Energy and Exergy analysis in an asphalt plant's rotary dryer

In this paper, energy and exergy analyses of a rotary dryer employed in a Hot Mix Asphalt (HMA) plant for heating and drying of the aggregates in the mixture is presented. In the analysis, the exergy method in addition to the more conventional energy analysis, is employed to identify and evaluate the ther modynamic losses. The results show that, at design conditions, the plant performs with energy and exergy efficiencies of 0.89 and 0.18, respectively. The energy losses are mainly due to the flue gases. The exergy distribution indicates that the combustion and the heat transfer at different temperatures in the burner yield the highest exergy destruction in the process. A parametric study is conducted for the plant under various operational production parameters, including different humidities of the aggregates and filler content in aggregates, working temperatures and ambient conditions, in order to determine the parameters that affect the plant performance. It is shown that the solids humidity has a great impact on energy requirements. A better and sustainable use of the heat source employed in the dryer is proposed to avoid the high irreversibilities found. Furthermore, operating corrections in the mix or in the exhaust gas temperature are proposed to optimize the performance of the plantThis work has been has been partially funded by the Spanish Government, Project DPI2009 10518 and the Fenix project Research on new concepts for more safe and sustainable roads (CENIT 2007 1014). Also, the authors aknowledge the support provided by Intrame S.APublicad

Near infrared and optical morphology of the dusty galaxy NGC972

Near infrared (NIR) and optical surface photometric analyses of the dusty galaxy NGC972 are presented. The photometric profiles in the BVRJHK bands can be fitted with a combination of gaussian and exponential profiles, corresponding to a starburst nucleus and a stellar disk respectively. The exponential scale length in the B-band is 2.8 times larger than in the K-band, which implies a central B-band optical depth as high as 11. A bulge is absent even in the NIR bands and hence the galaxy must be of a morphological type later than the usually adopted Sb type. Relatively low rotational velocity and high gas content also favor a later type, probably Sd, for the galaxy. Only one arm can be traced in the distribution of old stars; the second arm, however, can be traced in the distribution of dust and HII regions. Data suggest a short NIR bar, which ends inside the nuclear ring. The slowly rising nature of the rotation curve rules out a resonance origin of the the nuclear ring. The ring is most likely not in the plane of the galaxy, given its circular appearance in spite of the moderately high inclination of the galaxy. The off-planar nature of the star forming ring, the unusually high fraction (30%) of the total mass in molecular form, the presence of a nuclear starburst and the asymmetry of spiral arms, are probably the result of a merger with a gas-rich companion galaxy.Comment: Uses aas2pp4.sty and epsfig.sty, 12 pages To appear in Astronomical Journal, October 199

Simulating multiple quantum well solar cells

The quantum well solar cell (QWSC) has been proposed as a route to higher efficiency than that attainable by homojunction devices. Previous studies have established that carriers escape the quantum wells with high efficiency in forward bias and contribute to the photocurrent. Progress in resolving the efficiency limits of these cells has been dogged by the lack of a theoretical model reproducing both the enhanced carrier gen- eration and enhanced recombination due to the quantum wells. Here we present a model which calculates the incremental generation and recombination due to the QWs and is verified by modelling the experimental light and dark current-voltage characteristics of a range of III-V quantum well structures. We find that predicted dark currents are significantly greater than experiment if we use lifetimes derived from homostructure devices. Successful simulation of light and dark currents can be obtained only by introducing a parameter which represents a reduction in the quasi-Fermi level separation.Comment: Preprint submitted to the 28th IEEE Photovoltaic Specialists Conference, Anchorage, Alaska, USA, Sept. 2000, pp. 1304-130

Early Science with the Large Millimeter Telescope: an energy-driven wind revealed by massive molecular and fast X-ray outflows in the Seyfert Galaxy IRAS 17020+4544

We report on the coexistence of powerful gas outflows observed in millimeter and X-ray data of the Radio-Loud Narrow Line Seyfert 1 Galaxy IRAS 17020+4544. Thanks to the large collecting power of the Large Millimeter Telescope, a prominent line arising from the 12CO(1-0) transition was revealed in recent observations of this source. The complex profile is composed by a narrow double-peak line and a broad wing. While the double-peak structure may be arising in a disk of molecular material, the broad wing is interpreted as the signature of a massive outflow of molecular gas with an approximate bulk velocity of -660 km/s. This molecular wind is likely associated to a multi-component X-ray Ultra-Fast Outflow with velocities reaching up to ~0.1c and column densities in the range 10^{21-23.9} cm^-2 that was reported in the source prior to the LMT observations. The momentum load estimated in the two gas phases indicates that within the observational uncertainties the outflow is consistent with being propagating through the galaxy and sweeping up the gas while conserving its energy. This scenario, which has been often postulated as a viable mechanism of how AGN feedback takes place, has so far been observed only in ULIRGs sources. IRAS 17020+4544 with bolometric and infrared luminosity respectively of 5X10^{44} erg/s and 1.05X10^{11} L_sun appears to be an example of AGN feedback in a NLSy1 Galaxy (a low power AGN). New proprietary multi-wavelength data recently obtained on this source will allow us to corroborate the proposed hypothesis.Comment: Accepted for publication on ApJ Letters, 9 pages, 4 figure

Desarrollo de la Red Aerobiológica de Castilla y León (RACYL)

