4,937 research outputs found
An Audible Demonstration Of The Speed Of Sound In Bubbly Liquids
The speed of sound in a bubbly liquid is strongly dependent upon the volume fraction of the gas phase, the bubble size distribution, and the frequency of the acoustic excitation. At sufficiently low frequencies, the speed of sound depends primarily on the gas volume fraction. This effect can be audibly demonstrated using a one-dimensional acoustic waveguide, in which the flow rate of air bubbles injected into a water-filled tube is varied by the user. The normal modes of the waveguide are excited by the sound of the bubbles being injected into the tube. As the flow rate is varied, the speed of sound varies as well, and hence, the resonance frequencies shift. This can be clearly heard through the use of an amplified hydrophone and the user can create aesthetically pleasing and even musical sounds. In addition, the apparatus can be used to verify a simple mathematical model known as Wood's equation that relates the speed of sound of a bubbly liquid to its void fraction. (c) 2008 American Association of Physics Teachers.Mechanical Engineerin
Capturing the Spectrum of Interaction Effects in Genetic Association Studies by Simulated Evaporative Cooling Network Analysis
Evidence from human genetic studies of several disorders suggests that interactions between alleles at multiple genes play an important role in influencing phenotypic expression. Analytical methods for identifying Mendelian disease genes are not appropriate when applied to common multigenic diseases, because such methods investigate association with the phenotype only one genetic locus at a time. New strategies are needed that can capture the spectrum of genetic effects, from Mendelian to multifactorial epistasis. Random Forests (RF) and Relief-F are two powerful machine-learning methods that have been studied as filters for genetic case-control data due to their ability to account for the context of alleles at multiple genes when scoring the relevance of individual genetic variants to the phenotype. However, when variants interact strongly, the independence assumption of RF in the tree node-splitting criterion leads to diminished importance scores for relevant variants. Relief-F, on the other hand, was designed to detect strong interactions but is sensitive to large backgrounds of variants that are irrelevant to classification of the phenotype, which is an acute problem in genome-wide association studies. To overcome the weaknesses of these data mining approaches, we develop Evaporative Cooling (EC) feature selection, a flexible machine learning method that can integrate multiple importance scores while removing irrelevant genetic variants. To characterize detailed interactions, we construct a genetic-association interaction network (GAIN), whose edges quantify the synergy between variants with respect to the phenotype. We use simulation analysis to show that EC is able to identify a wide range of interaction effects in genetic association data. We apply the EC filter to a smallpox vaccine cohort study of single nucleotide polymorphisms (SNPs) and infer a GAIN for a collection of SNPs associated with adverse events. Our results suggest an important role for hubs in SNP disease susceptibility networks. The software is available at http://sites.google.com/site/McKinneyLab/software
Statistical properties of an ideal subgrid-scale correction for Lagrangian particle tracking in turbulent channel flow
One issue associated with the use of Large-Eddy Simulation (LES) to
investigate the dispersion of small inertial particles in turbulent flows is
the accuracy with which particle statistics and concentration can be
reproduced. The motion of particles in LES fields may differ significantly from
that observed in experiments or direct numerical simulation (DNS) because the
force acting on the particles is not accurately estimated, due to the
availability of the only filtered fluid velocity, and because errors accumulate
in time leading to a progressive divergence of the trajectories. This may lead
to different degrees of inaccuracy in the prediction of statistics and
concentration. We identify herein an ideal subgrid correction of the a-priori
LES fluid velocity seen by the particles in turbulent channel flow. This
correction is computed by imposing that the trajectories of individual
particles moving in filtered DNS fields exactly coincide with the particle
trajectories in a DNS. In this way the errors introduced by filtering into the
particle motion equations can be singled out and analyzed separately from those
due to the progressive divergence of the trajectories. The subgrid correction
term, and therefore the filtering error, is characterized in the present paper
in terms of statistical moments. The effects of the particle inertia and of the
filter type and width on the properties of the correction term are
investigated.Comment: 15 pages,24 figures. Submitted to Journal of Physics: Conference
Serie
An efficient and economic asymmetric synthesis of (+)-nootkatone, tetrahydronootkatone, and derivatives
Image Persented A facile route to enantiomerically pure (+)-nootkatone and derivatives has been established through conjunctive stereoselective Grignard/anionic oxy-Cope (AOC) reactions. © 2009 American Chemical Society
Pressure coefficients of Raman modes of carbon nanotubes resolved by chirality: Environmental effect on graphene sheet
Studies of the mechanical properties of single-walled carbon nanotubes are
hindered by the availability only of ensembles of tubes with a range of
diameters. Tunable Raman excitation spectroscopy picks out identifiable tubes.
