Technology Innovation - Electronic Game in the Brazilian Higher Education

The Information and Communication Technologies provide a world of discoveries, relations and leanings, presenting possibilities that can help the teaching and learning process to adapt to the new social dynamics introduced by its use. The electronic games (video games), in particular, for its playful nature and because they are familiar to the young people, may provide a great assistant in this adaptation. The research presented here takes a theoretical framework based on Brazilian and international reference authors, to through action research, implement video games about financial mathematics, in a discipline of a higher education course of a public university in Brazil. The results confirm that the use of electronic games is well received by the students, showing that they perceived them as a motivating practice and as an introductory agent of a new process of teaching and learning for higher educatio

Human Rights And Dams: Analysis Of Environmental And Economics Impacts In Rondonia

The proliferation of dams in the amazon is not a recent phenomenon in Rondonia, started in 80's and recovered in last years, because the water potential of the region. The impacts are being gradually senses and known by the people, directly or indirectly, however, is very necessary tell about the process and understand dimension of the impacts. This article proposes a discussion based on three points: geographical aspects of Rondonia, understanding of the processes and impacts of each of the installed hydropower or in the process of being in Rondonia (Samuel, Jirau, Santo Antonio and Tabajara) and, finally, an analysis of the environmental compensation and a critical about social and environmental impacts. Such discussions are important not only from the scientific and academic point of view, but also from a social point of view, since it's indispensable to understand the magnitude of the problems, in order to better guide the compensation and public policies to minimize the environmental impacts experienced by impacted communities directly or indirectly.132616719

Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure

BACKGROUND: Trypanosoma cruzi is the etiological agent of Chagas’ disease that is an endemic disease in Latin America and affects about 8 million people. This parasite belongs to the Trypanosomatidae family which contains a single mitochondrion with an enlarged region, named kinetoplast that harbors the mitochondrial DNA (kDNA). The kinetoplast and the nucleus present a great variety of essential enzymes involved in DNA replication and topology, including DNA topoisomerases. Such enzymes are considered to be promising molecular targets for cancer treatment and for antiparasitic chemotherapy. In this work, the proliferation and ultrastructure of T. cruzi epimastigotes were evaluated after treatment with eukaryotic topoisomerase I inhibitors, such as topotecan and irinotecan, as well as with dual inhibitors (compounds that block eukaryotic topoisomerase I and topoisomerase II activities), such as baicalein, luteolin and evodiamine. Previous studies have shown that such inhibitors were able to block the growth of tumor cells, however most of them have never been tested on trypanosomatids. RESULTS: Considering the effects of topoisomerase I inhibitors, our results showed that topotecan decreased cell proliferation and caused unpacking of nuclear heterochromatin, however none of these alterations were observed after treatment with irinotecan. The dual inhibitors baicalein and evodiamine decreased cell growth; however the nuclear and kinetoplast ultrastructures were not affected. CONCLUSIONS: Taken together, our data showed that camptothecin is more efficient than its derivatives in decreasing T. cruzi proliferation. Furthermore, we conclude that drugs pertaining to a certain class of topoisomerase inhibitors may present different efficiencies as chemotherapeutical agents

Investigation of the incidence of oral cancer in the municipalities of the state of Sao Paulo-Brazil: a retrospective observational cross-sectional study

Introduction: The etiology of Oral Cancer (OC) is multifactorial, resulting from several factors that predispose to the development of this pathology, with a high incidence and mortality, and is among the 10 most common pathologies in the world. Objective: It was to carry out a retrospective longitudinal observational study on the incidence of oral cancer in patients treated at public health units in the municipalities of the State of Sao Paulo-Brazil, as well as to present the main clinical and demographic characteristics of these patients. Methods: This study followed a retrospective observational cross-sectional model (2018-2022), following the rules of clinical research of the STROBE. The present study used the database of the public health system in Brazil on the incidence and prevalence of oral cancer in health units in 467 municipalities in the State of São Paulo-Brazil, whose data are available for public consultation and do not require approval. by the research ethics committee. Participants with oral cancer records of different ethnicities, aged over 20 years, and of both genders were included. Participants who had missing registration data were excluded. For data analysis, the database was built in a Microsoft Excel spreadsheet, which was exported to the Minitab 18® statistical program. One-Way ANOVA with p>0.05 was applied without a statistical difference in the CI95%. Results: The total number of municipalities in the State of São Paulo-Brazil analyzed was 467. Suspected oral malignancy did not present a significant statistical difference between the years 2018 and 2019 (0.33% vs. 0.30%), with p>0.05 in CI95 %. The highest incidences of suspected oral malignancy occurred in 2018 and 2019. In addition, it was evidenced that the most frequent histological type was squamous cell carcinoma in all the years analyzed. Also, bad habits such as alcoholism, smoking, excessive exposure to the sun, and also genetic predisposition, the presence of HPV did not show to influence statistically the occurrences of oral neoplasms. Conclusion: Based on the objective of this study, the incidence of oral cancer in the municipalities of the state of São Paulo-Brazil was higher in the years 2018 and 2019, regardless of the action of predictors such as smoking, alcohol consumption, HPV, genetic predisposition and age. However, further studies need to be carried out in the periods from 2020 to 2022 to know the population that was absent due to the COVID-19 pandemic

