Evidence Evaluation: Measure Z Corresponds to Human Utility Judgments Better than Measure L and Optimal-Experimental-Design Models

Evidence evaluation is a crucial process in many human activities, spanning from medical diagnosis to impression formation. The present experiments investigated which, if any, normative model best conforms to people’s intuition about the value of the obtained evidence. Psychologists, epistemologists, and philosophers of science have proposed several models to account for people’s intuition about the utility of the obtained evidence with respect either to a focal hypothesis or to a constellation of hypotheses. We pitted against each other the so called optimal-experimental-design models (i.e., Bayesian diagnosticity, log10 diagnosticity, information gain, Kullback-Leibler distance, probability gain, and impact) and measures L and Z to compare their ability to describe humans’ intuition about the value of the obtained evidence. Participants received words-and-numbers scenarios concerning two hypotheses and binary features. They were asked to evaluate the utility of “yes” and “no” answers to questions about some features possessed in different proportions (i.e., the likelihoods) by two types of extraterrestrial creatures (corresponding to two mutually exclusive and exhaustive hypotheses). Participants evaluated either how an answer was helpful or how an answer decreased/increased their beliefs with respect either to a single hypothesis or to both hypotheses. We fitted mixed-effects models and we used the Akaike information criterion (AIC) and the Bayesian information criterion (BIC) values to compare the competing models of the value of the obtained evidence. Overall, the experiments showed that measure Z was the best-fitting model of participants’ judgments of the value of obtained answers. We discussed the implications for the human hypothesis-evaluation process

OXTR Gene DNA Methylation Levels Are Associated with Discounting Behavior with Untrustworthy Proposers

Individual differences in temporal and probabilistic discounting are associated with a wide range of life outcomes in literature. Traditional approaches have focused on impulsiveness and cognitive control skills, on goal-oriented personality traits as well as on the psychological perception of time. More recently, literature started to consider the role of social and contextual factors in discounting behavior. Between others, higher generalized trust in human beings and specific trust in people who will deliver the future/probabilistic rewards have been related to a stronger willingness to wait and to assume risk. Moreover, the tendency to trust others has been associated with the oxytocin receptor gene regulation that can be modified by life experiences. In this perspective, we hypothesized that differences in the tendency to wait and to take risks for a more desirable reward according to the proposer’s trustworthiness could be related to a different level of DNA methylation at the oxytocin receptor gene. Findings confirmed that participants are less willing to wait and to risk when the proposer is considered highly untrustworthy and revealed how higher oxytocin receptor gene DNA methylation is associated with a stronger effect due to the presence of an untrustworthy proposer. Limits and future directions are outlined

Exploring the Potential of Portable Spectroscopic Techniques for the Biochemical Characterization of Roots in Shallow Landslides

In the present work, Raman, Fourier Transform Infrared (FTIR) and elemental Laser-Induced Breakdown Spectroscopy (LIBS) spectroscopic techniques were used for the assessment of the influence of plant root composition towards shallow landslide occurrence. For this purpose, analyses were directly carried out on root samples collected from chestnut forests of the Garfagnana basin (northern Apennines, Italy) in different areas devoid and affected by shallow landslides due to frequent heavy rain events. Results have highlighted a correlation between the biochemical constituents of wooden roots and the sampling areas. In particular, different content of lignin/cellulose, as well as minerals nutrients, have been detected in roots collected where shallow landslides occurred, with respect to more stable areas. The results achieved are in line with the scientific literature which has demonstrated the link between the chemical composition of roots with their mechanical properties and, in particular, tensile strength and cohesion. Finally, portable spectroscopic instrumentations were employed without the need for either any sample preparation for Raman and LIBS spectroscopy or minimal preparation for FTIR spectroscopy. This novel and fast approach has allowed achieving information on the content of the major constituents of the root cell, such as cellulose and lignin, as well as their mineral nutrients. This approach could be reasonably included among the vegetation protection actions towards instability, as well as for the evaluation of shallow landslide susceptibility, combining geological, vegetational and biochemical parameters with sustainability

Involvement of DAT1 gene on internet addiction. Cross-correlations of methylation levels in 5'-utr and 3’-UTR genotypes, interact with impulsivity and attachment-driven quality of relationships

Internet influences our communication, social and work interactions, entertainment, and many other aspects of life. Even if the original purpose was to simplify our lives, an excessive and/or maladaptive use of it may have negative consequences. The dopamine transporter (DAT1) gene was studied in relation to addictions, including excessive use of the Internet. The crucial role of DAT1 was previously underlined in modulating emotional aspects, such as affiliative behaviors. The present research follows a new approach based on cross-correlation between (de)methylation levels in couples of CpG loci, as previously shown. We investigated the possible relationships between Internet addiction, impulsivity, quality of attachment, DAT1 genotypes (from the 3′-untranslated region (UTR) variable number of tandem repeats (VNTR) poly-morphism), and the dynamics of methylation within the 5’-UTR of the DAT1 gene. From a normative sample of 79 youths, we extrapolated three subgroups a posteriori, i.e., one “vulnerable” with high Internet Addiction Test (IAT) scores (and high Barrat Impulsivity Scale (BIS) scores; n = 9) and two “controls” with low BIS scores and 10/10 vs. 9/x genotype (n = 12 each). Controls also had a “secure” attachment pattern, while genotypes and attachment styles were undistinguished in the vulnerable subgroup (none showed overt Internet addiction). We found a strongly positive correlation in all groups between CpG2 and CpG3. An unsuspected relationship between the 3’-UTR genotype and a 5’-UTR intra-motif link was revealed by CpG5–CpG6 comparison. The negative correlation between the CpG3–CpG5 positions was quite significant in the control groups (both with genotype 10/10 and with genotype 9/x), whereas a tendency toward positive correlation emerged within the high IAT group. In conclusion, future attention shall be focused on the intra-and inter-motif interactions of methylation on the CpG island at the 5′-UTR of DAT1

