Metamorfoses do Convento de São Francisco de Real: reconhecimento, análise, interpretação

A pesquisa apresentada foi realizada no âmbito da elaboração do Projecto para Instalação da Unidade de Arqueologia da Universidade do Minho no Convento de São Francisco de Real, em Braga, um trabalho desenvolvido no Centro de Estudos da Escola de Arquitectura da mesma universidade (CE.EAUM).Este trabalho tem o apoio financeiro do Projeto Lab2PT- Laboratório de Paisagens, Património e Território -AUR/04509 e da FCTMEC através de fundos nacionais e, quando aplicável do cofinanciamento do FEDER, no âmbito do novo acordo de parceria PT2020.Centro de Estudos da Escola de Arquitectura da Universidade do Minhoinfo:eu-repo/semantics/publishedVersio

Hydropic leiomyoma of the uterus presenting as a giant abdominal mass

We describe a case of a 35-year-old woman with a pedunculated uterine leiomyoma with diffuse hydropic degeneration presenting as a giant abdominal mass. The patient was admitted in the emergency department because of diffuse abdominal bloating and discomfort. Ultrasonography (US) showed a heterogeneous abdominopelvic mass. Magnetic resonance imaging (MRI) was performed to further characterise and revealed a myometrial pedunculated tumour. Despite its marked T2-signal heterogeneity and volume, there were no other suspicious findings to suggest a malignant nature; therefore, fertility-sparing myomectomy was performed. Leiomyomas frequently undergo degenerative changes altering their imaging appearances. Leiomyomas with uncommon degenerative changes may be difficult to differentiate from malignant myometrial tumours, based solely on imaging. To the best of our knowledge, a diffuse hydropic degeneration imaging appearance has only been described twice in the literature. We describe the imaging appearance of this rare form of lei

Sickle cell disease

Female patient with past medical history of anaemia associated with multiple painful crises, characterized by severe skeletal pain and fever

Oxidative Stress and Drugs of Abuse: An Update

Drug addiction is a public health and social burden. Presently, the most abused illicit substance is cannabis, followed by amphetamines, cocaine and opioids, with different prevalence in different countries. Several evidences support a role for oxidative stress in the toxicity induced by many drugs of abuse in different organs, such as the brain, heart, liver or kidneys. This leads to oxidation of important cellular macromolecules, and may culminate in cell dysfunction and death. In this review we describe the evidences for oxidative damage and depletion of antioxidants upon exposure to drugs of abuse, especially amphetamines, cocaine and opiates. We also discuss the sources of oxidative stress induced by drugs of abuse, including oxidative metabolism of drugs, oxidative metabolism of monoamines by monoamine oxidases or by auto-oxidation, mitochondrial dysfunction, excitotoxicity, microglial activation, inflammation, hyperthermia and the effects of drug interactions. These consolidate oxidative stress as a relevant mechanism contributing for the cytotoxicity of drugs of abuse and for behavioral changes associated with drug addiction