Does Seasonality Affect the Nest Productivity, Body Size, and Food Niche of Tetrapedia curvitarsis Friese (Apidae, Tetrapediini)?

Tetrapedia curvitarsis Friese is a widely distributed species, frequently attracted by trap-nests. Previous studies have revealed a higher frequency of nesting in the wet season and dimorphism between the sexes, with females exhibiting larger body size than males. We evaluated the effects of seasonality on the production of nests, food niche, and body size of T. curvitarsis. The study was conducted from April 2009 to March 2010 and from April 2012 to March 2013 at the Água Limpa Experimental Station, located in the Triângulo Mineiro, Minas Gerais State. The number of cells was positively correlated with length and diameter of trap-nests. However, the number of nests and the number of cells produced did not differed between the seasons. The females demonstrated a larger head width than males and both presented greater body size in the wet season. However, there was no interaction between sex and season. A higher food niche breadth was observed in the wet season and low similarity in the use of pollen sources between seasons (PS=39.05%). Thus, it is concluded that the season has no effect on the production of nests or cells, but rather on the body size of males and females and food niche breadth. The production of smaller individuals in the dry season could be related not only to the quantity but also the quality of food offered to immature bees

Mucositis en pacientes portadores de cáncer de cabeza y cuello sometidos a radioquimioterapia

The objective of present study was to classify oral mucositis according to the Common Toxicity Criterion (CTC) international parameters in head and neck tumor patients simultaneously treated with radio and chemotherapy, and characterize a patient profile in our area, observing the individuals' habits, tumor characteristics, treatment protocol and acute reaction intensity. Fifty patients undergoing simultaneous 66 to 70 Gy megavoltage radiotherapy and cisplatin/carboplatin chemotherapy were evaluated in this study. Weekly evaluations of the degree of mucositis were perfoemed according to CTC, a four-degree ordinal scale; 36% of all patients and 100% of those with diabetes discontinued treatment due to mucositis, showing that this pathology contributes to the severity of mucositis.El trabajo objetivó clasificar el grado de Mucositis oral de acuerdo a parámetros internacionales del CTC en pacientes portadores de tumores de cabeza y cuello sometidos a radioterapia y quimioterapia concomitantes, y caracterizar un perfil de pacientes en nuestro medio, verificando hábitos de los individuos, características del tumor, protocolo de tratamiento e intensidad de esta reacción aguda. Fueron evaluados 50 pacientes sometidos a radioterapia en megavoltaje con dosis entre 66 y 70 G y quimioterapia con cisplatino o carboplatino concomitante. Se evaluó semanalmente el grado de Mucositis según el Common Toxicity Criterio - CTC, una escala ordinal que presenta cuatro grados. Se observó interrupción del tratamiento por Mucositis en 36% del total de pacientes y en 100% de los pacientes diabéticos, lo que nos permite verificar que dicha patología potencia la gravedad de la mucositis.O objetivo do presente trabalho é classificar o grau de mucosite oral de acordo com os parâmetros internacionais do Common Toxicity Criterion (CTC) em pacientes portadores de tumor de cabeça e pescoço submetidos à radioterapia e quimioterapia concomitantes, e caracterizar um perfil dos pacientes em nosso meio, verificando os hábitos dos indivíduos, as características do tumor, o protocolo de tratamento e a intensidade desta reação aguda. Neste estudo foram avaliados 50 pacientes, submetidos à radioterapia em megavoltagem com doses entre 66 a 70 Gy e quimioterapia com cisplatina ou carboplatina concomitante. Semanalmente foi avaliado o grau de mucosite de acordo com o CTC, uma escala ordinal que apresenta 4 graus. Observou-se interrupção do tratamento por mucosite em 36% do total de pacientes e em 100% dos pacientes diabéticos, o que nos permitiu verificar que esta patologia contribui para a gravidade da mucosite.Universidade Federal de São Paulo (UNIFESP)Universidade Federal de São Paulo (UNIFESP) Departamento de Oncologia Programa de Pós-Graduação em RadioterapiaUniversidade Federal de São Paulo (UNIFESP) Departamento de Oncologia Setor de RadioterapiaUniversidade Federal de São Paulo (UNIFESP) Departamento de Oncologia Laboratório de Radioterapia ExperimentalUNIFESP, Depto. de Oncologia Programa de Pós-Graduação em RadioterapiaUNIFESP, Depto. de Oncologia Setor de RadioterapiaUNIFESP, Depto. de Oncologia Laboratório de Radioterapia ExperimentalSciEL

Mulheres com risco cardiovascular apos pre-eclampsia: ha seguimento no Sistema Unico de Saude?

