Papel de Cot/tpl-2 en inmunidad innata y migración celular

Tesis doctoral inédita leída en la Universidad Autónoma, Facultad de Medicina. Departamento de Bioquímica. Fecha de lectura 16 de Enero de 200

Qualitative analysis of the online tourist image of Zafra (Spain) through the comments in Tripadvisor

Los comentarios online realizados por turistas en diferentes plataformas se están convirtiendo en una valiosa fuente de información que permite a los destinos mejorar su posición competitiva mediante un análisis eficiente de dicha información. En el presente trabajo se realiza una aplicación de la técnica de análisis de contenido para el caso concreto de la ciudad de Zafra, Extremadura, utilizando para ello el contenido generado por los visitantes al destino en la plataforma de viajes Tripadvisor, mediante la asistencia del software NVIVO Pro 11. Los resultados obtenidos nos permiten conocer cuáles son los atractivos más comentados, las actividades mejor valoradas o los principales puntos de mejora. Dicho de otra forma, permiten conocer cuál es la imagen online percibida del destino.Online comments made by tourists on different platforms are becoming a valuable source of information that allows destinations to improve their competitive position through an efficient analysis of this information. This study employs content analysis to examine visitors’ comments about Zafra, in Extremadura, Spain, on the TripAdvisor travel platform. The visitor-generated data were analyzed using the software NVIVO Pro 11. The results obtained allow us to determine which are the most commented attractions, the best rated activities or the main points of improvement. In other words, they enable us to understand the perceived online image of the destination

Carbon Footprint Estimation Tool for Residential Buildings for Non-Specialized Users: OERCO2 Project

Existing tools for environmental certification of buildings are failing in their ability to reach the general public and to create social awareness, since they require not only specialized knowledge regarding construction and energy sources, but also environmental knowledge. In this paper, an open-source online tool for the estimation of the carbon footprint of residential buildings by non-specialized users is presented as a product from the OERCO2 Erasmus + project. The internal calculations, data management and operation of this tool are extensively explained. The ten most common building typologies built in the last decade in Spain are analysed by using the OERCO2 tool, and the order of magnitude of the results is analysed by comparing them to the ranges determined by other authors. The OERCO2 tool proves itself to be reliable, with its results falling within the defined logical value ranges. Moreover, the major simplification of the interface allows non-specialized users to evaluate the sustainability of buildings. Further research is oriented towards its inclusion in other environmental certification tools and in Building Information Modeling (BIM) environments

Articulación preescolar-primaria: recomendaciones al maestro

Al incorporarse a la vida escolar, el niño experimenta una reestructuración psicológica esencial, pero este niño que culmina su 6to. año de vida y comienza en el 1er. grado, mantiene aún, las características psicológicas propias de la edad preescolar, requiriendo un tiempo de adaptación a los nuevos cambios en su vida. Algunos maestros de 1er. grado, en su manejo pedagógico con los niños, pretenden convertirlos bruscamente en escolares, obviando que este momento constituye una necesidad y de hecho, un período de tránsito de preescolar a escolar, que ocurre en las condiciones físico-ambientales de una escuela. Por tanto, una problemática actual es la necesidad de la preparación de los docentes del 1er. grado en la utilización de estrategias que favorezcan la continuidad entre la educación preescolar y la escolar. Se trata entonces de orientar al maestro en la instrumentación de su labor pedagógica a fin de evitar que se produzca un cambio brusco de una etapa a otra

Life Cycle Assessment of Industrial Building Construction and Recovery Potential: Case Studies in Seville

In Spain, most businesses are medium to small size enterprises, representing 90% of the total, but there is a lack of studies of the types of building this sector uses. The main objective of this paper is to present a method for the evaluation of small industrial construction projects to facilitate the introduction of eco-efficient solutions. For this, it is necessary to identify the most representative buildings and the aspects of these which have the most environmental impact. A methodology in place for the evaluation of dwelling construction is adapted, for the first time, to evaluate industrial buildings. The construction solutions characterized are those traditionally used in the sector, as identified through 87 surveys. A standardized classification of work units is proposed to enable the use of environmental product information, such as eco-labels and/or EPD, and LCA databases. The carbon footprint (CF) and water footprint (WF) are the indicators selected because of their straightforward message. Finally, a comparative analysis is performed showing the high recycling potential of concrete and cement which, along with metals and aggregates, control the impact in terms of CF. With respect to the WF indicator, plastic substitute aggregates are among the materials with the greatest impac

Percepção empresarial da pandemia COVID-19 e seu impacto no turismo: uma análise qualitativa na região de Extremadura, na Espanha

The COVID-19 pandemic has caused substantial disruptions in the tourism sector. This situation has forced sectoral actors to adopt important measures, but on the other hand, it has also generated new business opportunities. Using qualitative analysis tools, this paper analyzed the perception of businesspeople in the sector regarding the COVID-19 pandemic and outlined the measures to be adopted to help the recovery of the sector in Extremadura, an emerging inland tourist destination in the southwest of Spain. The results show that their main concern is the economic impact that the crisis is having on their businesses, along with the main measures that the tourism businesspeople are requesting to overcome this situation.La pandemia de la COVID-19 ha provocado importantes perturbaciones en el sector turístico. Esta situación ha obligado a los agentes sectoriales a adoptar importantes medidas, pero también ha generado nuevas oportunidades de negocio. A partir de herramientas de análisis cualitativo, este trabajo analizó la percepción de los empresarios del sector sobre la pandemia por COVID-19 y esbozó las medidas que se deben adoptar para ayudar a la recuperación del sector en Extremadura, un destino turístico emergente de interior en el suroeste de España. Los resultados muestran que la principal preocupación de los empresarios es el impacto económico que la crisis está teniendo en sus negocios, además de las principales medidas que los empresarios turísticos solicitan para superar esta situación.A pandemia COVID-19 causou grandes perturbações no setor do turismo. Essa situação obrigou os agentes setoriais a adotarem medidas importantes, mas também gerou novas oportunidades de negócios. Com base em ferramentas de análise qualitativa, este trabalho analisou a percepção dos empresários do setor sobre a pandemia COVID-19 e delineou as medidas que devem ser adotadas para ajudar a recuperação do setor na região de Extremadura, um destino turístico interior emergente no sudoeste da Espanha. Os resultados mostram que a principal preocupação dos empresários é o impacto económico que a crise está gerando nos seus negócios, além das principais medidas que os empresários turísticos solicitam para ultrapassar esta situação

