Comparison of the sidereal angular velocity of subphotospheric layers and small bright coronal structures during the declining phase of solar cycle 23

Context. We compare solar differential rotation of subphotospheric layers derived from local helioseismology analysis of GONG++ dopplergrams and the one derived from tracing small bright coronal structures (SBCS) using EIT/SOHO images for the period August 2001 - December 2006, which correspond to the declining phase of solar cycle 23. Aims. The study aims to find a relationship between the rotation of the SBCS and the subphotospheric angular velocity. The northsouth asymmetries of both rotation velocity measurements are also investigated. Methods. Subphotospheric differential rotation was derived using ring-diagram analysis of GONG++ full-disk dopplergrams of 1 min cadence. The coronal rotation was derived by using an automatic method to identify and track the small bright coronal structures in EIT full-disk images of 6 hours cadence. Results. We find that the SBCS rotate faster than the considered upper subphotospheric layer (3Mm) by about 0.5 deg/day at the equator. This result joins the results of several other magnetic features (sunspots, plages, faculae, etc.) with a higher rotation than the solar plasma. The rotation rate latitudinal gradients of the SBCS and the subphotospheric layers are very similar. The SBCS motion shows an acceleration of about 0.005 deg/day/month during the declining phase of solar cycle 23, whereas the angular velocity of subsurface layers does not display any evident variation with time, except for the well known torsional oscillation pattern. Finally, both subphotospheric and coronal rotations of the southern hemisphere are predominantly larger than those of the northern hemisphere. At latitudes where the north-south asymmetry of the angular velocity increases (decreases) with activity for the SBCS, it decreases (increases) for subphotospheric layers.Comment: 6pages, 8 figures, Accepted for publication in Astronomy and Astrophysic

Strategy for Dynamic Wisp Removal in James Webb Space Telescope NIRCam Images

The James Webb Space Telescope (JWST) near-infrared camera (NIRCam) has been found to exhibit serious wisp-like structures in four of its eight short-wavelength detectors. The exact structure and strength of these wisps is highly variable with the position and orientation of JWST, so the use of static templates is non-optimal. Here we investigate a dynamic strategy to mitigate these wisps using long-wavelength reference images. Based on a suite of experiments where we embed a worst-case scenario median-stacked wisp into wisp-free images, we define suitable parameters for our wisp removal strategy. Using this setup we re-process wisp-affected public Prime Extragalactic Areas for Reionization and Lensing Science (PEARLS) data in the North Ecliptic Pole Time Domain Field (NEP-TDF) field, resulting in significant visual improvement in our detector frames and reduced noise in the final stacked images.Comment: 16 pages, 10 figures, submitted to PASP, comments welcom

Buoyancy-induced time delays in Babcock-Leighton flux-transport dynamo models

The Sun is a magnetic star whose cyclic activity is thought to be linked to internal dynamo mechanisms. A combination of numerical modelling with various levels of complexity is an efficient and accurate tool to investigate such intricate dynamical processes. We investigate the role of the magnetic buoyancy process in 2D Babcock-Leighton dynamo models, by modelling more accurately the surface source term for poloidal field. Methods. To do so, we reintroduce in mean-field models the results of full 3D MHD calculations of the non-linear evolution of a rising flux tube in a convective shell. More specifically, the Babcock-Leighton source term is modified to take into account the delay introduced by the rise time of the toroidal structures from the base of the convection zone to the solar surface. We find that the time delays introduced in the equations produce large temporal modulation of the cycle amplitude even when strong and thus rapidly rising flux tubes are considered. Aperiodic modulations of the solar cycle appear after a sequence of period doubling bifurcations typical of non-linear systems. The strong effects introduced even by small delays is found to be due to the dependence of the delays on the magnetic field strength at the base of the convection zone, the modulation being much less when time delays remain constant. We do not find any significant influence on the cycle period except when the delays are made artificially strong. A possible new origin of the solar cycle variability is here revealed. This modulated activity and the resulting butterfly diagram are then more compatible with observations than what the standard Babcock-Leighton model produces.Comment: 13 pages, 10 figures, accepted for publication in A&

Adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to Alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for Clinical Use

Abstract Platelet-derived growth factor (PDGF) gene therapy offers promise for tissue engineering of tooth-supporting alveolar bone defects. To date, limited information exists regarding the safety profile and systemic biodistribution of PDGF gene therapy vectors when delivered locally to periodontal osseous defects. The aim of this preclinical study was to determine the safety profile of adenovirus encoding the PDGF-B gene (AdPDGF-B) delivered in a collagen matrix to periodontal lesions. Standardized alveolar bone defects were created in rats, followed by delivery of matrix alone or containing AdPDGF-B at 5.5-108 or 5.5-109 plaque-forming units/ml. The regenerative response was confirmed histologically. Gross clinical observations, hematology, and blood chemistries were monitored to evaluate systemic involvement. Bioluminescence and quantitative polymerase chain reaction were used to assess vector biodistribution. No significant histopathological changes were noted during the investigation. Minor alterations in specific hematological and blood chemistries were seen; however, most parameters were within the normal range for all groups. Bioluminescence analysis revealed vector distribution at the axillary lymph nodes during the first 2 weeks with subsequent return to baseline levels. AdPDGF-B was well contained within the localized osseous defect area without viremia or distant organ involvement. These results indicate that AdPDGF-B delivered in a collagen matrix exhibits acceptable safety profiles for possible use in human clinical studies.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78106/1/hum.2008.114.pd

Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas

Diet is associated with cancer prognosis, including head and neck cancer (HNC), and has been hypothesized to influence epigenetic state by determining the availability of functional groups involved in the modification of DNA and histone proteins. The goal of this study was to describe the association between pretreatment diet and HNC tumor DNA methylation. Information on usual pretreatment food and nutrient intake was estimated via food frequency questionnaire (FFQ) on 49 HNC cases. Tumor DNA methylation patterns were assessed using the Illumina Goldengate Methylation Cancer Panel. First, a methylation score, the sum of individual hypermethylated tumor suppressor associated CpG sites, was calculated and associated with dietary intake of micronutrients involved in one-carbon metabolism and antioxidant activity, and food groups abundant in these nutrients. Second, gene specific analyses using linear modeling with empirical Bayesian variance estimation were conducted to identify if methylation at individual CpG sites was associated with diet. All models were controlled for age, sex, smoking, alcohol and HPV status. Individuals reporting in the highest quartile of folate, vitamin B12 and vitamin A intake, compared with those in the lowest quartile, showed significantly less tumor suppressor gene methylation, as did patients reporting the highest cruciferous vegetable intake. Gene specific analyses identified differential associations between DNA methylation and vitamin B12 and vitamin A intake when stratifying by HPV status. These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression

Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas

Diet is associated with cancer prognosis, including head and neck cancer (HNC), and has been hypothesized to influence epigenetic state by determining the availability of functional groups involved in the modification of DNA and histone proteins. The goal of this study was to describe the association between pretreatment diet and HNC tumor DNA methylation. Information on usual pretreatment food and nutrient intake was estimated via food frequency questionnaire (FFQ) on 49 HNC cases. Tumor DNA methylation patterns were assessed using the Illumina Goldengate Methylation Cancer Panel. First, a methylation score, the sum of individual hypermethylated tumor suppressor associated CpG sites, was calculated and associated with dietary intake of micronutrients involved in one-carbon metabolism and antioxidant activity, and food groups abundant in these nutrients. Second, gene specific analyses using linear modeling with empirical Bayesian variance estimation were conducted to identify if methylation at individual CpG sites was associated with diet. All models were controlled for age, sex, smoking, alcohol and HPV status. Individuals reporting in the highest quartile of folate, vitamin B12 and vitamin A intake, compared with those in the lowest quartile, showed significantly less tumor suppressor gene methylation, as did patients reporting the highest cruciferous vegetable intake. Gene specific analyses identified differential associations between DNA methylation and vitamin B12 and vitamin A intake when stratifying by HPV status. These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression