Gender essentialism and occupational segregation in insolvency practice

Advances towards egalitarianism in professional recruitment may be offset by processes of occupational re-segregation. Drawing on gender theory this paper investigates horizontal segregation in the UK insolvency profession, as revealed through the lived experiences of female and male practitioners. It is shown that horizontal segregation pervades at different levels of practice and is undergirded by various elements of gender essentialism. Physical essentialism explains why insolvency practice has been traditionally gendered male. Interactional essentialism combines with the management of work-life balance to define the subfields of corporate and personal insolvency as masculine and feminine respectively. Gender essentialist assumptions also pervade the distribution of roles and the allocation of work tasks. Networks are identified as arenas for the reproduction and perpetuation of occupational segregation. The findings indicate the continuing potency of gender in everyday professional life, the limitations of diversity-orientated policies and the complexities of formulating transformative agendas

An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma

The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60-80% of patients with metastatic tumors suffer relapse and die of disease. In addition, those who survive are often left with debilitating late effects. Clinical features aside from stage have proven inadequate to meaningfully classify patients for risk-stratified therapy. Therefore, there is a critical need to develop approaches to risk stratify patients with EwS based on molecular features. Over the past decade, new technology has enabled the study of multiple molecular biomarkers in EwS. Preliminary evidence requiring validation supports copy number changes, and loss of function mutations in tumor suppressor genes as biomarkers of outcome in EwS. Initial studies of circulating tumor DNA demonstrated that diagnostic ctDNA burden and ctDNA clearance during induction are also associated with outcome. In addition, fusion partner should be a pre-requisite for enrollment on EwS clinical trials, and the fusion type and structure require further study to determine prognostic impact. These emerging biomarkers represent a new horizon in our understanding of disease risk and will enable future efforts to develop risk-adapted treatment

Metacarpal trabecular bone varies with distinct hand-positions used in hominid locomotion

Trabecular bone remodels during life in response to loading and thus should, at least in part, reflect potential variation in the magnitude, frequency and direction of joint loading across different hominid species. Here we analyse the trabecular structure across all non-pollical metacarpal distal heads (Mc2-5) in extant great apes, expanding on previous volume of interest and whole-epiphysis analyses that have largely focussed on only the first or third metacarpal. Specifically, we employ both a univariate statistical mapping and a multivariate approach to test for both inter-ray and interspecific differences in relative trabecular bone volume fraction (RBV/TV) and degree of anisotropy (DA) in Mc2-5 subchondral trabecular bone. Results demonstrate that while DA values only separate Pongo from African apes (Pan troglodytes, Pan paniscus, Gorilla gorilla), RBV/TV distribution varies with the predicted loading of the metacarpophalangeal (McP) joints during locomotor behaviours in each species. Gorilla exhibits a relatively dorsal distribution of RBV/TV consistent with habitual hyper-extension of the McP joints during knuckle-walking, whereas Pongo has a palmar distribution consistent with flexed McP joints used to grasp arboreal substrates. Both Pan species possess a disto-dorsal distribution of RBV/TV, compatible with multiple hand postures associated with a more varied locomotor regime. Further inter-ray comparisons reveal RBV/TV patterns consistent with varied knuckle-walking postures in Pan species in contrast to higher RBV/TV values toward the midline of the hand in Mc2 and Mc5 of Gorilla, consistent with habitual palm-back knuckle-walking. These patterns of trabecular bone distribution and structure reflect different behavioural signals that could be useful for determining the behaviours of fossil hominins

Inappropriate asthma therapy-a tale of two countries:a parallel population-based cohort study

Funding was received by Respiratory Effectiveness Group and University Lyon 1.Peer reviewedPublisher PD

Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria

We thank Christopher Hunter and Bob Axtell for critical feedback, and the Flow Cytometry Laboratory at OUHSC for technical assistance.Author Summary Humoral immunity is essential for host resistance to pathogens that trigger highly inflammatory immune responses, including Plasmodium parasites, the causative agents of malaria. Long-lived, secreted antibody responses depend on a specialized subset of CD4 T cells called T follicular helper (Tfh) cells. However, anti-Plasmodium humoral immunity is often short-lived, non-sterilizing, and immunity rapidly wanes, leaving individuals susceptible to repeated bouts of malaria. Here we explored the relationship between inflammatory type I interferons, the regulation of pathogen-specific CD4 T cell responses, and humoral immunity using models of experimental malaria and systemic virus infection. We identified that type I interferons promote the formation and accumulation of pathogen-specific CD4 T regulatory 1 cells that co-express interferon-gamma and interleukin-10. Moreover, we show that the combined activity of interferon-gamma and interleukin-10 limits the magnitude of infection-induced Tfh responses, the secretion of parasite-specific secreted antibody, and parasite control. Our study provides new insight into the regulation of T regulatory 1 responses and humoral immunity during inflammatory immune reactions against systemic infections.Yeshttp://www.plospathogens.org/static/editorial#pee

When will anthropogenic climate change signals be detected in US tropical cyclone loss data?

No anthropogenic climate change influence on Atlantic tropical cyclone behaviour and concomitant damage has yet been detected, though such an influence is projected in the future. Using projections from a recent study in Science I show that anthropogenic signals are very unlikely to emerge in a time series of normalised US tropical cyclone losses at time scales of less than a century. This result extends more generally to global weather-related natural disaster losses.1 page(s

The Cost of natural disasters in Australia : the case for disaster risk reduction

After adjusting the Insurance Council of Australia’s Disaster List for 2006 societal conditions, we estimate Australia’s average annual insured loss due to natural perils to be around $1 billion. Worldwide, the costs of natural disasters are increasing (Swiss Reinsurance Company, 2006) leading to concerns that human-induced climate change is contributing to this trend. The authors demonstrate that demographic and societal changes are overwhelmingly responsible for the increasing costs of natural disasters in Australia. While there is no guarantee that this situation will continue, the authors proffer the case for increased efforts and policies aimed at reducing the vulnerability of communities to natural hazards. Any gains in disaster risk reduction made will stand Australia in good stead now and into the future.4 page(s

Is climate change responsible for increasing weather-related disasters?

There is ongoing debate both between and within climate scientists and the insurance industry as to whether climate change is responsible for increasing weather-related disasters. The argument against climate change being a dominant driver of increasing disaster losses is that more and more people are living in high risk coastal areas and the value of the property at risk is also increasing. Risk Frontiers has undertaken work for the Insurance Council of Australia (ICA) that involves updating their widely-cited database of disaster losses to reflect present day conditions. This study involves adjusting for the change in the time value of money, changes in exposure, and changes in personal wealth. The paper will briefly outline a new adjustment methodology as well as present results from the updated database. These new results will be placed within the context of historical building losses over the past century due to the various natural perils using Risk Frontiers databases.1 page(s

Normalised Australian insured losses from meteorological hazards : 1967-2006

Since 1967, the Insurance Council of Australia has maintained a database of significant insured losses. Apart from five geological events, all others (156) are the result of meteorological hazards—tropical cyclones, floods, thunderstorms, hailstorms and bushfires. In this study, we normalise the weather-related losses to estimate the insured loss that would be sustained if these events were to recur under year 2006 societal conditions. Conceptually equivalent to the population, inflation and wealth adjustments used in previous studies, we use two surrogate factors to normalise losses—changes in both the number and average nominal value of dwellings over time, where nominal dwelling values exclude land value. An additional factor is included for tropical cyclone losses: this factor adjusts for the influence of enhanced building standards in tropical cyclone-prone areas that have markedly reduced the vulnerability of construction since the early 1980s. Once the weather-related insured losses are normalised, they exhibit no obvious trend over time that might be attributed to other factors, including human-induced climate change. Given this result, we echo previous studies in suggesting that practical steps taken to reduce the vulnerability of communities to today's weather would alleviate the impact under any future climate; the success of improved building standards in reducing tropical cyclone wind-induced losses is evidence that important gains can be made through disaster risk reduction.8 page(s