Identifying Spatial Relationships between Built Heritage Resources and Short-Term Rentals before the Covid-19 Pandemic: Exploratory Perspectives on Sustainability Issues

Built heritage resources (BHRs) are multidimensional assets that need to be conceived under a sustainability and circular economy framework. Whereas it is essential that their conservation, management, and enjoyment are sustainable, it is also necessary that the environmental, cultural, and socio-economic contexts in which they are integrated are sustainable too. Like other amenities, BHRs can improve the quality of the urban environment and generate externalities; additionally, they may influence sectors such as real estate, hospitality, and tourism. In this framework, this contribution aims to identify spatial relationships occurring between BHRs and short-term rentals (STRs), i.e., a recent economic phenomenon facilitated by platforms such as Airbnb. Through the application of Exploratory Spatial Data Analysis techniques and taking Turin (Italy) as a case study, this article provides evidence that spatial correlation patterns between BHRs and STRs exist, and that the areas most affected by STRs are the residential neighborhoods located in the proximity of the historic center of the city. Relations with other sets of socio-economic variables are highlighted too, and conclusions suggest that future studies are essential not only to monitor sustainability issues and reflect on new housing models and sustainable uses of buildings, but also to understand the evolution of the phenomenon in light of the pandemic Covid-19. they may influence sectors such as real estate, hospitality, and tourism. In this framework, this contribution aims to identify spatial relationships occurring between BHRs and short-term rentals (STRs), i.e., a recent economic phenomenon facilitated by platforms such as Airbnb. Through the application of Exploratory Spatial Data Analysis techniques and taking Turin (Italy) as a case study, this article provides evidence that spatial correlation patterns between BHRs and STRs exist, and that the areas most aected by STRs are the residential neighborhoods located in the proximity of the historic center of the city. Relations with other sets of socio-economic variables are highlighted too, and conclusions suggest that future studies are essential not only to monitor sustainability issues and reflect on new housing models and sustainable uses of buildings, but also to understand the evolution of the phenomenon in light of the pandemic Covid-19

LA CREAZIONE DI NUOVI VALORI NEI PROCESSI DI RIGENERAZIONE URBANA E PERIURBANA: LA RISPOSTA SOCIAL IMPACT-ORIENTED DELLA DISCIPLINA DELLA VALUTAZIONE ECONOMICA DEI PROGETTI

Urban and periurban regeneration are now conceived as processes that need to combine the renewal of the physical environment with the enhancement of cultural, social and economic conditions. Coherently, initiatives of social innovation and aiming at achieving social impact are acquiring increasing importance, also in light of new hybrid entrepreneurial partnerships and impact investing paradigms. In this framework, the evaluation of social impact represents a key issue. Taking into account the challenges still associated to the measurement of social impact and proposing an original concept of value specifically related to social impact-oriented initiatives, this paper aims to outline the methodological perspectives that could inform an effective evaluation of such types of interventions. The presented concepts are then empirically applied to a selected case study, showing that the explicit integration of social impact objectives into regeneration plans, together with their evaluation, could enhance the overall value of the project

La creazione di nuovi valori nei processi di rigenerazione urbana e periurbana: la risposta Social Impact-Oriented della disciplina della valutazione economica dei progetti/The Creation of New Values in Urban and Periurban Regeneration Processes: the Social Impact-Oriented Response of the Discipline of Economic Evaluation of Projects

Urban and periurban regeneration are now conceived as processes that need to combine the renewal of the physical environment with the enhancement of cultural, social and economic conditions. Coherently, initiatives of social innovation and aiming at achieving social impact are acquiring increasing importance, also in light of new hybrid entrepreneurial partnerships and impact investing paradigms. In this framework, the evaluation of social impact represents a key issue. Taking into account the challenges still associated to the measurement of social impact and proposing an original concept of value specifically related to social impact-oriented initiatives, this paper aims to outline the methodological perspectives that could inform an effective evaluation of such types of interventions. The presented concepts are then empirically applied to a selected case study, showing that the explicit integration of social impact objectives into regeneration plans, together with their evaluation, could enhance the overall value of the projects

Impact of climate change on the energy performance of building envelopes and implications on energy regulations across Europe

This paper delves into the potential impact of a changing climate on the energy performance of European buildings. Research aims to provide a comprehensive evaluation of current energy requirements focusing on the envelope, considering existing regulations in national policies. Energy simulations are conducted at 94 locations across the European Union to cover the climatic variability and Koppen climate classification. The research analyzes future climate scenarios for the years 2030, 2050, and 2070, using three different Representative Concentration Pathways (RCP 2.6, 4.5, 8.5). According to a comprehensive analysis of heating, cooling, and overall energy performance, climate plays a significant role in buildings’ energy balance. In moderately cool climate countries, the demand for air conditioning is projected to decrease in the years ahead. Conversely, in countries with a warm climate, there is a projected increase in the overall energy demand. Consequently, a revision of current energy regulations should be a priority. Providing insights into the relation between building design, energy efficiency, and climate change, the research identifies policy adjustments to ensure buildings can effectively respond to changing climatic conditions. A holistic and dynamic approach can support building design accounting for long-term impacts of climate change to create resilient and energy-efficient structures

