Teaching Indigenous children : listening to and learning from indigenous teachers

This article is based on the findings of a qualitative case study that examined the professional experiences and career pathways of fifty current and former Australian Indigenous teachers. Here, we draw on data obtained from semi-structured interviews with the teachers to highlight their knowledge in three key areas: ‘Indigenous ways of knowing’, ‘Indigenous learners’ lives beyond the classroom’ and ‘Building relationships with Indigenous students and communities’. We suggest that Indigenous teachers can potentially play important roles as teacher educators and as mentors to non-Indigenous teachers and preservice teachers. We argue that it is important for schooling systems and teacher education to create and formalise opportunities for non-Indigenous teachers and preservice teachers to listen to, and learn from their Indigenous colleagues

STUDENTS WITH AUTISM SPECTRUM DISORDER SUPPORT WHILE ATTENDING A FOUR-YEAR INSTITUTION OF HIGHER EDUCATION

The number of children being diagnosed with Autism Spectrum Disorder (ASD), an impairment that affects an individual’s social-communication abilities and behavior, is currently 1 in 68. An estimated 50,000 students who have ASD are reaching adulthood and exiting secondary education annually―a phenomenon known as the Autism Tsunami. There is a lack of services available to support this wave of young adults with ASD to be self-sustaining, contributing members of their communities. This is evidenced by the 37% of adults in their early 20s, who have ASD, and who have never worked or attended any postsecondary educational program. Due to the lack of appropriate accommodations in many of these programs, there is a low rate of completion for those who enroll. With an increase in positive educational outcomes in K-12 education, there are a burgeoning number of individuals holding the diagnosis of ASD able to enroll in postsecondary education at IHEs. For these students, the predicament of attending an IHE may pose unique challenges despite their ability to complete academic work. There is an ever-increasing need to support individuals with ASD while they attend IHEs, however there is a scant amount of emerging literature on this topic. This exploratory case study was conducted to gain an in-depth understanding of the ways in which Nathan, a student with ASD, was supported while he attended North Coast University (NCU), with the intent to inform further research, and affect the practice of service providers who work with students with ASD who are attending IHEs. The results of this study yielded an in-depth understanding of how NCU Disability Service providers, David and Richard, and Nathan’s mother, Sandy, supported him as he attended NCU, and of his lived experience of support. The Interactional Model of Disability, a model that views disability as caused by both the individual’s impairment and external environmental influences, was used as the theoretical lens in this study. The findings of this study are as follows. Although Nathan has incredible perseverance and academic ability, without support he would not have had the same level of success. The early proactive, nonacademic approach to supporting students with ASD used by NCU was instrumental in Nathan’s success and in helping him to become more independent. Coaching an intervention used as part of the NCU approach was highly effective for Nathan. David and Richard’s dedication to positive student outcomes played a role in Nathan’s success. Support from his mom was essential, but needed to be invisible. The ubiquitous nature of the issue of disclosure of disability emerged, as well as how Nathan experiences ASD

Teaching Indigenous Children: Listening To And Learning From Indigenous Teachers

This article is based on the findings of a qualitative case study that examined the professional experiences and career pathways of fifty current and former Australian Indigenous teachers. Here, we draw on data obtained from semi-structured interviews with the teachers to highlight their knowledge in three key areas: ‘Indigenous ways of knowing’, ‘Indigenous learners’ lives beyond the classroom’ and ‘Building relationships with Indigenous students and communities’. We suggest that Indigenous teachers can potentially play important roles as teacher educators and as mentors to non-Indigenous teachers and preservice teachers. We argue that it is important for schooling systems and teacher education to create and formalise opportunities for non-Indigenous teachers and preservice teachers to listen to, and learn from their Indigenous colleagues

The experiences of spirituality among adults with mental health difficulties: a qualitative systematic review

