eBiblio, e-book lending services for public libraries

Spain’s Ministry of Education, Culture and Sport has promoted an ebooks project through which Spanish public libraries acquire the licenses for the use of e-books and a computer system that manages the loans. The eBiblio platform allows users of public libraries with internet access to download and read ebooks and audiobooks. The service has been available since September of 2014 through the library networks of various cities and regions

eBiblio, servicio de préstamo de libros electrónicos en bibliotecas públicas

eBiblio, e-book lending services for public libraries. Spain’s Ministry of Education, Culture and Sport has promoted an ebooks project through which Spanish public libraries acquire the licenses for the use of e-books and a computer system that manages the loans. The eBiblio platform allows users of public libraries with internet access to download and read ebooks and audiobooks. The service has been available since September of 2014 through the library networks of various cities and regions

Pregunte: las bibliotecas responden (Ask a librarian). Virtual reference services in Spain’s public libraries

Review and development of the Spanish virtual reference service Pregunte: las bibliotecas responden (Ask a librarian). Description of main characteristics, workflows and statistical analysis. Description of the recently established chat servic

Inmigración y prejuicio: actitudes de una muestra de adolescentes almerienses

The aim of this research is to know the concept a sample of adolescents living in an area with many foreign workers have about two immigrant groups (Black africans and Moroccans). A sample of 712 adolescents aged 13 to 18 filled up a version of the Modern Racism Scale (McConahay et al., 1981) and an Emotion Scale. Results show low prejudice levels towards both groups. Likewise, evoked emotions, either positive or negative, are low in intensity. There are no differences between subsamples, neither in Modern Racism nor in Emotions. However, some differences are found in some variables, sex and age, which establish different prejudice levels between groups. Traditional negative emotions are positively related to Modern Racism whereas positive emotions are negatively related to it. Results are discussed in relation to the literature and previous research carried out in the same region.ResumenEl objetivo del presente trabajo es conocer la imagen que los adolescentes de una zona con alta recepción de trabajadores extranjeros tienen acerca de dos grupos de inmigrantes: subsaharianos y marroquíes. Se empleó una muestra de 712 sujetos de entre 13 y 18 años, que respondían a una versión de la Escala de Racismo Moderno (McConahay y cols., 1981) y a una escala de emociones. Los resultados muestran un bajo índice de prejuicio hacia ambos grupos. Así mismo, las emociones evocadas por los inmigrantes, tanto positivas como negativas, tienen baja intensidad. No se aprecian diferencias entre las submuestras que evaluaban a cada grupo de inmigrantes, ni en racismo moderno ni en emociones, aunque sí en ciertas variables que establecen diferencias entre los grupos en los niveles de prejuicio (sexo y edad). Las emociones negativas tradicionales se relacionan positivamente con el racismo moderno, y las emociones positivas lo hacen de forma negativa. Los resultados se discuten en relación con la literatura y con resultados obtenidos previamente en la misma zona con otras muestras.AbstractThe aim of this research is to know the concept a sample of adolescents living in an area with many foreign workers have about two immigrant groups (Black africans and Moroccans). A sample of 712 adolescents aged 13 to 18 filled up a version of the Modern Racism Scale (McConahay et al., 1981) and an Emotion Scale. Results show low prejudice levels towards both groups. Likewise, evoked emotions, either positive or negative, are low in intensity. There are no differences between subsamples, neither in Modern Racism nor in Emotions. However, some differences are found in some variables, sex and age, which establish different prejudice levels between groups. Traditional negative emotions are positively related to Modern Racism whereas positive emotions are negatively related to it. Results are discussed in relation to the literature and previous research carried out in the same region

Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells

A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection through the use of an immunostimulatory odorant like menthol, analyzing its impact on the immune system and the cognitive capacity in healthy and Alzheimer’s Disease Mouse Models. We first found that repeated short exposures to menthol odor enhanced the immune response against ovalbumin immunization. Menthol inhalation also improved the cognitive capacity of immunocompetent mice but not in immunodeficient NSG mice, which exhibited very poor fear-conditioning. This improvement was associated with a downregulation of IL-1β and IL-6 mRNA in the brain´s prefrontal cortex, and it was impaired by anosmia induction with methimazole. Exposure to menthol for 6 months (1 week per month) prevented the cognitive impairment observed in the APP/PS1 mouse model of Alzheimer. Besides, this improvement was also observed by the depletion or inhibition of T regulatory cells. Treg depletion also improved the cognitive capacity of the APPNL-G-F/NL-G-F Alzheimer´s mouse model. In all cases, the improvement in learning capacity was associated with a downregulation of IL-1β mRNA. Blockade of the IL-1 receptor with anakinra resulted in a significant increase in cognitive capacity in healthy mice as well as in the APP/PS1 model of Alzheimer´s disease. These data suggest an association between the immunomodulatory capacity of smells and their impact on the cognitive functions of the animals, highlighting the potential of odors and immune modulators as therapeutic agents for CNS-related diseases

Metodologías grupales en el aula: desarrollo de procesos innovadores y aprendizaje continuado

El proyecto aborda la aplicación de metodologías grupales en el desarrollo y en el final de los procesos formativos. Recoge experiencias de 40 profesores de 6 universidades madrileñas

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

New multi-target indole and naphthalene derivatives containing the oxadiazolone scaffold as a bioisostere of the melatonin acetamido group have been developed. The novel compounds were characterized at melatonin receptors MT1R and MT2R, quinone reductase 2 (QR2), lipoxygenase-5 (LOX-5), and monoamine oxidases (MAO-A and MAO-B), and also as radical scavengers. We found that selectivity within the oxadiazolone series can be modulated by modifying the side chain functionality and coplanarity with the indole or naphthalene ring. In phenotypic assays, several oxadiazolone-based derivatives induced signalling mediated by the transcription factor NRF2 and promoted the maturation of neural stem-cells into a neuronal phenotype. Activation of NRF2 could be due to the binding of indole derivatives to KEAP1, as deduced from surface plasmon resonance (SPR) experiments. Molecular modelling studies using the crystal structures of QR2 and the KEAP1 Kelch-domain, as well as the recently described X-ray free-electron laser (XFEL) structures of chimeric MT1R and MT2R, provided a rationale for the experimental data and afforded valuable insights for future drug design endeavoursThe authors gratefully acknowledge the following financial supports: Spanish Ministry of Science, Innovation and Universities; Spanish Research Agency; and European Regional Development Funds (grants RTI2018-093955-B-C21 and SAF2015-64948-C2-1-R to M.I.R.-F.; RTI2018-095793-B-I00 to M.G.L., SAF2015-64629-C2- 2-R to F.G.), General Council for Research and Innovation of the Community of Madrid and European Structural Funds (grant B2017/BMD-3827 e NRF24ADCM), Health Institute Carlos III (Miguel Servet II ProgramCP16/00014 and grant PI17/01700 to R.L.). CH-A and P.M. thank their PhD fellowships from Spanish Ministry of Education (MEC, PhD grant FPU16/01704 and mobility grant FPUEST17/00233 to CH-A and FPU13/03737 to P.M.)

Guía de gestión integrada de plagas: mango

Coordinadores: Ángel Martín Gil y Gregoria Aranda Aranda

Guía de gestión integrada de plagas: aguacate

Coordinadores: Ángel Martín Gil y Gregoria Aranda Aranda