Preventing weight gain during adjuvant chemotherapy for breast cancer : a dietary intervention study

Adjuvant chemotherapy significantly decreases recurrences and improves survival in women with early breast cancer (BC). However, the side effects of chemotherapy include weight gain, which is associated with poorer prognosis. We have previously demonstrated that by means of a comprehensive dietary modification which aims at lowering insulin levels it is possible to reduce body weight and decrease the bioavailability of insulin, sex hormones and the growth factors linked to BC risk and prognosis. We are now going to present a randomized controlled study of adjuvant diet in BC patients undergoing chemotherapy. The diet was designed to prevent weight gain during chemotherapy treatment. Women of any age, operated for invasive BC, scheduled for adjuvant chemotherapy and without evidence of distant metastases, were randomized into a dietary intervention group and a control group. The intervention implied changing their usual diet for the whole duration of chemotherapy, following cooking classes and having lunch or dinner at the study centre at least twice per week. 96 BC patients were included in the study. The women in the intervention group showed a significant reduction in their body weight (2.9 kg on average), compared with the controls. They also significantly reduced body fat mass, waist and hip circumferences, biceps, underscapular and suprailiac skinfolds, compared with the women in the control group. Our results support the hypothesis that dietary intervention during adjuvant chemotherapy for BC is feasible and may prevent weight gain

Analysis of occurrence, bioaccumulation and molecular targets of arsenic and other selected volcanic elements in Argentinean Patagonia and Antarctic ecosystems

In Latin America, the high proportion of arsenic (As) in many groundwaters and phreatic aquifers is related to the volcanism of the Andean Range. Nevertheless, there is still very little published research on As and other elements occurrence, and/or transference to biota in Southern regions such as Argentinean Patagonia and the South Shetland Islands in Antarctica, where there are active volcanoes and geothermal processes. Therefore, this study was aimed to describe water quality from the main rivers of Argentinean Northern Patagonia through physicochemical analysis. The Patagonian and Antarctic biota (including samples of animal, plants, algae and bacteria) was characterized through the analysis of their As and other elemental concentrations (P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Se, Br, Rb and Sr), by synchrotron radiation x-ray fluorescence spectroscopy (SRXRF). Finally, the analysis of metal and As-proteins associations in As-accumulating organisms was performed by SRXRF after sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). A wide range of metal concentration including As (up to 950 μg/L As) was found in water samples from Patagonian rivers. A hierarchical cluster analysis revealed that the elemental concentration of analysed biological samples was related to volcanic environments and their place in the trophic chain. Moreover, the results suggest that Se, Co, Cu, Br, and Cl are strong predictors of As in biota. On the other hand, As was not detected in proteins from the studied samples, suggesting biotransformation into soluble As-organic compounds. This is the first study to describe environmental pollution as a consequence of active volcanism, and its influence on water quality and elemental composition of biota in Argentinean Northern Patagonia and Antarctica.Fil: Lamela, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina. Universidad Nacional del Comahue. Facultad de Ingeniería. Departamento de Química. Laboratorio de Investigaciones Bioquímicas, Químicas y de Medio Ambiente; ArgentinaFil: Navoni, Julio Alejandro. Universidade Federal do Rio Grande do Norte; BrasilFil: Perez, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Pérez, Carlos A.. Centro Nacional de Pesquisa em Energia e Materiais; BrasilFil: Vodopívez, Cristian L.. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; ArgentinaFil: Curtosi, Antonio. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; ArgentinaFil: Bongiovanni, Guillermina Azucena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina. Universidad Nacional del Comahue. Facultad de Ciencias Agrarias; Argentin

Silver nanoparticles synthesized and coated with pectin: An ideal compromise for anti-bacterial and anti-biofilm action combined with wound-healing properties.

The synthesis of Ag nanoparticles from Ag+ has been investigated, with pectin acting both as reductant and coating. ∼100% Ag+ to Ag(0) one-pot conversion was obtained, yielding p-AgNP, i.e. an aqueous solution of pectin-coated spherical Ag nanoparticles (d = 8.0 ± 2.6 nm), with a < 1 ppm concentration of free Ag+ cation. Despite the low free Ag+ concentration and low Ag+ release with time, the nature of the coating allows p-AgNP to exert excellent antibacterial and antibiofilm actions, comparable to those of ionic silver, tested on E. coli (Gram−) and S. epidermidis (Gram+) both on planctonic cells and on pre- and post-biofilm formation conditions. Moreover, p-AgNP were tested on fibroblasts: not only p-AgNP were found to be cytocompatible but also revealed capable of promoting fibroblasts proliferation and to be effective for wound healing on model cultures. The antibacterial activity and the wound healing ability of silver nanoparticles are two apparently irreconcilable properties, as the former usually requires a high sustained Ag+ release while the latter requires low Ag+ concentration. p-AgNP represents an excellent compromise between opposite requirements, candidating as an efficient medication for repairing wounds and/or to treat vulnerable surgical site tissues, including the pre-treatment of implants as an effective prophylaxis in implant surgery