Solid and cystic pseudopapillary tumor of the pancreas: A case report

Introduction Solid and cystic pseudopapillary tumor of the pancreas is a rare tumor of the pancreas, for the first time described by Frantz et al. in 1959. The majority of patients are young females and most of them are asymptomatic. Case Outline We report a case of 25-year old woman who was admitted to our institution with abdominal pain and a palpable mass in the left hypochondrial area. US and CT scan revealed a solid and cystic pseudopapillary tumor in the head of the pancreas. The patient was treated by Whipple procedure, modification Longmire-Traverso. There was no metastatic disease either in the liver or peritoneum. Histologically the tumor was diagnosed as a solid and cystic pseudopapillary tumor of the pancreas. Conclusion The unclear pre-operative diagnoses, together with incidence of potential malignancy as well as good outcome with resection, suggest that all suspected cystic tumors of the pancreas should be resected. The exact diagnosis is based on histological findings

INTER-ORGANIZATIONAL COLLABORATION FOR INNOVATION IN MANUFACTURING FIRMS

From day to day, taking part in the collaboration process in different business aspects, especially in the innovation process continues to gain in importance. Innovation enables companies to strive for a more powerful market position, while inter-organizational cooperation is perceived as an efficient means of enhancement of firm innovativeness. The purpose of this paper is to present the state of inter-organizational collaboration for innovation among manufacturing companies in Vojvodina, analyzing cooperation among manufacturing firms with different external parties, in different innovation areas. Furthermore, the aim is to examine the effects of inter-organizational collaboration on the innovativeness of manufacturing firms in Vojvodina. The data used in this paper was gathered within the international project European Manufacturing Survey. The results are presented using descriptive statistics and they demonstrate that the existence and frequency of inter-organizational collaboration, although quite present, depends on external parties as potential cooperation partners and on different innovation areas in which collaboration could occur. Also, the research shows there is a notable relation between interorganizational collaboration and firm innovativeness

SUSTAINABLE DEVELOPMENT OF TRUST AND POLICE PRESENCE IN SCHOOLS: IMPLICATIONS FOR SCHOOL SAFETY POLICY

The study aims to determine the trust and presence of police officers in schools in Serbia, as well as the perception of the principals and secretaries, teachers and staff, parents, and students on how successful the specific police units dedicated to schools were in fulfilling their tasks. The ex-post analysis was conducted through PEST/SWAT analysis, mapping the key actors and using batteries of online questionnaires, besides interviews with the MOI representatives, surveyed with personal interviewing, computer-aided surveying, desk analysis, and content analysis. The survey was conducted from September 2021 to June 2022. The research methods were implemented in 1140 schools in Serbia, and 8,617 people were included in surveys: police officers (308); principals and secretaries (1085); the team for protection against discrimination (982); teachers and staff (2988); parents (938) and students (2316). The relationships between the covariates and perception were investigated using the t-test, one-way ANOVA, multivariate linear regression, and binary regression. The results showed that a project of school police officers was not fully recognized as one of the strategically essential instruments for safe schools; trust is low, but presence is high. Besides that, the results suggest that the entire public believes that police are needed in schools and that it positively affects school safety. Regarding school safety policy, it is necessary to undertake three measures for the sustainable development of trust and the presence of police in school: regulatory, informative-educational, and institutional-organizational.

The development of METAL-WRF Regional Model for the description of dust mineralogy in the atmosphere

The mineralogical composition of airborne dust particles is an important but often neglected parameter for several physiochemical processes, such as atmospheric radiative transfer and ocean biochemistry. We present the development of the METAL-WRF module for the simulation of the composition of desert dust minerals in atmospheric aerosols. The new development is based on the GOCART-AFWA dust module of WRF-Chem. A new wet deposition scheme has been implemented in the dust module alongside the existing dry deposition scheme. The new model includes separate prognostic fields for nine (9) minerals: illite, kaolinite, smectite, calcite, quartz, feldspar, hematite, gypsum, and phosphorus, derived from the GMINER30 database and also iron derived from the FERRUM30 database. Two regional model sensitivity studies are presented for dust events that occurred in August and December 2017, which include a comparison of the model versus elemental dust composition measurements performed in the North Atlantic (at Izaña Observatory, Tenerife Island) and in the eastern Mediterranean (at Agia Marina Xyliatos station, Cyprus Island). The results indicate the important role of dust minerals, as dominant aerosols, for the greater region of North Africa, South Europe, the North Atlantic, and the Middle East, including the dry and wet depositions away from desert sources. Overall, METAL-WRF was found to be capable of reproducing the relative abundances of the different dust minerals in the atmosphere. In particular, the concentration of iron (Fe), which is an important element for ocean biochemistry and solar absorption, was modeled in good agreement with the corresponding measurements at Izaña Observatory (22% overestimation) and at Agia Marina Xyliatos site (4% overestimation). Further model developments, including the implementation of newer surface mineralogical datasets, e.g., from the NASA-EMIT satellite mission, can be implemented in the model to improve its accuracy.This study was supported by the Hellenic Foundation for Research and Innovation project Mineralogy of Dust Emissions and Impacts on Environment and Health (MegDeth - HFRI no. 703). Part of this study was conducted within the framing of the AERO-EXTREME (PID2021-125669NB-I00) project funded by the State Research Agency/Agencia Estatal de Investigación of Spain and the European Regional Development Funds

