5,631 research outputs found
Clustering and collisions of heavy particles in random smooth flows
Finite-size impurities suspended in incompressible flows distribute
inhomogeneously, leading to a drastic enhancement of collisions. A description
of the dynamics in the full position-velocity phase space is essential to
understand the underlying mechanisms, especially for polydisperse suspensions.
These issues are here studied for particles much heavier than the fluid by
means of a Lagrangian approach. It is shown that inertia enhances collision
rates through two effects: correlation among particle positions induced by the
carrier flow and uncorrelation between velocities due to their finite size. A
phenomenological model yields an estimate of collision rates for particle pairs
with different sizes. This approach is supported by numerical simulations in
random flows.Comment: 12 pages, 9 Figures (revTeX 4) final published versio
Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells.
β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic function of β-catenin. However, the effect of Siah1 on the cell membrane bound β-catenin has not been studied. In this study, we identified that the carcinogenic bacterium H. pylori increased ETS2 transcription factor-mediated Siah1 protein expression in gastric cancer cells (GCCs) MKN45, AGS and Kato III. Siah1 protein level was also noticeably higher in gastric adenocarcinoma biopsy samples as compared to non-cancerous gastric epithelia. Siah1 knockdown significantly decreased invasiveness and migration of H. pylori-infected GCCs. Although, Siah1 could not increase degradation of the cytosolic β-catenin and its nuclear translocation, it enhanced degradation of the membrane-bound β-catenin in the infected GCCs. This loss of membrane-bound pool of β-catenin was not associated with the proteasomal degradation of E-cadherin. Thus, this work delineated the role of Siah1 in increasing invasiveness of H. pylori-infected GCCs
An Audible Demonstration Of The Speed Of Sound In Bubbly Liquids
The speed of sound in a bubbly liquid is strongly dependent upon the volume fraction of the gas phase, the bubble size distribution, and the frequency of the acoustic excitation. At sufficiently low frequencies, the speed of sound depends primarily on the gas volume fraction. This effect can be audibly demonstrated using a one-dimensional acoustic waveguide, in which the flow rate of air bubbles injected into a water-filled tube is varied by the user. The normal modes of the waveguide are excited by the sound of the bubbles being injected into the tube. As the flow rate is varied, the speed of sound varies as well, and hence, the resonance frequencies shift. This can be clearly heard through the use of an amplified hydrophone and the user can create aesthetically pleasing and even musical sounds. In addition, the apparatus can be used to verify a simple mathematical model known as Wood's equation that relates the speed of sound of a bubbly liquid to its void fraction. (c) 2008 American Association of Physics Teachers.Mechanical Engineerin
Cassiopeia A: dust factory revealed via submillimetre polarimetry
If Type-II supernovae - the evolutionary end points of short-lived, massive
stars - produce a significant quantity of dust (>0.1 M_sun) then they can
explain the rest-frame far-infrared emission seen in galaxies and quasars in
the first Gyr of the Universe. Submillimetre observations of the Galactic
supernova remnant, Cas A, provided the first observational evidence for the
formation of significant quantities of dust in Type-II supernovae. In this
paper we present new data which show that the submm emission from Cas A is
polarised at a level significantly higher than that of its synchrotron
emission. The orientation is consistent with that of the magnetic field in Cas
A, implying that the polarised submm emission is associated with the remnant.
No known mechanism would vary the synchrotron polarisation in this way and so
we attribute the excess polarised submm flux to cold dust within the remnant,
providing fresh evidence that cosmic dust can form rapidly. This is supported
by the presence of both polarised and unpolarised dust emission in the north of
the remnant, where there is no contamination from foreground molecular clouds.
The inferred dust polarisation fraction is unprecedented (f_pol ~ 30%) which,
coupled with the brief timescale available for grain alignment (<300 yr),
suggests that supernova dust differs from that seen in other Galactic sources
(where f_pol=2-7%), or that a highly efficient grain alignment process must
operate in the environment of a supernova remnant.Comment: In press at MNRAS, 10 pages, print in colou
Team sport athletes’ perceptions and use of recovery strategies: a mixed-methods survey study
Background:
A variety of recovery strategies are used by athletes, although there is currently no research that investigates perceptions and usage of recovery by different competition levels of team sport athletes.
Methods:
The recovery techniques used by team sport athletes of different competition levels was investigated by survey. Specifically this study investigated if, when, why and how the following recovery strategies were used: active land-based recovery (ALB), active water-based recovery (AWB), stretching (STR), cold water immersion (CWI) and contrast water therapy (CWT).