OBJETIVOS: identificar mujeres con riesgo cardiovascular, cinco años después de la pre-eclampsia (PE), y averiguar el seguimiento de esas mujeres en el Sistema Único de Salud en Natal/RN. MÉTODOS: estudio exploratorio, cuantitativo, realizado en la Maternidad Escuela Januario Cicco - RN. La muestra fue compuesta de 130 mujeres, 65 con PE y 65 normotensas. RESULTADOS: se constató diferencia estadística significativa en lo que se refiere al índice de masa corpórea, peso, histórico familiar de enfermedades cardiovasculares (ECV) y complicación cardiovascular entre las mujeres con PE previa y las normotensas. Los grupos desconocen los factores de riesgos cardiovasculares y, además de eso, refieren dificultades de acceso en los servicios de atención primaria. CONCLUSIONES: las mujeres con histórico de PE poseen riesgo aumentado de desarrollar ECV, desconocen las complicaciones tardías de esa enfermedad y en relación a las normotensas no reciben seguimiento en ambulatorio especializado.OBJETIVOS: identificar mulheres com risco cardiovascular, cinco anos após a pré-eclâmpsia, e averiguar o seguimento dessas mulheres no Sistema Único de Saúde, em Natal, Rio Grande do Norte. MÉTODOS: estudo exploratório, quantitativo, realizado na Maternidade Escola Januário Cicco, em Natal. A amostra foi de 130 mulheres, 65 com pré-eclâmpsia e 65 normotensas. RESULTADOS: constatou-se diferença estatística significativa no que se refere ao índice de massa corpórea, peso, histórico familiar de doenças cardiovasculares e complicação cardiovascular entre as mulheres com pré-eclâmpsia prévia e as normotensas. Os grupos desconheciam os fatores de risco cardiovasculares e, além disso, referiam dificuldades de acesso aos serviços de atenção primária. CONCLUSÕES: as mulheres com histórico de pré-eclâmpsia possuíam risco aumentado de desenvolver doenças cardiovasculares, desconheciam as complicações tardias dessa doença e não recebiam seguimento ambulatorial diferenciado em relação às normotensas.OBJECTIVES: to identify women with cardiovascular risk, five years after a preeclampsic episode (PE), and identify the follow-up of these women within the Unified Health System (Sistema Único de Saúde - SUS), in the city of Natal/RN. METHODS: a quantitative and exploratory study conducted at the Januário Cicco University Maternity Ward/RN. The sample consisted of 130 women, 65 with a PE episode and 65 who were normotensive. RESULTS: we found statistical significance with regard to body mass index, weight, family history of cardiovascular disease (CVD) and cardiovascular complications when comparing women with previous PE to normotensive women. The groups were unaware of their cardiovascular risk factors and, in addition, they reported difficulties in accessing primary health care (PHC) services. CONCLUSIONS: women with a PE history are at increased risk of developing CVD, unaware of late PE complications, and lacked customized care when compared to normotensive patients

Estresse ocupacional e estratégias de enfrentamento entre profissionais de enfermagem em ambiente hospitalar