Newly identified climatically and environmentally significant high-latitude dust sources

Peer reviewe

Newly identified climatically and environmentally significant high-latitude dust sources

Dust particles from high latitudes have a potentially large local, regional, and global significance to climate and the environment as short-lived climate forcers, air pollutants, and nutrient sources. Identifying the locations of local dust sources and their emission, transport, and deposition processes is important for understanding the multiple impacts of high-latitude dust (HLD) on the Earth\u27s systems. Here, we identify, describe, and quantify the source intensity (SI) values, which show the potential of soil surfaces for dust emission scaled to values 0 to 1 concerning globally best productive sources, using the Global Sand and Dust Storms Source Base Map (G-SDS-SBM). This includes 64 HLD sources in our collection for the northern (Alaska, Canada, Denmark, Greenland, Iceland, Svalbard, Sweden, and Russia) and southern (Antarctica and Patagonia) high latitudes. Activity from most of these HLD sources shows seasonal character. It is estimated that high-latitude land areas with higher (SI ≥0.5), very high (SI ≥0.7), and the highest potential (SI ≥0.9) for dust emission cover >1 670 000 km$^{2}$, >560 000 km$^{2}$, and >240 000 km$^{2}$, respectively. In the Arctic HLD region (≥60$^{∘}$ N), land area with SI ≥0.5 is 5.5 % (1 035 059 km$^{2}$), area with SI ≥0.7 is 2.3 % (440 804 km$^{2}$), and area with SI ≥0.9 is 1.1 % (208 701 km$^{2}$). Minimum SI values in the northern HLD region are about 3 orders of magnitude smaller, indicating that the dust sources of this region greatly depend on weather conditions. Our spatial dust source distribution analysis modeling results showed evidence supporting a northern HLD belt, defined as the area north of 50$^{∘}$ N, with a “transitional HLD-source area” extending at latitudes 50–58∘ N in Eurasia and 50–55$^{∘}$ N in Canada and a “cold HLD-source area” including areas north of 60$^{∘}$ N in Eurasia and north of 58$^{∘}$ N in Canada, with currently “no dust source” area between the HLD and low-latitude dust (LLD) dust belt, except for British Columbia. Using the global atmospheric transport model SILAM, we estimated that 1.0 % of the global dust emission originated from the high-latitude regions. About 57 % of the dust deposition in snow- and ice-covered Arctic regions was from HLD sources. In the southern HLD region, soil surface conditions are favorable for dust emission during the whole year. Climate change can cause a decrease in the duration of snow cover, retreat of glaciers, and an increase in drought, heatwave intensity, and frequency, leading to the increasing frequency of topsoil conditions favorable for dust emission, which increases the probability of dust storms. Our study provides a step forward to improve the representation of HLD in models and to monitor, quantify, and assess the environmental and climate significance of HLD

Choledochal cyst: presentation of the disease with a case report.

Choledochal cyst is a rare disease of the biliary tract. There are five main types of choledochal cysts with a few recognized sub-types. The etiology of choledochal cysts still is unclear. The incidence of biliary tract cancer in patients with choledochal cysts increases with age. In the past, choledochal cysts were often treated using drainage procedures; however, the optimal treatment used today is likely to involve the complete excision of the extrahepatic duct, cholecystectomy, and Roux-en-Y hepaticojejunostomy. Endoscopic treatment of type III choledochocele should be limited to the management of smaller lesions. We report a case of 75 years old patient with distal choledochal diverticuly, Todani’s type III- choledochocele. Delay in the diagnosis increases the frequency of associated biliary pathology, malignant alternation and suboptimal surgical therapy. Often, intraoperative finding of choledochal cyst is the first contact with this rear entity, so awareness of possible presence of this uncommon disease is very important for surgeon

