Camptothecin Intermediates and Prodrugs and Methods of Preparation Thereof

The present invention relates to novel intermediates and prodrugs of camptothecin and related analogs

Highly Lipophilic Camptothecin Intermediates and Prodrugs and Methods of Preparation Thereof

The present invention relates to novel, highly lipophilic silatecan intermediates and prodrugs of DB-67 and other silatecans

Trends in aerosol abundances and distributions

The properties of aerosols that reside in the upper atmosphere are described. Special emphasis is given to the influence these aerosols have on ozone observation systems, mainly through radiative effects, and on ambient ozone concentrations, mainly through chemical effects. It has long been appreciated that stratospheric particles can interfere with the remote sensing of ozone distribution. The mechanism and magnitude of this interference are evaluated. Separate sections deal with the optical properties of upper atmospheric aerosols, long-term trends in stratospheric aerosols, perturbations of the stratospheric aerosol layer by volcanic eruptions, and estimates of the impacts that such particles have on remotely measured ozone concentrations. Another section is devoted to a discussion of the polar stratospheric clouds (PSC's). These unique clouds, recently discovered by satellite observation, are now thought to be intimately connected with the Antarctic ozone hole. Accordingly, interest in PSC's has grown considerably in recent years. This chapter describes what we know about the morphology, physical chemistry, and microphysics of PSC's

Equilibrium properties of the mixed state in superconducting niobium in a transverse magnetic field: Experiment and theoretical model

Equilibrium magnetic properties of the mixed state in type-II superconductors were measured with high purity bulk and film niobium samples in parallel and perpendicular magnetic fields using dc magnetometry and scanning Hall-probe microscopy. Equilibrium magnetization data for the perpendicular geometry were obtained for the first time. It was found that none of the existing theories is consistent with these new data. To address this problem, a theoretical model is developed and experimentally validated. The new model describes the mixed state in an averaged limit, i.e. %without detailing the samples' magnetic structure and therefore ignoring interactions between vortices. It is quantitatively consistent with the data obtained in a perpendicular field and provides new insights on properties of vortices. % and the entire mixed state. At low values of the Ginzburg-Landau parameter, the model converts to that of Peierls and London for the intermediate state in type-I superconductors. It is shown that description of the vortex matter in superconductors in terms of a 2D gas is more appropriate than the frequently used crystal- and glass-like scenarios.Comment: 8 pages, 9 figure

Land cover classification using multi-temporal MERIS vegetation indices

The spectral, spatial, and temporal resolutions of Envisat's Medium Resolution Imaging Spectrometer (MERIS) data are attractive for regional- to global-scale land cover mapping. Moreover, two novel and operational vegetation indices derived from MERIS data have considerable potential as discriminating variables in land cover classification. Here, the potential of these two vegetation indices (the MERIS global vegetation index (MGVI), MERIS terrestrial chlorophyll index (MTCI)) was evaluated for mapping eleven broad land cover classes in Wisconsin. Data acquired in the high and low chlorophyll seasons were used to increase inter-class separability. The two vegetation indices provided a higher degree of inter-class separability than data acquired in many of the individual MERIS spectral wavebands. The most accurate landcover map (73.2%) was derived from a classification of vegetation index-derived data with a support vector machine (SVM), and was more accurate than the corresponding map derived from a classification using the data acquired in the original spectral wavebands

ERS-2 SAR soil moisture and herbaceous biomass monitoring across a semi-arid transect in Israel

Relationships between radar backscattering coefficient (σº) and environmental parameters of volumetric soil moisture and biomass were empirically investigated in two sites. These sites represent an annual rainfall change from 450 mm to 250 mm across a semiarid transition zone between Mediterranean and arid environments in Israel. A strong linear correlation was found between ground measurements of volumetric soil moisture taken place at the two sites in three different dates and corresponding radar backscatter intensities measured from ERS-2 SAR images. The slope and intercept values of the regression equation are similar to those reported in other regions of the world. Relationships between the radar backscatter and Herbaceous biomass were examined in areas of homogenous vegetation cover. Results show strong linear correlation between Herbaceous biomass measured in the field and the ERS-2 backscatter

Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): A feasibility study

Background: Concurrent chemoradiotherapy has improved survival in inoperable stage III non-small cell lung cancer (NSCLC). This phase I trial was performed in order to establish a dose recommendation for oral vinorelbine in combination with cisplatin and simultaneous radiotherapy. Patients and Methods: Previously untreated patients with stage IIIB NSCLC received concurrent chemoradiotherapy with 66 Gy and 2 cycles of cisplatin and oral vinorelbine which was administered at 3 different levels (40, 50 and 60 mg/m(2)). This was to be followed by 2 cycles of cisplatin/vinorelbine oral consolidation chemotherapy. The study goal was to determine the maximal recommended dose of oral vinorelbine during concurrent treatment. Results: 11 stage IIIB patients were entered into the study. The median radiotherapy dose was 66 Gy. Grade 3-4 toxicity included neutropenia, esophagitis, gastritis and febrile neutropenia. The dose-limiting toxicity for concurrent chemoradiotherapy was esophagitis. 9 patients received consolidation chemotherapy, with neutropenia and anemia/thrombocytopenia grade 3 being the only toxicities. The overall response was 73%. Conclusion: Oral vinorelbine 50 mg/m(2) (days 1, 8, 15 over 4 weeks) in combination with cisplatin 20 mg/m2 (days 1-4) is the recommended dose in combination with radiotherapy (66 Gy) and will be used for concurrent chemoradiotherapy in a forthcoming phase III trial testing the efficacy of consolidation chemotherapy in patients not progressing after chemoradiotherapy

A Comprehensive Analysis of Swift/XRT Data: III. Jet Break Candidates in X-ray and Optical Afterglow Lightcurves

The Swift/XRT data of 179 GRBs (from 050124 to 070129) and the optical afterglow data of 57 pre- and post-Swift GRBs are analyzed, in order to systematically investigate the jet-like breaks in the X-ray and optical afterglow lightcurves. We find that not a single burst can be included in the ``Platinum'' sample, in which the data satisfy all the criteria of a jet break. By releasing one or more requirements to define a jet break, some candidates of various degrees could be identified. In the X-ray band, 42 out of the 103 well-sampled X-ray lightcurves have a decay slope of the post-break segment >1.5 (``Bronze'' sample), and 27 of them also satisfy the closure relations of the forward models (``Silver'' sample). The numbers of the ``Bronze'' and ``Silver'' candidates in the optical lightcurves are 27 and 23, respectively. Thirteen bursts have well-sampled optical and X-ray lightcurves, but only seven cases are consistent with an achromatic break, but even in these cases only one band satisfies the closure relations (``Gold'' sample). The observed break time in the XRT lightcurves is systematically earlier than that in the optical bands. All these raise great concerns in interpreting the jet-like breaks as jet breaks and further inferring GRB energetics from these breaks. By assuming that these breaks are jet breaks, we perform a similar analysis as previous work to calculate the jet opening angle (theta_j) and energetics (E_k) with the ``Silver'' and ``Gold'' jet break candidates. The derived E_K distribution reveals a much larger scatter than the pre-Swift sample. A tentative anti-correlation between theta_j and E_{K,iso} is found for both the pre-Swift and Swift GRBs, indicating that the E_K could still be quasi-universal, if the breaks in discussion are indeed jet breaks(abridge).Comment: 48 pages, including 5 tables and 8 figures. Accepted for publication in ApJ. This is the third paper of a series. Paper I and II see astro-ph/0612246 (ApJ, 2007, 666,1002) and arXiv:0705.1373 (ApJ, 2007, 669, n2,in press