An innovative, remote supported problem-based learning model in a South African medical curriculum during the COVID‑19 pandemic

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Discovery of an Optical Jet in the BL Lac Object 3C 371

We have detected an optical jet in the BL Lac object 3C 371 that coincides with the radio jet in this object in the central few kpc. The most notable feature is a bright optical knot 3 arcsec (4 kpc) from the nucleus that occurs at the location where the jet apparently changes its direction by ~30 degrees. The radio, near-infrared and optical observations of this knot are consistent with a single power-law spectrum with a radio-optical spectral index alpha = -0.81. One possible scenario for the observed turn is that the jet is interacting with the material in the bridge connecting 3C 371 to nearby galaxies and the pressure gradient is deflecting the jet significantly.Comment: 11 pages, LaTeX, 4 figures (1 eps, 3 gifs), accepted for publication in ApJ Letter

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

SummaryTo test whether highly crossreactive αβ T cell receptors (TCRs) produced during limited negative selection best illustrate evolutionarily conserved interactions between TCR and major histocompatibility complex (MHC) molecules, we solved the structures of three TCRs bound to the same MHC II peptide (IAb-3K). The TCRs had similar affinities for IAb-3K but varied from noncrossreactive to extremely crossreactive with other peptides and MHCs. Crossreactivity correlated with a shrinking, increasingly hydrophobic TCR-ligand interface, involving fewer TCR amino acids. A few CDR1 and CDR2 amino acids dominated the most crossreactive TCR interface with MHC, including Vβ8 48Y and 54E and Vα4 29Y, arranged to impose the familiar diagonal orientation of TCR on MHC. These interactions contribute to MHC binding by other TCRs using related V regions, but not usually so dominantly. These data show that crossreactive TCRs can spotlight the evolutionarily conserved features of TCR-MHC interactions and that these interactions impose the diagonal docking of TCRs on MHC

Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo

The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutionarily selected retroviral restriction factors, both in terms of gene copy number and sequence diversity. Primate genomes encode seven A3 genes, and while A3F and 3G are widely recognized as important in the restriction of HIV, the role of the other genes, particularly A3A, is not as clear. Indeed, since human cells can express multiple A3 genes, and because of the lack of an experimentally tractable model, it is difficult to dissect the individual contribution of each gene to virus restriction in vivo. To overcome this problem, we generated human A3A and A3G transgenic mice on a mouse A3 knockout background. Using these mice, we demonstrate that both A3A and A3G restrict infection by murine retroviruses but by different mechanisms: A3G was packaged into virions and caused extensive deamination of the retrovirus genomes while A3A was not packaged and instead restricted infection when expressed in target cells. Additionally, we show that a murine leukemia virus engineered to express HIV Vif overcame the A3G-mediated restriction, thereby creating a novel model for studying the interaction between these proteins. We have thus developed an in vivo system for understanding how human A3 proteins use different modes of restriction, as well as a means for testing therapies that disrupt HIV Vif-A3G interactions

Low-lying level structure of 56^{56}Cu and its implications on the rp process

The low-lying energy levels of proton-rich $^{56}$Cu have been extracted using in-beam $\gamma$-ray spectroscopy with the state-of-the-art $\gamma$-ray tracking array GRETINA in conjunction with the S800 spectrograph at the National Superconducting Cyclotron Laboratory at Michigan State University. Excited states in $^{56}$Cu serve as resonances in the $^{55}$Ni(p,$\gamma$)$^{56}$Cu reaction, which is a part of the rp-process in type I x-ray bursts. To resolve existing ambiguities in the reaction Q-value, a more localized IMME mass fit is used resulting in $Q=639\pm82$~keV. We derive the first experimentally-constrained thermonuclear reaction rate for $^{55}$Ni(p,$\gamma$)$^{56}$Cu. We find that, with this new rate, the rp-process may bypass the $^{56}$Ni waiting point via the $^{55}$Ni(p,$\gamma$) reaction for typical x-ray burst conditions with a branching of up to $\sim$40$\%$. We also identify additional nuclear physics uncertainties that need to be addressed before drawing final conclusions about the rp-process reaction flow in the $^{56}$Ni region.Comment: 8 pages, accepted for Phys. Rev.