PRIMENA HEART METODE ZA PROCENU LJUDSKE POUZDANOSTI – SRPSKO ISKUSTVO

In complex industrial systems, human error has been cited as a cause or a contributing factor in accidents and disasters. The need for improved Human Reliability Assessment (HRA) methodologies that should be applied in Probabilistic Safety Assessments, ever since the early 1990s, has motivated a number of major activities in research and development worldwide. Therefore, the main purpose of this paper is to show the practical application of Human Error Assessment and Reduction Technique (HEART) for HRA in Electric Power Company of Serbia (EPCS). The usefulness of this technique for HRA has been approved in a case study of an accident which occurred during a repair on a 10/0.4 kV steel lattice tower “Maričiće“, Kuršumlija (jurisdiction of EPCS, ED “Jugoistok”, Nis, Serbia). For the purpose of this study, a database on work-related injuries, accidents, and critical interventions that occurred over a 10-year period was created. The research comprised an analysis of 1074 workplaces, with a total of 3997 employees. The case study performed at the EPCS confirmed that the HEART is based on knowledge of human activities and relies on expert opinion to determine the Error Producing Condition (EPCs) that affected the situation. The HEART can be used in different industrial systems, as a risk assessment, accident investigation and design tool. In addition, it is a relatively fast tool for assessment of human error probability that is easily applied and understood. U kompleksnim industrijskim sistemima ljudska greška je često navedena kao uzrok ili glavni faktor koji dovodi do akcidenata i katastrofa. Potreba za poboljšanim metodologijama za procenu ljudske pouzdanosti, koje se primenjuju u probabilističkoj proceni bezbednosti, još od ranih 1990-tih motivisala je brojna istraživanja. Glavni cilj ovag rada je da prikaže praktičnu primenu “Tehnike za procenu i redukciju ljudske greške” u proceni ljudske pouzdanosti u preduzeću “Elektroprivreda Srbije”. Korisnost ovog alata, za ovu namenu, dokazana je u studiji slučaja u kojoj je izvršena analiza akcidenta do koga je došlo prilikom intervencije na čelično-rešetkastoj TS 10/0,4kV „Maričiće“, Kuršumlija, ED „Jugoistok“, Niš. Za potrebe ove studije kreirana je baza podataka o povredama na radu, akcidentima i kritičnim intervencijama u poslednjih 10 godina. Istraživanje je obuhvatilo analizu 1074 radna mesta sa ukupno 3997 zaposlenih. Studija slučaja koja je sprovedena u Elektroprivredi Srbije potvrdila je da se “Tehnika za procenu i redukciju ljudske greške” zasniva na poznavanju aktivnosti operatora i da za procenu “uslova za nastanak greške”, koristi stručno mišljenje eksperata. Tehnika za procenu i redukciju ljudske greške može da se koristi u različitim industrijskim sistemima kao alat za procenu rizika, analizu akcidenata i projektovanje. To je relativno brz, lako razumljiv i jednostavan alat za procenu verovatnoće ljudske greške

Mammaglobin expression in tissue as a predictor of breast carcinoma aggressiveness

Background/Aim. Human mammaglobin is considered to be one of the most significant markers of hematogenous dissemi-nation of breast carcinoma. This paper aimed to indicate the important role of peritumoral tissue as an active participant in the tumorigenesis process and the concentration/expression of mammaglobins in the peritumoral tissue as a significant prog-nostic factor. Methods. This research included 64 female pa-tients with primary breast carcinoma during the five-year fol-low-up period. To determine the concentration of mammaglo-bin A in samples of carcinoma tissue and peritumoral tissue, Enzyme-linked immunosorbent assay (ELISA) test was used, and for the determination of relative gene expression of mammaglobin A, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used. Results. The concentra-tion of mammaglobin A was increased in both the carcinoma tissue and peritumoral tissue with an increase in tumor size, number of affected lymph nodes, number of metastases, while relative expression of mammaglobin A was statistically signifi-cantly higher in carcinoma tissue than in peritumoral tissue, re-gardless of the tumor size, number of affected lymph nodes, number of metastases and tumor type. The concentration of mammaglobin A was higher in peritumoral tissue than in tissue of ductal carcinoma, while in the case of lobular carcinoma the concentration of mammaglobin A was higher in carcinoma tis-sue than in peritumoral tissue. Conclusion. Mammaglobin A concentration in peritumoral tissue higher than 0.6704221 ng/mL, and in carcinoma tissue higher than 0.5784426 ng/mL, as well as mammaglobin A relative gene expression in carcino-ma tissue higher than 1.003, were determined as cut-off values. These values may identify patients who are at higher risk of metastatic disease, which would be treated with early radical ad-juvant treatment

The concentration of matrix metalloproteinase 9 in the tumor and peritumoral tissue as a prognostic marker in the breast cancer patients

© 2019, Inst. Sci. inf., Univ. Defence in Belgrade. All rights reserved. Background/Aim. Breast cancer is one of the most common malignancies among women all over the world. Tumor microenvironment represents one of the main regulators of tumorigenesis. We investigated the role of matrix metalloproteinases 9 (MMP-9) concentration in peritumoral tissue as a prognostic marker in the breast cancer patients. Methods. The ELISA test was used to determine a total MMP-9 concentration in carcinoma and peritumoral tissue sample in the patients with breast cancer. Comparison of MMP-9 protein expression with the clinicopathological parameters was evaluated. Results. Peritumoral tissue at 3 cm distance from the tumor produces more MMP-9 than the tumor itself. The ratio of concentrations of MMP-9 in the tumor and peritumoral tissue considerably changes in favor of peritumoral tissue with the increase of tumor size and the involvement of axillary lymph nodes. In N0 stage, the concentration ratio of MMP-9 in the tumor and peritumoral tissues was 1: 1.44, but in the N2 stage, the ratio was 1: 26.5. Conclusion. In patients with breast cancer even in an early stadium there is a change in MMP-9 concentration in peritumoral tissue. We can extract the group of patients at increased risk for the development of lymph node metastasis. A statistically significant difference between the concentrations of MMP-9 in the peritumoral tissue and cancer tissue exists only in case of metastatic disease not in MO stadium implying need for early detection of still unknown metastases in such patients