Editors' Introduction

Hermeneutics has a long tradition in the history of philosophy. It carries the task of Hermes to bring God’s message to humans and translate it without betraying it. This special issue of the journal Critical Hermeneutics proposes a double research track: veritative hermeneutics and hermeneutic realism. This double track testifies to the original purpose of hermeneutics to formulate fundamental philosophical questions in light of human historical experience. Opposed to relativism, veritative hermeneutics and hermeneutic realism focus on truth, objectivity, the structure of reality, normativity, and meaning. The issue publishes contributions of this track’s pioneers (Gaspare Mura – veritative hermeneutics, Günter Figal, and Anton Friedrich Koch – hermeneutic realism) as well as authors that explore this track from various perspectives: ethics, personalism, normativity, testimony, Biblical hermeneutics and Jewish thought, religious language, meaning. In this introduction, we will first present the authors working on veritative hermeneutics, then those working on hermeneutic realism...

Editoriale

L’ermeneutica rappresenta una delle scienze più antiche della storia della filosofia. Disciplina tangente all’esegesi, alla filologia, alla linguistica, senza coincidere con nessuna di esse, da secoli svolge il duplice compito di Ermes: portare il messaggio arcano degli Dei agli uomini, e tradurlo per loro, senza tradirlo. Questo numero della rivista Critical Hermenutics propone un doppio filone di ricerca, quello dell’ermeneutica veritativa e quello del realismo ermeneutico. Questo doppio filone afferma il carattere originario dell'ermeneutica in quanto pensiero che riprende le domande fondamentali della filosofia, alla luce dell'esperienza umana storica. In opposizione al relativismo, l'ermeneutica veritativa e il realismo ermeneutico si concentrano sui temi della verità, dell'oggettività, della struttura della realtà, della normatività e del senso. Il numero pubblica contributi di autori fondativi di questo doppio filone (Gaspare Mura - ermeneutica veritativa, Günter Figal, Anton Friedrich Koch - realismo ermeneutico) e he esplorano il filone da prospettive diverse – etica, personalismo, normatività, testimonianza, ermeneutica Biblica e pensiero ebraico, linguaggio religioso, senso delle cose..

Editoriale

L’ermeneutica rappresenta una delle scienze più antiche della storia della filosofia. Disciplina tangente all’esegesi, alla filologia, alla linguistica, senza coincidere con nessuna di esse, da secoli svolge il duplice compito di Ermes: portare il messaggio arcano degli Dei agli uomini, e tradurlo per loro, senza tradirlo. Questo numero della rivista Critical Hermenutics propone un doppio filone di ricerca, quello dell’ermeneutica veritativa e quello del realismo ermeneutico. Questo doppio filone afferma il carattere originario dell'ermeneutica in quanto pensiero che riprende le domande fondamentali della filosofia, alla luce dell'esperienza umana storica. In opposizione al relativismo, l'ermeneutica veritativa e il realismo ermeneutico si concentrano sui temi della verità, dell'oggettività, della struttura della realtà, della normatività e del senso. Il numero pubblica contributi di autori fondativi di questo doppio filone (Gaspare Mura - ermeneutica veritativa, Günter Figal, Anton Friedrich Koch - realismo ermeneutico) e he esplorano il filone da prospettive diverse – etica, personalismo, normatività, testimonianza, ermeneutica Biblica e pensiero ebraico, linguaggio religioso, senso delle cose..

Editors' Introduction

Hermeneutics has a long tradition in the history of philosophy. It carries the task of Hermes to bring God’s message to humans and translate it without betraying it. This special issue of the journal Critical Hermeneutics proposes a double research track: veritative hermeneutics and hermeneutic realism. This double track testifies to the original purpose of hermeneutics to formulate fundamental philosophical questions in light of human historical experience. Opposed to relativism, veritative hermeneutics and hermeneutic realism focus on truth, objectivity, the structure of reality, normativity, and meaning. The issue publishes contributions of this track’s pioneers (Gaspare Mura – veritative hermeneutics, Günter Figal, and Anton Friedrich Koch – hermeneutic realism) as well as authors that explore this track from various perspectives: ethics, personalism, normativity, testimony, Biblical hermeneutics and Jewish thought, religious language, meaning. In this introduction, we will first present the authors working on veritative hermeneutics, then those working on hermeneutic realism...

