When a woman replaces a man: evaluating coach dismissal in professional tennis

Purpose: Previous research indicates gender discrimination in leadership positions. However, performance and not gender should be the key indicator when evaluating a leader. We examine the performance effect of changing from a female to a male coach and vice versa. Methodology: We analyze 1,093 Billie Jean King Cup singles matches from 2006 to 2016, with the match result as the dependent variable. First, we examine the very short-term effects arising from the change of a coach with a regression discontinuity design. Second, we evaluate the short-, medium-, and long-term performances. Findings: The results show that the gender of the new coach has no significant effect on performance. However, when a female coach succeeds another female coach, performance improves. This provides an argument in favor of female leadership. Practical Implications: Team managers should primarily focus on the quality of the coach instead of gender. The results also suggest that a continuum of female leadership is likely advantageous. Research Contribution: This paper contributes to the debate regarding the misrepresentation of women as head coaches and offers an avenue for further research

CRIMES SEXUAIS COMETIDOS POR MULHERES

O abuso sexual praticado pela mulheres, é caracterizado a principio como uma relação de afeto que faz com que a vitima acredite estar sendo amada e desejada. Na maioria das vezes as crianças são vítimas, por indivíduos que praticam no período em que os responsáveis não estão, ou até mesmo quando a própria mãe é a malfeitora. Entretanto o ato sexual, ainda que apenas beijos e caricias praticado com crianças são considerados crimes pela Constituição Federal brasileira, e precisam ser repassados a policia. Nada obstante, os crimes desta categoria praticados por mulheres, são denunciados com menor frequência, e com isso acaba ficando omisso a pratica deste a sociedade

A linguagem escrita na educa??o infantil com crian?as de 4 e 5 anos

The reflection held in this text is the result of an investigation about the usage of written language on 4 and 5 years old kids, on infant education environment. It is also a provisional synthesis of conclusion built in order to fulfill the assignment called Trabalho de Conclus?o de Curso ? TCC, which the idea and its first origins date back to some problematizations during the Supervised Internship on Infant Education, around the topic of written language and kids. The collation of the observations within the institutional context and the official documents, plus the theoretical studying were the catalysts of the problem which guided us on this path: how is the written language with the children in the Infant Education institutions being handled. The searching of possible answers was anchored methodologically through the analysis of Moraes? (1999) content, about the official documents that guide infant education: Diretrizes Curriculares Nacionais para a Educa??o Infantil - DCNEIs e Base Nacional Comum Curricular ? BNCC. Theoretically, through the historic-cultural theory of the human development, from Vigotski and collaborators. The initial results signal to some divergence in conception of the object between documents and some approximations when compared to the theory which support such analysis. In conclusive terms we can infer that a kid as a cultural subject, who has contact with written culture since they were born must reaffirm the contact in Infant Education. The care with the treatment of written language on kids in pre-school, however, needs much theoretical clarity by the teacher?s part.A reflex?o contida neste texto ? resultado de investiga??o sobre os usos da linguagem escrita com crian?as de 4 e 5 anos, no ?mbito da educa??o infantil. ? tamb?m uma s?ntese provis?ria de conclus?es constru?das para fins de cumprimento do Trabalho de Conclus?o de Curso - TCC, cuja origem primeira foram algumas problematiza??es constru?das durante a realiza??o do Est?gio Supervisionado em Educa??o Infantil, em torno do tema da linguagem escrita com crian?as. O cotejamento das observa??es do contexto institucional com os documentos oficiais e o aprofundamento te?rico, deu origem ao problema que nos orientou neste percurso: como est? sendo tratada a linguagem escrita com essas crian?as nas institui??es de Educa??o Infantil,. A busca de poss?veis respostas ancorou-se metodologicamente pela an?lise de conte?do de Moraes (1999), sobre os documentos oficiais que orientam a educa??o infantil: Diretrizes Curriculares Nacionais para a Educa??o Infantil - DCNEIs e Base Nacional Comum Curricular - BNCC. E, teoricamente pela media??o da teoria hist?rico-cultural de desenvolvimento humano de Vigotski e colaboradores. Os resultados iniciais sinalizam para uma pouca diverg?ncia de concep??o do objeto entre os documentos e para algumas aproxima??es quando cotejadas com a teoria que suporta a an?lise. Em termos conclusivos podemos inferir que a crian?a como sujeito cultural, que tem contato com a cultura escrita desde que nasce, deve sim reafirmar esse contato na Educa??o Infantil. Por?m o cuidado do trato da linguagem escrita com as crian?as da pr?-escola precisa de muita clareza te?rica por parte do professor

Contexts of vulnerabilities experienced by adolescents: challenges to public policies