The study aimed to analyze the occupational stress and coping strategies used by technicians and nursing assistants of a university hospital as well as its association with sociodemographic variables. Method: This is a cross-sectional study with a random sample of 310 technicians and nursing assistants. It was intended for evaluation of occupational stress and coping strategies applied to Job Stress Scale and the Scale Mode Confronting problems. The sample was mostly composed of women, with a mean age of 47.1 years, married or with a partner, who were nursing assistants, with only one employment and who had withdrawal the previous year. Of them, 17.1% of the sample was highly exposed to occupational stress. Results: The strategies focused on the problem proved to be protective with respect to stress. Conclusion: This way of dealing with stressors in the hospital can be optimally worked among professionals.El objetivo del estudio fue analizar el estrés laboral y las estrategias de afrontamiento utilizadas por técnicos y auxiliares de enfermería de un hospital universitario, así como su asociación con variables sociodemográficas. Método: Estudio transversal con una muestra aleatoria de 310 técnicos y auxiliares de enfermería. Para la evaluación del estrés laboral y las estrategias de afrontamiento se aplicó la Job Stress Scale y la Escala Modos de Enfrentamiento de Problemas. La muestra se compone de una mayoría de mujeres, con una edad media de 47,1 años, casadas o en pareja, auxiliares de enfermería, con único vínculo de empleo y que tuvieron trabajo en el último año. Estuvieron altamente expuestas al estrés laboral 17,1% de la muestra. Resultados: Las estrategias centradas en el problema resultaron ser protectoras en relación al estrés. Conclusiones: Esta manera de hacer frente a los factores de estrés en el hospital se puede trabajar de manera optimizada entre los profesionales.Objetivo: O estudo objetivou analisar o estresse ocupacional e as estratégias de enfrentamento utilizadas por técnicos e auxiliares de enfermagem de um hospital universitário, bem como a sua associação com variáveis sociodemográficas. Método: Estudo transversal realizado com uma amostra aleatorizada de 310 técnicos e auxiliares de enfermagem. Para avaliação do estresse ocupacional e estratégias de enfrentamento aplicou-se a Job Stress Scale e a Escala Modos de Enfrentamento de Problemas. A amostra foi composta por uma maioria de mulheres, com idade media de 47,1 anos, casados ou com companheiro, auxiliares de enfermagem, com único vínculo empregatício e que tiveram afastamento do trabalho no último ano. Estavam altamente expostos ao estresse ocupacional 17,1% da amostra. Resultados: As estratégias focadas no problema mostraram-se protetoras em relação ao estresse. Conclusiones: Esta forma de lidar com os estressores em ambiente hospitalar pode ser trabalhada de forma otimizada entre os profissionai

The relevance of trunk evaluation in Duchenne muscular dystrophy: the segmental assessment of trunk control

The aim was to describe trunk control in ambulant and non-ambulant patients with Duchenne muscular dystrophy (DMD). We conducted a cross-sectional analysis of a sample of 50 DMD patients, (M age = 16.7 years) who underwent the Segmental Assessment of Trunk Control (SATCo). A seven-level scale of trunk control was used (1: head control only7: control of entire trunk while unsupported). Static, active and reactive posture control were evaluated in ambulant and non-ambulant patients. Inter-rater reliability for all assessments was evaluated by calculating the kappa coefficient. More advanced disease (having higher Vignos scores), was associated with poorer trunk control. Ambulant patients showed better trunk control than non-ambulant patients (p = 0.003). There was strong inter-rater agreement for SATCo scale scores.Univ Fed Sao Paulo, Dept Ciencias Movimento Humano, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Neurol Neurocirurgia, Sao Paulo, SP, BrazilUniversidade Federal de São Paulo, Departamento de Ciências do Movimento Humano, São Paulo SP, BrasilUniversidade Federal de São Paulo, São Paulo SP, BrasilUniversidade Federal de São Paulo, Departamento de Neurologia/Neurocirurgia, São Paulo SP, BrasilWeb of Scienc

Trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination in Rio de Janeiro, Brazil / Tendências do número de admissões pediátricas da COVID-19 durante as primeiras 24 semanas de vacinação da COVID-19 no Rio de Janeiro, Brasil

Objective: To describe trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination.   Design: A retrospective study was conducted in children (0-18 years), admitted in two pediatric hospitals of Rio de Janeiro city, between January 17 and July 3, 2021 with confirmed COVID-19 by reverse transcription polymerase chain reaction or serological tests. Trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination in Rio de Janeiro, Brazil and the pre-vaccine period were measured by linear regression. Participants: Children admitted in pediatric hospitals in Rio de Janeiro, city, Brazil Results: The number of total admitted patients (with all diseases) were 5340 during the pre-vaccine period, being 94 (1.8%) of them with confirmed COVID-19, and 4182 children admitted during the vaccine period, with 86 confirmed COVID-19 patients (2.1 %) (p=0.29). Media of cases admitted per/week were 2.02 in pre-vaccine period and 3.6 during the first 24 weeks of COVID vaccination (p=0.009). One death was reported in the pre-vaccine period and four in the vaccine period (p=0.14). Trends of increase in the number of admitted cases were verified both in the pre-vaccine period as in the vaccine period, being more expressive in the last one. Conclusion: There was trend of increase in number of children admitted with confirmed COVID-19 during the first 24 weeks of COVID-vaccination in Rio de Janeiro, city. Considering that few people were fully vaccinated, reducing of number of admitted children with confirmed COVID-19 was not verified