Randomised clinical trial of a manual therapy programme to reduce the evolution time of axillary web syndrome in women affected by breast cancer: study protocol

Introduction Breast cancer is the most common malignant tumour in women, with more than 2 million new cases annually worldwide. One of the most frequent and well-known surgical and post-actinic sequelae is post-mastectomy lymphoedema. The axillary web syndrome is another sequela that limits the functionality of the patient and delays the protocol time of administering cancer treatments; and in many cases, this sequela is misdiagnosed. This surgical sequela usually disappears spontaneously after the third month of appearance, but this implies a long period of discomfort and limitations for the patient, at the same time, it may delay the application of radiotherapy within the indicated protocol deadline (due to a need for body posture). Methods and analysis With the present quasi-experimental study, we intend to show the application of physiotherapy and stretching from the beginning of the appearance of the axillary cord, in a controlled and scheduled way by the physiotherapist. It is possible to reduce the time in which the lymphatic thrombus is present and, therefore, recover functionality and mobility, reduce pain and be able to apply treatments within the established deadline. We intend to apply this therapy into the intervention group and compare thrombus evolution time with the control group. Ethics and dissemination This trial has the approval of the Andalucia Ethics Committee (PEIBA code 1909-N1-21, reg. number 171.21)

Investigating p62 Concentrations in Cerebrospinal Fluid of Patients with Dementia: A Potential Autophagy Biomarker In Vivo?

Several studies have revealed defects in autophagy in neurodegenerative disorders including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). SQSTM1/p62 plays a key role in the autophagic machinery and may serve as a marker for autophagic flux in vivo. We investigated the role of p62 in neurodegeneration, analyzing its concentrations in the CSF of AD and FTD patients. We recruited 76 participants: 22 patients with AD, 28 patients with FTD, and 26 controls. CSF p62 concentrations were significantly increased in AD and FTD patients when compared to controls, which persisted after adjusting for age (p = 0.01 and p = 0.008, respectively). In female FTD patients, p62 positively correlated with the neurodegenerative biomarkers t-Tau and p-Tau. A significant correlation between CSF p62 concentrations and several clinical features of AD was found. Our data show that p62 is increased in CSF of AD and FTD patients, suggesting a key role of autophagy in these two disorders. The levels of p62 in CSF may reflect an altered autophagic flux, and p62 could represent a potential biomarker of neurodegeneration

Cardiovascular risk in adult hypopituitaric patients with growth hormone deficiency: is there a role for vitamin D?

Hypovitaminosis D represent an environmental risk factors for cardiovascular (CV) disease. To investigate the prevalence of hypovitaminosis D and the correlation between GH/IGF-I deficiency and hypovitaminosis D with CV risk in GH deficiency (GHD) patients. A link between these hormones has been shown. Forty-one hypopituitaric patients with GHD (22 males, age 18-84 years) and 41 controls were enrolled in the study. Anthropometric parameters, blood pressure, glucose and lipid profile, parathyroid hormone (PTH), 25(OH) vitamin D (vitamin D), metabolic syndrome (MS), GH peak after GHRH + ARG, IGF-I, and standard deviation score (SDS) of IGF-I (zIGF-I) were assessed. Vitamin D levels were lower in patients than in controls (21.3 ± 12.3 vs. 28.2 ± 9.4, p = 0.006). Deficiency was found in 51 % of patients versus 14.6 % of controls (p < 0.01), insufficiency in 26.8 versus 41.4 % (p = 0.269) and normal vitamin D levels in 21.9 versus 43.9 % (p = 0.060). The prevalence of dyslipidemia was 51.2 % in patients versus 12.1 % in controls (p < 0.001), type 2 diabetes mellitus (DM) was 7.3 versus 17 % (p = 0.292), hypertension was 44 versus 22 % (p = 0.060), and MS was 17 versus 14.6 % (p = 0.957). In patients, an association was found between the presence of hypovitaminosis D and the prevalence of dyslipidemia, hypertension and MS and between zIGF-I and the prevalence of hypertension. Hypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension. GHD patients have an increased prevalence of hypovitaminosis D compared with controls. The presence of hypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension in GHD patients, suggesting the involvement of both factors in the CV risk in these patients

Measurement of Glutathionylated Haemoglobin by MALDI-ToF Mass Spectrometry as a Biomarker of Oxidative Stress in Heavy Smokers and in Occupational Obese Subjects

Glutathionyl-haemoglobin (Hb-SSG) is a minor form of haemoglobin characterized by the presence of a disulfide bond between the &#946;-93 cysteine residue and the thiol group of glutathione. Hb-SSG is naturally present in the erythrocytes at levels comparable to those of glycated haemoglobin and can be measured by MALDI mass spectrometry on very small samples of erythrocytes from peripheral blood. Since Hb-SSG has been recognized as a sensitive biomarker of oxidative stress in several degenerative diseases (diabetes, hyperlipidemia, kidney disease) and in healthy workers exposed to glutathione-depleting toxic agents such as butadiene, we have measured for the first time the levels of Hb-SSG in two groups: healthy heavy cigarette smokers and overweight-obese

Giant Aneurysm of the Right Atrial Appendage in a 39-Year-Old Woman

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