Compreender o contexto de vulnerabilidade vivenciado por adolescentes na perspectiva dos profissionais de saúde da Estratégia Saúde da Família. Estudo descritivo-exploratório, qualitativo, desenvolvido com 80 profissionais da Estratégia Saúde da Família na região Centro-Oeste do Brasil. A coleta de dados foi desenvolvida de julho a setembro de 2018 por meio de grupo focal, e submetidos à Análise Temática. Compreendeu-se que a vulnerabilidade vivenciada por adolescentes não é uma exposição a algo isolado, mas está ligada a fatores de risco e proteção, contextos socioeconômicos e culturais, políticas públicas e de saúde. Ainda existem lacunas nas políticas públicas para essa população, o que impacta no acesso e no desenvolvimento de ações de promoção pelos profissionais de saúde734CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE APOIO AO DESENVOLVIMENTO DO ENSINO, CIÊNCIA E TECNOLOGIA DO ESTADO DE MATO GROSSO DO SUL - FUNDECT03/2016não temTo understand the context of vulnerability experienced by adolescents from the perspective of health professionals from the Family Health Strategy. A descriptive-exploratory qualitative study developed with 80 Family Health Strategy professionals in the Midwest region of Brazil. Data collection was developed from July to September 2018 through a focus group, and submitted to Thematic Analysis. It was understood that the vulnerability experienced by adolescents is not an exposure to something isolated, but is linked to risk and protection factors, socioeconomic and cultural contexts, public and health policies. There are still gaps in public policies for this population, which impacts on the access and development of promotion actions by health professional

Recognition of early mortality in multiple myeloma by a prediction matrix

Early mortality (EM; death ≤ 6 months from diagnosis) has been reported in several newly diagnosed multiple myeloma (NDMM) trials. Before the era of novel agents, the incidence was 10%-14%. Causes of death included infections/pneumonia, renal failure, refractory disease, and cardiac events. Staging systems, such as the revised International Staging System (r-ISS), and prognostic factors including cytogenetics, lactate dehydrogenase levels, and myeloma-specific factors, are useful to assess overall prognosis; however, they cannot predict EM. We evaluated patients treated with novel agents in the Connect MM® Registry and identified risk factors of the EM cohort. Eligible patients were enrolled in the registry within 60 days of diagnosis. Univariate and multivariate analyses were conducted to evaluate associations between baseline characteristics and EM. Prediction matrices for EM were constructed from a logistic model. Between September 2009 and December 2011, 1493 patients were enrolled in the registry and had adequate follow-up. Of these patients, 102 (6.8%) had EM and 1391 (93.2%) survived for > 180 days. Baseline factors significantly associated with increased EM risk included age > 75 years, higher Eastern Cooperative Oncology Group performance status, lower EQ-5D mobility score, higher ISS stage, lower platelet count, and prior hypertension. Renal insufficiency trended toward increased EM risk. These risk factors were incorporated into a prediction matrix for EM. The EM prediction matrix uses differential weighting of risk factors to calculate EM risk in patients with NDMM. Identifying patients at risk for EM may provide new opportunities to implement patient-specific treatment strategies to improve outcomes

Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells

AbstractT-cell recovery following myeloablative preparatory regimens and cord blood transplantation in adult patients gen erally occurs between 1 and 3 years following allogeneic bone marrow transplantation. T-cell reconstitution may involve thymic education of donor-derived precursors or peripheral expansion of mature T-cells transferred in the graft. We measured quantitative and qualitative immunologic reconstitution, T-cell receptor spectratyping, and T-cell receptor excision circle (TREC) levels in adult recipients of umbilical cord blood transplants following a novel nonmyeloablative regimen. These results were compared to previously published results of similar patients receiving a myeloablative regimen and cord blood stem cells. With small numbers of patients treated so far, T-cells (CD3+) reached normal levels in adults 6 to 12 months following nonmyeloablative transplantation compared with 24 months in adults receiving a myeloablative regimen. At 12 months after transplantation, the numbers of phenotypically naive (CD45RA) T-cells were higher in those receiving the nonmyeloablative regimen. The T-cell repertoire in cord blood recipients treated with a nonmyeloablative regimen was markedly more diverse and robust compared with the repertoire in those receiving the myeloablative regimen at similar time points. TRECs (which are generated within the thymus and identify new thymic emigrants and those that have not divided) were detected 12 months after transplantation in the nonmyeloablative recipients, whereas TRECs were not detected in adults until 18 to 24 months in those receiving myeloablative regimens. Thus, in adults receiving a nonmyeloablative preparatory regimen, the quantitative and qualitative recovery of T-cells occurs through rapid peripheral expansion. The ability of patients receiving a nonmyeloablative regimen to recover within a few months suggests that the peripheral niches in which T-cells can proliferate are preserved in these patients compared to those receiving ablative regimens. Moreover, the presence of TREC-positive cells within 1 year suggests that thymic recovery is likewise accelerated in non myeloablative compared to myeloablative regimens.Biol Blood Marrow Transplant 2002;8(5):249-56

Promoção da Saúde e Medicalização: Notas Inquietantes em Conversas de Foucault com Canguilhem