ALMA observations of lensed Herschel sources: testing the dark matter halo paradigm

With the advent of wide-area submillimetre surveys, a large number of high-redshift gravitationally lensed dusty star-forming galaxies have been revealed. Because of the simplicity of the selection criteria for candidate lensed sources in such surveys, identified as those with S500 μm > 100 mJy, uncertainties associated with the modelling of the selection function are expunged. The combination of these attributes makes submillimetre surveys ideal for the study of strong lens statistics. We carried out a pilot study of the lensing statistics of submillimetre-selected sources by making observations with the Atacama Large Millimeter Array (ALMA) of a sample of strongly lensed sources selected from surveys carried out with the Herschel Space Observatory. We attempted to reproduce the distribution of image separations for the lensed sources using a halo mass function taken from a numerical simulation that contains both dark matter and baryons. We used three different density distributions, one based on analytical fits to the haloes formed in the EAGLE simulation and two density distributions [Singular Isothermal Sphere (SIS) and SISSA] that have been used before in lensing studies. We found that we could reproduce the observed distribution with all three density distributions, as long as we imposed an upper mass transition of ∼1013 M⊙ for the SIS and SISSA models, above which we assumed that the density distribution could be represented by a Navarro–Frenk–White profile. We show that we would need a sample of ∼500 lensed sources to distinguish between the density distributions, which is practical given the predicted number of lensed sources in the Herschel surveys

Studying advanced mathematics in England: findings from a survey of student choices and attitudes

The UK Government has set a goal that the ‘vast majority’ of students in England will be studying mathematics to 18 by the end of the decade. The policy levers for achieving this goal include new Core Maths qualifications, designed for over 200,000 students who have achieved good grades at the age of 16 but then opt out of advanced or A-level mathematics. This paper reports findings from a cluster-sampled survey of over ten thousand 17-year-olds in England in 2015. Participants’ views on post-16 mathematics are presented and discussed. The main finding is that they are strongly opposed to the idea of compulsory mathematical study, but are less antithetical to being encouraged to study mathematics beyond 16. We consider how attitudes vary by gender, prior attainment, study patterns and future aspirations. The paper considers the implications of these findings in the current policy landscape

Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo

The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutionarily selected retroviral restriction factors, both in terms of gene copy number and sequence diversity. Primate genomes encode seven A3 genes, and while A3F and 3G are widely recognized as important in the restriction of HIV, the role of the other genes, particularly A3A, is not as clear. Indeed, since human cells can express multiple A3 genes, and because of the lack of an experimentally tractable model, it is difficult to dissect the individual contribution of each gene to virus restriction in vivo. To overcome this problem, we generated human A3A and A3G transgenic mice on a mouse A3 knockout background. Using these mice, we demonstrate that both A3A and A3G restrict infection by murine retroviruses but by different mechanisms: A3G was packaged into virions and caused extensive deamination of the retrovirus genomes while A3A was not packaged and instead restricted infection when expressed in target cells. Additionally, we show that a murine leukemia virus engineered to express HIV Vif overcame the A3G-mediated restriction, thereby creating a novel model for studying the interaction between these proteins. We have thus developed an in vivo system for understanding how human A3 proteins use different modes of restriction, as well as a means for testing therapies that disrupt HIV Vif-A3G interactions.United States. Public Health Service (Grant R01-AI-085015)United States. Public Health Service (Grant T32-CA115299 )United States. Public Health Service (Grant F32-AI100512

Critical literacy as a pedagogical goal in English language teaching

In this chapter, the authors provide an overview of the area of critical literacy as it pertains to second language pedagogy (curriculum and instruction). After considering the historical origins of critical literacy (from antiquity, and including in first language education), they consider how it began to penetrate the field of applied linguistics. They note the geographical and institutional spread of critical literacy practice as documented by published accounts. They then sketch the main features of L2 critical literacy practice. To do this, they acknowledge how practitioners have reported on their practices regarding classroom content and process. The authors also draw attention to the outcomes of these practices as well as challenges that practitioners have encountered in incorporating critical literacy into their second language classrooms