The Gut Microbiome in Neuromyelitis Optica.

Neuromyelitis optica (NMO) is a rare, disabling, sometimes fatal central nervous system inflammatory demyelinating disease that is associated with antibodies ("NMO IgG") that target the water channel protein aquaporin-4 (AQP4) expressed on astrocytes. There is considerable interest in identifying environmental triggers that may elicit production of NMO IgG by AQP4-reactive B cells. Although NMO is considered principally a humoral autoimmune disease, antibodies of NMO IgG are IgG1, a T-cell-dependent immunoglobulin subclass, indicating that AQP4-reactive T cells have a pivotal role in NMO pathogenesis. When AQP4-specific proliferative T cells were first identified in patients with NMO it was discovered that T cells recognizing the dominant AQP4 T-cell epitope exhibited a T helper 17 (Th17) phenotype and displayed cross-reactivity to a homologous peptide sequence within a protein of Clostridium perfringens, a commensal bacterium found in human gut flora. The initial analysis of gut microbiota in NMO demonstrated that, in comparison to healthy controls (HC) and patients with multiple sclerosis, the microbiome of NMO is distinct. Remarkably, C. perfringens was the second most significantly enriched taxon in NMO, and among bacteria identified at the species level, C. perfringens was the one most highly associated with NMO. Those discoveries, along with evidence that certain Clostridia in the gut can regulate the balance between regulatory T cells and Th17 cells, indicate that gut microbiota, and possibly C. perfringens itself, could participate in NMO pathogenesis. Collectively, the evidence linking microbiota to humoral and cellular immunity in NMO underscores the importance for further investigating this relationship

Selecting social work students:lessons from research in Scotland

The issue of selection of students to social work programmes is one that remains highly contested. While it is clear that there is no single way of choosing the next generation of social work students, nevertheless, there are a number of strongly held beliefs about what ‘best practice’ means in this fraught field. These can be difficult to challenge, and even harder to shift, in spite of contrary evidence. This paper presents research conducted in Scotland in 2016 as part of the Scottish Government-sponsored Review of Social Work Education. The research set out to consider what selection processes were being used in Scotland and why; more fundamentally, it sought to explore the views of those involved in social work education alongside evidence about the outcomes of the selection processes (that is, data on student retention and success). The article concludes that while there is little evidence that one method of selection to social work programmes is intrinsically better than another, issues of fairness and transparency in selection, as well as diversity, remain pressing

Conceptual Hierarchies in a Flat Attractor Network: Dynamics of Learning and Computations

The structure of people’s conceptual knowledge of concrete nouns has traditionally been viewed as hierarchical (Collins & Quillian, 1969). For example, superordinate concepts (vegetable) are assumed to reside at a higher level than basic-level concepts (carrot). A feature-based attractor network with a single layer of semantic features developed representations of both basic-level and superordinate concepts. No hierarchical structure was built into the network. In Experiment and Simulation 1, the graded structure of categories (typicality ratings) is accounted for by the flat attractor network. Experiment and Simulation 2 show that, as with basic-level concepts, such a network predicts feature verification latencies for superordinate concepts (vegetable ). In Experiment and Simulation 3, counterintuitive results regarding the temporal dynamics of similarity in semantic priming are explained by the model. By treating both types of concepts the same in terms of representation, learning, and computations, the model provides new insights into semantic memory

Postactivation potentiation and change of direction speed in elite academy rugby players

This study investigated the effect of preceding pro-agility sprints with maximal isometric squats to determine if postactivation potentiation (PAP) could be harnessed in change of direction speed. Sixteen elite under-17 rugby union players (age: 16 +/- 0.41yrs; body mass: 88.7 +/- 12.1kg, height: 1.83 +/- 0.07m) from an Aviva Premiership rugby club were tested. Subjects performed a change of direction specific warm-up, followed by two baseline pro-agility tests. After 10 minutes recovery, 3 x 3-second maximal isometric squats with a 2 minute recovery between sets were completed as a conditioning activity (CA) on a force plate where peak force and mean rate of force development over 300 milliseconds were measured. The pro-agility test was repeated at set time intervals of 1, 3, 5 and 7 minutes following the CA. Overall pro-agility times were significantly slower (p < 0.05) at 1-minute post-CA compared to the baseline (3.3%), with no significant differences occurring at 3, 5 or 7 minutes post-CA. Therefore, it appears that performing multiple sets of maximal isometric squats do not enhance pro-agility performance

Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy

Ovarian cancer shows considerable heterogeneity in its sensitivity to chemotherapy both clinically and in vitro. This study tested the hypothesis that the molecular basis of this difference lies within the known resistance mechanisms inherent to these patients' tumours

Do fencers require a weapon-specific approach to strength and conditioning training?

There are three types of weapon used in Olympic fencing: the foil, épée and sabre. The aim of this study was to determine if fencers exhibited different physical characteristics across weapons. Seventy-nine male (n = 46) and female (n = 33) national standard fencers took part in this study. Fencers from each weapon (male and female), i.e., épée (n = 19 and 10), foil (n = 22 and 14) and sabre (n = 13 and 10) were (mean ± SD) 15.9 ± 0.7 years of age, 178.5 ± 7.9 cm tall, 67.4 ± 12.2 kg in mass and had 6.3 ± 2.3 years fencing experience; all were in regular training (~ 4 times per week). Results revealed that across all performance tests (lower body power, reactive strength index, change of direction speed and repeat lunge ability) there was no significant difference between weapons (p = 3.66). Differences were found however, when comparing genders, with males performing significantly better during the countermovement jump (p = 0.001), reactive strength index (p = 0.002), change of direction speed (p < 0.001) and repeat lunge ability (p < 0.001). The former findings may be due to similarities in bout intensity and time, movement types (lunging and changing direction) and the need to execute competition actions as explosively as possible. Based on the findings of the current study, it could be indicated that épée, foil and sabre fencers do not require a weapon specific approach to strength and conditioning training. Each fencer should target the area they are weakest at, rather than the area that they feel best represents the unique demands of their weapon