DSA-10: A prototype array for localizing fast radio bursts

The Deep Synoptic Array 10 dish prototype is an instrument designed to detect and localise fast radio bursts with arcsecond accuracy in real time. Deployed at Owens Valley Radio Observatory, it consists of ten 4.5m diameter dishes, equipped with a 250MHz bandwidth dual polarisation receiver, centered at 1.4GHz. The 20 input signals are digitised and field programmable gate arrays are used to transform the data to the frequency domain and transmit it over ethernet. A series of computer servers buffer both raw data samples and perform a real time search for fast radio bursts on the incoherent sum of all inputs. If a pulse is detected, the raw data surrounding the pulse is written to disk for coherent processing and imaging. The prototype system was operational from June 2017 - February 2018 conducting a drift scan search. Giant pulses from the Crab pulsar were used to test the detection and imaging pipelines. The 10-dish prototype system was brought online again in March 2019, and will gradually be replaced with the new DSA-110, a 110-dish system, over the next two years to improve sensitivity and localisation accuracy.Comment: 10 pages, 13 figures, accepted by MNRA

Socio-demographic and clinical characterization of patients with obsessive-compulsive tic-related disorder (OCTD) : An Italian multicenter study

© Copyright by Pacini Editore SrlIn the DSM-5 a new "tic-related" specifier for obsessive compulsive disorder (OCD) has been introduced, highlighting the importance of an accurate characterization of patients suffering from obsessive-compulsive tic-related disorder ("OCTD"). In order to characterize OCTD from a socio-demographic and clinical perspective, the present multicenter study was carried out. The sample consists of 266 patients, divided in two groups with lifetime diagnoses of OCD and OCTD, respectively. OCTD vs OCD patients showed a significant male prevalence (68.5% vs 48.5%; p < .001), a higher rate of psychiatric comorbidities (69.4 vs 50%; p < .001) - mainly with neurodevelopmental disorders (24 vs 0%; p < .001), a lower education level and professional status (middle school diploma: 25 vs 7.6%; full-Time job 44.4 vs 58%; p < .001). Moreover, OCTD vs OCD patients showed significantly earlier age of OCD and psychiatric comorbidity onsets (16.1 ± 10.8 vs 22.1 ± 9.5 years; p < .001, and 18.3 ± 12.8 vs 25.6 ± 9.4: p < .001, respectively). Patients with OCTD patients were treated mainly with antipsychotic and with a low rate of benzodiazepine (74.2 vs 38.2% and 20.2 vs 31.3%, respectively; p < .001). Finally, OCTD vs OCD patients showed higher rates of partial treatment response (58.1 vs 38%; p < .001), lower rates of current remission (35.5 vs 54.8%; p < .001) and higher rates of suicidal ideation (63.2 vs 41.7%; p < .001) and attempts (28.9 vs 8.3%; p < .001). Patients with OCTD report several unfavorable socio-demographic and clinical characteristics compared to OCD patients without a history of tic. Additional studies on larger sample are needed to further characterize OCTD patients from clinical and therapeutic perspectives.Peer reviewedFinal Published versio

A fast radio burst localised to a massive galaxy

Intense, millisecond-duration bursts of radio waves have been detected from beyond the Milky Way [1]. Their extragalactic origins are evidenced by their large dispersion measures, which are greater than expected for propagation through the Milky Way interstellar medium alone, and imply contributions from the intergalactic medium and potentially host galaxies [2]. Although several theories exist for the sources of these fast radio bursts, their intensities, durations and temporal structures suggest coherent emission from highly magnetised plasma [3,4]. Two sources have been observed to repeat [5,6], and one repeater (FRB 121102) has been localised to the largest star-forming region of a dwarf galaxy at a cosmological redshift of 0.19 [7, 8]. However, the host galaxies and distances of the so far non-repeating fast radio bursts are yet to be identified. Unlike repeating sources, these events must be observed with an interferometer with sufficient spatial resolution for arcsecond localisation at the time of discovery. Here we report the localisation of a fast radio burst (FRB 190523) to a few-arcsecond region containing a single massive galaxy at a redshift of 0.66. This galaxy is in stark contrast to the host of FRB 121102, being a thousand times more massive, with a greater than hundred times lower specific star-formation rate. The properties of this galaxy highlight the possibility of a channel for FRB production associated with older stellar populations