Hermeneutic Realism and Veritative Hermeneutics

Hermeneutics has a long tradition in the history of philosophy. It carries the task of Hermes to bring God’s message to humans and translate it without betraying it. This special issue of the journal Critical Hermeneutics proposes a double research track: veritative hermeneutics and hermeneutic realism. This double track testifies to the original purpose of hermeneutics to formulate fundamental philosophical questions in light of human historical experience. Opposed to relativism, veritative hermeneutics and hermeneutic realism focus on truth, objectivity, the structure of reality, normativity, and meaning. The issue publishes contributions of this track’s pioneers (Gaspare Mura – veritative hermeneutics, Günter Figal, and Anton Friedrich Koch – hermeneutic realism) as well as authors that explore this track from various perspectives: ethics, personalism, normativity, testimony, Biblical hermeneutics and Jewish thought, religious language, meaning. In this introduction, we will first present the authors working on veritative hermeneutics, then those working on hermeneutic realism

FAILURE MODES OF PVD COATINGS IN MOLTEN AL-ALLOY CONTACT

This paper deals with a study of the failure mode of thin PVD coatings in alternated contact with molten aluminum alloy. CrN and ZrN monolayer coatings deposited through cathodic arc evaporation were used. The coatings morphology was assessed by SEM and their mechanical properties evaluated by nanohardness test performed at room temperature. An experimental test rig which cyclically immerses coated steel samples in molten Al-alloy and in a cooling bath was applied. The thermal gradient from the coating to the steel core was exalted by internal cooling channels placed in the internal cavity of samples. Periodical SEM inspections were performed to assess the damaging levels introduced by the test and to study the related decrease of substrate protection capability. Descriptions and interpretations of the damages evolutions were derived. The main conclusions achieved are that both coatings suffered by the formation of corrosion pits, which were due to a corrosion attack of the steel substrate localized at coating defects sites. In particular, at pores locations the corrosion was fast, whereas at droplets sites it required a certain incubation time. Once corrosion pits were formed they exhibited an initial tendency to expand laterally, but they did rapidly stabilize in terms of lateral dimensions. Later on two different failure modes acted in ZrN and in CrN. Extended delamination due to a marked mismatch of mechanical properties between the coating and the steel substrate developed in ZrN. On the contrary, thermal cracking due to lower hardness levels developed in CrN, but with limited delamination. Accordingly the steel substrate protection capability was evaluated to be higher in CrN than in ZrN. Keywords: PV

The impact of COVID-19 on cancer care and oncology clinical research: an experts' perspective

The coronavirus disease-19 (COVID-19) pandemic promises to have lasting impacts on cancer clinical trials that could lead to faster patient access to new treatments. In this article, an international panel of oncology experts discusses the lasting impacts of the pandemic on oncology clinical trials and proposes solutions for clinical trial stakeholders, with the support of recent data on worldwide clinical trials collected by IQVIA. These lasting impacts and proposed solutions encompass three topic areas. Firstly, acceleration and implementation of new operational approaches to oncology trials with patient-centric, fully decentralized virtual approaches that include remote assessments via telemedicine and remote devices. Geographical differences in the uptake of remote technology, including telemedicine, are discussed in the article, focusing on the impact of the local adoption of new operational approaches. Secondly, innovative clinical trials. The pandemic has highlighted the need for new trial designs that accelerate research and limit risks and burden for patients while driving optimization of clinical trial objectives and endpoints, while testing is being minimized. Areas of considerations for clinical trial stakeholders are discussed in detail. In addition, the COVID-19 pandemic has exposed the underrepresentation of minority groups in clinical trials; the approach for oncology clinical trials to improve generalizability of efficacy and outcomes data is discussed. Thirdly, a new problem-focused collaborative framework between oncology trial stakeholders, including decision makers, to leverage and further accelerate the innovative approaches in clinical research developed during the COVID-19 pandemic. This could shorten timelines for patient access to new treatments by addressing the cultural and technological barriers to adopting new operational approaches and innovative clinical trials. The role of the different stakeholders is described, with the aim of making COVID-19 a catalyst for positive change in oncology clinical research and eventually in cancer care

Does lung ultrasound have a role in the clinical management of pregnant women with SARS COV2 infection?

Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection is a major health threat. Pregnancy can lead to an increased susceptibility to viral infections. Although chest computed tomography (CT) represents the gold standard for the diagnosis of SARS-CoV-2 pneumonia, lung ultrasound (LUS) could be a valid alternative in pregnancy. The objectives of this prospective study were to assess the role of LUS in the diagnosis of lung involvement and in helping the physicians in the management of affected patients. Thirty pregnant women with SARS-CoV-2 infection were admitted at the obstetrical ward of our Hospital. Mean age was 31.2 years, mean gestational age 33.8 weeks. Several LUS were performed during hospitalization. The management of the patients was decided according to the LUS score and the clinical conditions. Mean gestational age at delivery was at 37.7 weeks, preterm birth was induced in 20% of cases for a worsening of the clinical conditions. No neonatal complications occurred. In 9 cases with a high LUS score, a chest CT was performed after delivery. CT confirmed the results of LUS, showing a significant positive correlation between the two techniques. LUS seems a safe alternative to CT in pregnancy and may help in the management of these patient

Are motivational and self-regulation factors associated with 12 months’ weight regain prevention in the NoHoW study? An analysis of European adults

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecom‑ mons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the dataPurpose: Preventing weight regain can only be achieved by sustained changes in energy balance-related behaviors that are associated with weight, such as diet and physical activity. Changes in motivation and self-regulatory skills can support long-term behavioral changes in the context of weight loss maintenance. We propose that experiencing a supportive climate care is associated with enhanced satisfaction of basic psychological needs, intrinsic goals, and autonomous motivation. These factors are expected to be associate with the utilization of self-regulation skills, leading to more sustained behavior changes and ultimately preventing weight regain. This hypothesis was tested in this ancillary analysis of the NoHoW trial, where the study arms were pooled and followed for 12 months. Methods: The NoHoW was a three-center, large-scale weight regain prevention full factorial trial. In this longitudinal study, data were collected in adults who lost > 5% weight in the past year (N = 870, complete data only, 68.7% female, 44.10 ± 11.86 years, 84.47 ± 17.03 kg) during their participation in a 12-month digital behavior change intervention. Weight and validated measures of motivational- and self-regulatory skills-related variables were collected at baseline, six- and 12 months. Change variables were used in Mplus' path analytical models informed by NoHoW's logic model. Results: The bivariate correlations confirmed key mediators' potential effect on weight outcomes in the expected causal direction. The primary analysis showed that a quarter of the variance (r2 = 23.5%) of weight regain prevention was achieved via the mechanisms of action predicted in the logic model. Specifically, our results show that supportive climate care is associated with needs satisfaction and intrinsic goal content leading to better weight regain prevention via improvements in self-regulatory skills and exercise-controlled motivation. The secondary analysis showed that more mechanisms of action are significant in participants who regained or maintained their weight. Conclusions: These results contribute to a better understanding of the mechanisms of action leading to behavior change in weight regain prevention. The most successful participants used only a few intrinsic motivation-related mechanisms of action, suggesting that habits may have been learned. While developing a digital behavior change intervention, researchers and practitioners should consider creating supportive climate care to improve needs satisfaction and intrinsic goal contents. Trial registration: ISRCTN, ISRCTN88405328 , registered 12/22/2016.The NoHoW study has received funding from the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement number 643309).info:eu-repo/semantics/publishedVersio

Prognostic Value of 12-Leads Electrocardiogram at Emergency Department in Hospitalized Patients with Coronavirus Disease-19

BackgroundElectrocardiogram (ECG) offers a valuable resource easily available in the emergency setting.ObjectiveAim of the study was to describe ECG alterations on emergency department (ED) presentation or that developed during hospitalization in SARS-CoV-2-infected patients and their association with 28-day mortality.MethodsA retrospective, single-center study including hospitalized patients with SARS-CoV-2 was conducted. ECG was recorded on ED admission to determine: heart rhythm, rate, and cycle; atrio-ventricular and intra-ventricular conduction; right ventricular strain; and ventricular repolarization. A specialized cardiologist blinded for the outcomes performed all 12-lead ECG analyses and their interpretation.Results190 patients were included, with a total of 24 deaths (12.6%). Age (p < 0.0001) and comorbidity burden were significantly higher in non-survivors (p < 0.0001). Atrial fibrillation (AF) was more frequent in non-survivors (p < 0.0001), alongside a longer QTc interval (p = 0.0002), a lower Tp-e/QTc ratio (p = 0.0003), and right ventricular strain (p = 0.013). Remdesivir administration was associated with bradycardia development (p = 0.0005) but no increase in mortality rates. In a Cox regression model, AF (aHR 3.02 (95% CI 1.03-8.81); p = 0.042), QTc interval above 451 ms (aHR 3.24 (95% CI 1.09-9.62); p = 0.033), and right ventricular strain (aHR 2.94 (95% CI 1.01-8.55); p = 0.047) were associated with higher 28-day mortality risk.ConclusionsQTc interval > 451 ms, right ventricular strain, and AF are associated with higher mortality risk in SARS-CoV-2 hospitalized patients. ECG recording and its appropriate analysis offers a simple, quick, non-expensive, and validated approach in the emergency setting to guide COVID-19 patients' stratification