Autismo infantil, mirada a un paciente

Generalised disorders of the development are slightly frequent diseases; most known is the infantile autism. The diagnosis of this disease is clinical. A patient is presented to describe the forms of manifestation of this disease and to define its final diagnosis. The autism is considered to be the major mental disorder of the infancy, so these patients need a great dedication from their families and from the society to raise their quality of life. Its forecast depends, on a great extent, on the precocious diagnosis and a multidisciplinary opportune treatment and intersectorial. It was considered of interest to commen the principal clinical aspects of the disease to contribute to its rapid recognition from the primary level and its integral attention.Los trastornos generalizados del desarrollo son enfermedades poco frecuentes; el más conocido es el autismo infantil. El diagnóstico de esta enfermedad es clínico. Se presenta un paciente para describir las formas de manifestación de esta enfermedad y para definir su diagnóstico final. El autismo se considera el mayor desorden mental de la infancia, por lo que estos pacientes necesitan de una gran dedicación de sus familias y de la sociedad para elevar su calidad de vida. Su pronóstico depende, en gran medida, del diagnóstico precoz y de un tratamiento oportuno multidisciplinario e intersectorial. Se consideró de interés comentar los principales aspectos clínicos de la enfermedad para contribuir a su rápido reconocimiento desde el nivel primario y a su atención integral. 

Mayor producción de inmunoglobulina en ratas suplementadas con ácido linoleico conjugado durante la gestación y la lactancia

Conjugated linoleic acid (CLA) has been reported to exert beneficial physiological effects on body composition and the immune system. However, little information is available on the influence of CLA on immune function during early life periods. The present study evaluates the effect of feeding an 80:20 mixture of cis-9, trans-11- and trans-10, cis-12-CLA isomers during gestation and suckling on the systemic immune response of weaned Wistar rats. Pups received dietary CLA from dams through the placental barrier and during suckling by breast milk (group A) or by oral administration (group B). Pups from group C only received CLA during suckling by oral administration. Group D constituted the reference group. Milk from dams fed the CLA diet had a high content of CLA and higher IgA and IgG concentrations than rats fed the standard diet. The plasma of pups from groups A, B and C showed six, twelve and nine times higher content of the cis-9, trans-11-CLA isomer than that of the group D pups. Rats from group A exhibited higher serum IgG concentrations than rats from the rest of the groups (22·14 (sem 2·14) v. about 5 mg/ml; P < 0·05), whereas rats from groups A and B showed approximately 2-fold higher splenocyte IgM production than rats from groups C and D. However, CLA supplementation did not influence significantly the splenocyte proliferative response or cytokine secretion. Supplementation during gestation and suckling with an 80:20 cis-9, trans-11–trans-10, cis-12 CLA mix enhances the production of the main in vivo and in vitro Ig isotypes in Wistar rats

Interdisciplinarity: a Current Need to Improve the Teaching-Learning Process

The establishment of interdisciplinary relationships is a present imperative derived from scientific development. Education cannot ignore this development, on the contrary, should integrate it into the teaching process. Educational institutions should promote increased methodological activities, curriculum designs and educational actions using this approach in order to train students in correspondence with the time they live in, which will result in better preparation of professionals. This paper aims to update scholars about the possibilities offered by interdisciplinarity to improve the teaching-learning process. The theoretical and methodological premises of interdisciplinarity are analyzed through a literature review. It also presents different experiences from the implementation of this approach, which have enabled ratifying the need for interdisciplinary relationships in the teaching-learning process, the difficulties encountered when designing a proposal using this approach, and the benefits of its application

Dietary Epicatechin Is Available to Breastfed Infants through Human Breast Milk in the Form of Host and Microbial Metabolites

Polyphenols play an important role in human health. To address their accessibility to a breastfed infant, we planned to evaluate whether breast milk (BM) (colostrum, transitional, and mature) epicatechin metabolites could be related to the dietary habits of mothers. The polyphenol consumption of breastfeeding mothers was estimated using a food frequency questionnaire and 24 h recalls. Solid-phase extraction-ultra performance liquid chromatography-tandem mass spectrometry (SPE-UPLC-MS/MS) was applied for direct epicatechin metabolite analysis. Their bioavailability in BM as a result of dietary ingestion was confirmed in a preliminary experiment with a single dose of dark chocolate. Several host and microbial phase II metabolites of epicatechin were detected in BM among free-living lactating mothers. Interestingly, a modest correlation between dihydroxyvalerolactone sulfate and the intake of cocoa products was observed. Although a very low percentage of dietary polyphenols is excreted in BM, they are definitely in the diet of breastfed infants. Therefore, evaluation of their role in infant health could be further promoted