XV lnternational A.P.L.E. Symposium of Palynolog

Preliminary definitions for the sonographic features of synovitis in children

Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80% of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89% (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research

Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer

Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis, cellular stress, and sustained angiogenesis, invasiveness and metastatic potential. Cancer cells adequately adapt cell metabolism and integrate several intracellular and redox signaling to promote cell survival in an inflammatory and hypoxic microenvironment in order to maintain/expand tumor phenotype. The administration of tyrosine kinase inhibitor (TKI) constitutes the recommended therapeutic strategy in different malignancies at advanced stages. There are important interrelationships between cell stress, redox status, mitochondrial function, metabolism and cellular signaling pathways leading to cell survival/death. The induction of apoptosis and cell cycle arrest widely related to the antitumoral properties of TKIs result from tightly controlled events involving different cellular compartments and signaling pathways. The aim of the present review is to update the most relevant studies dealing with the impact of TKI treatment on cell function. The induction of endoplasmic reticulum (ER) stress and Ca2+ disturbances, leading to alteration of mitochondrial function, redox status and phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) signaling pathways that involve cell metabolism reprogramming in cancer cells will be covered. Emphasis will be given to studies that identify key components of the integrated molecular pattern including receptor tyrosine kinase (RTK) downstream signaling, cell death and mitochondria-related events that appear to be involved in the resistance of cancer cells to TKI treatments.This study was funded by Institute of Health Carlos III (ISCiii) (PI16/00090, PI19/00838 and PI19/01266), Spanish Ministry of Economy and Competitiveness (BFU2016-80006-P), Andalusian Ministry of Economy, Innovation, Science and Employment (BIO-216 and CTS-6264), Andalusian Ministry of Equality, Health and Social Policies (PI-0198-2016) and Valencian Ministry of Education, Culture and Sports (PROMETEO/2019/027). P de la C-O was supported by FPU predoctoral fellowship (FPU17/00026) from Spanish Ministry of Education, Culture and Sports. E N-V was supported by the the predoctoral i-PFIS IIS-enterprise contract in science and technologies in health (IFI18/00014) from ISCiii. We thank the Biomedical Research Network Center for Cardiovascular Diseases (CIBERcv), and the Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by the ISCiii and co-financed by European Regional Development Fund (ERDF) "A way to achieve Europe" for their financial support

A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol

© 2020, The Author(s). Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causative agent of coronavirus disease 2019 (COVID-19), may lead to severe systemic inflammatory response, pulmonary damage, and even acute respiratory distress syndrome (ARDS). This in turn may result in respiratory failure and in death. Experimentally, acetylcholine (ACh) modulates the acute inflammatory response, a neuro-immune mechanism known as the inflammatory reflex. Recent clinical evidence suggest that electrical and chemical stimulation of the inflammatory reflex may reduce the burden of inflammation in chronic inflammatory diseases. Pyridostigmine (PDG), an ACh-esterase inhibitor (i-ACh-e), increases the half-life of endogenous ACh, therefore mimicking the inflammatory reflex. This clinical trial is aimed at evaluating if add-on of PDG leads to a decrease of invasive mechanical ventilation and death among patients with severe COVID-19. Methods: A parallel-group, multicenter, randomized, double-blinded, placebo-controlled, phase 2/3 clinical trial to test the efficacy of pyridostigmine bromide 60 mg/day P.O. to reduce the need for invasive mechanical ventilation and mortality in hospitalized patients with severe COVID-19. Discussion: This study will provide preliminary evidence of whether or not -by decreasing systemic inflammation- add-on PDG can improve clinical outcomes in patients with severe COVID-19. Trial registration: ClinicalTrials.gov NCT04343963 (registered on April 14, 2020)

Hemispherical power asymmetry: parameter estimation from CMB WMAP5 data

We reexamine the evidence of the hemispherical power asymmetry, detected in the CMB WMAP data using a new method. At first, we analyze the hemispherical variance ratios and compare these with simulated distributions. Secondly, working within a previously-proposed CMB bipolar modulation model, we constrain model parameters: the amplitude and the orientation of the modulation field as a function of various multipole bins. Finally, we select three ranges of multipoles leading to the most anomalous signals, and we process corresponding 100 Gaussian, random field (GRF) simulations, treated as observational data, to further test the statistical significance and robustness of the hemispherical power asymmetry. For our analysis we use the Internally-Linearly-Coadded (ILC) full sky map, and KQ75 cut-sky V channel, foregrounds reduced map of the WMAP five year data (V5). We constrain the modulation parameters using a generic maximum a posteriori method. In particular, we find differences in hemispherical power distribution, which when described in terms of a model with bipolar modulation field, exclude the field amplitude value of the isotropic model A=0 at confidence level of ~99.5% (~99.4%) in the multipole range l=[7,19] (l=[7,79]) in the V5 data, and at the confidence level ~99.9% in the multipole range l=[7,39] in the ILC5 data, with the best fit (modal PDF) values in these particular multipole ranges of A=0.21 (A=0.21) and A=0.15 respectively. However, we also point out that similar or larger significances (in terms of rejecting the isotropic model), and large best-fit modulation amplitudes are obtained in GRF simulations as well, which reduces the overall significance of the CMB power asymmetry down to only about 94% (95%) in the V5 data, in the range l=[7,19] (l=[7,79]).Comment: 24 pages, 10 figures; few typos corrected; published in JCA