Aims Despite an increasing awareness of the importance of spirituality in mental health contexts, a ‘religiosity gap’ exists in the difference in value placed on spirituality and religion by professionals compared with service users. This may be due to a lack of understanding about the complex ways people connect with spirituality within contemporary society and mental health contexts, and can result in people’s spiritual needs being neglected, dismissed or pathologised within clinical practice. The aim of this qualitative systematic review is to characterise the experiences of spirituality among adults with mental health difficulties in published qualitative research. Methods An electronic search of seven databases was conducted along with forward and backward citation searching, expert consultation and hand-searching of journals. 38 studies were included from 4944 reviewed papers. The review protocol was pre-registered (PROSPERO:CRD42017080566). Results A thematic synthesis identified six key themes: Meaning-making (sub-themes: Multiple explanations; Developmental journey; Destiny versus autonomy), Identity, Service-provision, Talk about it, Interaction with symptoms (sub-themes: Interactive meaning-making; Spiritual disruption) and Coping (sub-themes: Spiritual practices; Spiritual relationship; Spiritual struggles; Preventing suicide), giving the acronym MISTIC. Conclusions This qualitative systematic review provides evidence of the significant role spirituality plays in the lives of many people who experience mental health difficulties. It indicates the importance of mental health professionals being aware of and prepared to support the spiritual dimension of people using services. The production of a theory-based framework can inform efforts by health-providers to understand and address people’s spiritual needs as part of an integrated holistic approach towards care

Scaling of Early Social Cognitive Skills in Typically Developing Infants and Children with Autism Spectrum Disorder

We delineate the sequence that typically developing infants pass tasks that assess different early social cognitive skills considered precursors to theory-of-mind abilities. We compared this normative sequence to performance on these tasks in a group of autistic (AUT) children. 86 infants were administered seven tasks assessing intention reading and shared intentionality (Study 1). Infants responses followed a consistent developmental sequence, forming a four-stage scale. These tasks were administered to 21 AUT children (Study 2), who passed tasks in the same sequence. However, performance on tasks that required following others’ eye gaze and cooperating with others was delayed. Findings indicate that earlier-developing skills provide a foundation for later-developing skills, and difficulties in acquiring some early social cognitive skills in AUT children

Bispectrum of the Sunyaev-Zel'dovich Effect

We perform a detailed study of the bispectrum of the Sunyaev-Zel'dovich effect. Using an analytical model for the pressure profiles of the intracluster medium, we demonstrate the SZ bispectrum to be a sensitive probe of the amplitude of the matter power spectrum parameter sigma_8. We find that the bispectrum amplitude scales as B_SZ ~ sigma_8^{11-12}, compared to that of the power spectrum, which scales as A_tSZ ~ sigma_8^{7-9}. We show that the SZ bispectrum is principally sourced by massive clusters at redshifts around z~0.4, which have been well-studied observationally. This is in contrast to the SZ power spectrum, which receives a significant contribution from less-well understood low-mass and high-redshift groups and clusters. Therefore, the amplitude of the bispectrum at l~3000 is less sensitive to astrophysical uncertainties than the SZ power spectrum. We show that current high resolution CMB experiments should be able to detect the SZ bispectrum amplitude with high significance, in part due to the low contamination from extra-galactic foregrounds. A combination of the SZ bispectrum and the power spectrum can sharpen the measurements of thermal and kinetic SZ components and help distinguish cosmological and astrophysical information from high-resolution CMB maps.Comment: 12 pages, 8 figures, published in The Astrophysical Journa

Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation

Discovering dominant epitopes for T cells, particularly CD4+ T cells, in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2-expressing patients with chronic beryllium disease (CBD), a debilitating granulomatous lung disorder characterized by accumulations of beryllium (Be)-specific CD4+ T cells in the lung. We discovered lung resident CD4+ T cells that expressed a disease-specific public CDR3β T cell receptor motif and were specific to Be-modified self-peptides derived from C-C motif ligands 4 (CCL4) and 3 (CCL3). HLA-DP2-CCL/Be tetramer staining confirmed that these chemokine-derived peptides represented major antigenic targets in CBD. Furthermore, Be induced CCL3 and 4 secretion in the lungs of mice and humans. In a murine model of CBD, the addition of LPS to Be oxide exposure enhanced CCL4 and CCL3 secretion in the lung and significantly increased the number and percentage of CD4+ T cells specific for the HLA-DP2-CCL/Be epitope. Thus, we demonstrate a direct link between Be-induced innate production of chemokines and the development of a robust adaptive immune response to those same chemokines presented as Be-modified self-peptides, creating a vicious cycle of innate and adaptive immune activation

Beryllium-specific CD4\u3csup\u3e+\u3c/sup\u3e T cells induced by chemokine neoantigens perpetuate inflammation

Discovering dominant epitopes for T cells, particularly CD4+ T cells, in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2–expressing patients with chronic beryllium disease (CBD), a debilitating granulomatous lung disorder characterized by accumulations of beryllium-specific (Be-specific) CD4+ T cells in the lung. We discovered lung-resident CD4+ T cells that expressed a disease-specific public CDR3β T cell receptor motif and were specific to Be-modified self-peptides derived from C-C motif ligand 4 (CCL4) and CCL3. HLADP2–CCL/Be tetramer staining confirmed that these chemokine-derived peptides represented major antigenic targets in CBD. Furthermore, Be induced CCL3 and CCL4 secretion in the lungs of mice and humans. In a murine model of CBD, the addition of LPS to Be oxide exposure enhanced CCL4 and CCL3 secretion in the lung and significantly increased the number and percentage of CD4+ T cells specific for the HLA-DP2–CCL/Be epitope. Thus, we demonstrate a direct link between Be-induced innate production of chemokines and the development of a robust adaptive immune response to those same chemokines presented as Be-modified self-peptides, creating a cycle of innate and adaptive immune activation

Prototyping the implementation of a suicide prevention protocol in primary care settings using PDSA cycles: a mixed method study

IntroductionIn Canada, approximately 4,500 individuals die by suicide annually. Approximately 45% of suicide decedents had contact with their primary care provider within the month prior to their death. Current versus never smokers have an 81% increased risk of death by suicide. Those who smoke have additional risks for suicide such as depression, chronic pain, alcohol, and other substance use. They are more likely to experience adverse social determinants of health. Taken together, this suggests that smoking cessation programs in primary care could be facilitators of suicide prevention, but this has not been studied.Study objectivesThe objectives of the study are to understand barriers/facilitators to implementing a suicide prevention protocol within a smoking cessation program (STOP program), which is deployed by an academic mental health and addiction treatment hospital in primary care clinics and to develop and test implementation strategies to facilitate the uptake of suicide screening and assessment in primary care clinics across Ontario.MethodsThe study employed a three-phase sequential mixed-method design. Phase 1: Conducted interviews guided by the Consolidated Framework for Implementation Research exploring barriers to implementing a suicide prevention protocol. Phase 2: Performed consensus discussions to map barriers to implementation strategies using the Expert Recommendations for Implementing Change tool and rank barriers by relevance. Phase 3: Evaluated the feasibility and acceptability of implementation strategies using Plan Do Study Act cycles.ResultsEleven healthcare providers and four research assistants identified lack of training and the need of better educational materials as implementation barriers. Participants endorsed and tested the top three ranked implementation strategies, namely, a webinar, adding a preamble before depression survey questions, and an infographic. After participating in the webinar and reviewing the educational materials, all participants endorsed the three strategies as acceptable/very acceptable and feasible/very feasible.ConclusionAlthough there are barriers to implementing a suicide prevention protocol within primary care, it is possible to overcome them with strategies deemed both acceptable and feasible. These results offer promising practice solutions to implement a suicide prevention protocol in smoking cessation programs delivered in primary care settings. Future efforts should track implementation of these strategies and measure outcomes, including provider confidence, self-efficacy, and knowledge, and patient outcomes

Evidence that abscisic acid promotes degradation of SNF1-related protein kinase (SnRK) 1 in wheat and activation of a putative calcium-dependent SnRK2

Sucrose nonfermenting-1 (SNF1)-related protein kinases (SnRKs) form a major family of signalling proteins in plants and have been associated with metabolic regulation and stress responses. They comprise three subfamilies: SnRK1, SnRK2, and SnRK3. SnRK1 plays a major role in the regulation of carbon metabolism and energy status, while SnRKs 2 and 3 have been implicated in stress and abscisic acid (ABA)-mediated signalling pathways. The burgeoning and divergence of this family of protein kinases in plants may have occurred to enable cross-talk between metabolic and stress signalling, and ABA-response-element-binding proteins (AREBPs), a family of transcription factors, have been shown to be substrates for members of all three subfamilies. In this study, levels of SnRK1 protein were shown to decline dramatically in wheat roots in response to ABA treatment, although the amount of phosphorylated (active) SnRK1 remained constant. Multiple SnRK2-type protein kinases were detectable in the root extracts and showed differential responses to ABA treatment. They included a 42 kDa protein that appeared to reduce in response to 3 h of ABA treatment but to recover after longer treatment. There was a clear increase in phosphorylation of this SnRK2 in response to the ABA treatment. Fractions containing this 42 kDa SnRK2 were shown to phosphorylate synthetic peptides with amino acid sequences based on those of conserved phosphorylation sites in AREBPs. The activity increased 8-fold with the addition of calcium chloride, indicating that it is calcium-dependent. The activity assigned to the 42 kDa SnRK2 also phosphorylated a heterologously expressed wheat AREBP