Under high pressure, the radial breathing mode shows a strong environmental
effect shown here to be largely independent of the nature of the environment .
For the G-mode, the pressure coefficient varies with diameter consistent with
the thick-wall tube model. However, results show an unexpectedly strong
environmental effect on the pressure coefficients. Reappraisal of data for
graphene and graphite gives the G-mode Grueuneisen parameter gamma = 1.34 and
the shear deformation parameter beta = 1.34.Comment: Submitted to Physical Review
Using the natural evolution of a rotavirus-specific human monoclonal antibody to predict the complex topography of a viral antigenic site
Conformational control of selectivity in the dienone-phenol rearrangement
We have explored the dienone-phenol rearrangement of substrates where: only the p-cresol pathway is possible and relative migratory aptitudes should play no role in determining the regiochemistry of the reaction. For these substrates the selectivity of the rearrangement was found to depend on the stereochemistry of the spirocyclic intermediate formed during the course of the rearrangement. Rearrangement of one of these substrates gave-surprisingly-a single regioisomeric product. Selectivity in this case can be correlated with the relative stability of cationic intermediates, which lie on the pathway between spirocycle and final product. © 2007 Elsevier Ltd. All rights reserved
Society Leadership and Diversity: Hail to the Women!
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138279/1/hep29392.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138279/2/hep29392_am.pd
Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains
Antigen recognition by mammalian antibodies represents the most diverse setting for protein-protein interactions, because antibody variable regions contain exceptionally diverse variable gene repertoires of DNA sequences containing combinatorial, non-templated junctional mutational diversity. Some animals use additional strategies to achieve structural complexity in the antibody combining site, and one of the most interesting of these is the formation of ultralong heavy chain complementarity determining region 3 loops in cattle. Repertoire sequencing studies of bovine antibody heavy chain variable sequences revealed that bovine antibodies can contain heavy chain complementarity determining region 3 (CDRH3) loops with 60 or more amino acids, with complex structures stabilized by multiple disulfide bonds. It is clear that bovine antibodies can achieve long, peculiarly structured CDR3s, but the range of diversity and complexity of those structures is poorly understood. We determined the atomic resolution structure of seven ultralong bovine CDRH3 loops. The studies, combined with five previous structures, reveal a large diversity of cysteine pairing variations, and highly diverse globular domains
Case mix, outcome and activity for patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database
INTRODUCTION: This report describes the case mix, outcome and activity for admissions to intensive care units (ICUs) of patients who require prior chronic renal dialysis for end-stage renal failure (ESRF), and investigates the effect of case mix factors on outcome. METHODS: This was a secondary analysis of a high-quality clinical database, namely the Intensive Care National Audit & Research Centre (ICNARC) Case Mix Programme Database, which includes 276,731 admissions to 170 adult ICUs across England, Wales and Northern Ireland from 1995 to 2004. RESULTS: During the eight year study period, 1.3% (n = 3,420) of all patients admitted to ICU were receiving chronic renal dialysis before ICU admission. This represents an estimated ICU utilization of six admissions (32 bed-days) per 100 dialysis patient-years. The ESRF group was younger (mean age 57.3 years versus 59.5 years) and more likely to be male (60.2% versus 57.9%) than those without ESRF. Acute Physiology and Chronic Health Evaluation II score and Acute Physiology Score revealed greater severity of illness on admission in patients with ESRF (mean 24.7 versus 16.6 and 17.2 versus 12.6, respectively). Length of stay in ICU was comparable between groups (median 1.9 days versus 1.8 days) and ICU mortality was only slightly elevated in the ESRF group (26.3% versus 20.8%). However, the ESRF group had protracted overall hospital stay (median 25 days versus 17 days), and increased hospital mortality (45.3% versus 31.2%) and ICU readmission (9.0% vs. 4.7%). Multiple logistic regression analysis adjusted for case mix identified the increased hospital mortality to be associated with increasing age, emergency surgery and nonsurgical cases, cardiopulmonary resuscitation before ICU admission and extremes of physiological norms. The adjusted odds ratio for ultimate hospital mortality associated with chronic renal dialysis was 1.24 (95% confidence interval 1.13 to 1.37). CONCLUSION: Patients with ESRF admitted to UK ICUs are more likely to be male and younger, with a medical cause of admission, and to have greater severity of illness than the non-ESRF population. Outcomes on the ICU were comparable between the two groups, but those patients with ESRF had greater readmission rates, prolonged post-ICU hospital stay and increased post-ICU hospital mortality. This study is by far the largest comparative outcome analysis to date in patients with ESRF admitted to the ICU. It may help to inform clinical decision-making and resource requirements for this patient population
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