Results:
Three hundred and thirty-one athletes were surveyed. Fifty-seven percent were found to utilise one or more recovery strategies. Stretching was rated the most effective recovery strategy (4.4/5) with ALB considered the least effective by its users (3.6/5). The water immersion strategies were considered effective/ineffective mainly due to psychological reasons; in contrast STR and ALB were considered to be effective/ineffective mainly due to physical reasons.
Conclusions:
This study demonstrates that athletes may not be aware of the specific effects that a recovery strategy has upon their physical recovery and thus athlete and coach recovery education is encouraged. This study also provides new information on the prevalence of different recovery strategies and contextual information that may be useful to inform best practice among coaches and athletes
Investigating the prevalence and causes of prescribing errors in general practice : the PRACtICe Study
Report prepared by the University of Nottingham, University of Reading and University of Hertfordshir
Heavy particle concentration in turbulence at dissipative and inertial scales
Spatial distributions of heavy particles suspended in an incompressible
isotropic and homogeneous turbulent flow are investigated by means of high
resolution direct numerical simulations. In the dissipative range, it is shown
that particles form fractal clusters with properties independent of the
Reynolds number. Clustering is there optimal when the particle response time is
of the order of the Kolmogorov time scale . In the inertial range,
the particle distribution is no longer scale-invariant. It is however shown
that deviations from uniformity depend on a rescaled contraction rate, which is
different from the local Stokes number given by dimensional analysis. Particle
distribution is characterized by voids spanning all scales of the turbulent
flow; their signature in the coarse-grained mass probability distribution is an
algebraic behavior at small densities.Comment: 4 RevTeX pgs + 4 color Figures included, 1 figure eliminated second
part of the paper completely revise
Statistical properties of an ideal subgrid-scale correction for Lagrangian particle tracking in turbulent channel flow
One issue associated with the use of Large-Eddy Simulation (LES) to
investigate the dispersion of small inertial particles in turbulent flows is
the accuracy with which particle statistics and concentration can be
reproduced. The motion of particles in LES fields may differ significantly from
that observed in experiments or direct numerical simulation (DNS) because the
force acting on the particles is not accurately estimated, due to the
availability of the only filtered fluid velocity, and because errors accumulate
in time leading to a progressive divergence of the trajectories. This may lead
to different degrees of inaccuracy in the prediction of statistics and
concentration. We identify herein an ideal subgrid correction of the a-priori
LES fluid velocity seen by the particles in turbulent channel flow. This
correction is computed by imposing that the trajectories of individual
particles moving in filtered DNS fields exactly coincide with the particle
trajectories in a DNS. In this way the errors introduced by filtering into the
particle motion equations can be singled out and analyzed separately from those
due to the progressive divergence of the trajectories. The subgrid correction
term, and therefore the filtering error, is characterized in the present paper
in terms of statistical moments. The effects of the particle inertia and of the
filter type and width on the properties of the correction term are
investigated.Comment: 15 pages,24 figures. Submitted to Journal of Physics: Conference
Serie
The Case Study Approach
The case study approach allows in-depth, multi-faceted explorations of complex issues in their real-life settings. The value of the case study approach is well recognised in the fields of business, law and policy, but somewhat less so in health services research. Based on our experiences of conducting several health-related case studies, we reflect on the different types of case study design, the specific research questions this approach can help answer, the data sources that tend to be used, and the particular advantages and disadvantages of employing this methodological approach. The paper concludes with key pointers to aid those designing and appraising proposals for conducting case study research, and a checklist to help readers assess the quality of case study reports
Incommensurate magnetic ordering in Cu2Te2O5X2 (X=Cl, Br) studied by single crystal neutron diffraction
Polarized and unpolarized neutron diffraction studies have been carried out
on single crystals of the coupled spin tetrahedra systems Cu2Te2O5X2 (X=Cl,
Br). A model of the magnetic structure associated with the propagation vectors
k'Cl ~ -0.150,0.422,1/2 and k'Br ~ -0.172,0.356,1/2 and stable below TN=18 K
for X=Cl and TN=11 K for X=Br is proposed. A feature of the model, common to
both the bromide and chloride, is a canted coplanar motif for the 4 Cu2+ spins
on each tetrahedron which rotates on a helix from cell to cell following the
propagation vector. The Cu2+magnetic moment determined for X=Br, 0.395(5)muB,
is significantly less than for X=Cl, 0.88(1)muB at 2K. The magnetic structure
of the chloride associated with the wave-vector k' differs from that determined
previously for the wave vector k~0.150,0.422,1/2 [O. Zaharko et.al. Phys. Rev.
Lett. 93, 217206 (2004)]
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