size) in 90 days; 20% of the ulcers completely healed within 56.67 days. There was an increase in epithelialization, significant reduction in the slough and edema, improved depth, in the type and amount of exudate (p < 0.0001). CONCLUSION 2% and 4% papain gels were effective in healing venous ulcers.OBJETIVO Analisar a efetividade dos géis de papaína a 2% e 4% no reparo tecidual das úlceras venosas. MÉTODO Estudo quase-experimental, com amostra consecutiva de 16 pacientes com 30 úlceras venosas, atendidos no ambulatório de um hospital universitário, de abril a novembro de 2011, com formulário para avaliação clínica do paciente e da lesão. Variáveis analisadas pelos testes de Wilcoxon e McNemar (p < 0,05). RESULTADOS Predomínio do sexo feminino; idade entre 51 e 59 anos; obesas; com Hipertensão Arterial Sistêmica. Quanto às úlceras, houve redução média de 7,9 cm2 (50% do tamanho) em 90 dias; 20% cicatrizaram completamente em 56,67 dias. Houve aumento da epitelização, redução significativa do esfacelo e do edema, melhora na profundidade, no tipo e na quantidade de exsudato (p < 0,0001). CONCLUSÃO Os géis de papaína a 2% e 4% foram efetivos na cicatrização de úlceras venosas.OBJETIVO Analizar la efectividad de los geles de papaína al 2% y al 4% en la reparación del tejido de las úlceras venosas. MÉTODO Estudio cuasi-experimental, con muestra consecutiva de 16 pacientes con 30 úlceras venosas, atendidos en el ambulatorio de un hospital universitario, de abril a noviembre de 2011, con formulario para evaluación clínica del paciente y la lesión. Variables analizadas por las pruebas de Wilcoxon y McNemar (p < 0,05). RESULTADOS Predominio del sexo femenino; edad entre 51 y 59 años; obesas; con Hipertensión Arterial Sistémica. En cuanto a las úlceras, hubo reducción media de 7,9 cm2 (el 50% del tamaño) en 90 días; el 20% cicatrizaron completamente en 56,67 días. Hubo incremento de la epitelización, reducción significativa de la esfacelación y el edema, mejora en la profundidad, la clase y la cantidad de exudado (p < 0,0001). CONCLUSIÓN Los geles de papaína al 2% y al 4% fueron efectivos en la cicatrización de úlceras venosas

New locality records, geographical distribution, and morphological variation in Cercosaura parkeri (Ruibal, 1952) (Squamata: Gymnophthalmidae) from western Brazil

The presence of the gymnophthalmid lizard Cercosaura parkeri (Ruibal, 1952) in western Brazil is confirmed, based on vouchered records for localities in the states of Mato Grosso and Mato Grosso do Sul. Morphological variation in a series of 20 males and 17 females is also presented

Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2

Submitted by Sandra Infurna ([email protected]) on 2020-03-10T12:29:17Z No. of bitstreams: 1 OrtrudBarth_DebraBarreto_etal_IOC_2007.pdf: 6204757 bytes, checksum: 46827ce79812b88ea66bc558554d3d3a (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2020-03-10T12:35:33Z (GMT) No. of bitstreams: 1 OrtrudBarth_DebraBarreto_etal_IOC_2007.pdf: 6204757 bytes, checksum: 46827ce79812b88ea66bc558554d3d3a (MD5)Made available in DSpace on 2020-03-10T12:35:33Z (GMT). No. of bitstreams: 1 OrtrudBarth_DebraBarreto_etal_IOC_2007.pdf: 6204757 bytes, checksum: 46827ce79812b88ea66bc558554d3d3a (MD5) Previous issue date: 2007Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Histological and ultrastructural alterations in lung tissue of BALB/c mice infected with dengue virus serotype 2 (non-neuroadapted), by intraperitoneal and intravenous routes were analyzed. Lung tissues were processed following the standard techniques for photonic and electron transmission microscopies. Histopathological and ultrastructural studies showed interstitial pneumonia, characterized by the presence of mononuclear cells. In the mouse model, the dengue virus serotype 2 seems to led to a transient inflammatory process without extensive damage to the interalveolar septa, but caused focal alterations of the blood-exchange barrier. Endothelial cells of blood capillaries exhibited phyllopodia suggesting activation by presence of dengue virus. Morphometrical analysis of mast cells showed an expressive increase of the number of these cells in peribronchiolar spaces and adjacent areas to the interalveolar septa. Alveolar macrophages showed particles dengue virus-like inside rough endoplasmic reticulum and Golgi complex, suggesting viral replication. The tissue alterations observed in our experimental model were similar to the observed in human cases of dengue fever and dengue hemorrhagic fever. Our results show that BALB/c mice are permissive host for dengue virus serotype 2 replication and therefore provides an useful model to study of morphological aspects of dengue virus infection

Desensitizing Agent Previously Applied During In-Office Bleaching: A Double-Blind Randomized Clinical Trial

Objective:&nbsp;To compare the clinical effect of two desensitizing agents used before the application of a bleaching gel based on 35% hydrogen peroxide (HP).&nbsp;Material and Methods:&nbsp;30 patients were selected, and two desensitizing agents with different mechanisms of action were applied: Fluorine Neutral 2% (FN), which acts by blocking dentinal canaliculi while Potassium Nitrate 5% with 2% Sodium Fluoride (PN/SF) that acts in nerve transmission and blockade. Desensitizers were used before the application of 35% HP. For whitening, three clinical sessions were performed, with an interval of seven days, with three applications of the bleaching gel for 15 minutes, totaling 45 minutes/session. Tooth sensitivity (TS) was assessed with the numerical analog scale, and a spectrophotometer was used to obtain the color variation (ΔE).ΔE were submitted to ANOVA and Tukey test (p&lt;0.05), and TS data were submitted to a two-way ANOVA analysis.&nbsp;Results:&nbsp;For sensitivity experience, the Tukey test indicated differences between PN/SF and the placebo I, but there was no statistically significant difference between FN and the placebo II. The TS was lower when the desensitizing gel was used during the bleaching procedure compared to after treatment, regardless of the desensitizing agents.&nbsp;Conclusion:&nbsp;PN/SF before in-office tooth bleaching can reduce TS intensity, and the use of desensitizing gel before bleaching did not affect the bleaching efficacy