 Este artigo visa problematizar práticas de promoção de saúde no Brasil, a partir da história da saúde pública no país, em uma analítica da medicalização e da gestão higienista do hospital, da cidade, dos pobres e do Estado. Busca-se pensar como emerge junto com a saúde na atenção básica um modo de gerir a política pública de saúde como tática medicalizante dos corpos, do espaço, do hospital, da comunidade e das relações sociais. Interroga-se no seguinte ensaio temático um conjunto de práticas que operam um mecanismo biopolítico e de governo da vida e das existências por meio de intensa medicalização na atuação preventivista da saúde. Portanto, questiona-se o estilo de vida saudável na sociedade contemporânea a partir de uma estratégia medicalizadora do direito à saúde com Michel Foucault e Georges Canguilhem.Palavras-chave: Saúde. Medicalização. Práticas. Biopolítica. Prevenção. Health Promotion And Medicalization: Disturbing Notes In Talk Of Foucault With CanguilhemABSTRACTThis article aims to problematize health promotion practices in Brazil, based on the history of public health in the country, in an analysis of medicalization and hygienist management of the hospital, the city, the poor and the State. It seeks to think about how a way to manage public health policy emerges together with health in primary care as a medicalizing tactic of bodies, space, hospital, community and social relations. in the following thematic essay a set of practices that operate a biopolitical and government mechanism of life and existences through intense medicalization in preventative health action. Therefore, the healthy lifestyle in contemporary society is questioned based on a medicalizing strategy of the right to health.Keywords: Health. Medicalization. Practices. Biopolitics. Prevention

COMPARAÇÃO ENTRE MÉTODOS DE IMPUTAÇÃO DE DADOS EM DIFERENTES INTENSIDADES AMOSTRAIS NA SÉRIE DE PRECIPITAÇÃO PLUVIAL DA ESALQ

Um problema frequente nas análises estatísticas de informações climatológicas é a ocorrência de dados faltantes, assim, o objetivo deste trabalho foi comparar três métodos de imputação de dados com observações da série de precipitação pluvial de uma estação climatológica convencional, no município de Piracicaba-SP, no período de 1917 a 1997, em diferentes intensidades amostrais (5%, 10% e 15%) de informações faltantes, geradas de forma aleatória. Para o “preenchimento” dessas informações, foram usados três métodos de imputação múltipla: PMM (Predictive Mean Matching), random forest e regressão linear, via método bootstrap, em cada intensidade amostral de informações faltantes. A comparação entre cada procedimento de imputação foi feita, por meio da raiz do erro quadrático médio, índice de acurácia de Willmott e o índice de desempenho. O método, que resultou em menores valores da raiz quadrada dos erros e maiores índices de desempenho e acurácia, foi o PMM, em especial, na intensidade de 10% de informações faltantes. O índice de desempenho, para os três métodos de imputação de dados, em todas as intensidades de observações faltantes, foi considerado insatisfatório, por isso, é necessária uma atenção maior quando se trata de observações tão variáveis espacialmente e temporalmente quanto as chuvas

A Phase II Study of Venetoclax in Combination With Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma

© 2021 The Authors.[Background]: Venetoclax is a selective BCL-2 inhibitor with clinical activity in relapsed/refractory multiple myeloma (RRMM). Combinations of venetoclax with agents that have complementary mechanisms of action may improve venetoclax efficacy in RRMM. This study evaluated venetoclax with pomalidomide and dexamethasone (VenPd) in RRMM. [Patients and Methods]: This phase II open label study (NCT03567616) evaluated VenPd in patients with RRMM who had received ≥ 1 prior therapy and were refractory to lenalidomide. Venetoclax was administered orally daily for days 1 to 28, pomalidomide was administered orally daily for days 1 to 21, and dexamethasone was administered weekly for each 28-day cycle. The primary objective was to characterize the safety and tolerability of VenPd. The secondary objectives were to evaluate the efficacy and pharmacokinetics. The study was terminated early due to partial clinical hold and decision to pursue biomarker driven strategy. [Results]: Eight patients were enrolled. Patients had a median age of 67.5 years. All patients received 400 mg venetoclax; 4 patients experienced dose-limiting toxicities and the dose was not escalated. All patients had a grade ≥ 3 adverse event, and the most common was neutropenia (n = 6); cytopenias were the most prevalent adverse events. Five patients (63%) had a confirmed response, and the median duration of response was 12.9 months. The median progression-free survival was 10.5 months. [Conclusions]: Given the limited enrollment, no clear safety or efficacy conclusions about VenPd can be drawn. Preliminary safety data, particularly the occurrence of cytopenias, can be used to guide dosing strategies for future combinations of venetoclax with immunomodulatory agents.AbbVie Inc is a private corporation, and funding is not associated with a grant number. Funding information is correct as stated

Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial

Background. Respiratory viral infections (RVIs) are frequent complications of hematopoietic stem cell transplant (HSCT). Surgical masks are a simple and inexpensive intervention that may reduce nosocomial spread